드레인 전류 잡음원만을 고려한 스케일링이 가능한 바이어스 의존 P-HEMT 잡음모델

윤경식,이창석,맹성재,이진희,박철순 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

게이트 길이가 0.2㎛인 P-HEMT에 대하여 드레인 바이어스 전류의 변화 및 게이트 폭에 대해 스케일링이 가능한 잡음모델을 제안하였다. 본 논문에서는 S-파라미터를 정확히 예측하기 위하여 x를 제외한 intrinsic 파라미터는 offset를 도입하여 정규화 한 후 스케일링을 하였다. 드레인 포화전류에 대한 드레인 전류의 비율과 게이트 폭을 변수로 하는 소신호 모델 파라미터의 맞춤함수를 구하였다. 또한, 잡음 파라미터를 정확히 예측하기 위하여 진성저항 잡음 온도 T_g, 게이트 단 전류 잡음원 등가잡음 컨덕턴스 G_ni 드레인 단 전류 잡음원 등가잡음 컨덕턴스 G_no를 잡음 모델정수로 사용하여 그 값을 추출하여 스케일링 하였다. 잡음 온도 T_g는 드레인 전류와 게이트 폭에 거의 추출되었다. 그러므로, G_no만을 잡음 모델정수로 하는 잡음모델과 T_g, G_ni, G_no를 잡음 모델정수로 하는 잡음모델을 측정값과 비교하여 본 결과 G_no만을 갖는 잡음모델도 측정된 잡음 파라미터와 잘 일치하였다. 따라서, 모델 정수 추출이 간단한 G_no 만을 갖는 잡음모델은 게이트 폭과 바이어스 전류에 대해 스케일링이 가능한 실용적인 잡음모델임을 확인하였다. Bias-dependent noise models of 0.2㎛ gate length P-HEMT's which are scalable with gate width are proposed. To predict S-parameters of the P-HEMT's the intrinsic parameters except for x subtracted the offsets introduced in this paper are normalized to the gate width and then scaled. The small-signal model parameters are expressed as fitting functions of the drain current to I_dss ratio and gate width. In addition, to estimate accurately noise parameters the noise temperature T_g of the intrinsic resistance, the equivalent noise conductance G_ni of the gate current noise source, and the equivalent noise conductance G_no of the drain current noise source are adopted as the noise model parameters. The extracted values of T_g are nearly independent of drain current and gate width and their average is arou

관성타원을 이용한 다관절의 로보트의 동특성 해석

윤영식,이상조 연세대학교 산업기술연구소 1987 논문집 Vol.19 No.1

The dynamic characteristics of multi-body such as an articulated arm is analyzed and simulated by using the generalized inertia ellipsoid(GIE). Unlike the inertia ellipsoid of a single body, the GIE of multi-body, changes its shape and orientation depending on the configuration of the arm because of nonlinear effects like Coriolis and centrifugal forces. The reciprocal of the square root of the maximum eigenvalue of generalized inertia tensor of the arm tip is corresponding to the minor axis and to the maximum resultant inertia. The speed of the arm tip is maximum along the direction of the eigenvector of the generalized inertia tensor (and vice versa). The results of this study can be applied to design of the robot structure, i.e. the design parameters of the robot can be determined to have an isotropic inertia characteristics and reduce the nonlinear effects through the working space of the robot.

Apoptosis and necroptosis‑inducing effects of arctigenin on nasal septum carcinoma RPMI‑2650 cells in 2D and 3D culture

Yoon‑Jin Lee,Kwan‑Sik Park,Byoung Joon Baek,Kyong‑Ae Lee,Sang‑Han Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an anticancer drug candidate by targeting various pathways involved in anticancer therapy. Methods Using 2D monolayer and 3D spheroid culture systems in nasal septum carcinoma RPMI-2650 cells, the effects of arctigenin and dexamethasone on cell viability, ROS levels, ATP level, mitochondrial function, apoptosis and necroptosis were examined. Results The combination treatment of both compounds induced strong cytotoxicity, accompanied by increases of sub-G0/ G1 peak, annexin V-PE-positive cells, and ROS levels, loss of mitochondrial membrane potential, and decrease of cellular ATP content. These changes were observed as simultaneous induction of DNA damage, apoptosis, and necroptosis. A series of changes by arctigenin and dexamethasone were efficiently restored by decreasing ROS levels or supplementing ATP. Treatment of 3D spheroids with arctigenin and dexamethasone decreased cell viability in the spheroids, but it was slightly resistant than cells under 2D conditions. In addition, this phenomenon was accompanied by an increase in mediators for both apoptosis and necroptosis. Conclusion Results of this study suggest that the apoptosis and necroptosis-inducing effects of arctigenin are associated with ATP depletion due to oxidative mitochondrial dysfunction.

