비부비동 반정성 유두종의 전산화 단층촬영상과 자기공명영상의 분석

배창훈,서영중,이석춘,천승민,백운희,정은채,송시연,김용대 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Computed tomography (CT) is commonly used to evaluate the degree of sinus involvement in case of inverted papilloma (IP). However, CT cannot differentiate tumor from adjacent inflammatory mucosa or retained secretions. By contrast, magnetic resonance imaging (MRI) has been reported to be useful in distinguishing IP from paranasal sinusitis. This study investigated whether preoperative assessment with MRI and CT accurately predict the extent of IP. Materials and methods: CT and MRI were retrospectively reviewed in 9 case of IP. Patients were categorized into staged based on CT and MRI findings according to the staging system proposed by Krouse. The involvement of IP in each sinus was also assessed. Results: Differentiation of IP from inflammatory disease may be more successful in routine case where the inflammatory mucosa has low signal intensity on T1-weighted images and very high signal intensity on T2-weighted images. CT imaging could not differentiate tumor from adjacent inflammatory mucosa or retained secretions. Conclusion: Preoperative MRI of IP can predict the location and extent of the tumor involvement in the paranasal sinuses and sometimes predicts malignant changes.

虹彩 體質 分析에서 心腎結合組織의 虛弱 體質과 高血壓 家族歷과 관련성 硏究

金鐘牛,黃祐準,琴坰樹,李始炯,李宗淳,都金錄,趙在運,趙州掌,金鐘煜 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

Iridology, developed more than 100 years ago, is the diagnosis of medical conditions through noting irregularities of the pigmentation in the iris The purpose of this study is to compare interrelation between CVA, hypertension family history and cardio-renal connective tissue in Iris Constitution through iris constitution examination. The subjects consist of 114 patients who were examined in Iris Constitution at Chonju Oriental Medicine Hospital attached to Wonkwang Univ. from September. 1St. 2000 to August. 31th. 2002. 1. In the distribution of Iris Constitution, among of 79cases, There are neurogenic type 13cases, abdominal connective tissue weakness constitution 31 cases, cardio-renal connective tissue weakness constitution 6 cases, cholesterol 7 cases and others 22 case in control group. 2. There are familial history of CVA and hypertention 32 cases, no familial history of CVA and hypertention1 3 cases, in 35cases of experimental group. These results imply that there is meaningfulness of interrelation between cardio-renal connective tissue weakness constitution and. CVA, hypertention.

Development of Surface Plasmon Resonance Immunosensor through Metal Ion Affinity and Mixed Self-Assembled Monolayer

( Si Ra Lee ),( Sang Jun Sim ),( Chul Hwan Park ),( Man Bock Gu ),( Un Yeon Hwang ),( Jong Heop Yi ),( Byung Keun Oh ),( Jin Won Lee ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.10

Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part I. Intracranial Aneurysm, Intracerebral Hemorrhage, and Arteriovenous Malformation

Lee, Si Un,Kim, Tackeun,Kwon, O-Ki,Bang, Jae Seung,Ban, Seung Pil,Byoun, Hyoung Soo,Oh, Chang Wan The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.1

