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RISS 인기검색어
- 검색키워드
- 저자 : Xinmeng Chen (검색결과 3 건)
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The structural performance of axially loaded CFST columns under various loading conditions
Fuyun Huang,Xinmeng Yu,Baochun Chen 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.5
Concrete filled steel tube (CFST) structures have been used widely in high-rise buildings and bridges due to the efficiency of structurally favourable interaction between the steel tube and the concrete core. In the current design codes only one loading condition in the column members is considered, i.e., the load is applied on the steel tube and concrete core at the same time. However, in engineering practice the tube structures may be subjected to various loading conditions such as loading on the concrete core only, preloading on the steel tube skeleton before filling of concrete core, and so on. In this research, a series of comparative experiments were carried out to study the structural performance of concrete filled circular steel tube columns subject to four concentric loading schemes. Then, a generalized prediction method is developed to evaluate the ultimate load capacity of CFST columns subject to various loading conditions. It is shown that the predictions by the proposed method agree well with test results.
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Hou, Xiangyu,Bai, Xupeng,Gou, Xiaoli,Zeng, Hang,Xia, Chen,Zhuang, Wei,Chen, Xinmeng,Zhao, Zhongxiang,Huang, Min,Jin, Jing Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatin-resistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3,4,5,5,7-Pentamethoxyflavone (PMF), a natural flavon extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
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Xiangyu Hou,Xupeng Bai,Xiaoli Gou,Hang Zeng,Chen Xia,Wei Zhuang,Xinmeng Chen,Zhongxiang Zhao,Min Huang,Jing Jin 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatinresistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
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