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Xinyu Guan,Yanyan Hu,Zengwang Jin,Kaixiang Peng 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.10
This paper is focused on the finite-time sliding mode fault-tolerant control problem for a class of discrete networked control systems with intermittent fault and time-varying delay under the event-triggered scheme. The intermittent fault is described as a randomly occurring fault obeying a Bernoulli distribution. The event-triggered mechanism is introduced to determine the transmission of signal, which can conserve communication resources and reduce network burdens. By means of the sliding mode observer method, a linear sliding mode function is constructed by employing the estimated state and fault information. Based on Lyapunov stability theory, sufficient criteria are derived, which can ensure the closed-loop system is finite-time bounded with pre-specified H∞ performance requirement satisfied. Then, the event-triggered observer-based sliding mode fault-tolerant controller is established to force the system state trajectories onto a pre-set sliding mode region. Afterward, the solvability of the non-convex problem is studied by testifying the feasibility of a minimization problem. Finally, a practice simulation result is provided to illustrate the effectiveness of the proposed theoretical results.
Protective activities of probiotics in letrozole-induced polycystic ovarian syndrome (PCOS) rats
Xinyu Li,Chenyang Xie,Qiuping Huang,Eun Mi Hwang,Bin Jin,Zhewen Dong,Zhen Zeng,Wen He,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of Bifidobacterium, C. butyricum and L. plantarum on the letrozole induced PCOS rats. All female SD rats were randomly divided into five groups, modeling PCOS rats, and respectively given intragastric administration of Bifidobacterium, C. butyricum, and L. plantarum solution (1×10<SUP>9</SUP> CFU/mL) for 30 days, and observed body weight (BW). The serum levels of testosterone (T), LH, E2, FSH, INS, TG, TC, LDL, HDL were determined by ELISA kits. The levels of TGF-β1, smad4, smad3, p-smad3, p-smad2, smad2 were detected by Western Blotting. Compared with normal group, the BW, T, LH, INS, TG, TC LDL-C in PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. Administrated with different probiotics can decrease the BW, T, LH, INS, TG, TC,LDL-C, and the levels of E2, FSH and HDL-C increased in PCOS rats. All probiotics significantly decreased the expression of p-smad2, p-smad3, smad4, TGF-β1. Our results showed that Bifidobacterium, C. butyricum and L. plantarum were all effective in regulating hormone levels, improving IR and dyslipidemia, and improving ovarian fibrosis in PCOS rats.
Long Jin,Nan Shen,Xinyu Wen,Weidong Wang,Sun Woo Lim,양철우 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.3
Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluated the effects of CTLA4-Ig on TAC-induced renal injury in terms of oxidative stress. Methods: In vitro study was performed to assess the effect of CTLA4-Ig on TAC-induced cell death, reactive oxygen species (ROS), apoptosis, and the protein kinase B (AKT)/forkhead transcription factor (FOXO) 3 pathway in human kidney 2 cells. In the in vivo study, the effect of CTLA4-Ig on TAC-induced renal injury was evaluated using renal function, histopathology, markers of oxidative stress (8-hydroxy-2’-deoxyguanosine) and metabolites (4-hydroxy-2-hexenal, catalase, glutathione S-transferase, and glutathione reductase), and activation of the AKT/FOXO3 pathway with insulin-like growth factor 1 (IGF-1). Results: CTLA4-Ig significantly decreased cell death, ROS, and apoptosis caused by TAC. TAC treatment increased apoptotic cell death and apoptosis-related proteins (increased Bcl-2-associated X protein and caspase-3 and decreased Bcl-2), but it was reversed by CTLA4-Ig treatment. The activation of p-AKT and p-FOXO3 by TAC decreased with CTLA4-Ig treatment. TAC-induced renal dysfunction and oxidative marker levels were significantly improved by CTLA4-Ig in vivo. Concomitant IGF- 1 treatment abolished the effects of CTLA4-Ig. Conclusions: CTLA4-Ig has a direct protective effect on TAC-induced renal injury via the inhibition of AKT/FOXO3 pathway.
