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Shin, J.I.,Song, K.S.,Kim, H.,Cho, N.H.,Kim, J.,Kim, H.S.,Lee, J.S. Blackwell Publishing Ltd 2011 British journal of dermatology Vol.164 No.6
<P><B>Summary</B></P><P><B>Background </B> Because inflammatory cytokines are known to be potent inducers of matrix metalloproteinases (MMPs), and MMPs themselves can promote inflammation, we speculated that MMP activation might be involved in the pathogenesis of Henoch–Schönlein purpura (HSP) vasculitis.</P><P><B>Objectives </B> To investigate the gene expression profile of all known MMPs and tissue inhibitors of metalloproteinases (TIMPs) in children with HSP and to examine the role, if any, of MMPs in the pathogenesis of HSP.</P><P><B>Methods </B> Peripheral blood samples were obtained from 10 patients with HSP (nine were in the acute stage, one had HSP nephritis) and four healthy controls. Peripheral blood samples were also taken from the nine patients with HSP when they reached the convalescent stage of the disease. From these samples, total RNA was purified and gene expressions were measured using real‐time polymerase chain reaction.</P><P><B>Results </B> MMP‐8 expression was decreased in patients with arthralgia (<I>P </I>=<I> </I>0·038), and MMP‐3 (<I>P </I>=<I> </I>0·03) and TIMP‐4 expressions (<I>P </I>=<I> </I>0·016) were elevated in HSP patients with nephritis. Soft tissue oedema was associated with decreased expressions of MMP‐26 (<I>P </I>=<I> </I>0·038) and MMP‐28 (<I>P </I>=<I> </I>0·038). MMP‐1, MMP‐8, MMP‐9, MMP‐10, MMP‐13, MMP‐16 and MMP‐26 levels were significantly higher in patients in the acute stage of HSP than in normal controls (<I>P </I><<I> </I>0·05). MMP‐9 (<I>P </I>=<I> </I>0·097) and MMP‐19 (<I>P </I>=<I> </I>0·054) levels decreased to borderline significance in patients in the convalescent stage compared with those in the acute stage. The duration of steroid administration was negatively correlated with MMP‐1, MMP‐2, MMP‐7, MMP‐10, MMP‐12, MMP‐19, MMP‐23 and TIMP‐1 levels (<I>P </I><<I> </I>0·05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs.</P><P><B>Conclusions </B> This is the first study to describe the expression profile of all known MMPs and TIMPs in children with HSP, and our results suggested that abnormal levels of MMP and TIMP activity may have a role in the pathogenesis of HSP.</P>
Shin, Ji‐,Ae,Kim, Jae‐,Jin,Choi, Eun‐,Sun,Shim, Jung‐,Hyun,Ryu, Mi Heon,Kwon, Ki Han,Park, Hee‐,Min,Seo, Jin‐,Young,Lee, Soo‐,Yeon,Lim, Do‐,Won,Cho, Nam Wiley Subscription Services, Inc., A Wiley Company 2013 Head & neck Vol.35 No.7
<P><B>Abstract</B></P><P><B>Background</B></P><P>The aims of this study were to evaluate the apoptotic activities and molecular mechanisms of methanol extracts of <I>Dianthus chinensis</I> (MEDC) and <I>Acalypha australis</I> L. (MEAL) in human oral cancer cells.</P><P><B>Methods</B></P><P>The apoptotic effects and related molecular mechanisms of MEDC and MEAL on oral cancer cells were evaluated using MTS assay, DAPI staining, immunostaining, Western blotting, and reverse transcriptase–polymerase chain reaction.</P><P><B>Results</B></P><P>Sp1 was overexpressed in oral tumor tissues compared with normal oral mucosa. Downregulation of Sp1 inhibited the growth of SCC‐15 and YD‐15 oral cancer cells. MEDC and MEAL inhibited cell growth and induced apoptosis in both cell lines by decreasing the expression of Sp1. In addition, treatment of cells with MEDC and MEAL decreased Mcl‐1 expression, which is a downstream target of Sp1.</P><P><B>Conclusion</B></P><P>Our results indicate that MEDC and MEAL are bioactive natural products that can potentially induce apoptosis of tumor cells that overexpress the Sp1 protein. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</P>
Shin, J.I.,Lim, H.Y.,Kim, H.W.,Seung, B.J.,Ju, J.H.,Sur, J.H. ACADEMIC PR 2016 JOURNAL OF COMPARATIVE PATHOLOGY Vol.155 No.1
<P>This study was designed to investigate the role of obesity in canine malignant mammary tumours (CMMTs), by assessing aromatase expression and the regulatory roles of immune mediators such as cyclo-oxygenase-2 (COX2), prostaglandin E-2 (PGE(2)), nuclear factor kappa beta (NF-kappa B), hypoxia inducible factor-1 alpha (HIF-1 alpha cc) and adipokines (i.e. leptin) in lean, optimal body weight, overweight and obese animals. Clinicopathological data, including the breed, body weight, body condition score and age and neutering status, were collected, together with histopathological characteristics (i.e. histological types, grading and lymphatic invasion). To determine the expression of each factor, immunohistochemistry was conducted with 60 samples of malignant CMMTs. CMMTs from overweight and obese animals had significantly elevated levels of PGE(2), and aromatase expression correlated significantly with PGE(2), NF-kappa B and leptin expression. However, no significant difference was observed in terms of histopathological characteristics. The results suggest that PGE(2), a known obesity-related immune mediator, could be upregulated in CMMTs from overweight and obese animals. In addition, PGE(2), NF-kappa B and leptin influenced the expression of aromatase, as observed in women. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Symbolic/Numeric Computations for Feedback Control System Design
Shinji Hara 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper focuses on symbolic/numeric hybrid computations for feedback control system design. Three resent approaches along this research directions, namely robust controller design by a parameter space approach, Sum of Root(SoR) characterization of H2 optimal control design, and symbolic-numeric hybrid integrated design, are reviewed.
