동종 반월상 연골 이식술의 임상적 결과 - 내측과 외측 및 동반 손상의 유무에 따른 비교 -

조승목,윤경호,이정환,배대경,송상준,강창민,Cho, Seung-Mok,Yoon, Kyoung-Ho,Lee, Jung-Hwan,Bae, Dae-Kyung,Song, Sang-Jun,Kang, Chang-Min 대한관절경학회 2009 대한관절경학회지 Vol.13 No.1

목적: 동종 반월상 연골 이식술의 결과를 내측과 외측 및 동반손상 유무에 따라 비교하고자 하였다. 대상 및 방법: 1999년 12월부터 2007년 6월까지 동종 반월상 연골 이식술을 시행하고 1년이상 추시가 가능했던 52례를 대상으로 하였다. 내측 이식군은 19례, 외측 이식군은 33례였고, 단독 손상군은 18례 동반 손상군은 34례였다. 평균나이는 34.2세(18세~51세) 평균 추시기간은 42.2개월(12개월~90개월)이었다. 임상적 결과의 판정을 위하여 슬관절 운동범위, VAS 점수, IKDC 주관적 평가 점수, Lysholm 점수, Tegner 점수, 환자 만족도 및 이차 관절경 또는 추시 MRI를 시행하였다. 결과: 수술 후 평균 관절운동 범위는 130.3도 였다. VAS 점수는 수술 전 5.96점에서 3.05점으로, IKDC 주관적 평가 점수 46.5점에서 64.52점으로(p<0.001), Lysholm 점수는 61.94점에서 79.58점으로(p=0.0019) Tegner점수는 수술 전 2.97에서 3.62점으로 향상되었으며 수술의 만족도는 '매우만족', '대체로 만족'이라고 대답한경우가 61.5% 였다. 수술 후임상적 점수의 향상이 있었지만 내측과 외측 이식술 군간 그리고 단독 손상군과 동반 손상군 간의 통계적 유의한 차이는 없었다. 이차 관절경을 시행한 18례중 10례에서 이식된 동종 반월상 연골의 변연부의 치유 소견이 관찰되었고 6례에서 부분파열이 2례에서는 복합 파열이 관찰되었다. 추시 MRI 촬영이 가능하였던 16례에서 아탈구는 12례에서 관찰되었다. 결론: 반월상 연골 이식술 후 내측과 외측 이식군 간의 임상적 결과는 차이가 없었으며 동반된 연골 손상이나 불안정성에 대한 치료를 병행한 경우 동반손상의 유무는 결과에 영향을 미치지 않았다. Purpose: To compare the clinical outcomes after meniscus allograft transplantation between lateral and medial or isolated and combined procedure groups. Materials and Methods: Of the patients who had undergone arthroscopic meniscal allograft transplantation between Dec. 1997 and Jun. 2007, 52 patients were available for retrospective evaluation. Patients were grouped into lateral(33 cases) and medial(19 cases) transplant groups as well as those with isolated(18 cases) and combined(34 cases) procedure. The average age was 34.2 years and the mean follow-up period was 42.2 months. Postoperative range of motion (ROM), visual analog scale (VAS), International Knee Documentation Committee (IKDC) subjective score, Lysholm score, Tegner score, patient's subjective satisfaction, $2^{nd}$ look arthroscopy and MRI were evaluated retrospectively. Results: Mean postoperative ROM was $130.3^{\circ}$. The VAS showed an improvement from 5.96 to 3.05 at the last follow up. IKDC subjective score and Lysholm score also showed an improvement from 46.5 to 64.5 and from 61.9s to 79.58 respectively. Tegner score was improved from 2.9 to 3.6. Overall, 61.5% of patients reported they were completely or mostly satisfied with procedure. There were no significant differences noted between lateral and medial groups as well as isolated and combined groups. In 2nd look arthroscopy, 10 of 18 cases showed good pheripheal healing and there were 6 cases of partial and 2 of complex tear. We observed graft subluxation or extrusion in 12 of 16 cases who were evaluated with follow-up MRI. Conclusion: Meniscus allograft transplantation alone or in combination with other procedure showed an improvement in knee pain and clinical score. But there were no significant difference between lateral and medial groups or isolated and combined procedure groups.

