Anti-Trypanosoma and toxicity potential of the extracts of Acacia nilotica, Bombax buonopozense and Khaya senegalensis

Sulaiman F. A.,Iyiola O. A.,Anifowoshe T. A.,Sulaiman A. A.,Bello O. K.,Akinyele T. J.,Jimoh A. M.,Maimako R. F.,Otohinoyi D. A.,Osemwegie O. O.,Adeyemi O. S. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1

The Trypanosoma brucei is the causative agent of African trypanosomiasis, a disease that affects both humans and animals. Chemotherapy which forms the major means of control for the disease has several shortcomings such as limited efficacy and adverse side effects amongst others. Thus, motivating the search for better therapies. In this study, extracts of some tropical plants including the Acacia nilotica, Bombax buonopozense and Khaya senegalensis were evaluated for therapeutic and prophylactic potential in mouse model of experimental trypanosomiasis. Both diminazene aceturate and isometamidium chloride were included as reference drugs. Results showed that T. brucei caused an elevation in rat plasma indirect bilirubin and a reduction in rat plasma albumin and total protein which suggest mild hepatic dysfunction due to experimental infection. Data also revealed that the plant extracts significantly reduced the rat parasite burden both in the prophylaxis and therapeutic treatment groups when compared with the negative drug control. The infection and treatments had no adverse effect on the rat organ and body weights. The infection did not alter the activity of rat plasma ALT, AST and ALP compared with the administered extracts of A. nilotica and B. buonopozense. Further, the plant extracts ameliorated some trypanosomiasisinduced pathologies in treated rats compared with negative drug control. Taken together, findings do not only lend credence to the folkloric use of these plants for medicinal purposes but also suggest these plant extracts have potential to serve as alternative source of anti-parasitic agents particularly for the control of trypanosomiasis

Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice

Hamizah, Sulaiman,Roslida, A.H.,Fezah, O.,Tan, K.L.,Tor, Y.S.,Tan, C.I. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Annona muricata L (Annonaceae), commonly known as soursop has a long, rich history in herbal medicine with a lengthy recorded indigenous use. It had also been found to be a promising new anti-tumor agent in numerous in vitro studies. The present investigation concerns chemopreventive effects in a two-stage model of skin papillomagenesis. Chemopreventive effects of an ethanolic extract of A. muricata leaves (AMLE) was evaluated in 6-7 week old ICR mice given a single topical application of 7,12-dimethylbenza(${\alpha}$)anthracene (DMBA 100ug/100ul acetone) and promotion by repeated application of croton oil (1% in acetone/twice a week) for 10 weeks. Morphological tumor incidence, burden and volume were measured, with histological evaluation of skin tissue. Topical application of AMLE at 30, 100 and 300mg/kg significantly reduced DMBA/croton oil induced mice skin papillomagenesis in (i) peri-initiation protocol (AMLE from 7 days prior to 7 days after DMBA), (ii) promotion protocol (AMLE 30 minutes after croton oil), or (iii) both peri-initiation and promotion protocol (AMLE 7 days prior to 7 day after DMBA and AMLE 30 minutes after croton oil throughout the experimental period), in a dose dependent manner (p<0.05) as compared to carcinogen-treated control. Furthermore, the average latent period was significantly increased in theAMLE-treated group. Interestingly, At 100 and 300 mg/kg, AMLE completely inhibited the tumor development in all stages. Histopathological study revealed that tumor growth from the AMLE-treated groups showed only slight hyperplasia and absence of keratin pearls and rete ridges. The results, thus suggest that the A.muricata leaves extract was able to suppress tumor initiation as well as tumor promotion even at lower dosage.

