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Transmission ability of Zika virus with artificially infected Aedes albopictus in Korea
Yang Sung‐Chan,Lee Hee-Il,Kim Hyunwoo,Lee Wook‐Gyo 한국곤충학회 2021 Entomological Research Vol.51 No.8
Zika virus (ZIKV), a virus mainly occurring in South America, is now globally distributed. Understanding the pathogen transmission cycle in a vector is exceptionally important in developing disease control strategies. In this study, we performed ZIKV microinjection in Aedes albopictus (Skuese), to estimate its vertical and horizontal transmission ability. The virus infection rate was confirmed by real-time qPCR in the F1 generation derived from the ZIKV-injected Ae. albopictus. The minimum infection rate (MIR) of the F1 generation was highest when they were injected with the virus at 6–12 h (MIR: 16.1) and lowest at 12–24 h (MIR: 4.7) after feeding. In the developmental stage of the F1 progeny, MIR values were 1.0, 1.3, and 6.7 in each egg, larval, and adult stage, respectively, but ZIKV was not detected in the pupa stage. Virus transmission ability was not significantly different between the collection areas (Tongyeong and Jeju). Ae. albopictus demonstrated a high venereal transmission rate of ZIKV and was detected in males (6 pool/7 pool) and females (6 pool/7 pool), confirming that ZIKV can be transmitted from infected mosquitoes to uninfected mosquitoes via mating. This is the first study of the administration of a ZIKV microinjection to Ae. albopictus in Korea and suggests a possibility of a potential mechanism for the virus to survive during adverse conditions via vertical transmission.
Sung-Chan Yang,E-Hyun Shin,Kyu-Sik Chang,Jong Yul Roh,Mi-Yeoun Park,Wook-Gyo Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
As a part of disease vector and possible overseas inflow caused by global warming monitoring around airport and port area, the distribution of domestic mosquitoes was investigated using BG-sentinel trap. Mosquitoes were collected during 5-days per each area in early September, using 10 traps in Cheongju (airport) and 15 traps in Pyeongtaek (port). The numbers of mosquitoes collected in Cheongju and Pyeongtaek area were 1,762 including 10 species and 1,042 including 11 species respectively. In Cheongju, Aedes albopictus (657 individuals, 37.3%) and Culex pipiens complex (415 individuals, 23.6%) were dominant species; while in Pyeongtaek, Cx. pipiens complex (806 individuals, 77.4%) was dominant followed by Anopheles spp. (90 individuals, 8.6%) and Ochlerotatus koreicus (79 individuals, 7.6%). Similar species were collected in both Choengju and Pyeongtaek area. Although most species collected in both Cheongju and Pyeongtaek area were the same, Cx. inatomii was only collected in Pyeongtaek. In case of the Genus Aedes, more number of Ae. albopictus was collected compared to Oc. koreicus in Cheongju; while Oc. koreicus was more in Pyeongtaek. In case of the genus Culex, the individuals belonging to the vishinui group were collected such as Cx. bitaeniorhynchus, Cx. tritaeniorhynchus and Cx. orientalis. This study may provide basic information for efficient prevention of vector mosquito and potential overseas inflow of diseases, also we would try to expand different area in Korea.
Isolation of novel bovine parainfluenza virus type 5 (bPIV5) and its incidence in Korean cattle
Yang, Dong-Kun,Nah, Jin-Ju,Kim, Ha-Hyun,Choi, Sung-Suk,Bae, You-Chan,Park, Jung-Won,Song, Jae-Young The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.2
Four viruses showing cytopathic effects in MDBK cells were isolated from brains of cattle showing downer cattle syndrome in 2012. The isolates were confirmed to belong to the genus Rubulavirus of the subfamily Paramyxovirinae. Isolate QIA-B1201 had the ability to hemagglutinate red blood cells from several species of animals and was capable of adsorbing guinea pig erythrocytes on the surface of infected Vero cells. Nucleotide sequence analysis showed that two isolates (QIA-B1201 and QIA-B1204) had high similarity with other human and animal PIV5 isolates ranging from 98.1 to 99.8%. The highest sequence similarity of the two isolates corresponded to strain KNU-11 (99.8% at the nucleotide and amino acid level) isolated from suckling piglets in Korea in 2012. To evaluate the virulence of strain QIA-B1201, we inoculated bPIV5 into 5 week-old mice via both the intraperitoneal and intracranial route. Body weight was not significantly altered in mice inoculated with QIA-B1201. In this study, we isolated and characterized novel bPIV5s from brain samples showing downer cattle syndrome, but were not able to elucidate the pathogenicity of the bPIV5s in mice.
