Ln₃Ba?Co₄O? (Ln = Sm, Pr, Er, Gd, Ho) 상의 합성과 결정구조에 관한 연구

송민석,이재열,송수호 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

The Ln₃Ba?Co₄O? phases were synthesized with Pr?O? Sm₂O₃, Er₂O₃, Gd₂O₃, Ho₂O₃, BaCO₃, and Co₃O₄by solid state reaction at 1200℃ with intermittent grinding. The phases with Pr and Sm formed hexagonal structure isostructural with Nd₃Ba?Co ₄O? phase Whereas the phases with Er, Ho, and Gd formed unknown cubic phases. The crystal structure of Sm₃Ba?Co₄O? phase were refined by X-ray diffraction powder data by means of Rietveld method. The starting model was based on the Nd₃Ba?Co₄O? structure. The Crystal system was hexagonal, space group P6₃mc, a=11.634(6)A, c=6.861(4)A for pr₃Ba?Co₄O? ; a=11.556(6)A, c=6.788(3)A for Sm₃Ba?Co₄O?. Final R values are : Rwp=0.121, Rp=0.084 for pr₃Ba?Co₄O?, Rwp=0.101, Rp=0.077 for Sm₃Ba?Co₄O? .

국내의 Acinetobacter baumannii와 Pseudomonas aeruginosa 임상분리주에 대한 Colistin과 Polymyxin B의 감수성 양상

송원근,이태재,박민정,김한성,김재석,우흥정,이규만 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : 다약제 내성 Acinetobacter baumannii와 Pseudomonas aeruginosa에 의한 감염의 증가로 인해 기존의 치료제를 대신할 수 있는 colistin이나 polymyxin B와 같은 대체 항균제들이 사용되고 있다. 이에 국내에서 분리된 A. baumannii와 P. aeruginosa에 대한 colistin과 polymyxin B의 감수성 현황을 알아보고자 하였다. 재료 및 방법 : 국내 5개 대학병원에서 분리된 균주 중 ceftazidime과 imipenem의 감수성에 따라 93주의 A. baumannii와 99주의 P. aeruginosa를 선택하였다. 액체배지 미량희석법으로 colistin과 polymyxin B의 감수성을 시험하였다. 결과 : Ceftazidime과 imipenem이 감수성인 균주에서는 기타 β-lactam제, aminoglycoside제 및 ciprofloxacin에 대한 감수성율(각각 58-100%, 50-100%, 75-100%)이 높았으나, ceftazidime 또는 imipenem이 내성인 균주에서는 위의 항균제에 대한 감수성율이(각각 ≤31%, ≤47%, ≤18%)이 낮았다(P<0.05). Colistin과 polymyxin B에 대한 A baumannii (MIC_(50/90), 1/2 ㎍/mL)와 P. aeruginosa(MIC_(50/90), 1/1 ㎍/mL)에의 항균 범위는 거의 유사하였고 두 약제 모두 매우 우수한 항균력을 보였다. A. baumannii에서는 1주(1.1%)가 colistin 내성(MIC, 4 ㎍/ mL)이 었으나 polymyxin B에는 감수성(MIC, 2 ㎍/mL)이었으며 이외의 모든 A. baumannii와 P. aeruginosa는 colistin과 polymyxin B에 감수성(MIC, ≤2 ㎍/mL)이었다. 결론 : 국내에서 colistin과 polymyxin B에 둘 다 내성인 A. baumannii나 P. aeruginosa 감염은 없었다. 따라서polymyxin제를 다약제 내성 A. baumannii나 P. aeruginosa 감염에 대한 대체 항균제로 유용하게 사용할 수 있을 것으로 생각된다. Background : The emergence of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa has become a major problem. The use of nontraditional agents such as colistin and polymyxin B have been tried. The purpose of this study was to evaluate the colistin and polymyxin B susceptibility of A. baumannii and P. aeruginosa isolates in Korea. Materials and Methods : According to susceptibility of ceftazidime and imipenem, selected 93 isolates of A. baumannii and 99 isolates of P. aeruginosa were collected from 5 university hospitals in Korea. Susceptibility to colistin and polymyxin B was tested using the reference broth microdilution method. Results : The rates of other β-lactams, aminoglycosides, and ciprofloxacin susceptibility were high (58-100%, 50-100%, and 75-100%, respectively) in ceftazidime- and imipenem-susceptible isolates but were low (≤31%, ≤47%, and ≤18%, respectively) in ceftazidime- or imipenem-resistant isolates (P<0.05). Colistin and polymyxin B displayed a nearly identical spectrum of activity, exhibiting excellent potency against A. baumannii (MIC_(50/90), 1/2 ㎍/mL) and P. aeruginosa (MIC_(50/90), 1/1 ㎍/mL). Only one of the A. baumannii isolates was resistant to colistin (MIC, 4 ㎍/mL), but the isolate was susceptible to polymyxin B (MIC, 2 ㎍/mL). Conclusion : In Korea, no A. baumannii and P. aeruginosa isolates were resistant to both colistin and polymyxin B. These data suggested that polymyxins may be alternative drugs for multidrug- resistant A. baumannii and P. aeruginosa isolates.

