Anti-Trypanosoma and toxicity potential of the extracts of Acacia nilotica, Bombax buonopozense and Khaya senegalensis

Sulaiman F. A.,Iyiola O. A.,Anifowoshe T. A.,Sulaiman A. A.,Bello O. K.,Akinyele T. J.,Jimoh A. M.,Maimako R. F.,Otohinoyi D. A.,Osemwegie O. O.,Adeyemi O. S. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.1

The Trypanosoma brucei is the causative agent of African trypanosomiasis, a disease that affects both humans and animals. Chemotherapy which forms the major means of control for the disease has several shortcomings such as limited efficacy and adverse side effects amongst others. Thus, motivating the search for better therapies. In this study, extracts of some tropical plants including the Acacia nilotica, Bombax buonopozense and Khaya senegalensis were evaluated for therapeutic and prophylactic potential in mouse model of experimental trypanosomiasis. Both diminazene aceturate and isometamidium chloride were included as reference drugs. Results showed that T. brucei caused an elevation in rat plasma indirect bilirubin and a reduction in rat plasma albumin and total protein which suggest mild hepatic dysfunction due to experimental infection. Data also revealed that the plant extracts significantly reduced the rat parasite burden both in the prophylaxis and therapeutic treatment groups when compared with the negative drug control. The infection and treatments had no adverse effect on the rat organ and body weights. The infection did not alter the activity of rat plasma ALT, AST and ALP compared with the administered extracts of A. nilotica and B. buonopozense. Further, the plant extracts ameliorated some trypanosomiasisinduced pathologies in treated rats compared with negative drug control. Taken together, findings do not only lend credence to the folkloric use of these plants for medicinal purposes but also suggest these plant extracts have potential to serve as alternative source of anti-parasitic agents particularly for the control of trypanosomiasis

Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice

Hamizah, Sulaiman,Roslida, A.H.,Fezah, O.,Tan, K.L.,Tor, Y.S.,Tan, C.I. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Annona muricata L (Annonaceae), commonly known as soursop has a long, rich history in herbal medicine with a lengthy recorded indigenous use. It had also been found to be a promising new anti-tumor agent in numerous in vitro studies. The present investigation concerns chemopreventive effects in a two-stage model of skin papillomagenesis. Chemopreventive effects of an ethanolic extract of A. muricata leaves (AMLE) was evaluated in 6-7 week old ICR mice given a single topical application of 7,12-dimethylbenza(${\alpha}$)anthracene (DMBA 100ug/100ul acetone) and promotion by repeated application of croton oil (1% in acetone/twice a week) for 10 weeks. Morphological tumor incidence, burden and volume were measured, with histological evaluation of skin tissue. Topical application of AMLE at 30, 100 and 300mg/kg significantly reduced DMBA/croton oil induced mice skin papillomagenesis in (i) peri-initiation protocol (AMLE from 7 days prior to 7 days after DMBA), (ii) promotion protocol (AMLE 30 minutes after croton oil), or (iii) both peri-initiation and promotion protocol (AMLE 7 days prior to 7 day after DMBA and AMLE 30 minutes after croton oil throughout the experimental period), in a dose dependent manner (p<0.05) as compared to carcinogen-treated control. Furthermore, the average latent period was significantly increased in theAMLE-treated group. Interestingly, At 100 and 300 mg/kg, AMLE completely inhibited the tumor development in all stages. Histopathological study revealed that tumor growth from the AMLE-treated groups showed only slight hyperplasia and absence of keratin pearls and rete ridges. The results, thus suggest that the A.muricata leaves extract was able to suppress tumor initiation as well as tumor promotion even at lower dosage.

Evaluation of partial discharge resistance of insulating sheets produced in Saudi Arabia under alternating stress

A.A. Al-Sulaiman 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.S1

This paper deals with the comparison of partial discharge (PD) characteristics of three kinds of insulating sheets produced by the local industry in Saudi Arabia; namely polycarbonate (PC), poly-methylmetacrylate (PMMA) and phenoplast resin (Bakelite). These were exposed to PDs under the IEC (b) electrode system, and the comparison was judged by the discharge onset; discharge propagation area, PD magnitude, surface erosion and elemental analysis of eroded zones. Results show that PD inception voltage is inversely proportional to the sample’s relative permittivity. For higher permittivity samples, the eroded area under a constant voltage is larger, while PD activity is also augmented significantly. The erosion depth was found to be deeper in Bakelite. In this case, the scanning electron microscope images show a larger concentration of scattered debris of the base material on the eroded area. Whereas, EDX elemental analysis of these areas exhibits presence of the native matrix for PC and PMMA sheets, a large content of copper and zinc was found on the Bakelite sheet, which also displays the erosion of the electrode.

