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뮤코펙트 정(염산암브록솔 30mg)에 대한 암브렉트 정의 생물학적 동등성
유정연,정선경,최미희,한상범,이경률,이희주 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3
A bioequivalence study of Ambrect^(™) tablets (Dong Wha Pharm. Ind. Co., Ltd.) to Mucopect^(™) tablets(Boe-hringer Ingelheim Korea, Ltd.) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the ambroxol hydorchoride dose of 30 ㎎ in a 2×2 crossover study. There was a one-week wash out period between the doses. Plasma concentrations of ambroxol were monitored by a high-performance liquid chromatography for over a period of 24 hours after the administration. Aug_(t)(the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compilied from the plasma concentraction-time data. Analysis of variance was carried out using logarithmically transformed AUC_(T) and C_(max). No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the AUC_(t) ratio and the C_(max) ratio for Ambrect^(™)/Mucopect^(™) were 0.89-1.01 and 0.89-1.02, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstarated the bioequivalence of Ambrect^(™) and Mucopect^(™) with respect to the rate and extent of absorption.
유남재,정길수,박병수,김경수 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B
Centrifuge model experiments were performed to investigate the confining effects of the sheet piles, installed to the sides of soft clay ground treated with sand compaction piles, on the bearing capacity and concentration ratio of composite ground. For the given g-level in the centrifuge model tests, replacement ratio of SCP and the width of surcharge loads on the surface of ground with SCP, the confining effects of installing the sheet piles on the edges of SCP ground on the bearing capacity, change of stress concentration ratio and failure mechanism were investigated. Kaolin, one of typical clay mineral, and Jumunjin standard sand were used as a soft clay ground and sand compaction pile irrespectively. As results of experiments, lateral confining effect by inserting the model sheet piles fixed to the loading plate was observed. For the strip surcharge loading condition, the yielding stress intensity in the form of the strip surcharge loads tends to increase with increasing the embedded depth of sheet piles. The stress concentration ratio was found not to be influenced consistently with the embedded depth of sheet piles whereas the effect of stress intensity on stress concentration ratio shows the general trend that values of stress concentration ratio are relatively high at the initial stage of loading and tend to decrease and converge to the certain values. For the failure mechanism in the case of reinforced with sheet piles, displacement behavior related to the punching failure, settlement right beneath the loading plate occurred since the soil was confined with sheet piles, was observed.
유영삼,우훈영,조경래,최정환 인제대학교 2008 仁濟醫學 Vol.29 No.-
Fibrous dysplasia is a rare fibroosseous lesion characterized by replacement of normal spongiosa and filling of the medullary cavity of affected bones by an abnormal fibrous tissue. the skeletal structure. Its appearance in infancy is extremely rare. The authors report a case of maxillary fibrous dysplasia observed in a 36 days old infant as a left maxillary swelling. Excisional biopsy was performed to confirm diagnosis. At 1 year follow up, no new growth has been observed without further treatment. This is the youngest case never reported at any references.
유경미,김세희,장정화,황인경,김경임,김성수,김영찬 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1
In order to develop a dandelion (Taraxacum officinale) with natural food applications, the effects of dandelion leaves and roots powder content on the physical, textural and sensory properties of sulggidduk were examined. Dandelion powders of leaves and roots at 0, 1, 2 and 3% were added to the dandelion sulgidduk. In the dandelion roots powder in sulgidduk, the color intensity of L values and the values and moisture content decreased however, the sensory color intensity, dandelion flavor and overall acceptability increased with increasing the dandelion powder content. The sensory overall acceptability indicated the dandelion roots powder content at 3% had the highest overall and flavor scores. As the dandelion leaves content was increased, the moisture contents, lightness, adhesiveness and cohesiveness of sulggidduk decreased, while the sensory color intensity, sensory hardness, hardness of texture properties and dandelion flavor increased. The addition at 1% of the dandelion leaves powder content with the dandelion sulggidduk and the addition at 3% of the dandelion roots powder content with the dandelion sulggidduk showed the highest overall acceptability.