신경이완제 악성 증후군 및 Lithium 중독과 병발한 하시모토 뇌병증 1예

송민경,박만석 全南大醫大 2003 전남의대학술지 Vol.39 No.4

Pseudomonas aeruginosa와 Acinetobacter baumannii에 대한 Imipenem, Panipenem 및 Meropenem의 시험관내 항균력 비교

송원근,우흥정,강희정,김재석,박민정,이규만 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

목적 : Pseudomonas aeruginosa와 Acinetobacter baumannii는 중요한 병원감염균으로 알려져 있으며 다약제 내성을 잘 유발한다. 최근 들어 전 세계적으로 carbapenem제에 대한 감수성이 떨어지고 있어 문제가 되고 있다. 이에 저자들은 한국에서 분리된 P. aeruginosa와 A. baumannii를 대상으로 imipenem, panipenem 및 meropenem의 항균력을 비교하고자 하였다. 방법 : 150주의 P.aeruginosa (imipenem 감수성, 62주; imipenem 내성. 88주)와 53주의 A.baumannii (imipenem 감수성, 9주; imipenem 내성 44주)를 대상으로 National Committee for Clinical Laboratory Standards의 기준에 따라 미량액체배지희석법으로 imipenem, panipenem. meropenem에 대한 최소억제농도(MIC)를 측정하였다. 결과 : 총 150주의 P. aeruginsa 균주의 MIC_50/MIC_90은 imipenem, panipenem 및 meropenem이 각각 16/64, 16/64 및 4/32㎍/mL이었다, 53주의 A.baumannii 균중의 MIC_50/MIC_90은 imipenem, panipenem 및 meropenem이 각각 32/64, 32/64 및 16/32 ㎍/mL이었다. 88주의 imipenem 내성 P. aeruginosa 균주 중 33주 (38%)는 감수성 결과를 보였으나 그 반대의 결과를 보인 경우는 없었다. 결과 : MIC 결과 상 imipenem에 내성인 P. aeruginosa와 A. baumannii에 대하여 meropenem이 impenem이나 panipenem보다 좀더 강한 활성이 있음을 알 수 있었다. Background : Pseidomonas aeruginosa and Acinetobacter baumannii are important nosocomial pathogens. Many strains are multi-drug resistant, with decreased susceptibility to carbapenem emerging worldwide. We investigated the in vitro activity of imipenem, panipenem, and meropenem against P. aeruginosa and A. baumannii isolates in Korea. Methods : One hundred and fifty strains of P. aeruginosa (imipenem-susceptible, 62strains; imipenem-resistant, 88 strains) and 53 strains of A baumannii (imipenem-susceptible, 9 strains; imipenem-resistant, 44 strains) were examined. Minimal inhibitory concentration (MIC) testing for imipenem, panipenem, and meropenem was performed using the broth microdilution method as described by the National Committee for Clinical Laboratory Standards. Resilts : The MIC_50/MIC_90 of imipenem, panipenem, and meropenem against the clinical isolates were: 16/64, 16/64, and 4/32 ㎍/mL, respectively, against P. aeruginosa; 32/64, 32/64, and 16/32 ㎍/mL against A. baumannii. 33 (38%) of the 88 strains of impenem-resistant P. aeruginosa were susceptible to meropenem but the reverse was observed in none. Conclusion : The MIC data showed that meropenem was more active than imipenem and panipenem against imipenem-resistant P. aeruginosa and A. baumannii isolates.

