Fouling characteristics of MgO particles under subcooled flow boiling

Siyuan Wang,Zhiming Xu,Jingtao Wang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.3

In order to investigate the particulate fouling characteristics, experiments of water based magnesia particulate suspensions were carried out in an annular test section under subcooled flow boiling. The sizes of magnesia particles were 40 nm and 10 μm, respectively. The influence of particle concentration, heat flux, mass flow rate and inlet temperature on fouling resistance were investigated, and the Chilton-Colburn analogy was applied to analyze the fouling process. The results show that the asymptotic value of fouling resistance increases with the increase of particle concentration. The asymptotic value of fouling resistance tends to fall when mass flow rate increases. As inlet temperature increases, there will be an obvious drop in the asymptotic value of fouling resistance. Regarding to heat flux, opposite variation trend was found between nano and micro-magnesia particles when changing the heat flux. Moreover, there is an obvious difference in asymptotical value of fouling resistance between nano-particles and micro-particles.

Effects of high power pulsed microwave on the enhanced color and flavor of aged blueberry wine

Siyuan Liu,Shuangjian Li,Siyuan Li,Ying Wang,Linlin Fan,Jianzhong Zhou 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.1

A new method of high-power pulsed microwave (HPPM) was applied to accelerate the aging of blueberry wine. The color changes of blueberry wines during aging were investigated through Chemical Wine Age and CIE-LAB measurement. Results showed that the blueberry wines treated by HPPM at low frequencies (50 and 100 Hz) exhibited improved color characteristics with L* value reaching 47.04 at 100 Hz, an increased maturity of wine body, and a shortened chemical wine age from 90 days to 75 days. Moreover, the aroma changes determined by GC-MS showed that HPPM accelerated the formation of esters in blueberry wine, which were increased by 18.44% and 56.97% respectively under the conditions of 50 and 150 Hz. The formation of acid substances was reduced compared with the original wine, with contents of acetic acid, caproic acid, and octanoic acid of 29.46 µg/mL, 15.60 µg/mL, 17.74 µg/mL, respectively, displaying an enhanced wine flavor.

Short-duration chemoprophylaxis might reduce incidence of deep vein thrombosis in Asian patients undergoing total knee arthroplasty

Zhang Siyuan,Htet Kway Swar,Tan Xin Yang,Wang Xinyu,Wang Wilson,Chua Weiliang 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Venous thromboembolism (VTE) is a serious complication that may occur after total knee arthroplasty (TKA), leading to the recommendation of routine chemoprophylaxis by international guidelines. This study aims to determine if short-duration chemoprophylaxis after TKA reduces the incidence of VTE in an Asian population.A retrospective study of 316 patients who underwent unilateral primary TKA between 1 January 2011 and 31 December 2013 was conducted. All patients received mechanical prophylaxis. One hundred seventeen patients (37%) received additional chemoprophylaxis, whereas 199 patients (63%) did not. A Doppler ultrasound (DUS) of both lower limbs was conducted for all patients within 6 days after surgery (median = 3 days) to assess for both proximal and distal DVT. Chemoprophylaxis in the form of enoxaparin (low molecular weight heparin; LMWH), aspirin, or heparin was administered until patients had a normal DUS, for a median duration of 4 days. Patients were followed up clinically for a minimum of 6 months to monitor for delayed or recurrent VTE and at least 2 years for patient-reported outcome measures. Overall, 24 patients (7.59%) developed deep vein thrombosis (DVT): three proximal and 21 distal DVTs. Twenty-three of the 24 patients were asymptomatic. Twenty of 199 patients (10.05%) with only mechanical prophylaxis developed DVT, whereas four of 117 patients (3.42%) with additional chemoprophylaxis developed DVT. Multivariate analysis showed that chemoprophylaxis use was associated with reduced incidence of DVT (odds ratio = 0.19, p value = 0.011). Other factors associated with increased DVT incidence include female gender (odds ratio = 5.45, p value = 0.034), positive history of cancer (odds ratio = 5.14, p value = 0.044), and increased length of stay in hospital (odds ratio = 1.19, p value < 0.001). Our study has shown that despite the low incidence of DVT in Asian patients undergoing TKA, short-duration chemoprophylaxis might be effective in reducing the incidence of DVT. However, most DVTs observed in our study were distal and may be of limited clinical significance. Further studies are needed to investigate the impact of chemoprophylaxis use on the incidence of PE and overall mortality rates among Asian patients.

TEM fitting considering TEPs of contact interface of meshing gear

Xigui Wang,Siyuan An,Yongmei Wang,Jiafu Ruan,ShuE Ji 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.10

This topic aims to clarify the method of optimizing tooth surface modification (TSM) fitting under thermoelastic lubrication (TEL) conditions to reveal the most popular and concerning mechanism issues in mechanical engineering. A traditional TSM numerical method has played an increasingly important role in our basic understanding of thermoelastic properties (TEPs) under TEL conditions, which is undoubtedly affirmative and effective. This subject involves the TSM fitting of the theoretical tooth surface superimposed structure, and performs 3D and diagonal modification optimization design, obtains the modified surface position and normal vectors, a variety of optimized modification models are established and complex curved surfaces are analyzed to fit the actual Interface thermoelastic contact numerical simulation, which has been further demonstrated and expressed in actual key working conditions and multiple influencing parameters, thereby reducing transmission error and vibration noise in order to improve gear meshing thermoelastic anti-scuffing load-bearing performance (TEASLBP).