Zhao, Xinyu,Song, Sung-Jin,Kim, Hak-Joon,Gang, Tie,Kang, Suk-Chull,Choi, Yong-Hwan,Kim, Kyung-Cho,Kang, Sung-Sik The Korean Society for Nondestructive Testing 2007 한국비파괴검사학회지 Vol.27 No.3
Ultrasonic inspection of austenitic steel weldments is a truly difficult task due to complicated wave propagation phenomena such as beam skewing, splitting and distortion. In order to understand these phenomena and design proper inspection procedures, simulation is increasingly paid more attention to. This article addresses a ray tracing based approach to determine incident angle and position of optimal wave mode ultrasonic beam for flaw detection in anisotropic and inhomogeneous austenitic steel weldments. Specially, the optimal mode of ultrasonic wave wave is selected by ray tracing simulation, and an optimization approach based on ray tracing and bi-section search is proposed in order to find the ray path connecting two given points in weldments. With help of this approach, the optimal incident angle and position of ultrasonic beam can be determined for a given flaw position.
Generation, purification and engineering of extracellular vesicles and their biomedical applications
Gao, Jin,Dong, Xinyue,Wang, Zhenjia Elsevier 2020 Methods Vol.177 No.-
<P><B>Abstract</B></P> <P>Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be excellent therapeutics and drug carriers. Although EVs are promising, the process to develop high-quality and scalable EVs for their translation is demanding. Within this research, we analyzed the production of EVs, their purification and their post-bioengineering, and we also discussed the biomedical applications of EVs. We focus on the developments of methods in producing EVs including biological, physical, and chemical approaches. Furthermore, we discuss the challenges and the opportunities that arose when we translated EVs in clinic. With the advancements in nanotechnology and immunology, genetically engineering EVs is a new frontier in developing new therapeutics in order to tailor to individuals and different disease stages in treatments of cancer and inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Scalability and high-quality of production of EVs is critical to their translation. </LI> <LI> The biomedical applications of EVs will be discussed. </LI> <LI> The challenges and opportunities of EVs in translation will be discussed. </LI> <LI> Genetically engineering EVs is a new direction to develop personalized medicine. </LI> </UL> </P>
Haoen Xu,Jin Huang,Xinyu Xu,Junqiang Zheng 한국자기학회 2023 Journal of Magnetics Vol.28 No.3
This paper presents how to select the proper slot and pole combination (SPC) and reasonable rotor topologies for an interior permanent-magnet (IPM) machine. Firstly, the selection principle of SPC is reported, and some electromagnet performances, including winding factor, stator space magneto-motive force (MMF) harmonics, radial force harmonics, and cogging torque, are analyzed and compared. Secondly, four PM rotor topologies are designed and discussed, including surface permanent-magnet (SPM), spoke type, V-shape, and multi-layer reluctance (MR) type. Their performances, such as back-EMFs, torque, and ripple and flux-weakening capability, are thoroughly analyzed and compared by the finite-element method (FEM). Finally, a 27-slot and 8-pole V-shape IPM machine is selected and designed optimally, which offers high power/torque density, high efficiency, and less torque ripple. In order to ensure the reliability of its rotor mechanical strength, the equivalent stress and deformation are analyzed by ANASY. Besides, its d-q axis mathematical model is built to verify its performance further. Then experiments on the prototypes are carried out for validation.
중국소비자의 지속가능 패션 소비 결정요인 연구 - 계획된 행동이론을 중심으로 -
후신위 ( Hu Xinyu ),정소원 ( So Won Jeong ),김은혜 ( Eunhye Kim ),이진화 ( Jin-hwa Lee ) 한국의류산업학회 2021 한국의류산업학회지 Vol.23 No.4
In the context of Sustainable development, China, the world's second-largest apparel market, is also concerned about the environmental impact of fiber waste. Currently, there is a great interest in sustainable fashion in both supply and demand in China. Based on the theory of planned behavior(TPB), the determinants of sustainable fashion consumption( SFC) of Chinese consumers were evaluated in this study: man-nature orientation(MNO) and environmental knowledge(EK) as motivation and perceived online-store accessibility(POA) and perceived money availability(PMA) as barriers. Wenjuanxing, a Chinese professional survey collection agency, conducted an online survey of millennials in Shanghai, China. The final sample size for the survey was 215. Partial least squares structural equation modeling was employed to test the proposed hypotheses. The results indicated that attitudes, subjective norms, and perceived behavioral control significantly affected the purchase intention towards sustainable fashion products. MNO and EK influenced the attitude, whereas EK, POA, and PMA influenced perceived behavioral control. This study contributes to the TPB literature through the examination of four antecedents: MNO, EK, POA, and PMA. The findings provide valuable insights for retailers and markets based on the identification of the motivations and barriers that enhance the purchasing intention of Chinese millennials toward SFC.