생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

알콜의 연속투여가 수면구조와 일부 정동에 미치는 영향

김세인,신석철,왕성근 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

To investigate the effects of short-term administration of alcohol on the sleep patterns and subjective physiological function(some aspects of emotion), the author applied polysomnography, reaction time and visual analogue test to the volunteer male students. The subjects were 8 healthy young adults, ranging in age from 21 to 26 years, without personal past nor present histories of singificant medical, neurological, or psychiatric illness and suffering from no current major sleep disturbances or parasomnias. After one night sleep of adaptation, each subject was ingested alcohol(43% whisky 3ml/kg) for 5 successive nights and was withdrawn for 3 days, and polysomnography was recorded in the sleep laboratory. Also, reaction time was performed and visual anlogue test were applied to measure the degree of fatigability, mood, and sleepiness for 5 times a day(at 9 : 00, at noon, at 15 : 00, at 18: 00 and at 21 : 00). The results were summarized as follows. 1. Compared with the baseline, sleep latency was significantly shortened during the period of alcohol drinking, and the absolute value(minutes) of stage 3, 4 sleep and SWS, and the relative value(%) of stage 4 sleep were increased significantly in the third drinking night. 2. REM latency was significantly increased in the third and fifth drinking night, and there were no significant change in REM number, REM cycle, and REM duration. 3. There was a significant positive correlation between all the period of drinking and withdrawal nights and the baseline on WASO(waking time after sleep onset), and a significant positive correlation between the 1st, 3rd and 5th drinking night and the baseline on the absolute value(minutes) of SWS and a significant positive correlation between the 3rd and 5th DN and the baseline on the relative value(%) of SWS. 4. Compared with the baseline, feeling of fatigue was significantly severe in the 3rd and 5th drinking day and in the 1st withdrawal day, and there was no difference in the 3rd withdrawal day. 5. Compared with the baseline, mood was significantly worse in the 3rd and 5th drinking day and in the 1st withdrawal day, and there was no difference in the 3rd withdrawal day. 6. Compared with the baseline, sleepiness was significantly increased in the 3rd and 5th drinking day and in the 1st withdrawal day, and there was no diffenence in the 3rd withdrawal day.

진단방사선영역에서 Ho 여과판 사용시 피폭선량 감소와 화질개선에 관한 연구

김영근,이성길 광주보건대학 2000 論文集 Vol.25 No.-

This work was reduction of exposure dose and improvement of image quality by use of Ho filter in diagnostic fadiology, From the results of experimental evaluation, it was founded that in the case of the Ho filter, the variety of X-ray property with kVp was less than those of Cu and Al. And the ratio of transit to surface-dose and the load of X-ray tube were increased in the order Al, Cu, Gd and Ho. The contrast of X-ray image showed the higher value in the order of Cu, Al, Gd and Ho.

승모판 대치술후에 발생한 좌심실유출로 폐색 1예

김도연,조홍근,정익모,박시훈,박성훈,신길자,정병철 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

X-선 발생 장치 촬영 Table의 수평 왜곡이 영상에 미치는 영향에 관한 고찰

김영근,김승국,이성길 광주보건대학 2001 論文集 Vol.26 No.-

This study has examined the horizontal image distortion of 71 tables of X-ray generators at the general hospitals and clinics in kwang-ju The results are as follows 1. The horizontal distortion rate at the clinics is up to 0˚~0.5˚, 0.5˚~1.0˚ which means that the quality control of tables(angle) of clinics of is 4% higher than general hospitals. 2. The horizontal image distortion rates of the devices which were made before 1985 are 0.5˚~1.0˚ and 1.0˚~1.5˚ which shows that these rates are 23% and 6% higher respectively than those of 1995. 3. the number of tables away from the first circle in the photography taken by the beam alignment test toll was 56(79%). If the imaging factors of X-ray photograph are divided into two parts, imaging and photographing. It is taught that the men who install and operator the devices should pay more attention to control.

加味牛膝湯이 實驗動物의 鎭痛에 미치는 影響

金炯均,權文鉉,오로사,金成宰,李彦政,李峰根 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

방사선 촬영실내 세균 오염도에 관한 연구

김영은,이성길,김창복 광주보건대학 2004 論文集 Vol.29 No.-

As a result of measuring the bacterial contamination level of radiographic room, It was examined 27 of Gram (+) cocci, 1 of Gram (-) Bacillus was found in the air of a cubic meter (㎥) radiographic room. As a result of measuring the radiographic table, a large number of Gram (+) cocci was detected in the B, F and Gram (+) Bacillus was detected in the F, G hospital. as a result of measuring the radiographic cassette, a large number of Gram (+) cocci was detected in the B, G hospital and Gram (+) Bacillus was detected in the B, G and D, E hospital. After independent culturing and monitoring, it was clear up the D, E, F, G hospital Gram (+) cocci was the simple Gram (+) Bacillus. On the contrary, the D, G hospital appeared saprophytic Staphylococcus epidermis. This study verifies that a number of saprophytic bacteria can survive in the air of the radliographic room, radiogrphic table and radiograhic cassette. There was the hospital which is uncountable, and was very detected. These results notified all visiting person and patients could be infected from the baterial contamination in radiographic room. Also, it means that all visitors could be changed baterial transmitter. It is provides comfortable environment and better medical service to the disinfection that minor filming is indoor and personal hygiene in order to prevent this bacillary infection and must listen to the safe department of radiology on bacillary infection in ten thousand. This study verifies that common potentially pathogenic bacteria can survive in radiographic processing room. Therefore, effective cleaning regimens are of fundamental importance in controlling and preventing potential nosocomial transmission in the diagnostic imaging department