농촌지역 노인들의 인지기능 장애와 사망과의 관련성

선병환,박경수,나백주,박요섭,남해성,신준호,손석준,이정애,Sun, Byeong-Hwan,Park, Kyeong-Soo,Na, Baeg-Ju,Park, Yo-Seop,Nam, Hae-Sung,Shin, Jun-Ho,Sohn, Seok-Joon,Rhee, Jung-Ae 대한예방의학회 1997 예방의학회지 Vol.30 No.3

60세이상 노인인구를 대상으로 '농촌지역 노인들의 우울 및 인지기능 장애에 관한 연구'를 한 이정애와 정향균의 연구대상 558명에 대해 농촌지역 노인들의 인지기능 장애와 사망과의 관련성을 살펴본 결과는 다음과 같다. 1) 3년동안 동안 전체 대상자의 사망률은 558명중 57명인 10.2%이었으며 353명의 정상 인지기능군 중 사망자는 30명으로 사망률 8.5%, 126명 의 경도 인지장애군중 사망자는 14명으로 사망률 11.1%, 79명의 중증 인지장애군중 사망자는 13명으로 사망률 16.5% 이었다(표 3). 2) 3년동안 전체 연구 대상자의 생존율은 0.91이었으며 정상, 경도, 중증 인지기능 장애군의 3년 생존율은 각각 0.92, 0.90, 0.86이었다. 로그 순위 검정법으로 인지기능 정상군과 경도 및 중증의 각 인지기능 장애군의 생존곡선을 비교한 결과 통계적으로 유의하지 않았다. 또한 인지기능 정상군과 경도 이상의 인지기능 장애군간 생존곡선을 비교한 결과도 유의한 차이는 없었다. 3) 혼란변인을 보정하지 않는 Cox의 비례위험 회귀 모형의 단변량분석의 결과 95% 신뢰구간(C.I. : Confidence Interval)에서 사망위험도가 유의한 변인은 연령, 월수입, 흡연습관, 신체장애 등이었으며, 인지기능 장애정도를 정상 그리고 경도 및 중증으로 분류한 분석에서는 정상군에 비해 경도 및 중증의 사망위험도가 유의하게 높지 않았으나, 인지기능 점수(MMSEK score)의 증가에 따른 분석 결과 사망위험도가 0.94로 유의하게 낮게 나타났다(표 4). 4) 잠재적 혼란변인들의 영향을 보정한 Cox의 비례위험 회귀모형의 다변량 분석의 결과 인지기능 장애정도 및 MMSEK 점수증가에 따른 사망위험도는 어느 모형에서도 인지기능 장애정도가 사망에 미치는 위험도는 통계적으로 유의하지 않았다(표 5). 5) 남녀별로 각각 인지기능 장애와 사망위험도와의 관계를 알아보기 위해 다변량 분석을 시행한 결과 인지기능 장애정도 및 MMSEK 점수 증가에 따른 사망위험도는 어느 모형에서도 인지기능 장애정도가 사망에 미치는 위험도는 통계적으로 유의하지 않았다(표 6, 표 7). 이상 본 연구는 농촌지역 노인들에서 인지기능 장애정도가 사망에 미치는 영향을 알아보고자 하였지만, 인지기능 장애정도가 사망에 미치는 영향을 통계적으로 유의하게 고찰하지 못하였다. The purpose of this study was to examine the mortality risk associated with cognitive impairment among the rural elderly. The subjective of study was 558 of 'A Study on the Depression and Cognitive Impairment in the Rural Elderly' of Jung Ae Rhee and Hyang Gyun Jung's study(1993). Cognitive impairment and other social and health factors were assessed in 558 elderly rural community residents. For this study, a Korean version of the Mini-Mental State Examination(MMSEK) was used as a global indicator of cognitive functioning. And mortality risk factors for each cognitive impairment subgroup were identified by univariate and multivariate Cox regression analysis. At baseline 22.6% of the sample were mildly impaired and 14.2% were severely impaired. As the age increased, the cognitive function was more impaired. Sexual difference was existed in the cognitive function level. Also the variables such as smoking habits, physical disorders had the significant relationship with cognitive function impairment. Across a 3-year observation period the mortality rate was 8.5% for the cognitively unimpaired, 11.1% for the mildly impaired, and 16.5% for the severly impaired respendents. And the survival probability was .92 for the cognitively unimpaired, .90 for the mildly impaired, and .86 for the severly impaired respondents. Compared to survival curve for the cognitively unimpaired group, each survival curve for the mildly and the severely impaired group was not significantly different. When adjustments models were not made for the effects of other health and social covariates, each hazard ratio of death of mildly and severely impaired persons was not significantly different as compared with the cognitively unimpaired. But, as MMSEK score increased, significantly hazard ratio of death decreased. Employing Cox univariate proportional hazards model, statistically other significant variables were age, monthly income, smoking habits, physical disorders. Also when adjustments were made for the effects of other health and social covariates, there was no difference in hazard ratio of death between those with severe or mild impairment and unimpaired persons. And as MMSEK score increased, significantly hazard ratio of death did not decrease. Employing Cox multivariate proportional hazards model, statistically other significant variables were age, monthly income, physical disorders. Employing Cox multivariate proportional hazards model by sex, at men and women statistically significant variable was only age. For both men and women, also cognitive impairment was not a significant risk factor. Other investigators have found that cognitive impairment is a significant predictor of mortality. But we didn't find that it is a significant predictor of mortality. Even though the conclusions of our study were not related to cognitive impairment and mortality, early detection of impaired cognition and attention to associated health problems could improve the quality of life of these older adults and perhaps extend their survival.

