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이찬,이용환,이윤조,신재호,홍윤선,최홍주 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.3
이 연구는 새터민의 고용현황 및 문제점을 고찰하고 새터민의 기초직업능력을 진단하여 직업능력개발 방향에 있어 시사점을 제공하는데 그 목적이 있었다. 새터민의 기초직업능력 진단을 위한 도구는 관련 문헌 고찰과 pilot test 및 새터민 교육ㆍ지원 담당자의 안면타당도 검증 등을 통하여 개발되었다. 연구의 목적을 달성하기 위하여 현재 하나원에서 사회 적응교육 및 직업교육을 받고 있는 새터민의 기초직업능력을 진단함으로써 우리나라에 거주하는 새터민의 기초직업능력을 파악하였다. 주요 결과는 다음과 같다. 첫째,새터민들의 기초직업능력 중에서 직업윤리능력은 상당히 갖추어져 있는 것으로 인식하고 있으며,정보능력,즉 컴퓨터 사용능력은 상대적으로 낮은 수준으로 평가하고 있다. 둘째,성별에 따라서는 기초직업능력에 있어서 통계적으로 유의미한 차이를 보이지 않았다. 연령에 따라서는 정보능력과 수리 능력,조직이해능력 영역에 있어서 통계적으로 유의미한 차이를 보였다. 셋째,학력에 따라서는 문제해결능력과 의사소통능력,수리능력,대인관계 영역에 있어서 통계적으로 유의미한 차이를 보였다. 넷째,새터민의 취업을 위한 기초직업능력 개발에 있어 정보능력,수리능력,의사소통능력의 비중 확대,수준별ㆍ맞춤형 교육프로그램개발,새터민을 위한 취업 및 사업정보 제공 등을 제시하였다. The purpose of this study was to explore the current employment status and HRD issues of North Korean refugees and to assess their level of the basic vocational competencies. The assessment tool for the basic vocational competencies was developed based on literature reviews and pilot tests from the North Korean refugees. The face validity was verified by educators and counselors for the North Korean refugees. The major findings in this study were as follows: First, among the basic vocational competencies of the North Korean refugees, the level of vocational ethics was the highest and the level of information teachnology competency was the lowest. Second, the North Korean refugees' basic vocational competencies showed no statistical differences by gender. Territories of information competency, mathematical competency, and communication competency showed statistical differences by age. Third, territories of problem-solving competency, communication competency, mathematical competency, mathematical competency, and communication competency showed statistical differences by education level. Fourth, to develop the basic vocational competencies for North Korean refugees, the following suggestions were presented.; 1) extend the importance of information technology, mathematical, and communication competencies,; 2) develop the customized training programs by competency level,; and 3) offer the employment information for North Korean refugees.
콩 단백질/펙틴/몬모릴로나이트 나노복합 필름의 특성 및 산소 투과도 연구
정세환,김성철,조규순,신용섭,장상희,홍기헌,이태진,신부영 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2
In this study, Mechanical property, thermal property, watervapor, and oxygen permeability of biodegradable Soy protein/Pectin-montmorillonite nanocomposite, prepared with Na^(+)-MMT, have been studied. X-ray diffraction and TEM experiments an polymer/silicate composite samples demonstrated that the intercalation of polymer chains leads to increase in the spacing between silicate layers. In addition, it were found that the intercalated Soy protein/Pectin/montmorillonite nanocomposite were prepared. It was found that the addition of only a small of clay was enough to improve the thermal stability and mechanical property of Soy protein/Pectin/montmorillonite nanocomposite. watervapor of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin. oxygen permeability of Soy protein/Pectin/montmorillonite nanocomposite was generally lower than that of Soy protein/Pectin.