Shinji Takahashi,Hiroyuki Inose,Koji Tamai,Masayoshi Iwamae,Hidetomi Terai,Hiroaki Nakamura 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Osteoporotic vertebral fractures (OVFs) can hinder physical motor function, daily activities, and the quality of life in elderly patients when treated conservatively. Vertebral augmentation, which includes vertebroplasty and balloon kyphoplasty, is a commonly used procedure for OVFs. However, there have been reports of complications. Although serious complications are rare, there have been instances of adjacent vertebral fractures, cement dislocation, and insufficient pain relief due to cement failure, sometimes necessitating revision surgery. This narrative review discusses the common risks associated with vertebral augmentation for OVFs, such as cement leakage and adjacent vertebral fractures, and highlights the risk of revision surgery. The pooled incidence of revision surgery was 0.04 (0.02– 0.06). The risks for revision are reported as follows: female sex, advanced age, diabetes mellitus, cerebrovascular disease, dementia, blindness or low vision, hypertension, hyperlipidemia, split type fracture, large angular motion, and large endplate deficit. Various treatment strategies exist for OVFs, but they remain a subject of controversy. Current literature underscores the lack of substantial evidence to guide treatment strategies based on the risks of vertebral augmentation. In cases with a high risk of failure, other surgeries and conservative treatments should also be considered as treatment options.
Extraction of Median Plane from Facial 3D Point Cloud Based on Symmetry Analysis Using ICP Algorithm
Shinji Yamada,Huimin Lu,Joo Kooi Tan,Hyoungseop Kim,Namiko Kimura,Takako Okawachi,Etsuro Nozoe,Norifumi Nakamura 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
Cleft lip is a kind of congenital facial morphological abnormality. In the clinical field of cleft lip, it is necessary to analyze symmetric shape. However, there is no method to analyze the cleft lip technique based on symmetrical viewpoints. On the other hand, in our previous method to find a symmetric axis using a 2D image, since the middle line is extracted only from the front view of the face moire image. There was a problem that low accuracy was obtained by slight rotation of the face and it was not possible to consider 3D information. In this paper, we propose a method to extract the median plane of the face by analyzing based on bilateral symmetry by using 3D point cloud on the face of front. By extracting the median plane, we believe that not only surgical assistance of doctor be possible but also become a clue to development of simulation software which is the end goal.
Image Analysis of Cleft Lip from Moire Image Based on Symmetry Analysis
Shinji YAMADA,Huimin LU,Joo Kooi TAN,Hyoungseop KIM,Namiko KIMURA,Takako OKAWACHI,Etsuro NOZOE,Norifumi NAKAMURA 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
About 4% of babies in Japan suffer from congenital anomalies. Cleft lip is the most common disorder among external malformations occurring at a rate of 1 in 500 people. The goal of treatment is to recover symmetric and functional lips and nose forms. However, in the case of unilateral cleft lip where the lips and nose themselves are shifted from the midline of the face, it is difficult to set the midline which is the symmetry axis for evaluating the degree of symmetry of the face. In this paper, we propose an image processing method for extracting the midline using zebra image and shadow image which are two dimensional image created based on three dimensional analysis. Also, we evaluate the degree of asymmetry of the face by using the midline as the axis. As a result of applying the proposed method to 25 cases, which indicated that the proposed method is useful.
Integrated Production Planning and Scheduling Using Backward/Forward Scheduling Simulation
Shinji Hirano,Shigeo Kobayashi,Toru Eguchi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper deals with release time planning to reduce lead times of jobs in make-to-order productionenvironments. In traditional MRP-based planningsystem, lead times are estimated using historical data and pastexperience without precisely considering capacity constraints.The proposed method in this paper is based on precisebackward and forward scheduling simulation. First, backward simulation in which simulation starts at each due date ofjob and sends it through the shop floor based on the backward sequence of its part routing is applied. Next, forwardsimulation is applied to modify the release times obtained by backward simulation. A genetic algorithm is also used tominimize lead times of jobs in the final step. Numerical experiments of planning and scheduling with processing timeuncertainty are carried out to examine the effectiveness of the proposed method.