Prevention of Particulate Matters Adhesion to the Surface by Increasing Hydrophobicity with Protrusion Structures of Marine-derived Powder Material

Jung Wook KANG,Mi Kyung SUNG,Bong Jun KIM,Sukwon Sunny KIM,Hyun Dae CHO 한국생물공학회 2020 한국생물공학회 학술대회 Vol.2020 No.10

Some medical personnel do not recognize management of the cuff of artificial airway (초)

( Sung Tae Kim ),( Min Gyu Kang ),( Ji Young Hong ),( Ji Woong Son ),( Eu Gene Choi ),( Moon Jun Na ),( Ji Hyae Kim ),( Sun Jung Kwon ) 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-

Poster Session : PS 1242 ; Pulmonology : A Case of Hemophagocytic Lymphohistiocytosis after Lung Transplantation

( Sung Woo Moon ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ),( Joon Chang ),( Se Kyu Kim ),( Hyo Chae Paik ),( Jun Won Cheong ),( Song Yee Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening complication after solid organ transplantation. HLH has been reported as problem related with kidney and liver transplant, and there are limited reports of HLH after lung transplantation. Case: A 60-year-old man with idiopathic pulmonary fibrosis underwent bilateral lung transplantation. After lung transplantation, acute rejection was suspected and high dose steroid therapy was done. Since postoperative day(POD) 25, thrombocytopenia( platelet 112*1000/uL) and leukopenia(2530/uL)) were presented. The patient complained of intermittent symptom of low-grade fever, chest discomfort and dyspnea. Echocardiography showed stress induced cardiomyopathy and results of peripheral blood smear was nonspeci. c. Pneumonia was developed and patient was treated with antibiotics. Hyperbilirubinemia(total bilirubin 2.1 mg/dL) started to present at POD 50. Results of abdomen sonography was nonspeci. C except for mild splenomegaly (11.4cm). By POD 80, bilirubin was getting higher(total bilirubin 33.3mg/dL, direct bilirubin 25.7mg/dL, gamma glutamyl transpeptidase 260IU/L) and leukopenia and thrombocytopenia was getting aggravated (white blood cell 2080/uL and platelet 57* 1000/uL). The . brinogen was mildly elevated (4210m/dL), triglyceride was normal (127 mg/dL), the ferritin was elevated (4518 ng/mL) and soluble interleukin-2 receptor was elevated (8730U/ml). However, the finding of peripheral blood smear was still nonspeci. c. The cause of pancytopenia, low grade fever and hyperbilirubinemia was unclear, and we conducted bone marrow biopsy on POD 82. The finding showed that histiocytes were frequently seen with occasional hemophagocytes. Taken together, cytopenia, bone marrow hemophagocytes, elevated soluble interleukin-2 receptor and elevated ferritin were positive among laboratory tests listed in diagnostic criteria of HLH. We managed with etoposide and high dose steroid, but patient deteriorated and died on POD 87. Summary: HLH is a significant diagnostic and therapeutic challenge in lung transplantation and is potentially lethal complication. Therefore, clinicians should consider HLH as possible diagnosis in clinical context.

