Effects of Ga-doping on the microstructure and magnetic properties of MnBi alloys

Yang, Yang,Kim, Jong-Woo,Si, Ping-Zhan,Qian, Hui-Dong,Shin, Yongho,Wang, Xinyou,Park, Jihoon,Li, Oi Lun,Wu, Qiong,Ge, Hongliang,Choi, Chul-Jin Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-

<P><B>Abstract</B></P> <P>The low temperature phase Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> (<I>x</I> = 0, 1, 3, 5, and 10) alloys were prepared by induction melting process with subsequent low temperature annealing. The effects of Ga-doping on the crystal structure and magnetic properties of the alloys were systematically studied. The room temperature coercivities of Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> after ball milling increased from 1.43 T for <I>x</I> = 0 to 1.66 T for <I>x</I> = 5, while the saturation magnetization decreased from 60.7 Am<SUP>2</SUP>/kg (<I>x</I> = 0) to 45.1 Am<SUP>2</SUP>/kg (<I>x</I> = 5). The maximum energy product (<I>BH</I>)<SUB>max</SUB> of Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga powders reached 7.87 MGOe. The Curie temperature of the Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> alloys increased from 633 K to 658 K with increasing Ga concentration in the range of 0 ≤ <I>x</I> ≤ 5.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of doping Ga on the microstructural and magnetic properties of MnBi alloy. </LI> <LI> The MnBi-Ga powders are achieved by surfactant assisted high energy ball milling. </LI> <LI> The maximum energy produce (<I>BH</I>)<SUB>max</SUB> shows 7.87 MGOe for Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga sample. </LI> <LI> The coercivity of Mn<SUB>55</SUB>Bi<SUB>40</SUB>Ga<SUB>5</SUB> after ball milling reached 1.66 T at room temperature. </LI> <LI> The elevated curie temperature (<I>T</I> <SUB>c</SUB>) by doping Ga makes it a possible candidate for high temperature applications. </LI> </UL> </P>

Prognostic Value of Baseline and Interim Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT in Patients with Follicular Lymphoma

Jin-Hua Liang,Yun-Ping Zhang,Jun Xia,Chong-Yang Ding,Wei Wu,Li Wang,Lei Cao,Hua-Yuan Zhu,Lei Fan,Tian-Nv Li,Jian-Yong Li,Wei Xu 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4

Purpose The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography computed tomography (PET-CT) scans. Materials and Methods The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2.0, 2.5, and 3.0 thresholding method, respectively. Results Median age was 53 years, 75.0% of patients had stage III to IV disease, 43.8% had a Follicular Lymphoma International Prognostic Index 1 (FLIPI1) score of 3 to 5 and 20.8% had a FLIPI2 score of 3 to 5. Receiver operating characteristic (ROC) curve analysis showed the optimal cut-off values for TMTV3.0 and TLG3.0 were 476.4 (sensitivity, 85.7%; specificity, 78.0%; area under the curve [AUC], 0.760; p=0.003) and 2,676.9 (sensitivity, 71.4%; specificity, 78.0%; AUC, 0.760; p=0.003). On multivariable analysis, TMTV3.0 and TLG3.0 were independent predictors of both progression-free survival (PFS) (hazard ratio [HR], 5.406; 95% confidence interval [CI], 1.326 to 22.040; p=0.019 and HR, 6.502; 95% CI, 1.079 to 39.182; p=0.042) and overall survival (OS) (HR, 4.111; 95% CI, 1.125 to 15.027; p=0.033 and HR, 5.885; 95% CI, 1.014 to 34.148; p=0.049). ROC curve analysis showed the optimal cut-off values for TMTV3.0 and TLG3.0 were 66.3% (sensitivity, 85.7%; specificity, 63.4%; AUC, 0.774; p < 0.001) and 64.5% (sensitivity, 85.7%; specificity, 65.9%; AUC, 0.777; p < 0.001). Conclusion Baseline TMTV and TLG are strong predictors of PFS and OS in FL. Furthermore, interim TMTV (TMTV > 66.3%) and TLG (TLG > 64.5%) reduction are valuable tools for early treatment response assessment in FL patients.

Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid

( Jin Fu Peng ),( Li Liu ),( Cheng Xian Guo ),( Shi Kun Liu ),( Xiao Ping Chen ),( Li Hua Huang ),( Hong Xiang ),( Zhi Jun Huang ),( Hong Yuan ),( Guo Ping Yang ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5

MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATPbinding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression by free fatty acids. When using free fatty acids to stimulate Chang liver cells, we found that the expression of miR-511 increased significantly while the expression of OATP1B1 decreased. We also proved that SLCO1B1 is the target gene of miR-511 with a bioinformatics analysis and using the dual luciferase reporter assay. Furthermore, the expressions of SLCO1B1 and OATP1B1 decreased if transfecting Chang liver cells with miR-511, but did not increase when transfecting the inhibitors of miR-511 into steatosis cells. Our study indicates that miR-511 may play an important role in the regulation of OATP1B1 expression by free fatty acids.

Efficient photodegradation of volatile organic compounds by iron-based metal-organic frameworks with high adsorption capacity

Li, Ping,Kim, Sungsoon,Jin, Jie,Do, Hyung Chun,Park, Jong Hyeok Elsevier BV 2020 Applied Catalysis B Vol.263 No.-

<P><B>Abstract</B></P> <P>The efficient removal of volatile organic compounds (VOCs) is still challenging, and suitable strategies and auxiliary materials are lacking. Herein, we propose a highly efficient and stable iron-based metal-organic framework (Fe-MOF) in which the adsorption removal and photodegradation regeneration step alternate to realize repeatable and efficient removal of VOCs. A group of morphology-controlled Fe-MOFs serves as both the adsorbent and photocatalyst under ambient conditions to remove typical VOCs, <I>e.g</I>., toluene by relying on their high porosity and catalytic activity. The optimized Fe-MOF exhibits 100% adsorption removal efficiency for a toluene concentration of 460 ppm, and the Fe-MOF could be regenerated by converting the adsorbed toluene into harmless CO<SUB>2</SUB> under 1 SUN (100 mW/cm<SUP>2</SUP>) solar irradiation. More importantly, the Fe-MOF showed excellent durability during repeated adsorption and degradation processes for 100 cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Adsorption and photodegradation integrate to remove VOCs. </LI> <LI> Fe-MOFs serve as both adsorbent and photocatalyst. </LI> <LI> Fe<SUP>2+</SUP> abundant surface promotes •OH formation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Gallic acid attenuates calcium calmodulin‐dependent kinase II‐induced apoptosis in spontaneously hypertensive rats

Jin, Li,Piao, Zhe Hao,Liu, Chun Ping,Sun, Simei,Liu, Bin,Kim, Gwi Ran,Choi, Sin Young,Ryu, Yuhee,Kee, Hae Jin,Jeong, Myung Ho John Wiley and Sons Inc. 2018 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.22 No.3

<P><B>Abstract</B></P><P>Hypertension causes cardiac hypertrophy and leads to heart failure. Apoptotic cells are common in hypertensive hearts. Ca<SUP>2+</SUP>/calmodulin‐dependent protein kinase II (CaMKII) is associated with apoptosis. We recently demonstrated that gallic acid reduces nitric oxide synthase inhibition‐induced hypertension. Gallic acid is a trihydroxybenzoic acid and has been shown to have beneficial effects, such as anti‐cancer, anti‐calcification and anti‐oxidant activity. The purpose of this study was to determine whether gallic acid regulates cardiac hypertrophy and apoptosis in essential hypertension. Gallic acid significantly lowered systolic and diastolic blood pressure in spontaneously hypertensive rats (SHRs). Wheat germ agglutinin (WGA) and H&E staining revealed that gallic acid reduced cardiac enlargement in SHRs. Gallic acid treatment decreased cardiac hypertrophy marker genes, including atrial natriuretic peptide (<I>ANP</I>) and brain natriuretic peptide (<I>BNP</I>), in SHRs. The four isoforms, α, β, δ and γ, of <I>CaMKII</I> were increased in SHRs and were significantly reduced by gallic acid administration. Gallic acid reduced cleaved caspase‐3 protein as well as <I>bax</I>,<I> p53</I> and <I>p300 </I>mRNA levels in SHRs. <I>CaMKII</I> δ overexpression induced <I>bax</I> and <I>p53</I> expression, which was attenuated by gallic acid treatment in H9c2 cells. Gallic acid treatment reduced DNA fragmentation and the TUNEL positive cells induced by angiotensin II. Taken together, gallic acid could be a novel therapeutic for the treatment of hypertension through suppression of CaMKII δ‐induced apoptosis.</P>

Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice

Li-Ping Guan,Ji-Xing Nan,Xue-Jun Jin,Qing-Hao Jin,곽경철,채규윤,Zhe-Shan Quan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1