Objective : To analyze the incidence and treatment trends of hemorrhagic stroke (HS), according to HS subtypes, using nationwide data in Korea from January 2008 to December 2016. Methods : We used data from the national health-claim database provided by the National Health Insurance Service for 2008-2016 using the International Classification of Diseases. The crude incidence and age-standardized incidence of each disease associated with HS, which included intracranial aneurysm (IA), hypertensive intracerebral hemorrhage (ICH), and arteriovenous malformation (AVM), were calculated and additional analysis was conducted according to age and sex. Changes in trends in treatment methods and number of treatments were analyzed for each cerebrovascular disease using the Korean Classification of Diseases procedure codes. Results : In 2016, the total number of newly diagnosed adult patients with HS was 24169, showing a decrease by 7.0% since 2008; the age-standardized incidence of HS was 46.2 per 100000 person-years. The age-standardized incidence of unruptured IA (UIA) in adults was 71.4 per 100000 person-years-increased by 2.6-fold since 2008-while that of ruptured IA (RIA) was 12.6 per 100000 person-years, which had decreased at a rate of 20.3% since 2008. The number of coil embolization (CE) for UIA increased by 3.4-fold over 9 years and exceeded that of clipping since 2008. With respect to RIA, CE increased by 2.0-fold over 9 years and exceeded that of clipping from 2014. As for spontaneous ICH in adults, the age-standardized incidence was 31.3 per 100000 person-years in 2016-decreased by 34.7% since 2008-and 14.6% of patients diagnosed with ICH were treated in 2016, which was not significantly different from the proportion of patients treated since 2008. The age-standardized incidence of unruptured AVM (UAVM) was 2.0 per 100000 person-year in 2016, while that of ruptured AVM (RAVM) was 2.4 per 100000 person-years in 2016, showing a decreasing rate of 17.2% from 2008. The total number of treated patients with AVM declined since 2014. Conclusion : In Korea, age-related cerebral vascular diseases, such as RIA, ICH, and RAVM, demonstrated a declining trend in age-standardized incidence; meanwhile, UIA and UAVM demonstrated an increased trend in both crude incidence and age-standardized incidence for 9 years. The increase in the elderly population, management of hypertension, and development of diagnostic and endovascular techniques appear to have influenced this trend.

Delayed Cerebral Ischemia and Vasospasm After Spontaneous Angiogram-Negative Subarachnoid Hemorrhage: An Updated Meta-Analysis

Lee, Si Un,Hong, Eun Pyo,Kim, Bong Jun,Kim, Sung-Eun,Jeon, Jin Pyeong Elsevier 2018 World neurosurgery Vol.115 No.-

<P><B>Objective</B></P> <P>To report clinical outcomes of delayed cerebral ischemia (DCI) and vasospasm in angiogram-negative subarachnoid hemorrhage (SAH) according to hemorrhage patterns, perimesencephalic hemorrhage (PMH) and non-PMH.</P> <P><B>Methods</B></P> <P>Online databases from January 1990 to December 2017 were systematically reviewed. A fixed-effects model was used to control heterogeneity. To resolve publication bias, the trim and fill method was used to estimate number of missing studies and adjusted odds ratio (OR). Subgroup analysis of data from studies that defined angiogram-negative subarachnoid hemorrhage by angiography repeated at least twice or computed tomography angiography was performed.</P> <P><B>Results</B></P> <P>Among 24 studies including 2083 patients, 23/985 patients (2.3%) with PMH and 144/1098 patients (13.1%) with non-PMH had DCI, indicating that patients with PMH experienced significantly lower DCI than patients with non-PMH (OR = 0.219; 95% confidence interval [CI], 0.144–0.334). Regarding vasospasm, 99/773 patients (12.8%) with PMH and 231/922 patients (25.1%) with non-PMH exhibited vasospasm, indicating that patients with PMH experienced significantly lower vasospasm than patients with non-PMH (OR = 0.445; 95% CI, 0.337–0.589). Funnel plots show asymmetry indicating possible publication bias. After trimming 10 studies for DCI and 7 for vasospasm, the adjusted ORs remained significant between PMH and lower risks of DCI and vasospasm. Subgroup analysis of 789 patients in 8 studies showed a lower risk of DCI (OR = 0.268; 95% CI, 0.151–0.473) and vasospasm (OR = 0.346; 95% CI, 0.221–0.538) in patients with PMH.</P> <P><B>Conclusions</B></P> <P>PMH showed a significantly lower risk of DCI and vasospasm than non-PMH. Clinical outcomes of angiogram-negative subarachnoid hemorrhage, based on meta-analysis of individual patient data, need to be investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This meta-analysis evaluated differences between PMH and non-PMH. </LI> <LI> Published data analyzed included recent studies that assessed DCI and vasospasm during follow-up. </LI> <LI> Subgroup analysis included studies that defined angiogram-negative SAH. </LI> <LI> PMH was associated with significantly lower incidence of DCI and vasospasm compared with non-PMH. </LI> </UL> </P>

