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A High Efficiency Integrated Step-down Cuk and Flyback converter for LED Power driver
Weiming Lin,Xu Yuzhen,QingLiang Zheng 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
Due to the enormous progress recently achieved in the technology of light emitting diodes (LEDs), they are expected to replace conventional lamps in automotive applications in the near future and incandescent, halogen and fluorescent lamps at least in some general illumination applications within a few years. Innovative driver circuits optimized with respect to functionality, efficiency, cost, size and reliability are an enabler for the successful introduction of new LED based lighting products. A low ripple and high efficiency single-stage power driver is proposed for LED lighting in this paper. The proposed single-stage power driver integrated a step-down Cuk rectifier for power-factor correction (PFC) with the isolated flyback converter for DC-DC power conversion. In the proposed single-stage stepdown Cuk rectifier achieve low input ripple and output ripple and lower switch stress, and reduce the two energy conversion stages to improve the driver efficiency. The analysis of the proposed converter is presented and experimental results based on 0.75A, 30 W prototype are provided to demonstrate the performance of the proposed driver.
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Xiang-Hong Xu,Yuanhui Jia,Xinyao Zhou,Dandan Xie,Xiaojie Huang,Linyan Jia,Qian Zhou,Qingliang Zheng,Xiangyu Zhou,Kai Wang,Li-Ping Jin 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Preeclampsia is a pregnancy-specific disorder that is a major cause of maternal and fetal morbidity and mortality with a prevalence of 6–8% of pregnancies. Although impaired trophoblast invasion in early pregnancy is known to be closely associated with preeclampsia, the underlying mechanisms remain elusive. Here we revealed that lysyl oxidase (LOX) and LOX-like protein 2 (LOXL2) play a critical role in preeclampsia. Our results demonstrated that LOX and LOXL2 expression decreased in preeclamptic placentas. Moreover, knockdown of LOX or LOXL2 suppressed trophoblast cell migration and invasion. Mechanistically, collagen production was induced in LOX- or LOXL2-downregulated trophoblast cells through activation of the TGF-β1/Smad3 pathway. Notably, inhibition of the TGF-β1/Smad3 pathway could rescue the defects caused by LOX or LOXL2 knockdown, thereby underlining the significance of the TGF-β1/ Smad3 pathway downstream of LOX and LOXL2 in trophoblast cells. Additionally, induced collagen production and activated TGF-β1/Smad3 were observed in clinical samples from preeclamptic placentas. Collectively, our study suggests that the downregulation of LOX and LOXL2 leading to reduced trophoblast cell migration and invasion through activation of the TGF-β1/Smad3/collagen pathway is relevant to preeclampsia. Thus, we proposed that LOX, LOXL2, and the TGF-β1/Smad3/collagen pathway can serve as potential markers and targets for clinical diagnosis and therapy for preeclampsia.
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