선형가속기를 이용한 뇌정위 방사선수술시 Isocentric sub system의 기하학적 오차

이석춘,오종영,김남석 대한방사선치료학회 1995 大韓放射線治療技術學會誌 Vol.7 No.1

목적 : 뇌정위 방사선수술은 AVM(ateriovenous malformation)이나 작은 크기의 종양에 1회에 고선량의 방사선을 조사하는 기술이다. 선형가속기를 이용한 방사선 수술을 하기 위하여 최근 본원에 설치한 Philips SL 75-5 선형가속기와 isocentric sub system(ISS)에 의한 뇌정위 방사선 수술에 있어서 표적의 위치선정과, gantry와 couch의 회전시 기하학적 오차가 중요시 되는데 isocentric sub system의 오차를 분석 하였다. 대상 및 방법 : 방사선원으로는 Philips SL 75-5 선형가속기의 5MV 광자선을 사용하였고, 원형의 작은 광자선속을 위하여 isocenter에서의 직경이 26mm인 secondary cone을 gimbal baaring에 삽입하여 사용하였다. 표적의 크기와 좌표를 정하기 위하여 CT나 angio localizer를 이용하고, 표적좌표 선정을 위하여 BRW phantom base와 target pointer를 이용하여 임의의 BRW-coordinator를 바꾸어 가면서 gantry angle와 ISS head 각도를 임의로 바꾸어 가면서 film에 방사선을 조사하였다. 흑화된 film을 view box 위에 놓고 광학판독기구로 film 가장자리의 오차를 scale 확대경으로 측정하여 오차를 분석하였다. 결과 : 표적좌표 선정의 정확도를 확인하기 위하여 임의의 표적좌표에 gantry의 10개각도 ISShead의 10개각도에서 각각 광자선을 조사시켜 film을 이용하여 오차를 측정한 결과 collimator cone의 직경이 26mm일때 전체 평균오차가 0.219+-0.03mm이었다. 결론 : Isocentric sub system은 gantry head와 ISS arm 사이에 gimbal bearing이 있어서 이 부위를 flexible하게 연결함으로 gantry의 회전에 무관하게 정확한 isocenter를 유지시켜 주고 ISS head는 couch와 독립되어 움직이므로 isocentric sub system isocenter의 오차를 최대한 줄일수 있음을 알았다.

수술중 방사선치료를 위한 LYON Intraoperative device를 이용한 전자선 선량분포의 특성

이석춘,최운홍,김남석,오종영 대한방사선치료학회 1992 大韓放射線治療技術學會誌 Vol.5 No.1

이성대상포진에서 성상신경차단술의 치료 효과에 대한 고찰

배창훈,이석춘,최영호,천승민,백운회,정은채,송시연,김용대 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.11

Background and Objectives:Facial palsy of herpes zoster oticus has rapid onset, is usually severe in degree, and poorer inprognosis than Bells palsy. In the past, herpes zoster oticus has usually been treated with acyclovir and steroid, but recently,applying stellate ganglion block for herpes zoster oticus has been recognized as an additional treatment that may improvefacial palsy. This study was designed to evaluate the effect of stellate ganglion block on herpes zoster oticus. Subjects andMethod:We reviewed retrospectively the medical records of 30 patients with herpes zoster oticus who were treated withacyclovir, steroid and stellate ganglion block between January 1995 and December 2004. The follow-up period was at leastover than 6 months. Results:All patients suffered from otalgia, vesicle, and facial palsy. The average degree of House-Brackmann classification on admission was 3.26 in the complete recovery patients and 4.61 in the incomplete recovery patients.Seventeen patients were completely recovered from facial palsy (56.7%), and 13 showed residual facial palsy 13 patients(43.3%). The poor prognosis may be related with early onset of facial palsy, high degree of House-Brackmann classificationon admission and high degenerative ratio on electroneurography of facial nerve. Conclusion:The additional treatment ofstellate ganglion block in herpes zoster oticus may not be effective on improving the complete recovery rate and prognosis.(Korean J Otolaryngol 2006;49:1065-70)

인체 호흡기상피세포에서 Macrolide에 의한MUC4 점액유전자의 발현

우현재,이석춘,최윤석,최성원,김민한,전보성,송시연,김용대,배창훈 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.9

Background and Objectives:such as asthma, chronic bronchitis and rhinosinusitis. Macrolide antibiotics is considered one of the efective drugs inhibiting mucus secretion for chronic bronchitis and rhinosinusitis with nasal polyp. However, the anti-secretory efect of macrolide is not clear. This study was designed to investigate whether macrolide can supress interleukin-1β (IL-1β)-induced MUC4 gene expression and mucin secretion in the cultured human nasal polyp epithelial cells and NCI-H292 epithelial cells. :Nasal polyps were obtained from 20 patients with chronic rhinosinusitis with nasal polyp during endoscopic sinus surgery. We observed the efect of roxithromycin on the IL-1β-induced MUC4 gene and mucin secretion by reverse transcriptase-polymerase chain reaction (RT-PCR) with enzyme-linked imunosorbent assay (ELISA) method. Results:Roxithromycin attenuated the IL-1β-induced MUC4epithelial cels and NCI-H292 epithelial cels. Conclusion:This result suggests that roxithromycin may be considered as an effec-tive anti-hypersecretory agent for its down-regulation of the MUC4 gene. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ; 50 :784-8)

