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Yang, S.M.,Na, Yong-Su,Na, D.H.,Park, J.-K.,Shi, Y.J.,Ko, W.H.,Lee, S.G.,Hahm, T.S. International Atomic Energy Agency 2018 Nuclear fusion Vol.58 No.6
<P>Perturbative experiments have been carried out using tangential neutral beam injection (NBI) and non-resonant magnetic perturbation (NRMP) to analyze the momentum transport properties in KSTAR H-modes. Diffusive and non-diffusive terms of momentum transport are evaluated from the transient analysis. Although the operating conditions and methodologies applied in the two cases are similar, the momentum transport properties obtained show clear differences. The estimated momentum diffusivity and pinch obtained in the NBI modulation experiments is larger than that in the NRMP modulation experiments. We found that this discrepancy could be a result of uncertainties in the assumption for the analysis. By introducing time varying momentum transport coefficients depending on the temperature gradient, the linearized equation shows that if the temperature perturbation exists, the evolution of toroidal rotation perturbation could be faster than the transport rate of mean quantity, since the evolution of toroidal rotation perturbation is related to <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0029-5515/58/6/066008/nfaab90eieqn001.gif'/>, a momentum diffusivity from perturbative analysis. This could explain the estimated higher momentum diffusivity using time independent transport coefficients in NBI experiments with higher ion temperature perturbation compared to that in NRMP modulation experiments. The differences in the momentum transport coefficient with NRMP and NBI are much reduced by considering time varying momentum transport coefficients in the time dependent transport simulation.</P>
Jang, Dae-Sik,Park, Eun-Jung,Kang, Young-Hwa,Su, Bao-Ning,Hawthorne, Michael-E.,Vigo, Jose-Schunke,Graham, James-G.,Cabieses, Fernando,Fong, Harry H.S.,Mehta, Rajendra-G.,Pezzuto, John-M.,Kinghorn, A. The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.8
Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (OR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 11-methoxyquindoline (3), N-trans-feruloyltyramine (4), vomifoliol (5), loliolide (6), 4-ketopinoresinol (7), scopoletin (8), evofolin-A (9), and evofolin-B (10), along with five inactive compounds of known structure, ferulic acid, sinapic acid, syringic acid, ($\pm$)-syringaresinol, and vanillic acid. These isolates were identified by physical and spectral data measurement. A new derivative of quindolinone, 5,10-dimethylquindolin-11-one (1a) was synthesized and characterized spectroscopically. Of the active substances, compounds 1-3 and 1a exhibited the most potent QR activity, with observed CD (concentration required to double induction) values ranging from 0.01 to 0.12 $\mu$ g/mL. Six compounds were then evaluated in a mouse mammary organ culture assay, with cryptolepinone (2), N-trans-feruloyltyramine (4), and 5,10-dimethylquindolin-11-one (1a) found to exhibit 83.3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 $\mu\textrm{g}$/mL.
[ $Bi_2Sr_2CaCu_2O{8+\delta}$ ] Intrinsic Josephson Junctions in a Parallel Magnetic Field
Lee, J.H.,Chong, Yon-Uk,Lee, Su-Youn,Khim, Z.G. The Korean Superconductivity Society 2000 Progress in superconductivity Vol.1 No.2
We have investigated the Josephson vortex dynamics in $Bi_2Sr_2CaCu_2O{8+\delta}$ intrinsic Josephson junctions subjected to a magnetic field parallel to $CuO_2$ planes. We investigated mesas with $40\times40{\mu}m^2$ in size and containing 6 and 20. intrinsic junctions. The zero field I-V characteristics exhibited a typical hysteretic, multi-branched nature of the intrinsic Josephson effect. At high magnetic fields (H>1.5 T), I-V characteristics showed flux flow steps. The Swihart velocity obtained from this observation was about $4.2\times10^5$ m/s, which was the lowest mode electromagnetic wave velocity of N coupled stack. The experimental I-V curves fitted well into the simple model of Cherenkov radiation including Ohmic and non-linear dissipation terms. This suggests that the dissipation mechanism of Josephson vortex be due to both Cherenkov radiation and quasiparticle tunneling current.