Nanoscale <i>in situ</i> detection of nucleation and growth of Li electrodeposition at various current densities

Jung, Haesung,Lee, Byeongdu,Lengyel, Miklos,Axelbaum, Richard,Yoo, Jeeyoung,Kim, Youn Sang,Jun, Young-Shin The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.11

<P>Li metal batteries can store at least ten times more energy than currently existing Li-ion batteries. However, during routine charging and discharging, Li dendrites grow on the Li metal electrode, which can lead to capacity loss by the consumption of Li salt at the surface of the Li dendrites, and be a safety hazard resulting from the potential for short-circuits. Although past efforts have provided useful information about the morphology and surface area of Li dendrite formation at the microscale, a nanoscale understanding of nucleation and growth of Li nanoparticle electrodeposition is still elusive. In this study, using a new electrochemical cell for transmission mode grazing incidence small angle X-ray scattering, we obtained, for the first time, the primary nucleus size of Li nanoparticles, their size evolution and their fractal structures at various current densities and in real-time. The measured average radius of gyration, <I>R</I>g, at current densities of 0.1, 0.5, and 2.0 mA cm<SUP>−2</SUP> is 5.4 ± 0.4, 4.5 ± 0.3, and 3.5 ± 0.3 nm, respectively. This variation in size with current density is noteworthy when recognizing that the surface area-to-volume ratio of the Li nanoparticles is 3.7 times higher at 2.0 mA cm<SUP>−2</SUP> than at 0.1 mA cm<SUP>−2</SUP>. We also compared a hierarchical fractal structure of Li particles from the nanometer to micrometer scale. Our findings illuminate the role of overpotential in the reactive surface area of Li dendrites at the nanoscale, and provide a novel research platform for suppressing Li dendrite formation in Li metal battery systems.</P>

Poster Session : PS 1013 ; GI Motility : Treatment Outcome and Clinical Characteristics of Patients with Cancer-Positive Lateral Margin after Endoscopic Submucosal Dissection for Early Gastric Cancer

( Sang Hyun Yoon ),( Da Hyun Jung ),( Jun Chul Park ),( Sung Kwan Shin ),( Sang Kil Lee ),( Yong Chan Lee ),( Hyun Soo Chung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Rate of cancer-positive lateral margin (LM) after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) have been reported 2 to 12%. Sometimes cancer cells abut to multiple lateral margins. The aim of this study was to compare clinicopathologic characteristics and treatment outcomes between single and multiple cancer-positive LM group. Methods: From September 2010 to April 2014, 1346 patients underwent ESD for EGC. Among them, 33 patients (2.5%) had cancer-positive LM. Clinicopathological data of these patients were investigated. Results: There were 25 patients with single positive LM (group LM1+) and 8 with multiple positive LM (group LM2+). No patients met the absolute indication of ESD, and all patients met the expanded indication (n=17) or beyond indication (n=16). LM2+ group tended to have more undifferentiated carcinoma (62.5% vs. 36.0%) and larger size of the lesion (>30mm) (62.5% vs. 28%), but there were no statistical signifi cance. Sixteen patients (64%) and 1 patient (12.5%) met expanded indication of ESD in LM1+ and LM2+ group, respectively. After ESD, 5 patients (20.0%) and 1 patient (12.5%) underwent regular endoscopic follow-up, and 11 patients (36.4%) and 1 patient (12.5%) underwent local control with redo-ESD or argon plasma coagulation in LM1+ and LM2+ group, respectively. There were no locoregional or distant metastasis during the follow-up periods (median 25.1 months). Nine (36.0%) in LM1+ group and 6 (75.0%) in LM2+ group underwent surgery after ESD. Residual cancer was detected in 69.2% (9/13) and 66.7% (4/6) after surgery or redo-ESD in LM1+ and LM2+ group, respectively. Conclusions: Even though there was no statistical signifi cance, proportions of large lesion size (>3cm) and undifferentiated carcinoma were higher in LM2+ group than LM1+ group. Careful investigation of margin is necessary for these patients.

