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( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
( Sang Gyune Kim ),( Jeong Joo Yoo ),( Young Seok Kim ),( Bora Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Young Don Kim ),( Gab Jin Cheon ),( Boo Sung Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Several real-time two-dimensional shear wave elastography (2D-SWE) have been developed to assess liver fibrosis with readily use of combining elastography and traditional ultrasound imaging. However, compared with transient elastography (fibroscan), the diagnostic accuracy and clinical usefulness of these methods were not fully validated. In this study, newly developed 2D-SWE (LOGIQ E9, GE healthcare, UK) was evaluated for predicting liver fibrosis stage and compared with fibroscan. Methods: Out of 1,395 patients who received 2D-SWE during May 2015 to Apr 2016, seventy (5.0%) who failed to get available value of 2D-SWE due to obesity and 131 (9.4%) with high value of AST or ALT were excluded in the analysis. Liver biopsy was performed in 177 patients. 2D-SWE measurement was considered valid when homogenous color pattern in a region of interest of at least 10 mm was shown at 10 different sites. Diagnostic performance was calculated using area under the receiver operating characteristics curve (AUROC). Results: Patients were male predominant (60.8%), their mean age was 50.4±12.4 years old and most common etiology of liver disease was hepatitis B (40.3%) followed by alcohol (26.1%). Liver fibrosis stage consisted of F0 (14.1%), F1 (12.4%), F2 (28.8%), F3 (18.1%) and F4 (26.6%). Overall, 2D-SWE was well correlated with transient elastography (r=0.788, P<0.001). 2D-SWE median values (kPa) increased with increasing stage of liver fibrosis [ F0 (5.0±1.5), F1 (6.4±2.3), F2 (6.5±2.0), F3 (9.0±2.7), F4 (12.7±2.9)] (p for trend <0.001). For the diagnosis of liver cirrhosis, AUROCs and optimal cutoff of 2D-SWE were 0.928 (95% confidence interval [CI], 0.890-0.967) and 10.1 kPa. The sensitivity, specificity, positive predictive value and negative predictive value for predicting cirrhosis were 82.2%, 92.2%, 78.7% and 93.7% respectively. For diagnosing significant liver fibrosis (≥F2), AUROCs and optimal cutoff of 2D-SWE were 0.913 (95% CI, 0.870-0.956) and 7.99 kPa. Conclusions: With effective comparability to fibroscan and availability of a conventional ultrasound examination, 2D-SWE is an useful tool for stratifying liver fibrosis stage and diagnosing liver cirrhosis.
( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: There are various treatment options of psoriasis, including phototherapy, systemic oral agents and, recently, biologics. These therapies include immune regulation, so it is necessary to confirm the risk of malignancy and infections. Objectives: To evaluate the risk of malignancies and hospitalized infectious disease (HID) in patients with psoriasis by treatments, comparing with general population (GP). Methods: The study population consisted of 159,423 patients for malignancies and 272,475 patients for HID during 2005 to 2018 from the National Health Insurance Service (NHIS). Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of mild (ML), phototherapy (PH), oral systemics (OR) and biologics (BI) cohort were evaluated. Results: For HID, the results (aHRs; CIs) were ML (1.12; 1.11-1.14), PH (1.05; 1.00-1.09), OR (1.19; 1.15-1.24) and BI (0.85; 0.62-1.17). For tuberculosis (Tb), a particular infectious disease, the results (aHRs; CIs) were ML (1.11; 1.06-1.16), PH (1.11; 0.96-1.28), OR (1.21; 1.08-1.36) and BI (8.83; 6.62-12.5). For malignancies, the results (aHRs; CIs) were ML (1.12; 1.10-1.15), PH (1.20; 1.12-1.29), OR (1.15; 1.08-1.21) and BI (1.47; 0.93-2.43). Conclusion: Patients with psoriasis showed a significantly higher risk of malignancies and HID than GP. Biologics were not seemed to be a significant risk factor for these diseases, but appeared to increase the risk of Tb. Therefore, in choosing a treatment for psoriasis, these risks should be considered.
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chan 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Bart’s syndrome is a rare hereditary mechanobullous disorder, first described by Bart et al in 1966. It is characterized by clinical manifestations: aplasia cutis congenita (ACC) over the lower extremities, epidermolysis bullosa (EB), and nail abnormalities. Previous genetic study revealed glycine substitution mutation in type VII collagen gene (COL7A1) indicated that Bart’s syndrome is a clinical variant of dominant dystrophic EB. The patient was a 1-day-old male newborn who presented with well-demarcated absence of skin over both lower extremities and erosive patches with blisters on nostril, lip, and hand since birth. He was born by Cesarean section at the 37th weeks of gestation. There was no family history of genetic disorder. There was no systemic involvement such as pyloric atresia, renal abnormalities, or arthrogryposis. Histopathologic findings from blister on hand showed subepidermal blister formation, and electron microscopy showed separation of below lamina densa layer. We performed mutation analysis of 118 exons of COL7A1. These result disclosed two novel heterogenous frameshift mutations (c.3841_3843delGGTinsTGGGG in exon 31 and c.8109_81014delGGTGAG in exon 109). Therefore, he was diagnosed as Bart’s syndrome with recessive dystrophic EB. Herein, we report a very rare case of Bart' syndrome which is clinical variant of recessive dystrophic EB, and review genetic mutation in this syndrome.
Development of Communication Framework for Unmanned Ground Vehicle
Sang Jin Lee,Dong Myung Lee,Jae Cheon Lee 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
This article introduces new concepts for the communication framework of unmanned ground vehicles (UGV). Despite the incompatibility of communication with other UGVs which conform to the Joint Architecture for Unmanned Systems (JAUS) specification, it focuses on achieving performance and stability, and building an extendible framework so that it is easily adaptable to new UGVs with different hardware specifications. The communication framework includes a publisher and subscriber architecture with static registrations of communication information, message buffers which make it possible to asynchronously process input and output messages, and a watchdog function which ensures stable execution of processes for each component.
Structural properties of Riordan matrices and extending the matrices
Cheon, Gi-Sang,Jin, Sung-Tae Elsevier 2011 Linear algebra and its applications Vol.435 No.8
<P><B>Abstract</B></P><P>We consider an infinite lower triangular matrix L=[<SUB>ℓn,k</SUB><SUB>]n,k∈<SUB>N0</SUB></SUB> and a sequence Ω=(<SUB>ωn</SUB><SUB>)n∈<SUB>N0</SUB></SUB> called the (<I>a,b</I>)-sequence such that every element <SUB>ℓn+1,k+1</SUB> except lying in column 0 can be expressed as<SUB>ℓn+1,k+1</SUB>=∑i=0⌊(n-k)/m⌋<SUB>ωi</SUB><SUB>ℓn-ai,k+bi</SUB>,<SUB>ω0</SUB>∉0where <I>a</I> and <I>b</I> are integers with a+b=m>0 and b⩾0. This concept generalizes the <I>A</I>-sequence of a Riordan matrix. As a result, we explore several structural properties of Riordan matrices by means of (<I>a,b</I>)-sequences. In particular, if <I>b</I><0 then this leads to an extended Riordan matrix which is a bilaterally infinite matrix.</P>