Monitoring and Identification of Various Glucose Levels of Diabetes Patients Using Edge Based Machine Learning Approach

Maheshwari A.,Hemalatha B.,Lakshmi G.,Kavitha A.,Tata Ravi Kumar,Taqui Syed Noeman,Al Obaid Sami,Alharbi Sulaiman Ali,Raghavan S. S. 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

The diabetes is a disease that can become a serious disorder for a lifetime. It kills more than a million people every year. This disease can afect anyone. Diabetes occurs when the body is unable to process all the sugar (glucose) in the bloodstream; its complications can move to heart issues, caress, vision loss, and kidney stoppage and leg amputation problems. Many people with diabetes inject their body daily and feel that their work is done. Diabetes is an incurable disease because of poor health. The diabetes be able to be divided keen on2 types. The type-1 diabetes is hereditary. It is not easy to cure. People with type 2 diabetes can greatly reduce their risk of developing diabetes by following a proper, proper lifestyle. In addition it helps reduce the risk of diabetes. The proposed model of managing diabetics explains this disease as a specifc lifestyle. The existence of an efective system for the treatment of diabetes, according to the tasks currently set out, provides for the achievement of goals. The proposed edge based machine learning approach was achieved 85% of results compared with the Blood glucose level prediction, Adaptive multivariable closed-loop control, neural model of blood glucose level and Detecting Undiagnosed Diabetes.

INVESTIGATION OF DEPOSIT FORMATION IN DIRECT-INJECTION SPARK-IGNITION ENGINE POWERED ON SYNGAS

F. Y. HAGOS,A. R. A. AZIZ,S. A. SULAIMAN 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.3

A direct-injection spark-ignition engine was investigated for deposit formation after running on syngas. The study was part of an initiative to substitute fossil derived gaseous fuels with syngas. The fuel injector and spark plug were periodically inspected during the shutdown and the preliminary inspection indicated traces of deposits. As a result, the cylinder head was dismantled and inspected thoroughly after the run. The surface morphology was characterized by FESEM and its elemental contents were evaluated by EDX. Among the components, the spark plug was found to be best suitable for scanning in FESEM and EDX. Tests were conducted on the sides with and without deposit of the spark plug. The results from both sides were compared. No feed marks were formed even at higher magnification at the clean side. However, the side with deposit of the spark plug shows a spongy texture foreign material. Besides, the colour and morphology was different at different locations. Chemical composition was evaluated on atomic and weight percentage. The deposit was found to be iron oxide produced from the decomposition of iron pentacarbonyl contaminant from the storage tank as the result of carbon monoxide reaction with metallic wall of the tank at high pressure storage.

Influence of toluene–tetramethylbenzene transalkylation on heavy aromatics conversion to xylenes

Sulaiman S. Al-Khattaf,Syed A. Ali,Mogahid S. Osman,Abdullah M. Aitani 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

Transalkylation of toluene–tetramethylbenzene (TeMB) over MOR and BEA was investigated at 250–400 8C. Conversion of TeMB was higher than trimethylbenzene (TMB) and toluene. Xylene yield was inthe following order: ½toluene TMB TeMB >½toluene TeMB >½toluene TMB ½toluene . Kineticmodeling for reaction network consisting of toluene–TeMB transalkylation; toluene disproportionation;and toluene–TMB transalkylation was carried out. Toluene–TeMB transalkylation rate was >50% higherthan the toluene–TMB transalkylation while the toluene disproportionation was an order of magnitudeslower than transalkylation reactions. An addition of 5–10 wt.% TeMBs to the heavy reformate causedminor impact on the xylene yield but an improvement in xylene selectivity.

Standardization of composite connections for trapezoid web profiled steel sections

A. Saggaff,M.M. Tahir,A. Sulaiman,S.P. Ngian,J. Mirza 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.4

Connections are usually designed either as pinned usually associated with simple construction or rigid normally is associated with continuous construction. However, the actual behaviour falls in between these two extreme cases. The use of partial strength or semi-rigid connections has been encouraged by Euro-code 3 and studies on semi-continuous construction have shown substantial savings in steel weight of the overall construction. Composite connections are proposed in this paper as partial or full strength connections. Standardized connection tables are developed based on checking on all possible failure modes as suggested by “component method” for beam-to-column composite connection on major axis. Four experimental tests were carried out to validate the proposed standardised connection table. The test results showed good agreement between experimental and theoretical values with the ratio in the range between 1.06 to 1.50. All tested specimens of the composite connections showed ductile type of failure with the formation of cracks occurred on concrete slab at maximum load. No failure occurred on the Trapezoidal Web Profiled Steel Section as beam and on the British Section as column.