경막외 혈액 봉합술을 시행받은 자발성 두개내 저압 환자의 분석

김두식,유수봉,윤상호 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background : Spontaneous intracranial hypotension(SIH) is found as a not uncommon cause of headache recently. We wanted to study its demographic characteristics, presenting symptoms and findings and the effect of autologous epidural blood patch (AEBP). Methods : We retrospectively analyzed medical records of 11 patients who were diagnosed of spontaneous intracranial hypotension and treated with AEBP from March of 2006 to October of 2009. Results : Age of patients(10 female and 1 male) was ranged from 29 to 51 years (mean 38.8 years). Their presenting symptoms included typical postural headache(11/11), nausea and vomiting(7/11), dizziness(2/11), stiff neck or neck pain(2/11), shoulder pain(2/11), and back pain(1/11). In nine patients CSF pressure was checked, CSF pressure was less than 6 cmH2O in 8 patients. In nine of eleven patients, CSF leakage was detected in cisternography. Brain MRI showed diffuse meningeal enhancement in six patients and subdural hematoma in one. VAS of postural headache decreased from 8-10(mean 9.6) to 1-5(mean 1.6) after AEBP. Conclusion : Most of the SIH patients were otherwise healthy people. It was prevalent among women, especially young adult. AEBP showed as an excellent treatment modality.

퍼머제의 중금속 농도에 관한 연구

윤복연,문덕환,박명희,황용식,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted to prepare the fundamental data on heavy metal concentration in hair permanents agents and to prevent the health impairment due to heavy metal. Methods and Material : The author determined of 5 heavy metals(Pb, Cr, Mn, Ni, and Cu) concentration hair permanent agents in the market with flameless atomic absorption spectrophotometer. Results : The results were as follows: 1. The geometic mean concentrations of total subjects were 0.04㎍/g for Pb, 0.09㎍/g for Cr, 0.06㎍/g for Mn, 0.03㎍/g for Ni, and 0.04㎍/g for Cu. 2. The most highest mean concentrations of heavy metals in hair permanent agents by using type were Cr for wave agent and straight cream agent, Cu for setting iron agent, Cr and Cu for coating perm agent. 3. Metal most hlghest mean concentrations of heavy in hair permanent agents by type of color was green for Cu. 4. The mean concentration of Cu among 5 heavy metals in hair permanent agents by marker was most highest. 5. There was most statistically significant difference on mean concentration in hair permanent agents between domestic and foreign products. 6. The exposure amount of heavy metal concentration by one time using the permanent agent were 4.O㎍ for Pb, 9.O㎍ for Cr, 6.0㎍ for Mn, 3.O㎍ for Ni and 4.0㎍ for Cu. Conclusion : As above results author suggest to prepare the preventive program of health impairment due to heavy metal by long term chronic exposure to who were using the hair permanent agents hair designer and customers.

국내 원자력발전소의 사용후핵연료 선원항 평가에 관한 연구

윤인식,정운관,김성영,염유선,심재학 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.2

우리나라에서도 원자력발전이 상용화된지 이십여년을 넘어서면서 원자력발전을 하고 있는 다른 나라와 마찬가지로 사용후핵연료 관리가 국가적인 문제로 심각히 대두되고 있다. 중간저장 시설은 1997년부터 운영예정이었으나 현재 그의 부지가 아직 확보되지 못한 상태에서 그 운전개시 시점이 불확실하다. 그리고 중간저장 이후의 사용후핵연료 정기관리 전략이 아직 마련되어 있지 못한 실정이다. 그러므로 발전소에서 발생되는 사용후핵연료 양과 그에 따른 선원항 평가는 반드시 선행되어야 할 것이다. 이제 본 연구에서는 국내 사용후핵연료 형태중 17×17에 대해서 농축도와 연소도 그리고 냉각시간별로 선원항 평가를 하였다. 사용후핵연료 선원항 평가를 위해 미국 Nuclear Regulatory Commission(NRC)의 인·허가 코드인 SCALE 코드를 이용하였다. 선원항 평가는 SCALE 코드의 모듈을 이용하였다. 선원항 평가 결과 농축도와 3.5 w/o와 연소도 35 GWD/MTU 일때 Cooling Time 0.3년은 7.5651E+16, 1년 2.8954E+16, 3년 9.8242E+15, 5년 5.4000E+15, 10년 3.0945E+15으로 계산되었으며, Cooling Time이 0.3년일때와 10년일때의 Source Term이 크게 차이가 남을 알 수 있었다. 방사선량율은 10 ㎝부터 500 ㎝ 까지 거리에 따라 선량율에 대하여 10 ㎝ 4.8365E+03(㏉/hr)에서 500 ㎝ 7.8456E+01으로 감소함을 알 수 있었다. 현재 국내 사용후핵연료에 대한 선원항 평가가 이루어지지 않았으며, Data Base 구축이 기초단계 이므로 이러한 기초자료는 추후 저장조가 건설되면 사용후핵연료 안전성과 관련하여 사용할 수 있는 것이고 기초 Data Base구축하는데 이용할 수 있을 것이다 As nuclear power has been used in our country over 20 years, spent fuel management is raised seriously as one of the national`s problems, which lies in similar situation to other countries having nuclear power plants. An interim storage facility has been planned to operate in 1997, it is highly uncertain whether this facility will start to operate by the time because the site has not been decided yet. After the intermediate storage, the spent fuel periodical management strategy has not prepared yet. Therefore it has to be preceded that the spent fuel quantity which is happening at the power station and the following source term. Now the main have evaluated the source term according to enrichment, burn-up, and cooling time for 17×17 of spent fuel form. I used the SCALE code which were certified by Nuclear Regulatory Commission(NRC) for the source term calculations of Spent Fuel. The source term was calculated, which reflected the feature of target nuclear fuel using ORIGEN-S, a module of the SCALE Code, and the exposure dose rates were calculated by using the QADS modules, considering the geometry. When the enrichment in the evaluated result of source term is 3.5 w/o and the burn-up is 35 GWD/MTU, the cooling time 0.3year is 7.561E+16(photon/second), 1year 2.8954E+16, 3year 9.8242E+15, 5year 5.400E+15, 10year 3.0945E+15 and found that the big difference in Photon Spectrum of cooling time 0.3year and 10year. I have found that radiation dose rate is decreased in 10㎝ 4.8365E+03(㏉/hr) into 500 ㎝ 7.8456E+01 for dose rate according to distance from 10 ㎝ to 500 ㎝. It is not made the source term evaluation on the domestic spent fuel, and since the data base construction is basic level, some time later, if the storage place is constructed, in connection with the safety, these basic data can be used and we can construct these basic data base.

