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RISS 인기검색어
- 검색키워드
- 저자 : Toru Saito (검색결과 11 건)
- 무료
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Numerical Prediction of Effect of Seawater-Quality Enhancer Installed in Isahaya Bay
Saito, Shu,Sato, Toru,Kitazawa, Daisuke The Korean Association of Ocean Science and Techno 2006 Journal of Ocean Science and Technology Vol.3 No.1
Since the construction of Isahaya Dyke, it is said that the tidal current in Ariake Bay has changed. The change may bring on the environmental deterioration in Ariake Bay. Especially in Isahaya Bay and the offshore of Oura, the emergence of oxygen-deficient water has been prominent. In this study, firstly, we simulated the emergence of oxygen-deficient water by incorporating an ecosystem model into an ocean current model to elucidate the mechanism of the oxygen-deficient water both from physical and biological viewpoints. Next, we proposed a local engineering solution, a seawater-quality enhancer, and simulated numerically the diffusion of nutrient-rich water emitted by the apparatus and its effects on the ecosystems, particularly, on the oxygen-deficient water. The apparatus spreads horizontally the intermediate-density mixture of surface and deep waters. The numerical model considered 8 principal rivers because the nutrient-rich density currents of fresh water largely affect the currents and the ecosystems in Ariake Bay. It was shown that 16 % of the oxygen-deficient water in Isahaya Inlet was reduced by the apparatus, which emits 100-million-ton water per day, at 8 weeks after the start of operation. This may imply the possibility of improvement of water quality by this engineering countermeasure.
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Toru Mizoguchi,Isao Takehara,Tohru Masuzawa,Toshiro Saito,Yo Naoki 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
In order to clarify the physiological effects of Chlorella intake on subjects with high-risk factors for lifestyle-related diseases, we conducted Chlorella ingestion tests on 17 subjects with high-risk factors for lifestyle-related diseases and 17 healthy subjects over a 16-week period, including a 4-week post-observation period. We conducted blood biochemical tests and analyzed gene expression profile in whole blood cells in the peripheral blood before and after Chlorella intake. We confirmed that in both groups, Chlorella intake resulted in noticeable reductions in body fat percentage, serum total cholesterol, and fasting blood glucose levels. Through gene expression analysis, we found that gene expression profiles varied with Chlorella intake and identified many genes that exhibited behavior such that after the completion of the intake period, expression levels returned to pre-intake expression ones. Among these were genes related to signal transduction molecules, metabolic enzymes, receptors, transporters, and cytokines. A difference in expression level was found between the two groups at the start of the tests, and we were able to identify genes with noticeable variance in expression level resulting from Chlorella intake in the high-risk factor group. These included genes involved in fat metabolism and insulin signaling pathways, which suggests that these pathways could be physiologically affected by Chlorella intake. There were clear variations in the expression profiles of genes directly related to uptake of glucose resulting from Chlorella intake, indicating that the activation of insulin signaling pathways could be the reason for the hypoglycemic effects of Chlorella.
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Formation Control for Multi–Vehicle System using Adaptive Control Method
Kazuya Sato,Toru Saito,Nobuhisa Maeda 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
In this paper, an adaptive control method for formation control problem is considered. We assume that there existan uncertainty in the information exchange between anagent and all of its neighbors on the network. We regard that the uncertainty in the information exchange can be described by the perturbation of the elements of adjacent matrix. Our proposed method can estimate the perturbation of the elements in the notion of adaptive control strategy. Numerical simulation results are given to illustrate the effectiveness of our proposed method.
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Keita Odashiro,Kazuyuki Saito,Takeshi Arita,Toru Maruyama,Takehiko Fujino,Koichi Akashi 대한고혈압학회 2015 Clinical Hypertension Vol.21 No.19
Introduction: Hypertension is associated with microcirculatory disturbance, and erythrocyte deformability is a major determinant of the microcirculation. However, impairment of erythrocyte deformability in hypertensive patients in relation to antihypertensive treatment is unclear. The present study aimed to investigate this impairment in hypertensive patients under treatment using a highly sensitive and quantitative nickel mesh filtration technique. Methods: Deformability was evaluated by filterability, defined as the flow rate of a hematocrit-adjusted erythrocyte suspension relative to that of saline under a specific filtration pressure in a pressure-flow curve obtained by continuous filtration. Baseline characteristics of hypertensive patients (n = 101) and age-matched normotensive subjects (n = 14) were obtained from medical records, and diabetic patients were excluded. Results: Erythrocyte deformability in the hypertensive group was significantly (p = 0.010) lower (87.8 ± 2.2 %) than that of the normotensive group (89.4 ± 1.7 %) and inversely proportional (r = −0.303, p = 0.002) to the mean blood pressure (BP) measured on blood sampling for the filtration study. Stepwise multiple regression analysis demonstrated that this impairment was mostly attributable to the mean BP (p = 0.001), whereas current smoking and episodes of stroke or coronary artery disease were not contributors. Discussion: These findings indicate that erythrocyte deformability is impaired in the hypertensive patients, which depends on the current BP control rather than target organ damage.
