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- 저자 : Yuanhui Jia (검색결과 2 건)
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Wei Cai,Yuanhui Zhang,Jun Xie,Li Li,Shun Jia,Shaohua Hu,Luoke Hu 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2
Energy performance improvement is a basic significant way of addressing both energy security and environment concerns, which can promote energy-saving and emission-reduction. There are various measures of energy performance, with different purposes and applications. However, there are few models or approaches for measuring and quantifying energy saving potential in machining systems. To better perform the energy performance analysis and evaluating energy saving potential in machining, an energy performance evaluation method based on energy benchmark in machining systems is addressed. Energy performance characteristics is analysed, and some energy performance concepts and indicators are proposed. The energy performance evaluation based on energy benchmark is developed for machining systems. Furthermore, a case study involving the establishment of an energy performance evaluation and energy saving potential for gears in a real machining plant was examined, illustrating the practicability of the proposed method.
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Xiang-Hong Xu,Yuanhui Jia,Xinyao Zhou,Dandan Xie,Xiaojie Huang,Linyan Jia,Qian Zhou,Qingliang Zheng,Xiangyu Zhou,Kai Wang,Li-Ping Jin 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Preeclampsia is a pregnancy-specific disorder that is a major cause of maternal and fetal morbidity and mortality with a prevalence of 6–8% of pregnancies. Although impaired trophoblast invasion in early pregnancy is known to be closely associated with preeclampsia, the underlying mechanisms remain elusive. Here we revealed that lysyl oxidase (LOX) and LOX-like protein 2 (LOXL2) play a critical role in preeclampsia. Our results demonstrated that LOX and LOXL2 expression decreased in preeclamptic placentas. Moreover, knockdown of LOX or LOXL2 suppressed trophoblast cell migration and invasion. Mechanistically, collagen production was induced in LOX- or LOXL2-downregulated trophoblast cells through activation of the TGF-β1/Smad3 pathway. Notably, inhibition of the TGF-β1/Smad3 pathway could rescue the defects caused by LOX or LOXL2 knockdown, thereby underlining the significance of the TGF-β1/ Smad3 pathway downstream of LOX and LOXL2 in trophoblast cells. Additionally, induced collagen production and activated TGF-β1/Smad3 were observed in clinical samples from preeclamptic placentas. Collectively, our study suggests that the downregulation of LOX and LOXL2 leading to reduced trophoblast cell migration and invasion through activation of the TGF-β1/Smad3/collagen pathway is relevant to preeclampsia. Thus, we proposed that LOX, LOXL2, and the TGF-β1/Smad3/collagen pathway can serve as potential markers and targets for clinical diagnosis and therapy for preeclampsia.
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