A Study on the Community of Waterbirds and Protective value at Gangjin Bay in Jeollanamdo, Korea

Shin, Yong-Un,Cho, Hae-Jin,Lee, Si-Wan,Lee, Han-Soo,Lee, Doo-Pyo National Science Museum of Korea 2011 Journal of Korean nature Vol.4 No.1

This study was conducted in Gangjin Bay of Jeollanam-do over a total of 8 sessions, once each month, between October of 2009 and May of 2010. A total of 9,647 birds of 63 species were observed during the study period. The most dominant species was Aythya ferina (18.5%), followed by, in decreasing order, Anas platyrhynchos (11.5%), Calidris alpine (9.6%) and Cygnus Cygnus (7.7%). Species which appeared in all months (100% occurrence rate) included a total of 5 species of Ardea cinerea, Egretta alba modesta, Egretta garzetta, Anas crecca and Anas poecilorhyncha. Furthermore, the study showed a total of 13 government protected species, 3 class-I endangered species, 8 class-II endangered species and 8 natural monument species. The Gangjin Bay region includes the Nakdong estuary, natural monument number 179, and provides stopping grounds for the Cygnus Cygnus, at the next highest number of birds. Furthermore, the region is characterized by the wintering of Cygnus Cygnus at a bird count higher than that of the Jindo Cygnus Cygnus migration destination, natural monument number 101. Therefore, there is a need for the designation of natural monuments and protected wetlands, as well as continued maintenance, in the Gangjin Bay region.

Case report : Gemcitabine-Induced Hemolytic Uremic Syndrome in Pancreatic Cancer: A Case Report and Review of the Literature

( Hye Won Lee ),( Moon Jae Chung ),( Huap Yong Kang ),( He Un Choi ),( Youn Jeong Choi ),( Kyung Joo Lee ),( Seung Woo Lee ),( Seung Hyuk Han ),( Jin Seok Kim ),( Si Young Song ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.1

Hemolytic uremic syndrome (HUS) is a rare thrombotic complication characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS may be caused by several different conditions, including infection, malignancy, and chemotherapeutic agents, such as mitomycin, cisplatin, and most recently, gemcitabine. The outcome of gemcitabine-induced HUS is poor, and the disease has a high mortality rate. This study reports a case of gemcitabine-induced HUS in a patient with pancreatic cancer in Korea. (Gut Liver 2014,8:109-112)

Intravenous Fluid Selection for Unruptured Intracranial Aneurysm Clipping : Balanced Crystalloid versus Normal Saline

Kang, Jian,Song, Young Joo,Jeon, Sujeong,Lee, Junghwa,Lee, Eunsook,Lee, Ju-Yeun,Lee, Euni,Bang, Jae Seung,Lee, Si Un,Han, Moon-Ku,Oh, Chang Wan,Kim, Tackeun The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.4

Objective : While balanced crystalloid (BC) could be a relevant fluid regimen with buffer system compared with normal saline (NS), there have been no studies on the optimal fluid for surgery of an unruptured intracranial aneurysm (UIA). This study aimed to compare the effects of fluid regimens between NS and BC on the metabolic and clinical outcomes of patients who underwent surgery for UIA. Methods : This study was designed as a propensity score matched retrospective comparative study and included adult patients who underwent UIA clipping. Patient groups were categorized as NS and BC groups based on the types of pre-operative fluid and the amount of fluid administered during surgery. The primary outcomes were defined as electrolyte imbalance and acidosis immediately after surgery. The secondary outcomes were the length of stay in the intensive care unit (ICU) and duration from the end of the operation to extubation. Results : A total of 586 patients were enrolled in this study, with each of 293 patients assigned to the NS and BC groups, respectively. Immediately after surgery, serum chloride levels were significantly higher in the NS group. Compared to the NS group, the BC group had lower incidence rates of acidemia (6.5% vs. 11.6%, p=0.043) and metabolic acidosis (0.7% vs. 4.4%, p=0.007). As compared to NS group, BC group had significantly shorter duration from the end of the operation to extubation (250±824 vs. 122±372 minutes, p=0.016) and length of stay in ICU (1.37±1.11 vs. 1.12±0.61 days, p=0.001). Throughout multivariable analysis, use of BC was found to be significant factor for favorable post-operative results. Conclusion : This study showed that the patients who received BC during UIA clipping had lower incidence of metabolic acidosis, earlier extubation and shorter ICU stay compared to those who received NS. Therefore, using BC as a peri-operative fluid can be recommended for patients who undergo surgery for UIA.

