한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

유해화학물질 운송 파이프의 안정성 진단 센서 개발을 위한 기초연구

신상희(Shin, Sang_Hee) 대한토목학회 2019 대한토목학회 학술대회 Vol.2019 No.10

장을 이용한 요로전환술 후 요석형성 위험인자의 변화

신관희,한광희,정원일,이형래,이상철,김원재 충북대학교 의학연구소 2002 忠北醫大學術誌 Vol.12 No.2

연구목적: 장을 이용한 요로전환술을 받은 환자들에게는 여러 가지 대사적 장애에 따른 합병증이 발생하게 되는데 그 중 하나인 요석형성의 위험인자에 대해 대사적 검사를 실시하였다. 대상 및 방법: 장을 이요한 요로전환술을 시행 받은 후 적어도 6개월간 추적관찰이 가능했던 30명(회장 도관술 24명, Mainz pouch 4명, 방광 확대술 2명)을 환자군으로 하였고 요석의 과거력이 없는 건강한 38명을 대조군으로 선정하였다. 요로감염이나 항생제를 투여하는 경우에는 대상에서 제외하였고 식이 제한을 하지 않은 상태에서 24시간 소변을 외래에서 모았다. 소변량, 나트륨, 인, 요산, 크레아티닌, 칼슘, 마그네슘, 수산, 구연산 등의 요검사 항목을 조사하여 환자군과 대조군의 측정치 및 크레아티닌으로 보정한 측정값을 각 성별에 따라 비교하였다. 결과: 혈중 칼슘, 인, 요산, 나트륨, 칼륨, 크레아티닌, 혈액요소질소 (BUN) 등 대부분의 혈중 검사 항목들은 환자군과 대조군 사이에 차이가 없었으나 혈중 단백질 수치만이 차이를 보였다. 23명의 남성 환자에게서 수산의 요 배설량이 대조군에 비해 현저히 높았으며 반대로 구연산과 요산은 대조군에 비해 낮았다 (p=0.006, p=0.001, and p=0.005, respectively). 또한, 남성 환자의 칼슘의 요 배설량은 대조군보다 오히려 적게 나타나 환자군의 칼슘/수산 비가 현저히 감소하였다 (p<0.001). 요중 칼슘, 나트륨, 인 및 요산은 크레아티닌의 농도와 관련성을 보였으며, 오직 수산만이 크레아티닌 보정 후에도 남성 환자군과 대조군 사이에 유의한 차이를 보였다. 한편, 7명의 여성 환자들에게서 대조군에 비해 마그네슘의 배설이 감소한 것 이외에 유의한 차이는 나타나지 않았다 (p=0.04). 결론: 본 연구의 결과로 볼 때 요로전환술을 받은 환자에게 요중 칼슘, 마그네슘, 구연산 등이 요석형성에 영향을 끼치는 인자로 작용하지만, 요중 수산 배설의 증가와 이에 따른 칼슘/수산 비율의 감소가 보다 더 주된 위험 요인이라 할 수 있다. Purpose: The present study was performed to assess the risk factors for urolithiasis in patients receiving urinary intestinal diversion due to certain underlying etiology. Materials and Methods: This study included 30 patients who had undergone various forms of urinary intestinal diversion (24 of ileal conduits, 4 of Mainz continent diversions, and 2 of augmentation cystoplasties) with post-operative duration of at least 6 months and 38 age-matched normal controls. Urine samples (24-hour) were randomly collected on an outpatient basis without any dietary restriction when the patients were free of urinary tract infection or antibiotics. Investigation of urinary analytes comprised urine volume, sodium, phosphorus, uric acid, creatinine, calcium, magnesium, oxalate, and citrate. Data were compared in original values and adjusted values by creatinine in each sex. Results: Almost serum analytes such as calcium, phosphorus, uric acid, sodium, potassium, creatinine, and BUN were not significantly different between patients and controls except protein. In 23 male patients, mean urinary excretion of oxalate was significantly greater than control group and conversely in that of citrate and uric acid (p=0.006, p=0.001 and p=0.005, respectively). Unexpectedly, urinary excretion of calcium in male patients was lower than in control (p=0.002) resulting in significant decrease in the ratio of calcium to oxalate (p<0.001). Among the urinary analytes, excretions of calcium, sodium, phosphorus, and uric acid were significantly correlated with that of creatinine. Oxalate was only different analyte when adjusted by creatinine between male patients and controls. In 7 female patients, decreased excretion of magnesium was observed when compared to control (p=0.04). Conclusions: Our study indicated that urinary intestinal diversion cause increased excretion of urinary oxalate leading to decreased calcium to oxalate ratio, as major metabolic alteration for urolithiasis, although urinary calcium, magnesium, or citrate may take a role.