Development of Predictive Models of E. coli O157:H7 Growth in Lettuce at 15℃

Jun Wang,Tian Ding,S. M. E. Rahman,Na-Jung Choi,Ha-Na Kim,Jae-ho Choi,Uranchimeg Purev,Sang-Do Ha,Gyung-Jin Bahk,Myung-Sub Chung,Hyang-Sook Chun,Deog-Hwan Oh 동아시아식생활학회 2010 동아시아식생활학회 학술발표대회논문집 Vol.2010 No.11

Determination of Chimera Types and Ploidy Level of Sports from ‘Campbell Early’ Grape (Vitis labruscana)

Jung Ho Noh(노정호),Kyo Sun Park(박교선),Hae Keun Yun(윤해근),Gyung Ran Do(도경란),Youn Young Hur(허윤영),Seung Hui Kim(김승희),Han Chan Lee(이한찬),Myung Sang Ryou(류명상),Seo Jun Park(박서준),Sung Min Jung(정성민) 한국원예학회 2010 원예과학기술지 Vol.28 No.6

‘캠벨얼리’ 아조변이체의 배수성을 flow cytometry(FCM)를 이용하여 검정하였다. 2배체 포도인 ‘캠벨얼리’와 4배체 포도인 ‘거봉’과는 달리 ‘캠벨얼리’에서 발생한 아조변이 3계통의 경우, 잎에서 2배체와 4배체 peak가 동시에 나타났다. 또한 ‘캠벨얼리’ 포도의 과육과 과피의 배수성은 2배체 peak를 보인 반면, ‘캠벨얼리’ 아조변이체는 과피의 배수성은 2배체로, 과육의 배수성은 4배체로 검정되었다. 정확한 염색체 숫자를 알아보기 위해 ‘캠벨얼리’ 유래 아조변이체, ‘캠벨어리’, ‘거봉’ 포도의 근단 조직 염색체 숫자를 현미경 검경하였다. ‘캠벨얼리’와 ‘거봉’은 각각 38, 76개의 염색체로 나타난 반면 아조변이체는 2x=38, 4x=76개의 염색체가 혼재한 것으로 나타났다. ‘캠벨얼리’ 아조변이체의 키메라 형태를 알아보기 위하여 신초 정단 분열조직을 현미경 관찰하였다. 대조구로 이용된 2배체 ‘캠벨얼리’와 4배체 ‘거봉’ 포도는 2개의 tunica 층이 corpus층을 덮고 있었으며, 반면에 아조변이체의 경우 첫번째 tunica 층이 독특하게 분할되어 있었다. ‘거봉’ 포도의 정단분열 조직의 세포 크기는 대체로 ‘캠벨얼리’ 포도보다 더 컸다. 아조변이체의 L-2, L-3 층을 이루고 있는 세포 크기는 4배체인 ‘거봉’ 세포와 유사하였으며 가장 바깥쪽 L-1층을 이루고 있는 세포의 크기는 ‘캠벨얼리’ 포도와 유사한 크기였다. 따라서 본 시험의 결과 ‘캠벨얼리’ 포도 품종에서 발생한 아조변이체들은 2-4-4형 키메라의 가능성이 높은 것으로 판단되었다. Flow cytometry (FCM) was used to measure the ploidy level of three different sports from ‘Campbell Early’ (Vitis labruscana) grape. Results of the study showed different ploidy levels. FCM analysis for ‘Campbell Early’ grape which contains 2C DNA diploid cells showed single peak around 35-40 while ‘Kyoho’ grape with 4C DNA tetraploid cells had a different level of 70-80. However, analysis of the sports displayed a histogram with 2 peaks containing both 2C and 4C nuclei. There was no difference in histograms of 2C DNA flesh and pericarp; on the other hand, 4C DNA flesh type of sports had a different histogram from that of the 2C DNA pericarp. Chromosome numbers of diploid (‘Campbell Early’), tetraploid (‘Kyoho’), and three sports were counted under the microscope. ‘Campbell Early’ and ‘Kyoho’ have 38 and 76 chromosomes, respectively. Three different sports are mixoploids with mixtures of diploid and tetraploid cells. Microscopic observations of shoot apical meristems in sports from ‘Campbell Early’ grape were carried out to determine the type of plant chimera. ‘Campbell Early’ grape (diploid) and ‘Kyoho’ grape (tetraploid) showed that both had 2 tunica layers covering corpus cells, while the three different sports had tunica layers showing mostly oblique division. Most cells from ‘Kyoho’ grape were larger than ‘Campbell Early’ grape. Cells from L-2 and L-3 layers of the three sports were similar to ‘Kyoho’ grape in size, although all cells in L-1 surface layer were uniform in size like ‘Campbell Early’ grape. Results of FCM analysis indicated that both normal and polyploid cells could be intermixed in sports and could become mixoploidy consisting of diploid and tetraploid. All sports used in the tests were periclinal chimera plants with two distinct L-1 and L-2 cell layers. The result of this study suggests that all three sports which originated from ‘Campbell Early’ grape might be 2-4-4 type chimera formation.