Monitoring and Identification of Various Glucose Levels of Diabetes Patients Using Edge Based Machine Learning Approach

Maheshwari A.,Hemalatha B.,Lakshmi G.,Kavitha A.,Tata Ravi Kumar,Taqui Syed Noeman,Al Obaid Sami,Alharbi Sulaiman Ali,Raghavan S. S. 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

The diabetes is a disease that can become a serious disorder for a lifetime. It kills more than a million people every year. This disease can afect anyone. Diabetes occurs when the body is unable to process all the sugar (glucose) in the bloodstream; its complications can move to heart issues, caress, vision loss, and kidney stoppage and leg amputation problems. Many people with diabetes inject their body daily and feel that their work is done. Diabetes is an incurable disease because of poor health. The diabetes be able to be divided keen on2 types. The type-1 diabetes is hereditary. It is not easy to cure. People with type 2 diabetes can greatly reduce their risk of developing diabetes by following a proper, proper lifestyle. In addition it helps reduce the risk of diabetes. The proposed model of managing diabetics explains this disease as a specifc lifestyle. The existence of an efective system for the treatment of diabetes, according to the tasks currently set out, provides for the achievement of goals. The proposed edge based machine learning approach was achieved 85% of results compared with the Blood glucose level prediction, Adaptive multivariable closed-loop control, neural model of blood glucose level and Detecting Undiagnosed Diabetes.

Generation of a Decision Support System to Enhance the Efficiency of Lean Manufacturing

Effendi Mohamad,Mohd Amran Ibrahim,Muhamad Arfauz A. Rahman,Mohd Rizal Salleh,Mohd Amri Sulaiman 대한산업공학회 2019 Industrial Engineeering & Management Systems Vol.18 No.2

Lean manufacturing (LM) is an established process that employs an array of instruments to eradicate waste. A variety of methods have been applied (some more successfully than others) to enhance the effectiveness of this process. This study delves into the introduction of the Intelligent Lean Tools Simulation (iLeTS) to overcome the deficiencies in the LM process and reduce the failure ratio. Fabricated with the use of modelling software, the performance of iLeTS was enhanced by way of an amalgamation involving the visual basic application (VBA) and the multi agent system (MAS). This merging served to enhance the user friendliness of iLeTS, which in turn reduced the required period of usage. Face validity and a usability study were harnessed to evaluate the performance of iLeTS. While face validity was used to authenticate the multi-agent system flow in iLeTS; the usability study was engaged to determine the proficiency of iLeTS when it comes to managing a number of arbitrarily occurring incidents. Subsequent to a thorough examination of a wide range of simulation results (deriving from authentic data), we arrived at the conclusion that (a) the iLeTS is suitable for the automation of the manufacturing process, and (b) the iLeTS can be relied upon for making prompt and appropriate choices.

Standardization of composite connections for trapezoid web profiled steel sections

A. Saggaff,M.M. Tahir,A. Sulaiman,S.P. Ngian,J. Mirza 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.4

Connections are usually designed either as pinned usually associated with simple construction or rigid normally is associated with continuous construction. However, the actual behaviour falls in between these two extreme cases. The use of partial strength or semi-rigid connections has been encouraged by Euro-code 3 and studies on semi-continuous construction have shown substantial savings in steel weight of the overall construction. Composite connections are proposed in this paper as partial or full strength connections. Standardized connection tables are developed based on checking on all possible failure modes as suggested by “component method” for beam-to-column composite connection on major axis. Four experimental tests were carried out to validate the proposed standardised connection table. The test results showed good agreement between experimental and theoretical values with the ratio in the range between 1.06 to 1.50. All tested specimens of the composite connections showed ductile type of failure with the formation of cracks occurred on concrete slab at maximum load. No failure occurred on the Trapezoidal Web Profiled Steel Section as beam and on the British Section as column.

