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Xiangyu Huang,Zhen Huang,Xiaoyong Xu,Wan Li,Zhijian Jin 한국초전도.저온공학회 2019 한국초전도저온공학회논문지 Vol.21 No.4
The critical current is one of the key parameters of high temperature superconducting (HTS) racetrack coils. Therefore, it is significant to calculate critical currents of HTS coils. This paper introduces a fast iterative algorithm for calculating the critical current of second generation (2G) HTS coils. This model does not need to solve long charging transients which greatly reduced the amount of calculation. To validate this model, the V-I curve of four 2G HTS double racetrack coils are measured. The effect of the silicon steel sheet on the critical current of the racetrack coil is also studied based on this algorithm.
Effective 3-D FEM for large-scale high temperature superconducting racetrack coil
Xiangyu Huang,Zhen Huang,Xiaoyong Xu,Wan Li,Zhijian Jin 한국초전도.저온공학회 2019 한국초전도저온공학회논문지 Vol.21 No.3
In various types of large-scale electrical applications, the number of coil turns in such machines is usually large. Electromagnetic simulation of large-scale superconducting coils (tens to hundreds of turns) is indispensable in the design process of superconducting electrical equipment. However, due to the large scale of the coil and the large aspect ratio of super-conducting material layer in HTS coated conductor, it is usually difficult or even unable to perform 3-D transient electromagnetic simulation. This paper introduces an effective 3-D electromagnetic simulation method for large-scale HTS coated conductor coil based on T-A formulation. The simulation and experimental results show that the 3-D model based on the T-A formulation using homogeneous strategy is more accurate than the traditional 2-D models. The memory usage is not sensitive to the number of turns and this model will be even more superior as the number of turns becomes larger.
Huang, Xiangyu,Huang, Zhen,Xu, Xiaoyong,Li, Wan,Jin, Zhijian The Korea Institute of Applied Superconductivity a 2019 한국초전도저온공학회논문지 Vol.21 No.4
The critical current is one of the key parameters of high temperature superconducting (HTS) racetrack coils. Therefore, it is significant to calculate critical currents of HTS coils. This paper introduces a fast iterative algorithm for calculating the critical current of second generation (2G) HTS coils. This model does not need to solve long charging transients which greatly reduced the amount of calculation. To validate this model, the V-I curve of four 2G HTS double racetrack coils are measured. The effect of the silicon steel sheet on the critical current of the racetrack coil is also studied based on this algorithm.
Effective 3-D FEM for large-scale high temperature superconducting racetrack coil
Huang, Xiangyu,Huang, Zhen,Xu, Xiaoyong,Li, Wan,Jin, Zhijian The Korea Institute of Applied Superconductivity a 2019 한국초전도저온공학회논문지 Vol.21 No.3
In various types of large-scale electrical applications, the number of coil turns in such machines is usually large. Electromagnetic simulation of large-scale superconducting coils (tens to hundreds of turns) is indispensable in the design process of superconducting electrical equipment. However, due to the large scale of the coil and the large aspect ratio of super-conducting material layer in HTS coated conductor, it is usually difficult or even unable to perform 3-D transient electromagnetic simulation. This paper introduces an effective 3-D electromagnetic simulation method for large-scale HTS coated conductor coil based on T-A formulation. The simulation and experimental results show that the 3-D model based on the T-A formulation using homogeneous strategy is more accurate than the traditional 2-D models. The memory usage is not sensitive to the number of turns and this model will be even more superior as the number of turns becomes larger.