Antimicrobial Activity of a Halocidin-Derived Peptide Resistant to Attacks by Proteases
Shin, Yong Pyo,Park, Ho Jin,Shin, Seo Hwa,Lee, Young Shin,Park, Seungmi,Jo, Sungho,Lee, Yong Ho,Lee, In Hee American Society for Microbiology 2010 Antimicrobial Agents and Chemotherapy Vol.54 No.7
<B>ABSTRACT</B><P>Cationic antimicrobial peptides (AMPs) have attracted a great deal of interest as a promising candidate for a novel class of antibiotics that might effectively treat recalcitrant infections caused by a variety of microbes that are resistant to currently available drugs. However, the AMPs are inherently limited in that they are inevitably susceptible to attacks by proteases generated by human and pathogenic microbes; this vulnerability severely hinders their pharmaceutical use in human therapeutic protocols. In this study, we report that a halocidin-derived AMP, designated HG1, was found to be resistant to proteolytic degradation. As a result of its unique structural features, HG1 proved capable of preserving its antimicrobial activity after incubation with trypsin, chymotrypsin, and human matrix metalloprotease 7 (MMP-7). Additionally, HG1 was observed to exhibit profound antimicrobial activity in the presence of fluid from human skin wounds or proteins extracted from the culture supernatants of <I>Staphylococcus aureus</I> and <I>Pseudomonas aeruginosa</I>. Greater understanding of the structural motifs of HG1 required for its protease resistance might provide feasible ways to solve the problems intrinsic to the development of an AMP-based antibiotic.</P>
( Yong Suk Jo ),( Junsu Choe ),( Sun Hye Shin ),( Hyeon-kyoung Koo ),( Won-yeon Lee ),( Yu Il Kim ),( Seung Won Ra ),( Kwang Ha Yoo ),( Ki Suck Jung ),( Hye Yun Park ),( Yong-bum Park ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.1
Background: Fractional exhaled nitric oxide (FeNO) is regarded as a potential biomarker for identifying eosinophilic inflammation. We aimed to evaluate the clinical implication of FeNO and its influence on inhaled corticosteroids (ICS) prescription rate in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: FeNO level and its association with clinical features were analyzed. Changes in the prescription rate of ICS before and after FeNO measurement were identified. Results: A total of 160 COPD patients were divided into increased (≥25 parts per billion [ppb], n=74) and normal (<25 ppb, n=86) FeNO groups according to the recommendations from the American Thoracic Society. Compared with the normal FeNO group, the adjusted odds ratio for having history of asthma without wheezing and with wheezing in the increased FeNO group were 2.96 (95% confidence interval [CI], 1.40-6.29) and 4.24 (95% CI, 1.37-13.08), respectively. Only 21 out of 74 patients (28.4%) with increased FeNO prescribed ICS-containing inhaler and 18 of 86 patients (20.9%) with normal FeNO were given ICS-containing inhaler. Previous exacerbation, asthma, and wheezing were the major factors to maintain ICS at normal FeNO level and not to initiate ICS at increased FeNO level. Conclusion: Increased FeNO was associated with the history of asthma irrespective of wheezing. However, FeNO seemed to play a subsidiary role in the use of ICS-containing inhalers in real-world clinics, which was determined with prior exacerbation and clinical features suggesting Th2 inflammation.
( Yong Suk Jo ),( Hye Yun Park ),( Sun Hye Shin ),( Deog Kyeom Kim ),( Sang-heon Kim ),( Tae Rim Shin ),( Ki-Suck Jung ),( Kwang Ha Yoo ),( Ki-eun Hwang ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Inhaled corticosteroids (ICS) remain widely overused in clinical practice, even among patients with chronic obstructive pulmonary disease (COPD) who are less symptomatic and at low risk of future exacerbations. As most clinical trials have been performed in more symptomatic and higher-risk patients, evidence regarding treatment in patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A COPD are limited. We assessed the distribution of inhaler treatment and sought to investigate the association between ICS use and future exacerbation in this GOLD group A COPD patients. Methods Patients with GOLD group A COPD who received maintenance inhalers were identified from a multicenter, prospective cohort in the South Korea. Patients were categorized as group A when they had less symptom (mMRC 0-1 and CAT < 10) and did not experience severe exacerbation in the previous year. Development of moderate or severe exacerbation during 1-year followup was analyzed according to the baseline inhaler treatment. Results In 286 patients with GOLD group A COPD, mono-bronchodilator (37.8%), dual-bronchodilator (29.0%), triple therapy (17.5%) and ICS/long-acting beta-2 agonist (15.4%) were used (Figure 1). Compared to patients without ICS-containing inhaler (N = 191), those using ICS (N = 95) were more dyspneic, more likely to have asthma history, lower lung function, and bronchodilator response. During 1-year follow-up, moderate or severe exacerbations occurred in 66 of 286 (23.1%) patients. In multivariable logistic regression analysis, ICS-containing inhaler use was not associated with the development of exacerbation (Table 1). Even in subgroup with high probability of asthma-COPD overlap, this association was not significant. Conclusion Although about one third of patients with GOLD group A COPD was using ICS-containing inhalers, use of ICS was not associated with the reduction of future development of exacerbation.
