http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shang Jian,Liu Xiu,Bi Yanqing,Yan LiXia,Tian Cuiping,Guan Yu 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Background Breast cancer is one of the solid tumors investigated for gene expression. Objective Our research aimed to investigate the roles of transmembrane protein 106C (TMEM106C) on breast cancer and the underlying mechanisms. Results The results from GEPIA website indicated that TMEM106C was up-regulated in breast cancer and the TMEM106C over-expression was concerned with poor outcomes in breast cancer patients. Moreover, western blotting and qRT-PCR assay also showed that TMEM106C level was up-regulated in breast cancer cells. Our results showed that over-expression of TMEM106C accelerated the malignant phenotypes of MCF7 cells, while TMEM106C silencing displayed the opposite outcomes in MDA-MB-231 cells. Furthermore, TMEM106C over-expression activated PI3K/AKT/mTOR signaling, which reversed by Wortmannin. Similarly, TMEM106C silencing inhibited PI3K/AKT/mTOR signaling, which abolished by 740YP. Moreover, we also confirmed that 740Y-P significantly reversed the function of TMEM106C silencing on the malignant phenotypes of MDA-MB-231 cells. Conclusion This study indicated that TMEM106C could promote the malignant phenotypes of breast cancer cells by activating PI3K/AKT/mTOR signaling.
Comparison of multiaxial fatigue damage models under variable amplitude loading
Hong Chen,De-Guang Shang,Yu-Jie Tian,Jian-Zhong Liu 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.11
Based on the cycle counting method of Wang and Brown and on the linear accumulation damage rule of Miner, four multiaxial fatigue damage models without any weight factors proposed by Pan et al., Varvani-Farahani, Shang and Wang, and Shang et al. are used to compute fatigue damage. The procedure is evaluated using the low cycle fatigue experimental data of 7050-T7451 aluminum alloy and En15R steel under tension/torsion variable amplitude loading. The results reveal that the procedure is convenient for engineering design and application, and that the four multiaxial fatigue damage models provide good life estimates.
Shang-Hui Yang,Jian-Shian Lin,Fuh-Shyang Juang,Ding-Chin Chou,Ming-Hua Chung,Chen-Ming Chen,Lung-Chang Liu 한국물리학회 2013 Current Applied Physics Vol.13 No.5
In this paper, white light emitting diodes (LEDs) with good color rendering indices (CRI) and high luminous efficiencies have been fabricated by the encapsulation of mixed and double-deck phosphors. Experimental results revealed that white LEDs with the encapsulation of double-deck phosphors exhibited better CRI and higher luminous efficiencies than those with the encapsulation of mixed phosphors because no secondary excitation took place. The hue, CRI, and luminous efficiencies of white LEDs with double-deck phosphors under 200 mA were CIEx,y =(0.357, 0.348), 90, and 62.3 lm/W,respectively while the hue, CRI, and luminous efficiencies of white LEDs with mixed phosphors under 200 mA were CIEx,y = (0.366, 0.354), 89, and 56.5 lm/W, respectively.
Jian Sun,Shi-Jie Zhang,Hai-Bo Li,Wei Zhou,Wei-Xiao Hu,Shang Shan 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Twenty two new 5-fluorouracil (5-FU) derivatives, 2-butoxy-4-substituted 5-fluoropyrimidines, were synthesized and characterized by IR, 1H NMR, MS, HRMS. All compounds were preliminarily evaluated by MTT assay on human liver BEL-7402 cancer cell line in vitro. Ten compounds were selected to test their cytotoxic activity against A549, HL-60 and MCF-7 cancer cell lines in vitro. These compounds were more sensitive to BEL-7402 than other cell lines, particularly, cytotoxic activity of compounds 6b, 6d-f, 6p, 6s-u were in sub-micromolar scale. The highest cytotoxic potency against A549, HL-60 and MCF-7 was shown by 2-butoxy-4-chloro-5- fluoropyrimidine (5) with IC50 values of 0.10, 1.66 and 0.59 μM, respectively. Compounds 6d and 6e were effective against MCF-7 with IC50 9.73 μM and HL-60 with IC50 8.83 μM, respectively.
Jian Chen,Man Feng Gong,Shang Hua Wu 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.2
WC-3TiN-0.8Cr3C2-8Co cemented carbides were sintered in de-nitriding and nitriding conditions to use as the cutting tools for HT250 gray cast iron, respectively. Their microstructures and mechanical properties were studied, and the influence of feed rate on tool wear mechanism was investigated. Tool wear mechanism was analyzed by SEM and EDS. Denitriding cemented carbides with the same composition and grain size were prepared for comparison. The results showed that the inserts of nitriding WC-3TiN-0.8Cr3C2-8Co cemented carbides possess higher hardness, and better cutting performance than denitriding inserts under the same cutting condition. There were abrasive wear, oxidative wear and obviously abrasive wear on the flank of nitriding inserts. As for denitriding inserts, there were combination of adhesive wear, oxidative wear, built-upedge (BUE) and abrasive wear on the flank face. Their dominant failure mechanism was abrasive wear. In addition, adhesive wear also played a role in the tools failure to some extent for both nitriding and denitriding cemented carbides cutting tools.