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Koji Matsuo,Muneaki Shimada,Tsuyoshi Saito,Kazuhiro Takehara,Hideki Tokunaga,Yoh Watanabe,Yukiharu Todo,Kenichirou Morishige,Mikio Mikami,Toru Sugiyama 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1
Objective: To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo PAN dissection at radical hysterectomy. Methods: This is a retrospective analysis of a nation-wide cohort study of surgically-treated stage IB–IIB cervical cancer (n=5,620). Multivariate models were used to identify independent surgical-pathological predictors for PAN metastasis/recurrence. Results: There were 120 (2.1%) cases of PAN metastasis at surgery with parametrial involvement (adjusted odds ratio [aOR]=1.65), deep stromal invasion (aOR=2.61), ovarian metastasis (aOR=3.10), and pelvic nodal metastasis (single-node aOR=5.39 and multiple-node aOR=33.5, respectively) being independent risk factors (all, p<0.05). Without any risk factors, the incidence of PAN metastasis was 0.9%, while women exhibiting certain risk factor patterns (>20% of the study population) had PAN metastasis incidences of ≥4%. Among 4,663 clinically PAN-negative cases at surgery, PAN recurrence was seen in 195 (4.2%) cases that was significantly higher than histologically PAN-negative cases (2.5%, p=0.046). In clinically PAN-negative cases, parametrial involvement (adjusted hazard ratio [aHR]=1.67), lympho-vascular space invasion (aHR=1.95), ovarian metastasis (aHR=2.60), and pelvic lymph node metastasis (single-node aHR=2.49 and multiple-node aHR=8.11, respectively) were independently associated with increased risk of PAN recurrence (all, p<0.05). Without any risk factors, 5-year PAN recurrence risk was 0.8%; however, women demonstrating certain risk factor patterns (>15% of the clinically PAN-negative population) had 5-year PAN recurrence risks being ≥8%. Conclusion: Surgical-pathological risk factors proposed in this study will be useful to identify women with increased risk of PAN metastasis/recurrence.
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일본 남자고등학생의 신체구성과 체력에 대한 상관관계의 검증
藤井勝紀(Katsunori Fujii),田中望(Nozomi Tanaka),石垣享(Toru Ishigaki),藤由美(Yumi Saito),김준동(Jun Dong Kim),노호성(Ho Sung Nho) 한국발육발달학회 2009 한국발육발달학회지 Vol.17 No.3
The declining trend in the physical fitness of young people poses a severe problem. This trend in physical fitness is considered one of the important factor occurring due to the difference in morphological quality judged by body composition. However, few studies of the kind reported. In the present study, the physical fitness based on difference of morphological quality is confirmed in high school boys. The sample size consists of 146 high school boys aged 16 years. Height, weight, body mass index (BMI), body fat mass, percentage of body fat, soft lean mass (SLM), bone mass and bone mineral density for physique and body composition were measured, in addition to, grip strength, sit-up, sit & reach, side step, 20m shuttle run, 50-m dash, standing long jump and hand ball throwing were measured as physical fitness tests. 20m shuttle run, sit-up and hand ball throwing showed a significant difference among "slim type," "normal type" and "fatty type", classified by the fatty-slim degree judgment based on BMI. Next, a regression polynomial evaluation chart of fat percentage for BMI was constructed in order to examine the physical fitness based on the difference of morphological quality. Physical fitness was examined based on the difference in the degree of qualitative accumulation of fat (excessive development of fat, normal fat, excessive underdevelopment of fat) derived from the evaluation chart. As a result, the student with excessive development of fat was significantly inferior and the excessive underdevelopment of fat type student was significantly superior in grip strength, standing long jump and hand ball throwing ability of the excessive development type. The result indicated a difference in physical fitness based on the difference in the degree of qualitative accumulation. This suggests that the fat percentage was a negative factor for motor ability.
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Wirasak Fungfuang,Misao Terada,Noriyuki Komatsu,Changjong Moon,Toru R. Saito 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.3
The integration of metabolism and reproduction involves complex interactions of hypothalamic neuropeptides with metabolic hormones, fuels, and sex steroids. Of these, estrogen influences food intake, body weight, and the accumulation and distribution of adipose tissue. In this study, the effects of estrogen on food intake, serum leptin levels, and leptin mRNA expression were evaluated in ovariectomized rats. Seven-week-old female Wistar-Imamichi rats were ovariectomized and divided into three treatment groups: group 1 (the control group) received sesame oil, group 2 was given 17β-estradiol benzoate, and group 3 received 17β-estradiol benzoate plus progesterone. The body weight and food consumption of each rat were determined daily. Serum leptin levels and leptin mRNA expression were measured by ELISA and quantitative RT-PCR, respectively. Food consumption in the control group was significantly higher (P<0.05) than that in groups 2 and 3, although body weight did not significantly differ among the three groups. The serum leptin concentration and leptin mRNA expression were significantly higher (P<0.05) in groups 2 and 3 than in group 1, but no significant difference existed between groups 2 and 3. In conclusion, estrogen influenced food intake via the modulation of leptin signaling pathway in ovariectomized rats.
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Pudcharaporn Kromkhun,Masahiro Katou,Haruo Hashimoto,Misao Terada,Changjong Moon,Toru R. Saito 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.2
Ultrasonic vocalizations (USVs) are essential communicative sounds used between rodent pups and their mother. Rat pups emit USVs in stressful situations, such as when they are cold or separated from the nest. We verified the ontogenetic changes in USVs emitted by infant rats isolated from their mother during the pre-weaning period. The number of calls, and the median frequency and first peak of frequency of the calls were measured at 1, 3, 5, 7, 10, 12, and 14 days postnatal age in Wistar-Imamichi rats. Pups were placed in a cold glass beaker and USVs were recorded for 5 min. The number of calls increased to a peak on day 5 and then gradually decreased. The median frequency of calls decreased slowly during the first 12 days, and then increased slightly on day 14. Similarly, the first peak frequency of calls was the highest on day 1, and then decreased gradually by day 12. A small increase was observed on day 14. These changes in frequency were correlated with the physical development of the pups, whose body weights increased significantly with age except during postnatal days 7-10.
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