附子를 包含하는 方藥合編處方에 대한 考察

宋仁善,吳旼錫,宋泰元 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1

Acontii Tuber is very toxious material, but In oriental medicine frequently used for emergency state like shock, coma, and severe pain and author study about Acontii Tuber in Bang-Yak-Hap-Pyun(方藥合編). Bang-Yak-Hap-Pyun(方藥合編) is widely used for clinical herbal prescpition book. Acontii Tuber has alkaloid, this chemical compound make toxious state like arrythmia, heart arrest, weakness, numbness, itching. And using this material must be careful. In Bang-Yak-Hap-Pyun(方藥合編) Acontii Tuber is used 1.2g ∼12g. and it decrease pain, inflammaiton, increase activity of heart., and Acontii Tuber' commom use is severe pain disease. Raw Acontii Tuber(生附子) is rarely used, mostly roasted Acontii Tuber(포附子). In case of Acontii Tuber toxic state, in oriental medicine Gam-du-tang(甘豆湯) & Go-sam(苦蔘) is used, in western medicine atropine & lidocane is used.

과전류 보호계전기용 광섬유 전류센서

송민호,양창순,안성준,박병석,이병호 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.5

과전류 보호계전기에 사용할 목적으로 광섬유를 센서헤드로 사용하는 광 전류센서를 구성하였다. 전류측정의 원리는 도체 주변에 감겨진 광섬유 코일을 따라 광신호의 선형편광축이 자기장에 의하여 회전하는 정도를 측정하여 이로부터 전류의 값을 산출하는 편광측정 방법이 사용되었다. 센서코일은 10/125 mm 규격의 일반 통신용 광섬유를 미터당 20회전 이상 비틀어 제작하여 온도나진동 등의 환경적 영향을 최소화하였다. 코일의 한쪽 끝은 Faraday Rotator Mirror를 장착한 반사형으로 설계하여 계통을 해체하지 않은 상태에서도 센서의 탈×부착이 가능하고 코일의 회전수에 따라 센서의 민감도 조절이 용이하며 폐회로형 구조이므로 인근 신호원에 의한 간섭을 차단할 수 있다. 편광 빛가르개 등을 이용한 광학 신호처리부를 구성하고 표준 전류원을 이용한 전류측정 실험을 수행한 결과로 이론적인 해석과 동일한 형태의 출력을 얻을 수 있었다. 본 논문에서는 구성한 광 전류센서의 이론적 모델을 기술하고 전류측정 실험의 결과와 이론치에 대하여 비교 분석한다. A robust, accurate, broad-band, alternating current sensor using fiber-optics is being developed as a part of optical over current protection relay system. The sensor uses the Faraday effect in optical fiber and polarimetric measurements to sense electrical current. The current sensing coil consists of a length of twisted optical fiber and Faraday rotator mirror to suppress the linear birefringence effect. Due to its single-ended closed path structure, it can not only be easily installed to the target with great isolation from other fields in the vicinity, but the sensitivity can be increased by using multiple turns. This paper reports on the theoretical backgrounds of the sensor design and the preliminary experimental results.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