지역사회 거주 저소득층 노인의 우울증상 유병률과 관련인자

신희영,이훈,신일선,김재민,김성완,양수진,윤진상 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.5

Objectives : This study aimed to investigate the prevalence and correlates of depressive symptoms in community-dwelling low income elderly. Methods : A community survey of 1,351 low income residents aged 65 or over was conducted in Buk district of Gwangju, Korea. Depressive symptom was evaluated by the Korean Form of the Geriatric Depression Scale (KGDS). Their Sociodemographic factors, the precence of chronic physical illness, and cognitive functions were investigated. Results : The prevalence rate of depressive symptoms was 69.8%. In multiple logistic regression, chronic physical illness (Odds Ratio : 2.68, 95% Confidence Interval : 1.98-3.63), low education (Odds Ratio : 1.84, 95% Confidence Interval : 1.39-2.43), and cognitive impairment (Odds Ratio : 1.61, 95% Confidence Interval : 1.20-2.16) were independently associated with depressive symptoms. Conclusion : Depressive symptoms in community-dwelling low income elderly were very common, particularly related to current chronic physical illnesses. The results of this study can be useful for the development of community-based prevention and management programs for depression. Of elderleg.

섬유강화형 포스트를 이용한 치관-치근 파절의 치료: 증례 보고

임화신,라지영,이광희,안소연,김윤희,금기석,이상봉 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The crown-root fracture is defined as a fracture of tooth that contains enamel, dentin and cementum with or without pulp exposure. Generally the fracture lines place obliquely from labial surface, between incisal edge of the crown and marginal gingiva, to palatal surface subgingivally. If the fracture line is located supragingivally, the removal of tooth fragment and supragingival restoration can be performed. In subgingival fracture line, the surgical exposure, orthodontic eruption or surgical eruption can be considered. If the fracture line is too deep to restorate, extraction or decoronation can be selected. In children and adolescents, the extraction should be the last option. Another option to select before extraction is the restoration using fiber-reinforced post and the reattachment of tooth fragment. The fiber-rainforced post enhances the retention and the durability of tooth fragment. The reattachment of crown fragment using resin adhesive system is considered minimal invasive treatment biologically. This case reports the treatment of crown-root fracture using the reattachment of crown fragment and the insertion of fiber-reinforced post. 치관-치근 파절은 법랑질, 상아질, 백악질이 모두 포함된 치아의 파절로, 파절선이 대부분 절단연이나 순측의 변연부 치은 에서 구개측 치은열구 하방으로 사선으로 진행된다. 파절선의 위치가 치은 연상이라면 파절편의 제거 및 치은연상 수복을 시 행하고, 치은 연하라면 파절면의 외과적 노출술, 교정적 정출술, 외과적 정출술을 이용한 치아의 수복이 이루어진다. 그 외에 섬유 강화형 포스트를 삽입하여 치관 수복물의 유지력을 높이고, 레진 접착 시스템을 사용하여 치관 파절편을 재부착함으로 써 생물학적으로 최소한으로 침습적인 치료를 하는 방법도 있다. 만약 파절의 정도가 치은 연하로 깊은 경우 발치나 치관절제 술을 이용한 치근의 유지 등을 고려할 수 있다. 본 증례는 치관-치근파절로 내원한 12세 환아로 섬유강화형 포스트를 사용하여 치관 파절편 재부착을 시행하였으며 양호 한 경과를 보여 이를 보고하는 바이다.

