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Jie Liu,Shuang Li,Fan Yang,Tianyu Li,Rui Li,Yousuf Waheed,Chen Meng,Shulin Li,Kun Liu,Yanshan Tong,Haisheng Xu,Chuankuo Tian,Xinglei Zhou 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.3
Background/Aims: Roxadustat, an oral medication for treating renal anemia, is a hypoxia-inducible factor prolyl hydroxylase inhibitor used for regulating iron metabolism and promoting erythropoiesis. To investigate the efficacy and safety of roxadustat in patients undergoing peritoneal dialysis (PD) with erythropoietin hyporesponsiveness. Methods: Single-center, retrospective study, 81 PD patients (with erythropoietin hyporesponsiveness) were divided into the roxadustat group (n = 61) and erythropoiesis-stimulating agents (ESAs) group (n = 20). Hemoglobin (Hb), total cholesterol, intact parathyroid hormone (iPTH), brain natriuretic peptide (BNP), related indicators of cardiac function and high-sensitivity C-reactive protein (hs-CRP) were collected. Additionally, adverse events were also recorded. The follow-up period was 16 weeks. Results: The two groups exhibited similar baseline demographic and clinical characteristics. At baseline, the roxadustat group had a mean Hb level of 89.8 ± 18.9 g/L, while the ESAs group had a mean Hb level of 95.2 ± 16.0 g/L. By week 16, the Hb levels had increased to 118 ± 19.8 g/L (p < 0.05) in the roxadustat group and 101 ± 19.3 g/L (p > 0.05) in the ESAs group. The efficacy of roxadustat in improving anemia was not influenced by baseline levels of hs-CRP and iPTH. Cholesterol was decreased in the roxadustat group without statin use. An increase in left ventricular ejection fraction and stabilization of BNP were observed in the roxadustat group. Conclusions: For PD patients with erythropoietin hyporesponsiveness, roxadustat can significantly improve renal anemia. The efficacy of roxadustat in improving renal anemia was not affected by baseline levels of hs-CRP0 and iPTH.
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Heart Failure Is Associated with Increased Risk of Long-Term Venous Thromboembolism
Tianyu Xu,Yuli Huang,Zuheng Liu,Yujia Bai,Zhuang Ma,Xiaoyan Cai,Yuhui Zhang,Jian Zhang 대한심장학회 2021 Korean Circulation Journal Vol.51 No.9
Background and Objectives: Venous thromboembolism (VTE), consisting of deep vein thrombosis (DVT) and pulmonary embolism (PE), is highly prevalent in in-hospital HF patients and contributes to worse prognoses. However, the risk of VTE in out-patients with HF in long-term period is controversial. This study aimed to evaluate the associations between HF and the risk of VTE in a long-term follow-up duration. Methods: We searched for studies investigating the risk of VTE, PE, and DVT in patients with HF before April 15, 2020, in PubMed, MEDLINE, and Embase databases. Cohort studies and post hoc analysis of RCTs were eligible for inclusion if they reported relative risk of VTE, DVT or PE in patients with HF in more than 3-month follow-up period. Results: We identified 31 studies that enrolled over 530,641 HF patients. Overall, patients with HF were associated with an increased risk of VTE (risk ratio [RR]=1.57, 95% confidence interval [CI]=1.34–1.84) and PE (RR=2.00, 95% CI=1.38–2.89). However, the risk of DVT was not significantly increased in HF patients (RR=1.33, 95% CI=0.67–2.63). Subgroup analysis showed that patients with chronic HF (RR=1.54, 95% CI=1.32–1.80) had a higher risk of VTE than those with acute HF (RR=0.95, 95% CI=0.68–1.32). Conclusions: In conclusion, HF was an independent risk for VTE and PE but not DVT in a long-term follow-up period. Patients with chronic HF were prone to suffer from VTE than acute HF.
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Haochi Liu,Lan Ding,Ligang Chen,Yanhua Chen,Tianyu Zhou,Huiyu Li,Yuan Xu,Li Zhao,Ning Huang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.69 No.-
Biomass carbon dots (CDs) prepared by sweet potato peels were superior fluorophores with low toxicity and excellent photostability. A novel designed fluorescence probe for specific recognition and sensitive detection of oxytetracycline (OTC) was fabricated with CDs and molecularly imprinted polymer (MIP). The quenching of CDs happened when rebinding with OTC due to electron-transfer-induced fluorescence quenching mechanism. The fluorescence probe was successfully applied in honey with the recoveries ranging from 90.2% to 97.3%. The detection limit of OTC was 15.3 ng mL−1. This work provides promising perspectives that the development of fluorescent MIP will be valuable for rapid analysis in complex samples.
