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Lidocaine, Thrombin, Epinephrine 의 항균효과
김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.
송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3
Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.
shadow 방식을 이용한 주기억장치 데이타베이스에서의 회복 기법
우승균(Seung Kyoon Woo),홍석희(Seok Hee Hong),이윤준(Yoon Joon Lee),김명호(Myoung Ho Kim) 한국정보과학회 1995 한국정보과학회 학술발표논문집 Vol.22 No.2A
주기억장치 데이타베이스에서는 주기억장치의 휘발성 때문에 오류가 발생했을 때 모든 데이타들을 잃어버리게 되므로 데이타베이스를 일관성 있는 상태로 다시 복귀시켜주는 회복 기능은 매우 중요한 기능이다. 본 논문에서는 비휘발성의 안정된 메모리를 사용하지 않고 shadow 기법을 사용하는 회복 기법을 제시한다. 이 기법은 undo 로그를 전혀 만들거나 기록하지 않으므로써 트랜잭션 수행 시에 디스크에 대 한 I/O 시간을 줄이고 회복 시에도 빠른 처리를 할 수 있다.
그림자 갱신과 퍼지 검사점 방식을 이용한 주기억장치 데이타베이스 시스템에서의 회복기법
우승균(Seung-Kyoon Woo),김명호(Myoung-Ho Kim),이윤준(Yoon-Joon Lee) 한국정보과학회 1997 정보과학회논문지(B) Vol.24 No.3
본 논문에서는 그림자 갱신 기법을 기반으로 하고 퍼지 검사점 방식을 사용하는 주기억장치 데이타베이스의 회복 기법을 제안한다. 이 기법은 시스템간 이식성을 높이기 위하여 비휘발성인 안정된 메모리를 사용하지 않는 일반적인 범용 시스템 환경을 기반으로 한다. 또한 MMDB에서 퍼지 검사점 수행시 WAL 방식에 의한 위반을 효율적으로 없애는 방식도 제안한다. 본 논문에서 제안하는 회복 기법은 트랜잭션의 재수행 로그만을 기록하게 하여 디스크에 대한 입출력을 줄이고 회복시에도 재수행 처리에 의한 빠른 회복을 할 수 있다. 그리고 기존에 제안된 방법들과 성능 비교를 통하여 본 논문에서 제안한 방법의 우수성을 보인다. In this paper we propose a new recovery method in main memory database (MMDB) that is based on fuzzy checkpointing and shadow updating. Our proposed method is highly applicable to general purpose system environment because it does not use a special-purpose stable memory that is often assumed in other works on the literature. We also present an efficient mechanism avoiding the violation caused by WAL protocol, which may occur when fuzzy checkpoinging is used carelessly in MMDB and thus needs a special attention. In the proposed method only redo log records are written, which leads to a low I/O cost and fast recovery processing. We also compare the performance of our proposed method with other methods and show that our method works better than others proposed previously.
임현균(Hyun Kyoon Lim),박세진(Se-Jin Park),황지수(Jisoo Hwang),박승남(Seung-Nam Park),김시경(Sikyung Kim),이근우(Geun Woo Lee),김승관(Seung Kwan Kim),박성종(Seongchong Park),오승빈(Seung Bin Oh),노기용(Ki Yong Noh),김원식(Wuon-Shik K 대한인간공학회 2010 대한인간공학회 학술대회논문집 Vol.2010 No.10
Lighting for home and road in modern society is one of the most important design factors. To date, standards for colors to human sensation are well made under the bright (=photopic vision) and dark (=scotopic vision) environment. However, the measurement method is not objective and therefore, new method is in need. In this study, we recorded electroencephalogram while a subject was watching light-emitting diode (LED) panel. Red, green, and blue color appeared sequentially from dark (=0) and to the most bright color level (=256) step by step. A subject was asked to press a button when he/she see any colors on the screen. EEG data from five subjects (34 ? 5.9 years) was analyzed. As results, subjects pressed button 37.1 seconds for red, 36.5 s for green, and 36.5 s for blue. Subjects showed also EEG changes by optical stimulation post onset of lighting stimulation. As a conclusion, EEG analysis may be a new objective measurement method to detect brain response by the optical stimulation. To get firm evidence for the response, additional subjects should be recruited more in the same test. Test-retest reliability should be also made for the evidence based standards of visual sensitivity.
