http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Genotoxic Effects of the Cooked - Food - Related Mutagens IQ and Trp - p - 2 in Drosophila
Lee, Won Ho,Yoo, Mi Ae,Park, Tae Dong,Choo, Jong Kil 한국유전학회 1987 Genes & Genomics Vol.9 No.4
The heterocyclic amines, IQ and Trp-p-2 are the cooked-food-related carcinogens. To know genotoxic effects of IQ and Trp-p-2 in Drosophila, sensitivity to killing, somatic gene mutations and somatic chromosome mutations were measured in repair-deficient strain and repair-proficient strain after larval treatment. Gene mutations were detected with eye-color spot test system and chromosome mutations with wing spot test system. The relative potency of these two compounds in Drosophila will be discussed with the different response of mammalian system and Salmonella system.
Structural Diversification of Macrolactones by Substrate-Flexible Cytochrome P450 Monooxygenases
Lee, Sang ,Kil,Basnet, Devi ,B.,Hong, Jay ,Sung ,Joong,Jung, Won ,Seok,Choi, Cha ,Yong,Lee, Hei ,Chan,Sohng, Jae ,Kyung,Ryu, Keun ,Garp,Kim, Dae WILEY-VCH 2005 Advanced Synthesis & Catalysis Vol.347 No.10
<P>The substrate flexibilities of several cytochrome P450 monooxygenases involved in macrolide biosynthesis were investigated to test their potential for the generation of novel macrolides. PikC hydroxylase in the pikromycin producer Streptomyces venezuelae accepted oleandomycin as an alternative substrate and introduced a hydroxy group at the C-4 position, which is different from the intrinsic C-12 hydroxylation position in the natural substrate. This is the first report of C-4 hydroxylation activity of cytochrome P450 monooxygenase involved in the biosynthesis of 14-membered macrolides. EryF hydroxylase from the erythromycin biosynthetic pathway of Saccharopolyspora erythraea and OleP oxidase from the oleandomycin biosynthetic pathway of Streptomyces antibioticus also showed a certain degree of plasticity towards alternative substrates. In particular, EryF and OleP were found to oxidize a 12-membered macrolactone as an alternative substrate. These results demonstrate the potential usefulness of these enzymes to diversify macrolactones by post-PKS oxidations.</P>
( Won Seok Kang ),( Joon Seok Lim ),( Jae Hee Cheon ),( Yong Chan Lee ),( Won Ho Kim ),( Sang Kil Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Stomach cancer is the most common from of cancer, and is the second leading cause of cancer related death in Korea. 3.4% of stomach cancer patients have synchronous of metachronous cancer with colorectal cancer as the most common type (0.6%). Patients with stomach cancer might carry a high risk for colorectal cancer that requires surveillance colonoscopy. CT colonography (CTC) provides for effective and relatively noninvasive risk stratification as a method for colon cancer screening. This study aims at determining the usefulness of CTC as a postoperative follow-up surveillance study after stomach cancer surgery. Methods: From May 2006 to April 2007, contrast-enhanced CTC was performed in Yonsei University severance Hospital for detection of recurrent lesions in 410 consecutive patients (275 male, 135 female) who have had surgery for stomach cancer CTC interpretation was performed with primary three-dimensional polyp detection. Patients with polyp(s) measuring 6mm or larger were referred for optical colonoscopy (OC). Results: Of 410 stomach cancer postoperative patients, recurrence of stomach cancer was not noted and 45 colorectal polyp(s) were detected on CTC in 36 (8.8%) patients. OC was recommended in these patients and concordant lesions were identified in 27 (60.0%) of 45 polyps. Eighty-six polyps were detected on OC in 31 patients, and no polyps were detected on OC in 5 patients. Four colorectal carcinomas were detected in 4 patients CTC. Sensitivity and positive predicitive value of CTC for polyp detection were 60.0% and 62.8%, respectively. Total 46 polyps were missed on CTC. The most common site of missed polyps was sigmoid colon. Eighteen (39.1%) were larger than 6 mm and 1 carcinoma was included in the missed polyps. Conclusion: For patients who have undergone surgical treatment for stomach cancer, CTC is clinically useful as their follow-up surveillance study. However, more efforts are needed to find the ways to improve the low sensitivity of CTC.
Ginseng for improving semen quality parameters : A protocol of systematic review
Lee, Hye Won,Kil, Ki-Jung,Lee, YoungJoo,Lee, Myeong Soo Williams & Wilkins Co 2018 Medicine Vol.97 No.4
<P><B>Abstract</B></P><P><B>Background:</B></P><P>The aim of this systematic review is to determine whether ginseng is effective in improving sperm quality.</P><P><B>Methods and analysis:</B></P><P>Twelve databases will be searched from their inception to the present date: PubMed, EMBASE, AMED, the Cochrane Library, 5 Korean medical databases (KoreaMed, DBpia, OASIS, the Research Information Service System [RISS], and the Korean Studies Information Service System [KISS]), and 3 Chinese medical databases (China National Knowledge Infrastructure [CNKI], the Wanfang Database, and the Chinese Scientific Journals Database [VIP]). We will include all prospective clinical trials including randomized controlled trials (RCTs), controlled trials, and uncontrolled observational studies. We will exclude case study and case series, and retrospective studies in which healthy men or men with subfertility are treated with any type of ginseng. We will exclude studies comparing the 2 different forms of ginseng. The selection of the studies, data abstraction, and validations will be performed independently by 2 researchers. The risk of bias of the RCTs will be evaluated using the Cochrane's risk of bias assessment tool.</P><P><B>Ethics and dissemination:</B></P><P>The findings will be disseminated to appropriate audiences via peer-reviewed publications and conference presentations. Our review will provide readers the opportunity to access studies originally published in East Asian languages that they would otherwise be unable to read.</P><P>Trial registration number: PROSPERO 2017 CRD42017078797</P>
Lee, Ho-Sup,Park, Won-Kyu,Son, Hoe-Joo,Lee, Sung-Sook,Kim, Joon-Kyum,Ahn, Soon-Kil,Hong, Chung-Il,Min, Hye-Ki,Kim, Myung-Soo,Myung, Seung-Woon The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.2
The pharmacokinetics of CKD-732 (6-0-4-[dimethyl-aminoethoxy)cinnamoyl]-fumagillolㆍhemioxalate) was investigated in male SD rats and beagle dogs after bolus intravenous administration. The parent compound and metabolites obtained from in vitro and in vivo samples were determined by LC/MS. The main metabolite was isolated and identified as an N-oxide form of CKD-732 by NMR and LC/MS/MS. CKD-732 was metabolized into either M11 or others by rapid hydroxylation, demethylation, and hydrolysis. The blood level following the intravenous route declined in first-order kinetics with $T_{1}$2/$\beta$ values of 0.72-0.78 h for CKD-732 and 0.92-1.09 h for M11 in rats at a dose of 7.5-30 mg/kg. In dogs, $T_{1}$2/$\beta$ values of CKD-732 and M11 were 1.54 and 1.79 h, respectively. Moreover, AUC values increased dose dependently for CKD-732 and M11 in rats and dogs. The CLtot and Vdss did not change significantly with increasing dose, indicating linear pharmacokinetic patterns. The excretion patterns through the urine, bile, and feces were also examined in the animals. The total amount excreted in urine, bile, and feces was 2.13% for CKD-732 and 1.29% for M11 in rats, and 1.58% for CKD-732 and 2.28% for M11 in dogs.