Jo, Yong Gu,Shin, Eun Joo,Lee, Young Jae,Yoon, Won Sik,Han, Sung Soo,Lee, Yang Hun,Lee, Yong Rok,Noh, Seok Kyun,Gal, Yeong Soon,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.113 No.3
<P>To enhance the thermal stability of poly(vinyl alcohol) (PVA) fiber, the fiber was prepared from the gel spinning of high molecular weight (HMW) PVA by using dimethyl sulfoxide/water (8/2, v/v) as a solvent, accompanied with the cross-link by boric acid (B-PVA). In addition, the structure and properties of the B-PVA fiber were compared with those of the HMW PVA fiber obtained by using the same spinning system without cross-linking (NB-PVA). Through a series of experiments, it turned out that cross-linking actualized by an optimum amount of boric acid (0.3 wt % based on PVA) and zone drawing caused significant changes in the properties of HMW PVA gel fiber. That is, cross-linking increased thermal degradation temperatures at each degradation step and amounts of final residues, resulting in improving thermal properties of the PVA fiber. On the contrary, it was found that in the case of the B-PVA fiber, some broadening of the original PVA unit cell occurred, which was identified by the peak shift to lower angle in X-ray diffractogram. The tensile strength and Young's modulus of B-PVA fiber with draw ratio of 15 are 23.1 and 308.3 g/d, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>
Chung, Yong Sik,Kang, Sung Il,Kwon, Oh Wook,Shin, Dong Soo,Lee, Se Geun,Shin, Eun Joo,Min, Byung Gil,Bae, Han Jo,Han, Sung Soo,Jeon, Han Yong,Noh, Seok Kyun,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of applied polymer science Vol.106 No.5
<P><B>Abstract</B></P><P>To prepare hydroxyapatite (HA)/poly(vinyl alcohol) (PVA) composite fibers with high processibility applicable to various biomedical fields, HA/PVA composite powders were synthesized through a coprecipitation method and then mixed with pure PVA in dimethyl sulfoxide at 90°C for 2 h to prepare wet‐spinning dopes. HA/PVA solutions with HA contents of 0, 1, 3, 5, 10, and 15 wt % were analyzed with a rheometer to elucidate the effect of HA particles on the shear viscosities of the spinning dopes. The spinning dopes with pure PVA and an HA/PVA concentration of 12 wt % showed non‐Newtonian flow behaviors, and as the HA content increased from 1 to 15 wt %, the shear viscosities increased simultaneously because of the complex formation between PVA chains, citric acid, and HA particles acting as crosslinkers. The increased viscosities of the spinning dopes diminished the breakage of PVA fibers and enhanced the spinnability. Through the addition of citric acid interacting with both PVA and HA particles, the aggregation of HA particles was suppressed, and it was possible to prepare HA/PVA composite fibers with smooth surfaces. An adequate amount of HA in the PVA fibers improved the thermal and mechanical properties of the fibers because uniformly dispersed HA particles interacting with PVA chains through hydrogen bonding in the PVA matrix complemented the structural defects. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007</P>