Effect of Solution-treated on Electrochemical Properties of AZ91 Magnesium Alloy Anode
Zhiquan, Huang,Yanjie, Pei,Renyao, Huang,Xiangyu, Gao,Jinchao, Zou,Lianyun, Jiang The Korean Electrochemical Society 2022 Journal of electrochemical science and technology Vol.13 No.4
The effect of solution-treated on the self-corrosion performance and discharge performance of AZ91 magnesium alloy as anode material was analyzed by microscopic characterization, immersion tests, electrochemical measurements, and discharge performance tests. The study shows that the β-phase in the AZ91 magnesium alloy gradually dissolved in the matrix with the increase of the solution temperature, and the electrochemical activity of the magnesium alloy anode was significantly improved. Through the comparison of three different solution-treated processes, it is found that the AZ91 magnesium alloy has the most vigorous activity and better discharge performance after solution-treated of 415℃+12 h. In addition, the proportion and distribution of β-phase AZ91 magnesium alloy have a direct impact on its discharge performance as an anode material.
Xiangyu Hou,Xupeng Bai,Xiaoli Gou,Hang Zeng,Chen Xia,Wei Zhuang,Xinmeng Chen,Zhongxiang Zhao,Min Huang,Jing Jin 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatinresistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
Hou, Xiangyu,Bai, Xupeng,Gou, Xiaoli,Zeng, Hang,Xia, Chen,Zhuang, Wei,Chen, Xinmeng,Zhao, Zhongxiang,Huang, Min,Jin, Jing Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatin-resistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3,4,5,5,7-Pentamethoxyflavone (PMF), a natural flavon extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
Elbow flow analysis and optimal exhaust port profile design
Yang Xu,Shuhe Huang,Liwang Su,Xiangyu Zhang,Yikai Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3
In this study, the exhaust port profile of a diesel engine was numerically analyzed and optimized. First, the elbow profile results show that the separation loss of lower profile plays the main role in overall separation loss, it decreases sharply and then slowly with an increase of r lower /d. Within the range of 0 ≤ r lower /d ≤ 5, the total secondary flow loss increases sharply and then slowly with an increase of r lower /d. Under the same condition of relative pressure difference and lower profile, the elbow discharge coefficient increases with an increase of d mid /r upper and remains almost constant when d mid /r upper >1. The maximum discharge coefficient under a certain r lower condition increases with an increase of r lower . Afterwards, the applicability of elbow profile results to exhaust port were verified and an exhaust port profile design method was established based on a circular arc profile. Finally the feasibility of exhaust port profile design method was verified experimentally.
Xiang-Hong Xu,Yuanhui Jia,Xinyao Zhou,Dandan Xie,Xiaojie Huang,Linyan Jia,Qian Zhou,Qingliang Zheng,Xiangyu Zhou,Kai Wang,Li-Ping Jin 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Preeclampsia is a pregnancy-specific disorder that is a major cause of maternal and fetal morbidity and mortality with a prevalence of 6–8% of pregnancies. Although impaired trophoblast invasion in early pregnancy is known to be closely associated with preeclampsia, the underlying mechanisms remain elusive. Here we revealed that lysyl oxidase (LOX) and LOX-like protein 2 (LOXL2) play a critical role in preeclampsia. Our results demonstrated that LOX and LOXL2 expression decreased in preeclamptic placentas. Moreover, knockdown of LOX or LOXL2 suppressed trophoblast cell migration and invasion. Mechanistically, collagen production was induced in LOX- or LOXL2-downregulated trophoblast cells through activation of the TGF-β1/Smad3 pathway. Notably, inhibition of the TGF-β1/Smad3 pathway could rescue the defects caused by LOX or LOXL2 knockdown, thereby underlining the significance of the TGF-β1/ Smad3 pathway downstream of LOX and LOXL2 in trophoblast cells. Additionally, induced collagen production and activated TGF-β1/Smad3 were observed in clinical samples from preeclamptic placentas. Collectively, our study suggests that the downregulation of LOX and LOXL2 leading to reduced trophoblast cell migration and invasion through activation of the TGF-β1/Smad3/collagen pathway is relevant to preeclampsia. Thus, we proposed that LOX, LOXL2, and the TGF-β1/Smad3/collagen pathway can serve as potential markers and targets for clinical diagnosis and therapy for preeclampsia.