The hepatoprotective effects of chalcone derivatives were evaluated in D-galactosamine/ lipopolysaccharide (D-GalN/LPS)-induced fulminant hepatic failure in mouse. Thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum. Chalcone preparations were injected into mice at 12 h and 1 h before intraperitoneal injection of D- GalN/LPS. After abdominal administration, changes in AST and ALT between the control and treated groups were observed. Ten of the synthesized chalcone derivatives exhibited inhibitory effects on D-GalN/LPS-induced levels of AST and ALT in mice. Compounds 2, 3, 8, 9, and 12 markedly reduced serum AST and ALT at 8 h, inhibited hepatocyte necrosis and showed significant hepatoprotective activities. The activity of compound 3 was compared with the bifendate (DDB) through oral administration. Compound 3 showed much higher inhibitory effects than bifendate for decreasing AST and ALT activity. The results indicate that compound 3 has strong hepatoprotective activity through suppression of tumor necrosis factoralpha (TNF-alpha) preduction, reduction of the histological change in the liver, and attenuated of hepatocyte apoptosis confirmed by DNA fragmentation assay.

No Association Between the USP7 Gene Polymorphisms and Colorectal Cancer in the Chinese Han Population

Li, Xin,Wang, Yang,Li, Xing-Wang,Liu, Bao-Cheng,Zhao, Qing-Zhu,Li, Wei-Dong,Chen, Shi-Qing,Huang, Xiao-Ye,Yang, Feng-Ping,Wang, Quan,Wang, Jin-Fen,Xiao, Yan-Zeng,Xu, Yi-Feng,Feng, Guo-Yin,Peng, Zhi-Ha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.

Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment.

Sun, Ping-Li,Kim, Ji Eun,Yoo, Seol Bong,Kim, Hyojin,Jin, Yan,Jheon, Sanghoon,Kim, Kwhanmien,Lee, Choon Taek,Chung, Jin-Haeng Raven Press 2014 Annals of Surgical Oncology Vol.21 No.suppl4

<P>Yes-associated protein (YAP) has been reported to be associated with the prognosis of various cancers and also to affect epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) activity in ovarian cancer cell lines. However, few studies have evaluated YAP protein expression in lung cancer, and the results have lacked consistency.</P>

Multivariate Analysis of Molecular Indicators for Postoperative Liver Metastasis in Colorectal Cancer Cases

Qian, Li-Yuan,Li, Ping,Li, Xiao-Rong,Chen, Dao-Jin,Zhu, Shai-Hong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Aims: To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX-2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (${\alpha}$ inclusion= 0.10, ${\alpha}$ elimination = 0.15, R2 = 0.718). Conclusions: Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers.

Hydrogen peroxide is involved in abscisic acid-induced adventitious rooting in cucumber (Cucumis sativus L.) under drought stress

Xue-Ping Li,Qing-Qing Xu,Wei-Biao Liao,Zhan-Jun Ma,Xiao-Ting Xu,Meng Wang,Peng-Ju Ren,Li-Juan Niu,Xin Jin,Yong-Chao Zhu 한국식물학회 2016 Journal of Plant Biology Vol.59 No.5

Abscisic acid (ABA) and hydrogen peroxide (H2O2) are important regulatory factors involved in plant development under adversity stress. Here, the involvement of H2O2 in ABA-induced adventitious root formation in cucumber (Cucumis sativus L.) under drought stress was determined. The results indicated that exogenous ABA or H2O2 promoted adventitious rooting under drought stress, with a maximal biological response at 0.5 μM ABA or 800 μM H2O2. The promotive effects of ABA-induced adventitious rooting under drought stress were suppressed by CAT or DPI, suggesting that endogenous H2O2 might be involved in ABA-induced adventitious rooting. ABA increased relative water content (RWC), leaf chlorophyll content, chlorophyll fluorescence parameters (Fv/Fm, ΦPS II and qP), water soluble carbohydrate (WSC) and soluble protein content, and peroxidase (POD), polyphenol oxidase (PPO) and indoleacetate oxidase (IAAO) activities, while decreasing transpiration rate. However, the effects of ABA were inhibited by H2O2 scavenger CAT. Therefore, H2O2 may be involved in ABA-induced adventitious root development under drought stress by stimulating water and chlorophyll content, chlorophyll fluorescence, carbohydrate and nitrogen content, as well as some enzyme activities.