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Yinghui Liu,Yunsu Shi,Yanchun Song,Tianyu Wang,Yu Li 한국식물학회 2010 Journal of Plant Biology Vol.53 No.2
In this paper, a full-length cDNA-encoding cytosolic nicotinamide adenine dinucleotide phosphatedependent isocitrate dehydrogenase was isolated from maize and named ZmICDH. Analysis of the deduced protein sequence revealed that this gene had considerably high homologies with other plant ICDH genes such as those from rice, Arabidopsis and poplar. The gene was transcribed in all tissues tested, with the highest amount of transcript in root. Subcellular localization results indicated that ZmICDH was localized in cytosol. In an attempt to further understand the role of ZmICDH in maize, the functional characterization of the gene was conducted. The results indicated that the expression of ZmICDH was induced by drought and salt stresses. ZmICDH enhanced salt tolerance in transgenic Arabidopsis.
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Spatio-temporal Semantic Features for Human Action Recognition
( Jia Liu ),( Xiaonian Wang ),( Tianyu Li ),( Jie Yang ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.10
Most approaches to human action recognition is limited due to the use of simple action datasets under controlled environments or focus on excessively localized features without sufficiently exploring the spatio-temporal information. This paper proposed a framework for recognizing realistic human actions. Specifically, a new action representation is proposed based on computing a rich set of descriptors from keypoint trajectories. To obtain efficient and compact representations for actions, we develop a feature fusion method to combine spatial-temporal local motion descriptors by the movement of the camera which is detected by the distribution of spatio-temporal interest points in the clips. A new topic model called Markov Semantic Model is proposed for semantic feature selection which relies on the different kinds of dependencies between words produced by “syntactic” and “semantic” constraints. The informative features are selected collaboratively based on the different types of dependencies between words produced by short range and long range constraints. Building on the nonlinear SVMs, we validate this proposed hierarchical framework on several realistic action datasets.
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Ion-imprinted antifouling nanocomposite membrane for separation of lithium ion
Dongshu Sun,Tianyu Zhou,Yang Lu,Yongsheng Yan,Chunbo Liu,Guangbo Che 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.9
Membrane fouling is a primary challenge restricting the practical application of membrane separation technology. Inspired by the idea that improving hydrophilicity would lead to antifouling performance of membrane material. In this work, ion-imprinted antifouling nanocomposite membrane (LiI-NcMs) blended with GO and TiO2 nanomaterialwas fabricated for selective separation of lithium ion. As a result, markedly improved hydrophilicity was achievedon LiI-NcMs (55.1o for contact angle). LiI-NcMs also showed good selective adsorption capacity in the mixed solutionof Mg2+ and Li+. Moreover, LiI-NcMs exhibited superior stability; after 20 adsorption/desorption cycles a maximumadsorption capacity of 88.1% can be maintained. This work demonstrates a new and facile approach to prepare novelmembrane separation material for a particular substance for efficient selective separation in industrial applications.
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Qin Haihong,Liu Tianyu 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.4
With the continuous development of MMG (Multi-Microgrid) technology, the coordinated operation among microgrids is of a positive signifi cance to improve the power system resilience. SoS (System of Systems) is considered as an eff ective approach to study the resource scheduling problem of MMG systems with complex interaction behaviors. In this context, this paper establishes a hierarchical SoS architecture suitable for MMG systems and proposes a RO-OMS (Robust Optimization Outage Management Strategy). In the pre-disturbance prevention phase, a robust optimization method is used to model the microgrid, and distributed energy resources are rationally dispatched and corrected to prepare for the next phase. In the post-disturbance recovery phase, microgrids are dynamically dispatched through grid reconfi guration to ensure power to critical loads while minimizing load shedding. Based on this, resilience metrics are defi ned to quantitatively analyze the resilience of MMG systems. Finally, the proposed model is tested under diff erent scenarios and damage levels in a modifi ed IEEE 33-node test system to verify the eff ectiveness of the proposed model.
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Yang Gang,Liu Xin,Huang Tianyu,Ding Ruyuan,Wang Yuanyin 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.1
BACKGROUND: Teeth can be used as a raw material for preparing bone substitutes due to their similar chemical composition to bone. The objective of our study was to evaluate the effect of odontogenic biphasic calcium phosphate (BCP) incorporating dentin noncollagenous proteins (DNCPs) on osteogenesis and stability in maxillary sinus augmentation. METHODS: The composition, structure and morphology of the odontogenic BCP were tested by X-ray powder diffraction (XRD), Brunauer–Emmett–Teller, and scanning electron microscopy methods. The biocompatibility and osteoinduction of DNCPs and materials were examined in vitro and their bone regeneration capacity was verified in vivo. RESULTS: The results showed that the cells adhered and proliferated well on the DNCP-loaded BCP scaffold. The odontogenic BCP and DNCPs promoted osteogenic differentiation of cells, The new bone formation in the BCP groups and DNCP subgroups was significantly higher than the new bone formation in the control, and the new bone quality was better. The bone regeneration effect of odontogenic BCP was similar to the effect of deproteinized bovine bone mineral, but b- TCP did not maintain the height and volume of bone reconstruction. CONCLUSION: In conclusion, the combined application of DNCPs and odontogenic BCP is an effective strategy for tissue engineering osteogenesis in the maxillary sinus region. The biomimetic strategy could provide a new approach for patients requiring maxillary sinus lifting.
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