악관절 강직증에 관한 임상적 연구

민병일,송민석 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

Temporomandibular joint ankylosis is the movemental obstacle of mandible which depend on proliferation of bony or fibrous tissue in temporomandibular joint structure by various causes. In order to treat this, various surgical methods have been performed, but no operative methods have been produced consistently successful results. This research has been performed to the patients who had been operated due to temporomandibular joint ankylosis by studying classification, cause, onset, duration, anesthesia and treatment method, symptom, change of mouth opening, complication through medical record, X-ray, follow-up for being a help to proper selection of treatment method and evaluation of prognosis. The author obtained the following results by analyzing 44 cases among patients who had been operated due to temporomandibular joint ankylosis during 8 year hospitalization from 1986 to 1993 in Dept. of Oral & Maxillofacial Surgery of Seoul National University Hospital. 1. The occurrence was in the order of below 10, 20's, 10's, 30's. The average of occurrence was 12.95. Illness period was 50.0% within 10 years and 50% beyond 10 years. The average period of illness was 13.33 years. 2. Trauma occupied 54.5% of causes and inflammation occupied 45.5%. Men had more occurrences due to trauma and there was no difference in case of inflammation. 3. In nasotracheal intubations for general anesthesia, the cases of using fiberoptic larygoscope occupied 40.9%, direct or blind nasotracheal intubation occupied 40.9% and the cases of using tracheostomy occupied 18.2%. 4. In operative approaching methods, submandibular & preauricular approach were mainly applied, and in operative methods, high condylectomy(Group I) occupied 11.4%, arthroplasty without interpositional material following condylectomy or gap ostectomy(Group Ⅱ) occupied 11.4%, with interpositional material following high condylectomy (Group Ⅲ) occupied 40.9%, and using condylar reconstruction following condylectomy or gap ostectomy(Group Ⅳ) occupied 36.6%. 5. In change of mouth opening reformed after surgery, Group Ⅲ showed the best result of average 23.5mm, Group Ⅳ showed 16.3mm, Group Ⅰ showed 14.9mm and Group Ⅱ showed 10.2mm of reformation. Summarizing the results as written above, it is considered that early treatment is important as soon as possible in Temporomandibular joint ankylosis. It is recommended in surgical method what can lead to postoperative early movement maintaining anatomaical & functional form, and then the development of various surgical methods will be requested.

國內企業의 對北韓 役資에 관한 硏究

宋珉錫 건국대학교 1995 대학원 학술논문집 Vol.41 No.-

The purpose of this study is to explain the present conditions and problems of the investment in North Korea of Domestic firms, and further explore the activationary plan of the investment in North Korea Domestic firms. Reflecting on the thirty years which have passed since Korea was divided, it is clear that since 1953 the economy of the two Koreas has undergone may changes under their two different social and economic systems, and that the two economies will continue to follow different courses in the future. North Korea has acted a passive attitude toward the foreign trade, because she has pursued the autarchic economic development policy on the basis of the socialistic economic system as yet. Therefore, she has congnized that it is impossible to develop the economy by the principle of the self-revival what is to say a self-support national economy and the closed trade system which has been excuted in the countries centering on the Communistic Area. So she had to change to the foreign trade system as the open system by transforming the autarchic system they hierto adhered to. This brief overview of recent developments attempts to compare various economic indicators and thus show how rapidly the Congress. This remains a principal government policy down to the present day. Judging from these circumstances as mentioned above, it can be suggested that the economy of North Korea holds certain structural defects which will eventually bring aboutq a transformation from the presently closed society to an open one. Any dramatic changes in the basic policy guidelines which have been followed to date, however, would mean the abandonment of the fundamental ideology and the political posture which supports the present system. As a result, it seems probable that the 1990s will be a period of expand bilateral partnership in the areas of economy between South and North Korea.

주기성 마비 患者 1例에 대한 臨床報告

송인선,김종국,윤일지,오민석 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

Periodic paralysis associated with thyrotoxicosis is characterized by intermittent flaccid paralysis of the skeletal muscle. The paralysis usually involve the skeletal muscle of the limbs, especially lower extremities. In general sensory function is intact. The underlying pathophysiology of the syndrome is not yet to be well characterized and remains controversial, we report a case of hypokalemic periodic paralysis presenting a spontaneous recovery.