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Mu Xian,Siyuan Ma,Kuiji Wang,Hongfei Lou,Yang Wang,Luo Zhang,Chengshuo Wang,Cezmi A. Akdis 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.1

Purpose: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study therefore aimed to assess the direct impact of PM with an aerodynamic diameter less than 2.5 μm (PM2.5) on the barrier function and TJ molecular expression of human nasal epithelial cells. Methods: Air-liquid interface cultures were established with epithelial cells derived from noninflammatory nasal mucosal tissue collected from patients undergoing paranasal sinus surgery. Confluent cultures were exposed to 50 or 100 μg/mL PM2.5 for up to 72 hours, and assessed for 1) epithelial barrier integrity as measured by transepithelial resistance (TER) and permeability of fluorescein isothiocyanate (FITC) 4 kDa; 2) expression of TJs using real-time quantitative polymerase chain reaction and immunofluorescence staining, and 3) proinflammatory cytokines by luminometric bead array or enzyme-linked immunosorbent assay. Results: Compared to control medium, 50 and/or 100 μg/mL PM2.5-treatment 1) significantly decreased TER and increased FITC permeability, which could not be restored by budesonide pretreatment; 2) significantly decreased the expression of claudin-1 messenger RNA, claudin-1, occludin and ZO-1 protein; and 3) significantly increased production of the cytokines interleukin-8, TIMP metallopeptidase inhibitor 1 and thymic stromal lymphopoietin. Conclusions: Exposure to PM2.5 may lead to loss of barrier function in human nasal epithelium through decreased expression of TJ proteins and increased release of proinflammatory cytokines. These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas.

Creative Illustration of Traditional Chinese Medicine

Qi Siyuan,Sun Yifei,Wang Yilin 한국콘텐츠학회 2023 ICCC International Digital Design Invitation Exhib Vol.2023 No.12

Creative Illustration of Traditional Chinese Medicine

Qi Siyuan,Sun Yifei,Wang Yilin 한국콘텐츠학회 2023 한국콘텐츠학회 ICCC 논문집 Vol.2023 No.12

Thermal-hydraulic analysis of He-Xe gas mixture in 2×2 rod bundle wrapped with helical wires

Chenglong Wang,Siyuan Chen,Wenxi Tian,G.H. Su,Suizheng Qiu Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

Gas-cooled space reactor, which adopts He-Xe gas mixture as working fluid, is a better choice for megawatt power generation. In this paper, thermal-hydraulic characteristics of He-Xe gas mixture in 2×2 rod bundle wrapped with helical wires is numerically investigated. The velocity, pressure and temperature distribution of the coolant are obtained and analyzed. The results show that the existence of helical wires forms the vortexes and changes the velocity and temperature distribution. Hot spots are found at the contact corners between helical wires and fuel rods. The highest temperature of the hot spots reach 1600K, while the mainstream temperature is less than 400K. The helical wire structure increases the friction pressure drop by 20%-50%. The effect extent varies with the pitch and the number of helical wires. The helical wire structure leads to the reduction of Nusselt number. Comparing thermal-hydraulic performance ratios (THPR) of different structures, the THPR values are all less than 1. It means that gas-cooled space reactor adopting helical wires could not strengthen the core heat removal performance. This work provides the thermal-hydraulic design basis for He-Xe gas cooled space nuclear reactor.

Integrated analysis of transcriptomic and proteomic analyses reveals different metabolic patterns in the livers of Tibetan and Yorkshire pigs

Duan, Mengqi,Wang, Zhenmei,Guo, Xinying,Wang, Kejun,Liu, Siyuan,Zhang, Bo,Shang, Peng Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.5

Objective: Tibetan pigs, predominantly originating from the Tibetan Plateau, have been subjected to long-term natural selection in an extreme environment. To characterize the metabolic adaptations to hypoxic conditions, transcriptomic and proteomic expression patterns in the livers of Tibetan and Yorkshire pigs were compared. Methods: RNA and protein were extracted from liver tissue of Tibetan and Yorkshire pigs (n = 3, each). Differentially expressed genes and proteins were subjected to gene ontology and Kyoto encyclopedia of genes and genomes functional enrichment analyses. Results: In the RNA-Seq and isobaric tags for relative and absolute quantitation analyses, a total of 18,791 genes and 3,390 proteins were detected and compared. Of these, 273 and 257 differentially expressed genes and proteins were identified. Evidence from functional enrichment analysis showed that many genes were involved in metabolic processes. The combined transcriptomic and proteomic analyses revealed that small molecular biosynthesis, metabolic processes, and organic hydroxyl compound metabolic processes were the major processes operating differently in the two breeds. The important genes include retinol dehydrogenase 16, adenine phosphoribosyltransferase, prenylcysteine oxidase 1, sorbin and SH3 domain containing 2, ENSSSCG00000036224, perilipin 2, ladinin 1, kynurenine aminotransferase 1, and dimethylarginine dimethylaminohydrolase 1. Conclusion: The findings of this study provide novel insight into the high-altitude metabolic adaptation of Tibetan pigs.

The role of exosomal lncRNAs in cancer biology and clinical management

Zhang Wuwen,Wang Qinshi,Yang Yi,Zhou Siyuan,Zhang Ping,Feng Tongbao 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Exosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.