6-hydmxydopamine 파킨슨병 모델에서 Apomorphine의 투여에 따른 회전운동 변화의 시간적 추이

홍근식,김병곤,전범석,윤병우,이광우,노재규,이상복,명호진 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

남중 육상경기 선수의 Foot Ratio와 체력과의 상관

윤길환,서국웅,이훈식,정미라,윤양진,박승범 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

Foot ratio and physical fitness were measured and multiple-compared in the level of P<.05 on the subject of 28 prize winners from Men's part of middle school in the field and track events of the "P" youth athletic tournament in 1998 and 7 general students adopted by random sampling. These are conclusions from the result of relative analysis of foot length measured by X-ray, Medial longitudinal arch's height, foot ratio and physical fitness in the level of P<.05. 1. No significance was discovered in FR but throwing group is better than medium and long distance group. 2. Flexibility and endurance have meaning in physical fitness. The short distance group has better flexibility than the medium and long, throwing and general one. And medium and long distance/ throwing group have better endurance than general one. 3. FR and physical fitness show a negative correlation in the muscular strength of throwing group.

정수처리공정상 염소소독부산물형성에 미치는 오존의 영향

성낙창,박현석,이성식,이용희,이종팔,윤태경 한국환경과학회 2004 한국환경과학회지 Vol.13 No.1

The effect of ozone on the formation and the removal of disinfection byproducts(DBPs) of chlorination process was studied to elucidate the performance of water treatment process. The samples of raw water, prechlorination process, and preozonation process were analyzed quantitatively according to the Standard Methods for the Examination of drinking water. As a result, most of total trihalomethanes(THMs) which were formed in prechlorine treatment process was not removed in the preozonation process. Most of haloacetic acids(HAAs), haloacetonitriles(HANs), and chloral hydrate(CH) was removed in sedimentation and biological activated carbon(BAC) filtration processes. However, DBPs were increased more or less by postchlorine step. In particular, the formation of THMs and HAAs depends on ozone more than chlorine, but, the formation of HANs and CH depends on chlorine more than ozone. The seasonal variation of DBPs concentration for the year needs to be investigated to study the temperature effect because DBPs strongly depend on temperature among various efficient factors.

Paraquat 중독환자의 초기검사로서 sodium dithionite를 이용한 소변내 paraquat검출의 임상적 의의

윤갑준,임경수,이진웅,김영식,이부수,박덕우,김선만,이강현,황성오,안무업 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Mortality from paraquat intoxication depends upon plasma paraquat concentration. To know the severity of paraquat intoxication is important for directing therapeutic modality and predicting prognosis. Sodium dithionite test for urinary paraquat provides an easy and simple method to determine the severity of paraquat intoxication in emergency department. purpose : To determine whether the result urinary paraquat test by sodium dithionite can predict outcome in patients with paraquat intoxication in emergency department. Subjects : 48 patients(male 31, female 17, mean age 37 years) who had exposure to paraquat and presented within 24 hours after exposure. Result : Thirty five patients were positive in paraquat urine test and thirteen patients were negative. Clinical manifestations were more severe in positive patients than in negatives. Complication was much more in positives than in negatives. 28 of 35 patients(80%) in positives and 2 of 13 patients(15%) in negatives died. Conclusion : Positive test for urinary paraquat is associated with high mortality and morbidity from paraquat intoxication, and qualitative test for urinary paraquat by sodium dithionite is an useful method to determine the severity of paraquat intoxication in emergency department.