요부수핵탈출증에서 Thermography의 진단적 가치

신현택,신승우,송재철,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Lumbar radiculopathy is a common disease in oriental rehabilitation medicine. It can be diagnosed by physical examination, plain X-ray, Myelography, CT, MRI, EMG etc. But those methods are not useful in observing the clinical procedure. Objectvie evaluating the clinical procedure is very important in treatment of lumbar radiculopathy. Mehthods : We studied the clinical efficacy of thermography in lumbar radiculopathy during conservative managements. We studied 36 patients with lumbar radiculopathy convinced by MRI. The had low back pain and radiating pain on one side. Thermography had taken before an after 4 weeks treatments, and compared with clinical procedure Results and conclusions : Thermography is not pertinent as a primary diagnostic method in lumbar radiculopathy, but useful in observing the clinical procedure. And it can be recommended as a objective evaluation for lumbar radiculopathy.

急性中毒肝의 組織學的 및 組織化學的 變化와 肝機能檢査에 關한 硏究

申誠姬,崔三任,金象皓 (사)한국여자의사회 1983 한국여자의사회지 Vol.8 No.1

지역사회 거주 노인에서 장애 변화의 예측인자

신희영,신일선,김재민,김성완,양수진,윤진상 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : This study aimed to identify the predictors for change in disability measured by the Korean version of World Health Organization Disability Assessment Schedule II (WHODAS II-K) m community-dwelling elderly population. Methods : Of 1204 community participants aged 65 years or over, 717 were reevaluated by WHODAS II-K 2 years later. At baseline, information on demographic characteristics (age, gender, living area, marital status, and religion), socioeconomic status (education, type of accommodation, number of rooms, previous occupation, current employment, and social network), and clinical characteristics (number of physical illness, depression by the Korean version of Geriatric Mental State Schedule B3, and cognitive impairment by Korean version of Mini-Mental State Examination) were collected. Results : Scores on the WHODAS II-K increased by 17.5 in 2 years. Age (B coefficient 0.52, 95% CI : 0.21~0.84), number of rooms (B coefficient -1.92, 95% CI : -3.53~-0.30), and depression (B coefficient 1.84, 95% CI : 0.43~3.25) were independently significant predictors for change in disability. Conclusion : Change in the level of disability measured by the WHODAS II-K was mainly affected by age, number of rooms, and depression. These results can be useful for the development of community-based health promotion program for the elderly.

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

서목태(Rhynchosia nulubilis) 추출물이 고지방 및 고콜레스테롤 식이 급여 흰쥐의 혈청 지질 농도에 미치는 영향

신미경,한성희 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.1

The effects of the Rhynchosia nulubilis extracts on serum lipid concentrations were evaluated in rats. Forty-two male Sprague-Dawley rats weighing 100±10g were divided into six groups and fed high fat and high cholesterol diets for four weeks. Experimental groups were administered with following diets; basal fat diet(control) and basal and high fat diets with 1% cholesterol and Rhynchosia nulubilis extract(40㎎/㎏, 400㎎/㎏ and 4000㎎/㎏). The concentrations of serum triglyceride in rats fed the Rhynchosis mulubilis extract, high fat, 1% cholesterol, and RN-HFC(-40, -400, 4000㎎/㎏) groups were lower than those in other groups. The concentrations of total cholesterol in the RN-HFC (-40, -400, -4000㎎/㎏) groups were lower than those in fat diet groups. The concentrations of HDL-cholesterol in serum of the RN-HFC(-40, -400, 4000㎎/㎏) groups were significantly higer than those of other groups. The levels of LDL-cholesterol in serum of the RN-HFC(-40, -400, -4000㎎/㎏) groups were tended to be lower than those of other groups. These results suggest that Rhynchosia nulubilis extract may reduce elevated levels of serum lipid concentrations in rats fed high fat diets.