Design of Ultra-sonication Pre-Treatment System for Microalgae CELL Wall Degradation
Yang, Seungyoun,Mariappan, Vinayagam,Won, Dong Chan,Ann, Myungsuk,Lee, Sung Hwa The Institute of Internet 2016 International journal of advanced smart convergenc Vol.5 No.2
Cell walls of microalgae consist of a polysaccharide and glycoprotein matrix providing the cells with a formidable defense against its environment. Anaerobic digestion (AD) of microalgae is primarily inhibited by the chemical composition of their cell walls containing biopolymers able to resist bacterial degradation. Adoption of pre-treatments such as thermal, thermal hydrolysis, ultrasound and enzymatic hydrolysis have the potential to remove these inhibitory compounds and enhance biogas yields by degrading the cell wall, and releasing the intracellular algogenic organic matter (AOM). This paper preproposal stage investigated the effect of different pre-treatments on microalgae cell wall, and their impact on the quantity of soluble biomass released in the media and thus on the digestion process yields. This Paper present optimum approach to degradation of the cell wall by ultra-sonication with practical design specification parameter for ultrasound based pretreatment system. As a result of this paper presents, a microalgae system in a wastewater treatment flowsheet for residual nutrient uptake can be justified by processing the waste biomass for energy recovery. As a conclusion on this result, Low energy harvesting technologies and pre-treatment of the algal biomass are required to improve the overall energy balance of this integrated system.
Pulmonary function and toxicities of proton versus photon for limited-stage small cell lung cancer
Sang Hoon Seo,Hongryull Pyo,Yong Chan Ahn,Dongryul Oh,Kyungmi Yang,Nalee Kim,Jong-Mu Sun,Sehhoon Park,Hyun Ae Jung,Se-Hoon Lee,Jin Seok Ahn,Myung-Ju Ahn,Jae Myoung Noh 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4
Purpose: We aimed to compare the oncological outcomes and toxicities of definitive proton beam therapy (PBT) and photon beam therapy in patients with limited-stage small cell lung cancer (LS-SCLC). Materials and Methods: We retrospectively reviewed 262 patients with newly diagnosed LS-SCLC who underwent definitive PBT (n = 20; proton group) or photon beam therapy (n = 242; photon group) with concurrent chemotherapy between January 2016 and February 2021 and compared overall survival (OS), progression-free survival (PFS), dose-volume parameters, and toxicities between the groups. Results: The median follow-up duration was 24.5 months (range, 3.7 to 78.7). Baseline lung function was significantly worse and clinical target volume (CTV) was larger in the proton group (CTV: 296.6 vs. 215.3 mL; p = 0.080). The mean lung V10 was 37.7% ± 16.8% and 51.6% ± 24.5% in the proton and photon groups, respectively (p = 0.002). Two-year OS and PFS rates were 57.2% and 35.7% in the proton group and 65.3% and 40.8% in the photon group, respectively (p = 0.542 and 0.748, respectively). Grade ≥2 radiation pneumonitis and esophagitis occurred in 5 (25.0%) and 7 (35.0%) PBT-treated patients and 66 (27.3%) and 40 (16.5%) photon beam therapy-treated patients, respectively (p = 0.826 and 0.062, respectively). Conclusion: Although the proton group had poorer lung function and a larger CTV than that in the photon group, both groups exhibited comparable treatment outcomes and radiation-related toxicities in LS-SCLC. PBT may be a valuable therapeutic modality in patients with poor pulmonary function or extensive disease burden owing to its lung-sparing ability.
Full-mouth rehabilitation with immediate loading and guided implant surgery: a case report
Chan-Ho Jung,Yang-Yeol Tae,Sung-Ouk Kim,Hyun-Jun Park,Kwan-Soo Park 대한치과이식임플란트학회 2020 The Korean Academy of Implant Dentistry Vol.39 No.4
This case report presents a case of immediate loading with guided surgery in a patient who had complete edentulous jaws. The patient experienced discomfort in the upper and lower removable complete dentures, and wanted to change it fixed complete prosthesis. The full-mouth rehabilitation was planned using 16 implant fixtures, eight each for maxilla and mandible. For guided surgery, surgical templates were fabricated by implant planning system, and provisional prostheses and customized abutments for immediate loading were fabricated by computer aided design and computer aided manufacturing technology. 28 months after the surgery, clinical and radiologic complications were not observed, and the patient’s masticatory function and esthetics were well-maintained.
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chan 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Bart’s syndrome is a rare hereditary mechanobullous disorder, first described by Bart et al in 1966. It is characterized by clinical manifestations: aplasia cutis congenita (ACC) over the lower extremities, epidermolysis bullosa (EB), and nail abnormalities. Previous genetic study revealed glycine substitution mutation in type VII collagen gene (COL7A1) indicated that Bart’s syndrome is a clinical variant of dominant dystrophic EB. The patient was a 1-day-old male newborn who presented with well-demarcated absence of skin over both lower extremities and erosive patches with blisters on nostril, lip, and hand since birth. He was born by Cesarean section at the 37th weeks of gestation. There was no family history of genetic disorder. There was no systemic involvement such as pyloric atresia, renal abnormalities, or arthrogryposis. Histopathologic findings from blister on hand showed subepidermal blister formation, and electron microscopy showed separation of below lamina densa layer. We performed mutation analysis of 118 exons of COL7A1. These result disclosed two novel heterogenous frameshift mutations (c.3841_3843delGGTinsTGGGG in exon 31 and c.8109_81014delGGTGAG in exon 109). Therefore, he was diagnosed as Bart’s syndrome with recessive dystrophic EB. Herein, we report a very rare case of Bart' syndrome which is clinical variant of recessive dystrophic EB, and review genetic mutation in this syndrome.