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조리 방법에 따른 고구마줄기의 Phytochemical 함량과 항산화 활성 비교
양세희, 정혜진, 성예지, 이하나, 이세윤, 양진우, 이준수 忠北大學校 農業科學硏究所 2017 農業科學硏究 Vol.33 No.1
Vegetable consumption is associated with health benefits. Recently, the interest in these food groups has grown among due to the identification of new compound in their chemical composition. Most of the vegetables are cooked by blanching, boiling, steaming, microwaving before consumed. These cooking processes may change not only food physical characteristics but also chemical composition. The present study was undertaken to investigate the effect of different cooking methods on phytochemical content and antioxidant capacity in Ipomoea batatas (L.) Lam stem. The result of study, Total polyphenol of phytochemical in Ipomoea batatas (L.) Lam stem was 6.88-12.65 mg GAE/100 g and flavonoid was 3.16-10.46 mg CE/100 g. Compared with the raw of Ipomoea batatas (L.) Lam stem, all cooking methods were found to significant correlations between the antioxidant activity assessed by ABTS, DPPH and polyphenol(p<0.05). These results can be provide the basic data how to prevent lose of nutrition in Ipomoea batatas (L.) Lam stem when cooking.
Yang, Sehee,Kwon, Kisung,Choi, Jangduck,Jo, Cheon-Ho 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.3
Chloropropanols such as 3-monochloropropane-1,2-diol (3-MCPD) and 1,3-dichloropropan-2-ol (1,3-DCP) are produced by heat treatment in the presence of fat and hydrochloric acid during the manufacture of food stuffs such as hydrolyzed vegetable protein and soy sauce. 3-MCPD and 1,3-DCP have been detected in several foods. An efficient, highly selective GC-MS method was developed to determine the concentration of 3-MCPD and 1,3-DCP in food. Calibration curves for 3-MCPD and 1,3-DCP were constructed, and a correlation of determination $(r^2){\geq}0.9990$ was obtained. The limits of detection and quantitation for 3-MCPD in food were 0.6 and $2.0{\mu}g/kg$, respectively, and those for 1,3-DCP were 0.2 and $0.6{\mu}g/kg$, respectively. To the best of our knowledge, this GC-MS-based method is a newly improved analytical procedure for the simultaneous separation and determination of 3-MCPD and 1,3-DCP, at once and at low levels (${\mu}g/kg$).
조세희 ( Sehee Jo ),김태준 ( Tae Jun Kim ),이혁 ( Hyuk Lee ),민양원 ( Yang Won Min ),민병훈 ( Byung-Hoon Min ),이준행 ( Jun Haeng Lee ),손희정 ( Hee Jung Son ),이풍렬 ( Poong-Lyul Rhee ),백선영 ( Sun-Young Baek ),김선우 ( Sun Woo 대한소화기학회 2018 대한소화기학회지 Vol.71 No.1
Background/Aims: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. Methods: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants. The associations between allergies and gastric cancer were analyzed using univariable and multivariable logistic regression analyses with complex sampling, while adjusting for confounding factors that included age, sex, body mass index, smoking status, alcohol intake, and level of education. Results: Multivariable logistic regression analyses that were adjusted for the potential confounders determined that a history of allergic diseases tended to be associated with reduced risk of gastric cancer; however, this relationship was not statistically significant (any allergy: odds ratio [OR], 0.62; 95% confidence interval [CI], 0.34-1.12; atopic dermatitis: OR, 0.34; 95% CI, 0.50-1.72; allergic rhinitis: OR, 0.71; 95% CI, 0.34-1.46; asthma: OR, 0.44; 95% CI, 0.15-1.29). Multivariable analysis showed that a history of atopic dermatitis was associated with reduced risk of gastric cancer in men (OR, 0.16; 95% CI, 0.03-0.75). Conclusions: This findings of this study suggest that individuals with allergies tend to have a reduced risk of gastric cancer, without a statistically significant association. Furthermore, atopic dermatitis was associated with reduced risk of gastric cancer, particularly in men. (Korean J Gastroenterol 2018;71:38-44)
퍼지 추론을 이용한 임플란트 상부구조물 선택 전문가시스템 개발
이세희(Sehee Lee),양정삼(Jeongsam Yang) (사)한국CDE학회 2012 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2012 No.2
Dental implant is a medical operation used to restore functions of teeth where they are damaged or not exist. In this study was implemented that the dentist can choose expert system for Best Selection of Dental Implant Abutments more systematically. The system was that based on anatomical information and included rules for selection abutment. And also considered both the patient"s physical and anatomical at the same time. Implementation that the E"s Abutment product information, classify the type of fuzzy rule base and practices based on statistics case base were stored in the expert system program. Deduced from the analysis of the results window, as a result of the CAD system to model is visualized through CAD Modeling Viewer.