Su, X H,Duan, R,Sun, Y Y,Wen, J F,Kang, D G,Lee, H S,Cho, K W,Jin, S N The Society 2014 Journal of physiology and pharmacology Vol.65 No.3
<P>Rubus chingii Hu (Rosaceae) is an important traditional Chinese medicine that has been used to improve function of the kidney and treat excessive polyuria. However, the effects of Rubus chingii on the cardiovascular system and its pharmacological mechanisms of action have not been studied. The aim of the present study was to evaluate the cardiovascular effects of ethanol extract of Rubus chingii (ERC) in rats. The changes in systolic blood pressure and heart rate of rats and vascular tone of aortic rings in in vitro were measured using pressure transducer and force transducer, respectively, connected to a multichannel recording system. ERC decreased systolic blood pressure and heart rate in a concentration-dependent manner. ERC induced vasorelaxation in a concentration-dependent manner. The ERC-induced vasorelaxation was not observed in the absence of the endothelium. The vasorelaxant effect of ERC was significantly attenuated by inhibition of endothelial NO synthase (eNOS), soluble guanylyl cyclase (sGC), or Ca(2+) entry from extracellular sources with L-NAME, ODQ, diltiazem, or extracellular Ca(2+) depletion, respectively. Similarly, an inhibition of Akt with wortmannin attenuated the ERC-induced vasorelaxation. Modulators of the store-operated Ca(2+) entry, thapsigargin, Gd(3+), and 2-aminoethyl diphenylborinate markedly attenuated the ERC-induced vasorelaxation. Furthermore, 4-aminopyridine an inhibitor of voltage-dependent K(+) (KV) channel, significantly attenuated the ERC-induced vasorelaxation. However, tetraethylammonium and glibenclamide, had no significant effect on the ERC-induced vasorelaxation. Indomethacin, atropine, and propranolol had no effects on the ERC-induced vasorelaxation. The present study demonstrates that ERC induces vasorelaxation via endothelium-dependent two-step signaling: an activation of the Ca(2+)-eNOS-NO signaling in the endothelial cells and then subsequent stimulation of the NO-sGC-cGMP-KV channel signaling in the vascular smooth muscle cells. The Akt-eNOS pathway is also suggested to be involved in this relaxation. Also, the findings suggest that the ERC-induced vasorelaxation is closely related to the hypotensive action of the agent.</P>
Li, H.,Su, H.,Kim, S.B.,Chang, Y.K.,Hong, S.K.,Seo, Y.G.,Kim, C.J. Society for Bioscience and Bioengineering, Japan ; 2012 Journal of bioscience and bioengineering Vol.113 No.2
Trehalose production in Escherichia coli DH5α was explored by overexpressing otsBA operon encoding trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase. Production and subsequent degradation of trehalose resulted in low production of trehalose in engineered cells overexpressing otsBA, which was primarily due to the concomitant expression of endogenous trehalase. Through an in vitro enzyme assay and flask cultures of engineered cells, trehalase expression was shown to be directly related to the expression of otsBA rather than osmotic stress. Validamycin A effectively inhibited E. coli trehalase and the intracellular accumulation of trehalose was markedly enhanced in the presence of validamycin A at an optimal concentration in the medium. The trehalose production was further increased upon growth in a hypertonic medium in the presence of validamycin A, with most trehalose accumulating as an intracellular product. The highest titer was obtained when otsBA expression was induced by a medium-copy vector, ptrc99A, with 0.5mM of isopropyl β-d-1-thiogalactopyranoside. Trehalose titer was 1.7g/L in controlled bioreactor cultures using synthetic M9 medium supplemented with 40g/L glycerol, 0.1mM validamycin A, and 300mM NaCl.
Observation of the intrinsic rotation in KSTAR Ohmic L-mode plasmas
Na, D.H.,Na, Yong-Su,Lee, S.G.,Angioni, C.,Yang, S.M.,Kim, H.-S.,Hahm, T.S.,Ko, W.H.,Jhang, H.,Lee, W.J. International Atomic Energy Agency 2016 Nuclear fusion Vol.56 No.3
<P>Two types of experiments were carried out to conduct an intrinsic rotation study in KSTAR. The first was a density ramp-up experiment without neutral beam injection, and the second was an experiment with beam blip technique. In these experiments, some characteristics of the intrinsic rotation were observed in the KSTAR Ohmic L-mode plasmas including: (i) a non-monotonic dependence of the core intrinsic rotation, called U-curve behaviour, with respect to the electron density and the collisionality related to the gradient of the toroidal rotation profile; and (ii) the behaviour of the anchor point in the intrinsic rotation profile for which the region exhibits a roughly flat shape and stays at nearly the same value even if the gradient of the toroidal rotation changes significantly in the core region. The location of the anchor point seems to be related to the <I>q</I> profile, and the toroidal rotation at the anchor point changes with the plasma operation parameters. These observations in the KSTAR Ohmic L-mode plasmas seem to be related to the rotation reversal phenomenon. A transport analysis was performed for the beam blip experiments in order to evaluate the intrinsic torque so that the U-curve behaviour can be further understood. The first results of the transport analysis in the KSTAR Ohmic L-mode plasmas show a correlation of the momentum fluxes and the intrinsic torques with the electron density and the collisionality. The rough magnitude and profiles of the intrinsic torque was experimentally obtained, and their possible mechanism is briefly discussed.</P>
Experiment and simulation of tearing mode evolution with electron cyclotron current drive in KSTAR
Kim, Kyungjin,Na, Yong-Su,Kim, Minhwa,Jeon, Y.M.,Lee, K.D.,Bak, J.G.,Choi, M.J.,Yun, G.S.,Lee, S.G.,Park, S.,Jeong, J.H.,Terzolo, L.,Na, D.H.,Yoo, M.G. Elsevier 2015 CURRENT APPLIED PHYSICS Vol.15 No.4
<P><B>Abstract</B></P> <P>The tearing mode (TM) plasma instability was observed in low confinement (L-mode) plasmas when non-axisymmetric magnetic perturbation (MP) was applied using external coils during 2011 campaign of KSTAR. Based on the collected information of the magnetic island location in a plasma, a discharge was designed for suppression of a (2,1) TM mode by adjusting electron cyclotron (EC) launcher angles to the estimated island position. Here, the (m,n) notation describes the poloidal mode number and the toroidal mode number of the TM, respectively. The discharge is analysed with experimental observations and numerical simulations. Mirnov coil (MC) arrays and electron cyclotron emission (ECE) are used for analysis of the island width and the location as well as the mode number. The EC deposition and its alignment with the island are estimated by X-ray imaging crystal spectroscopy (XICS) and ECE measurements. An integrated numerical system is employed for modelling of this discharge to analyse a temporal evolution of the mode activity by integrating plasma equilibrium, transport, heating and current drive, and the magnetic island evolution, in a self-consistent way. The effect of EC current drive is discussed by comparing with another TM discharge but without ECCD. Some possibilities for classifying this mode to neoclassical tearing mode (NTM) and stabilisation effect of ECCD are suggested based on the experimental observation and the simulation results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Suppression of (2,1) TM/NTM by applying ECH/CD for the first time in KSTAR. </LI> <LI> Suppression of the mode examined by experimental observations and simulations. </LI> <LI> Simulation of a mode without ECCD to compare with/without the applied control. </LI> </UL> </P>