Experimental Tests on Composite and Non-composite Connections Using Trapezoid Web Profiled Steel Sections

Mahmood Md Tahir,Sulaiman A,Anis S 한국강구조학회 2008 International Journal of Steel Structures Vol.8 No.1

The use of partial strength or semi-rigid connections has been encouraged by Eurocode 3 and studies on the mater knownas semi-continuous construction have proven that substantial savings in steel weight of the overall construction. The objectiveof this paper is to present the performance of the strength, the rotational stifness, and the ductility of the composite connectionsand non-composite conection using trapezoidal web profiled steel (TWP) sections. Eight full scales testing of beam-to-columnconfigurations have ben carried out. The tests results showed good agreement betwen the experimental and the predictedvalues. The test also concluded that composite connections have higher moment resistance, higher stiffness, and less ductilecompared with the non-composite connections. The size of TWP steel section should be limited to 50m deep for bothcomposite and non-composite connections.

Growth Performance, Carcass and Meat Characteristics of Black Goat Kids Fed Sesame Hulls and Prosopis juliflora Pods

Abdullah, Abdullah Y.,Obeidat, Belal S.,Muwalla, Marwan M.,Matarneh, Sulaiman K.,Ishmais, Majdi A. Abu Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.9

Finding alternative feeds, such as sesame hulls and Prosopis juliflora species can attenuate difficulties of feed shortage and reduce the cost of animal feed in arid and semi-arid countries. Thirty-two Black male kids with similar initial weights (BW = $16.7{\pm}0.80\;kg$) and $120{\pm}5\;d$ of age, were used to evaluate the effect of replacing barley grains and soybean meal with Prosopis juliflora pods (PJP) and sesame hulls (SH) on growth performance, digestibility and carcass and meat characteristics. Kids were equally divided into four dietary treatment groups for an 84-d fattening period. Treatment diets had similar crude protein (CP) and metabolizable energy (ME). The treatment groups were: (T1) no PJP nor SH, (T2) 10% PJP and 20% SH, (T3) 15% PJP and 15% SH, and (T4) 20% PJP and 10% SH. A tendency was detected (p<0.08) for dry matter (DM), crude protein (CP), organic matter (OM) and neutral detergent fiber (NDF) intakes that were greater for T2 than T3 and T4 while T1 was not different from all other treatment groups. Ether extract (EE) intake was the greatest (p<0.05) for T2 and the lowest for T1. Acid detergent fiber (ADF) intake was greater (p<0.05) for T2 than T1 while T3 and T4 were intermediate. Final live weight, average daily gain (ADG) and feed conversion ratio (FCR) were comparable among different treatment groups. Digestibility of DM, OM, CP, NDF and ADF were similar among all treatment groups, however, EE digestibility was the lowest (p<0.05) for T1 when compared to other treatments. In addition, nitrogen intake, nitrogen in urine and retained and retention percentages were similar among all treatment groups. However, N loss in feces was higher (p<0.05) for T2 than T3 and T4 while T1 was intermediate. No differences were observed among treatment groups with respect to fasting live weight, hot and cold carcass weights, dressing-out percentages, mesenteric fat, visceral organs, carcass cuts percentages and carcass linear dimensions. No differences were also observed for dissected loin, leg, rack and shoulder tissues except in the total bone % for loin cuts and in the meat to bone ratio for rack cuts. T3 has the greatest total bone % and the lowest meat to bone ratio when compared to all other treatment groups. No differences were observed between treatment groups in all quality characteristics of the longissimus muscle. The present study demonstrates the potential of using PJP and SH for growing kids without adverse effects on growth performance, carcass characteristics and meat quality.