Microscopic Age Estimation from the Anterior Cortex of the Femur in Korean Adults
Han, Seung-Ho,Kim, Sang-Hyun,Ahn, Yong-Woo,Huh, Gi-Yeong,Kwak, Dai-Soon,Park, Dae-Kyoon,Lee, U-Young,Kim, Yi-Suk Wiley (Blackwell Publishing) 2009 Journal of Forensic Sciences Vol.54 No.3
<P>The purpose of this study was to develop age-predicting equations from the anterior cortex of the femur of Korean adults. Seventy-two femoral samples (44 male and 28 female) were obtained from Korean cadavers and used to develop the equations. The thin sections (<100-microm thick) were prepared by manual grinding; the sections were not decalcified and were stained with Villanueva bone stain reagent. Analysis of covariance showed no significant differences in age-adjusted histomorphological variables between sexes. In stepwise regression analysis, osteon population density, average osteon area, and the most anterior cortical width were selected for an age-predicting equation which produced a high regression correlation (R(2) = 0.789). The average Haversian canal area was not significantly related to age for any specimen.</P>
Young Woo Park,Seung Wook Lee,Hyung-Kyoon Choi,SeungOk Yang,Young-Suk Kim,Ho-Nam Chun,Pahn-Shick Chang,JaeHwan Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.2
Distribution of isoflavones and fatty acids in soymilk fermented with 7 Lactobacilli (L-type), 7 Bifidobacteria (Btype), or 5 Streptococci (S-type) were monitored. Total isoflavones in fermented soymilk ranged from 5.24 to 8.59 μ㏖/g dry basis while those in unfermented soymilk were 8.06 μ㏖/g dry basis. Depending on the types of inoculated microorganisms, fermented soymilk showed different profiles in isoflavones, especially aglycones and β-glucosides. Four L-type fermented soymilk had significantly higher aglycone content (33.69-46.21%) and low β-glucosides compared to control (p<0.05). All Btype fermented soymilk showed significantly high aglycone levels (p<0.05). Out of 5 Streptococci, 4 strains produced over 82.2% aglycones. Lipid content ranged from 162 to 224 ㎎/g and linoleic acid was the highest, followed by oleic, linolenic, palmitic, and stearic acids. Average ratio of unsaturated to saturated fatty acids in control, L-, B-, and S-type fermented soymilks was 6.30, 6.09, 6.30, and 5.94, respectively. This study can help to develop a fermented soymilk containing high isoflavone aglycones and low fat content.
증예(症例) : 혈관육종의 전이로 인한 상부 위장관 출혈 1예
남상우 ( Sang Woo Nam ),윤현정 ( Hyun Jung Yoon ),김성훈 ( Seong Hun Kim ),김상균 ( Sang Kyoon Kim ),민경훈 ( Kyung Hoon Min ),이호경 ( Ho Kyung Lee ),이나리 ( Na Ri Lee ),마명신 ( Myung Sin Ma ),이승옥 ( Seung Ok Lee ),김대곤 ( D 전북대학교 의과학연구소 2003 全北醫大論文集 Vol.27 No.1
Angiosarcoma is a rare malignant tumor which accounts for 1% to 2% of all soft tissue sarcomas. A 47-year-old man was presented to our emergency room because of general weakness and melena for 3 days. He had received a surgery for angiosarcoma of the aorta one year ago. Six months before the admission, angiosarcoma recurred at the anastomosis of site of the aorta, and metastatic lesions were found in the lung, pleura and skin of the buttock. Gastric fiberoscopy revealed two peanut sized, protuberant masses with ongoing bleeding at the body of the stomach and duodenum. Hemostatic procedure was performed immediately by a snare. No more active bleeding was noted and the patient was no report of upper gastrointestinal bleeding due to angiosarcoma in Korea, and we are hearby reporting with review of literature.