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors :

Lee, Kwang-Il,Moon, Seong-Hwan,Kim, Hyang,Kwon, Un-Hye,Kim, Ho-Joong,Park, Si-Nae,Suh, Hwal,Lee, Hwan-Mo,Kim, Hak-Sun,Chun, Heoung-Jae,Kwon, Il-Keun,Jang, Ju-Woong Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2012 1528-1159) Vol.37 No.6

<P>In vitro experiment using rabbit nucleus pulposus (NP) cells seeded in atelocollagen scaffolds under the stimulation of growth factors.</P>

Characteristics of low - fat Chedder cheese made with added Micrococcus sp .

Lee, Si Kyung,P다, Un Hua,Joo, Hyun Kyu,Marth, Elmer H 한국농화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.5

The main purpose of this study was to determine the effects of Micrococcus sp. LL3 on accelerating proteolysis, flavor development and characteristics of low-fat Cheddar cheese as a potential agent for industrial application, and to optimize cultural conditions for cell mass production. Optimum temperature for cell growth and caseinolysis was 30 ℃ and 35 ℃ respectively, and optimum pH was 7.0. Monosaccharides like glucose, mannose and fructose were more excellent as carbon source, but arabinose and xylose markedly inhibited cell growth and caseinolysis. Among the organic nutrients, yeast extract was more effective for cell growth and for caseinolysis. However, inoranic nitrogen sources were less effective than organic sources. Urea inhibited cell growth severely. Cell growth and caseinolysis were rather increased a little in broth containing 1% NaCl, and Micrococcus sp. LL3 was very tolerant until NaCl concentration in broth added to 9%. Addition of vitamin did not affect cell growth and caseinolysis in level of 0.1 ㎍/㎖ concentration. Cell growth and caseinolysis were activiated by addition of glutamic acid and MgSO₄ with concentration of 0.2% and 0.5% respectively. Production of aminopeptidase which cleaved polypeptides was the highest in early stationary phase during cell growth. There was no difference in acidity changes in the course of cheese manufacture and in chemical component in 6-month old cheese through addition of Micrococcus sp. LL3 to cheese. It was however possible to note a significant increase in the value for TCA solube N and PTA soluble N in cheese with added adjunct compared to the control cheese. Values for TCA soluble N were 14, 21 and 28% higher khan that of the control cheese for 6-month old cheeses with added CFE, FD and live cells of Micrococcus sp. LL3. Using electrophoresis in polysacrylamide gels, casein hydrolysis appeared also to be more extensive in experimental cheeses ripened at 10 ℃ for 5 and 6 months than in the control cheese. The population of starter and lactic acid bacteria was not affected by addition of Micrococcus sp. LL3 as ajunct. Starter bacteria decreased slowly but lactic acid bacteria increased rapidly with time. Microflora of 3-month old low-fat Cheddar cheese represented a sequene of changes in which Lactobacillus sp. replaced the initial flora of Streptococcus sp. When Micrococcus sp. LL3 was added in cheese, no marked flavor defects developed and bitterness decreased more than in control cheese. Panelists gave higher flavor score and overall preference score to experimental cheeses than to the control cheese.