이세희(Sehee Lee),양정삼(Jeongsam Yang) (사)한국CDE학회 2011 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2011 No.1
Long time ago the purpose of dental implants were not for recovery such as natural teeth, but now in the area has been progressing rapidly of the tooth damage, anodontia and masticatory movement for recovery. Dental implants function and esthetics was also an important factor. Dental implant is composed of Fixture and Abutment and Crown, in past studies were intended to focus attention on osseointegration with Fixture to success rate of surgery, while the current aesthetic other natural teeth and good match that has been placing emphasis on Abutment. Accordingly, Abutment has various designs of type and size of model name. The dentist should choose the most appropriate Abutment considering the radiographic images of the patient. In this study was implemented that the dentist can choose expert system for Best Selection of Dental Implant Abutments more systematically. The system was that based on anatomical information and included rules for selection abutment. And also considered both the patient"s physical and anatomical at the same time. Implementation that the E"s Abutment product information, classify the type of fuzzy rule base and practices based on statistics case base were stored in the expert system program. Deduced from the analysis of the results window, as a result of the CAD system to model is visualized through CAD Modeling Viewer.
Lee Eunyoung,Park Sehee,Choi Jae-Phil,Kim Min-Kyung,Yang Eunmi,Ham Sin Young,Lee Seungjae,Lee Bora,Yang Jeong-Sun,Park Byoung Kwon,Kim Da Sol,Lee So-Young,Lee Joo-Yeon,Jang Hee-Chang,Jeon Jaehyun,Park 대한의학회 2023 Journal of Korean medical science Vol.38 No.8
Background: Information on the effectiveness of nirmatrelvir/ritonavir against the omicron is limited. The clinical response and viral kinetics to therapy in the real world need to be evaluated. Methods: Mild to moderate coronavirus disease 2019 (COVID-19) patients with risk factors for severe illness were prospectively enrolled as a treatment group with nirmatrelvir/ritonavir therapy versus a control group with supportive care. Serial viral load and culture from the upper respiratory tract were evaluated for seven days, and clinical responses and adverse reactions were evaluated for 28 days. Results: A total of 51 patients were analyzed including 40 in the treatment group and 11 in the control group. Faster symptom resolution during hospitalization (P = 0.048) was observed in the treatment group. Only minor adverse reactions were reported in 27.5% of patients. The viral load on Day 7 was lower in the treatment group (P = 0.002). The viral culture showed a positivity of 67.6% (25/37) vs. 100% (6/6) on Day 1, 0% (0/37) vs. 16.7 (1/6) on Day 5, and 0% (0/16) vs. 50.0% (2/4) on Day 7 in the treatment and control groups, respectively. Conclusions: Nirmatrelvir/ritonavir against the omicron was safe and resulted in negative viral culture conversion after Day 5 of treatment with better symptomatic resolution.
Lee, Kang-Yo,Oh, Sehee,Choi, You-Jin,Oh, Seon-Hee,Yang, Young-Su,Yang, Mi-Jin,Lee, Kyuhong,Lee, Byung-Hoon Oxford University Press 2013 Toxicological sciences Vol.136 No.1
<P>Amiodarone, bi-iodinated benzofuran derivative, is one of the most frequently prescribed and efficacious antiarrhythmic drugs. Despite its low incidence, amiodarone-induced pulmonary toxicity is of great concern and the leading cause of discontinuation. Autophagy is an essential homeostatic process that mediates continuous recycling of intracellular materials when nutrients are scarce. It either leads to a survival advantage or initiates death processes in cells under stress. In the present study, we investigated the role of autophagy in amiodarone-induced pulmonary toxicity. Amiodarone treatment–induced autophagy in H460 human lung epithelial cells and BEAS-2B normal human bronchial epithelial cells was demonstrated by increased LC3-II conversion, <I>Atg7</I> upregulation, and autophagosome formation. Autophagic flux, as determined by the lysosomal inhibitor bafilomycin A1, was also increased following amiodarone treatment. To determine the role of autophagy in amiodarone toxicity, amiodarone-induced cell death was evaluated in the presence of 3-methyladenine or by knocking down the autophagy-related genes <I>Atg7</I>. Inhibition of autophagy decreased cellular viability and significantly increased apoptosis. Intratracheal instillation of amiodarone in rats increased the number of inflammatory cells recovered from bronchoalveolar lavage fluid, and periodic acid-Schiff-positive staining in bronchiolar epithelial cells. However, induction of autophagy by rapamycin treatment inhibited amiodarone-induced pulmonary toxicity. In conclusion, amiodarone treatment induced autophagy, which is involved in protection against cell death and pulmonary toxicity.</P>