두경부에 발생한 중복암에 대한 임상적 고찰 70예

배창훈,천승민,이석춘,정은채,백운회,최성원,최윤석,김용대,송시연 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.8

Background and Objectives:Recent advances in medical management, along with increased life span, have contributed to the increased oportunity for detecting multiple primary malignancy (MPM)and clinical characteristics of MPM in the head and neck region. Subjects and Method:We reviewed retrospectively the med-ical records of 984 patients with malignant tumors of head and neck who had been diagnosed histopathologicaly and treated be-tween August 1985 to July 2005. Results:Seventy patients (7.11%) were diagnosed as having MPM (double, n= 66;triple, n= 4). This group consisted of 67 men and 3 women (p<0.01). Twenty-five patients (36% ) had synchronous double primary malig-nancy (SDPM) and 45 patients (64% ) had metachronous double primary malignancy (MDPM). The hypopharynx was the most fre-quently involved site of the index tumor. The most common index tumors were squamous cell carcinoma histopathologically. Second primary malignancies were found in esophagus, stomach and lung. Fifty-five patients were found with first primary ma-lignancy in head and neck, and 25 were with second primary malignancy. The patients with first and second primary malignancy (average of survival 11.1 months) was very por. Patients with MPM have high cigaretes smoking and alcohol drinking habit. Conclusion:Patients with head and neck malignancies will require care-ful folow up for prevention, early detection, and the treatment of second primary malignancy. (Korean J Otorhinolaryngol Head Neck Surg 2007 ;50 :694-8)

비부비동 반정성 유두종의 전산화 단층촬영상과 자기공명영상의 분석

배창훈,서영중,이석춘,천승민,백운희,정은채,송시연,김용대 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Computed tomography (CT) is commonly used to evaluate the degree of sinus involvement in case of inverted papilloma (IP). However, CT cannot differentiate tumor from adjacent inflammatory mucosa or retained secretions. By contrast, magnetic resonance imaging (MRI) has been reported to be useful in distinguishing IP from paranasal sinusitis. This study investigated whether preoperative assessment with MRI and CT accurately predict the extent of IP. Materials and methods: CT and MRI were retrospectively reviewed in 9 case of IP. Patients were categorized into staged based on CT and MRI findings according to the staging system proposed by Krouse. The involvement of IP in each sinus was also assessed. Results: Differentiation of IP from inflammatory disease may be more successful in routine case where the inflammatory mucosa has low signal intensity on T1-weighted images and very high signal intensity on T2-weighted images. CT imaging could not differentiate tumor from adjacent inflammatory mucosa or retained secretions. Conclusion: Preoperative MRI of IP can predict the location and extent of the tumor involvement in the paranasal sinuses and sometimes predicts malignant changes.

입상활성탄(GAC)공정에 의한 정수처리 특성

김영진,전유찬,강용태,이석춘 한국수처리기술연구회 1993 한국수처리학회지 Vol.1 No.2

비부비동 반전성 유두종의 전산화 단층촬영상과 자기공명영상의 분석

배창훈 ( Chang Hoon Bai ),서영중 ( Young Jung Seo ),이석춘 ( Seok Choon Lee ),천승민 ( Seung Min Chen ),백운회 ( Un Hoi Baek ),정은채 ( Eun Chae Jung ),송시연 ( Si Youn Song ),김용대 ( Yong Dae Kim ) 영남대학교 기초/임상의학연구소 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Background: Computed tomography (CT) is commonly used to evaluate the degree of sinus involvement in cases of inverted papilloma (IP). However, CT cannot differentiate tumor from adjacent inflammatory mucosa or retained secretions. By contrast, magnetic resonance imaging (MRI) has been reported to be useful in distinguishing IP from paranasal sinusitis. This study investigated whether preoperative assessment with MRI and CT accurately predict the extent of IP.1) Materials and methods: CT and MRI were retrospectively reviewed in 9 cases of IP. Patients were categorized into stages based on CT and MRI findings, according to the staging system proposed by Krouse. The involvement of IP in each sinus was also assessed. Results: Differentiation of IP from inflammatory disease may be more successful in routine cases where the inflammatory mucosa has low signal intensity on T1-weighted images and very high signal intensity on T2-weighted images. CT imaging could not differentiate tumor from adjacent inflammatory mucosa or retained secretions. Conclusion: Preoperative MRI of IP can predict the location and extent of the tumor involvement in the paranasal sinuses and sometimes predicts malignant changes.