Heat transfer and flow characteristics of forced convection in PDMS microchannel heat sink

Jung, Sung Yong,Park, Jun Hong,Lee, Sang Joon,Park, Hanwook Elsevier 2019 Experimental thermal and fluid science Vol.109 No.-

<P><B>Abstract</B></P> <P>Recently, microfluidic devices are being widely used in various heat transfer applications and, thermal management in microchannels is a challenging issue. As a solution, different types of microchannel heat sinks have been employed to enhance the heat transfer. The flow characteristics in the microchannel heat sink have influence on the heat transfer rate and thermal management performance. Therefore, the simultaneous measurement of temperature and velocity fields is highly required to understand the single-phase heat transfer phenomena in the PDMS microchannel heat sink. In this study, μPIV-μLIF technique which can provide the velocity and temperature field information of micro-scale thermofluid flow was newly developed to analyze the heat transfer of forced convection in PDMS microchannel heat sink. Especially, flow characteristics in the microchannel heat sink were systematically investigated. At a high <I>Re</I> flow (<I>Re</I> = 10) with heating, a high-speed crossflow occurs in the microchannel heat sink. Spanwise vorticity and Reynolds shear stress, which contribute to heat transfer in the microchannel, exhibit higher values at <I>Re</I> = 10 with heating compared to the non-heating case. Variations in velocity and local <I>Nu</I> number were also compared to explain heat transfer enhancement in the microchannel heat sink. Temporal variations in the temperature field were evaluated to demonstrate the effect of flow on heat transfer. The results presented herein would be helpful for understanding heat transfer in microscale thermofluid flows and for designing microscale heat transfer devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Velocity and temperature fields in microchannels were measured by μPIV and μLIF. </LI> <LI> Flow characteristics near the heat sink were systematically investigated. </LI> <LI> High-speed crossflow occurs in the heat sink of the microchannel when <I>Re</I> = 10. </LI> <LI> Velocity fluctuations and local <I>Nu</I> number were compared to explain heat transfer. </LI> <LI> Temporal variations in temperature were evaluated to analyze the heat transfer. </LI> </UL> </P>