유영삼,우훈영,조경래,최정환 인제대학교 2008 仁濟醫學 Vol.29 No.-
An accessory ostium can be found in the posterior fontanelle of the maxillary sinus during endoscopic examination of the nasal cavity in approximately one quarter of patients. It is not uncommon to find an accessory ostium in a CT scan. Recently, we removed a polyp from inferior meatus of a thirteenyears old girl. After polypectomy, we found accessory ostium of maxillary sinus in the inferior meatus. As far as we know, this is the first case of ectopic accessory ostium of maxillary sinus.
유종수,방면호,정해곤,정태숙,최명숙,이경태,김세영,백남인 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1
강화 특화작목의 건강기능성 식품 제품화의 가능성을 타진하고 재배작물의 표준화 연구를 위해 사자발쑥, 싸주아리쑥 그리고 순무에 대해 총 폴리페놀과 총 플라보노이드 함량을 측정하였다. 총 폴리페놀 함량은 사자발쑥이 9.5mg/g, 싸주아리쑥이 7.4mg/g, 순무가 1.8mg/g으로 총 플라보노이드 함량은 사자발쑥이 4.3mg/g, 싸주아리쑥이 3.6mg/g, 순무가 0.4mg/g으로 확인 되었다. 또한 강화 약쑥의 유효지표성분인 eupatilin과 jaceosidin이 사자발쑥에는 각각 208mg/100g, 118mg/100g, 싸주아리쑥에는 199mg/100g, 111mg/100g 함유된 것을 HPLC를 통해 확인하였다. This study was conducted to investigate the contents of total polyphenol and total flavonoid of three Ganghwa indigenous crops, two varieties of Artemisia princeps Pampanini (Sajabalssuk, Sajuarissuk) and Brassica campestris ssp rapa. Total polyphenol and total flavonoid contents of Sajabalssuk were 9.5 and 4.3 mg/g, those of Sajuarissuk were 7.4 and 3.6 mg/g, those of B. campestris ssp rapa were 1.8 and 0.4 mg/g, respectively. The contents of eupatilin and jaceosidin in A. princeps Pampanini which were calculated by HPLC, were determined 208 mg/100g, 118 mg/100g in Sajabalssuk and 199 mg/100g, 111 mg/100g in Sajuarissuk, respectively.
싸주아리쑥(Artemisia herba)으로부터 phytol의 분리
유종수,방면호,정해곤,정태숙,최명숙,이경태,백남인 경희대학교식량자원개발연구소 2006 硏究論文集 Vol.25 No.-
싸주아리쑥 지상부의 80% MeOH 추출물로부터 얻어진 EtOAc 분획물에 대하여 silica gel 및 ODS column chromatography를 반복하여 diterpene을 분리하였다. 화합물의 화학구조는, NMR, MS 및 IR 등의 스펙트럼을 해석하여 phytol로 동정하였다. The aerial part of Artemisia herba was extracted with 80% aqueous MeOH and the concentrated extract was partitioned with EtOAc, n-BuOH and H_(2)O, successively. From the EtOAc fraction, a terpenoid was isolated through the repeated silica gel and ODS column chromatographies. From the result of physico-chemical data including NMR, MS and IR, the chemical structure of the compound was determined as phytol.
유영삼,우훈영,조경래,최정환 인제대학교 2008 仁濟醫學 Vol.29 No.-
Benign symmetric lipomatosis is a rare disease. Its main characteristic is the symmetric massive deposits of adipose tissue, in unencapsulated form, predominatly on the neck, shoulder, back and upper exterimities. We report a case of a sixty one years old man with benign symmetric lipomatosis. He had a history of alcoholic liver cirrhosis. Due to cosmetic defomity, he wanted surgical treatment. We did a cervical lipectomy. He was satisfied with the result, and there was no evidence of recurrence.