A Dissimilarity with Dice-Jaro-Winkler Test Case Prioritization Approach for Model-Based Testing in Software Product Line

( R. Aduni Sulaiman ),( Dayang N. A. Jawawi ),( Shahliza Abdul Halim ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.3

The effectiveness of testing in Model-based Testing (MBT) for Software Product Line (SPL) can be achieved by considering fault detection in test case. The lack of fault consideration caused test case in test suite to be listed randomly. Test Case Prioritization (TCP) is one of regression techniques that is adaptively capable to detect faults as early as possible by reordering test cases based on fault detection rate. However, there is a lack of studies that measured faults in MBT for SPL. This paper proposes a Test Case Prioritization (TCP) approach based on dissimilarity and string based distance called Last Minimal for Local Maximal Distance (LM-LMD) with Dice-Jaro-Winkler Dissimilarity. LM-LMD with Dice-Jaro-Winkler Dissimilarity adopts Local Maximum Distance as the prioritization algorithm and Dice-Jaro-Winkler similarity measure to evaluate distance among test cases. This work is based on the test case generated from statechart in Software Product Line (SPL) domain context. Our results are promising as LM-LMD with Dice-Jaro-Winkler Dissimilarity outperformed the original Local Maximum Distance, Global Maximum Distance and Enhanced All-yes Configuration algorithm in terms of Average Fault Detection Rate (APFD) and average prioritization time.

Wet Cupping — Traditional Hijamah Technique versus Asian Cupping Technique in Chronic Low Back Pain Patients: A Pilot Randomized Clinical Trial

Sulaiman M. Al-Eidi,Ashry Gad Mohamed,Raid A. Abutalib,Abdullah M. AlBedah,Mohamed K.M. Khalil 사단법인약침학회 2019 Journal of Acupuncture & Meridian Studies Vol.12 No.6

To evaluate the feasibility of comparing the effect of the traditional Hijamah and the Asian wet cupping techniques in the management of patients with chronic low back pain (CLBP), a randomized clinical trial comparing traditional and Asian wet cupping techniques for CLBP was conducted in two secondary care hospitals in Saudi Arabia. Seventy eligible participants with CLBP were randomized to receive one session of wet cupping using either Asian technique (34 patients) or traditional Hijamah technique (36 patients). Cupping was performed at four sites of the bilateral bladder meridian (BL23, BL24, and BL25). The numeric rating scale, Present Pain Intensity, and Oswestry Disability Questionnaire scores were measured immediately after intervention, at seven days, and 14 days after intervention. In both groups, there was a significant decrease in the numeric rating scale, Present Pain Intensity, and Oswestry Disability Questionnaire scores, immediately after intervention, at seven days, and 14 days after intervention. However, there was no significant difference between the two groups across all the outcome measures up to 14 days after intervention. The study did not show a superiority of one technique compared with the other. Longer follow-up periods and more than one cupping session may be needed to evaluate the difference, if any, between both the techniques. Trial Registration: NCT02012205.

INVESTIGATION OF DEPOSIT FORMATION IN DIRECT-INJECTION SPARK-IGNITION ENGINE POWERED ON SYNGAS

F. Y. HAGOS,A. R. A. AZIZ,S. A. SULAIMAN 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.3

A direct-injection spark-ignition engine was investigated for deposit formation after running on syngas. The study was part of an initiative to substitute fossil derived gaseous fuels with syngas. The fuel injector and spark plug were periodically inspected during the shutdown and the preliminary inspection indicated traces of deposits. As a result, the cylinder head was dismantled and inspected thoroughly after the run. The surface morphology was characterized by FESEM and its elemental contents were evaluated by EDX. Among the components, the spark plug was found to be best suitable for scanning in FESEM and EDX. Tests were conducted on the sides with and without deposit of the spark plug. The results from both sides were compared. No feed marks were formed even at higher magnification at the clean side. However, the side with deposit of the spark plug shows a spongy texture foreign material. Besides, the colour and morphology was different at different locations. Chemical composition was evaluated on atomic and weight percentage. The deposit was found to be iron oxide produced from the decomposition of iron pentacarbonyl contaminant from the storage tank as the result of carbon monoxide reaction with metallic wall of the tank at high pressure storage.

Modelling CO₂ and NO<SUB>x</SUB> on signalized roundabout using modified adaptive neural fuzzy inference system model

Ghassan Sulaiman,Mohammad K. Younes,Ghassan A. Al-Dulaimi 대한환경공학회 2018 Environmental Engineering Research Vol.23 No.1

Air quality and pollution have recently become a major concern; vehicle emissions significantly pollute the air, especially in large and crowded cities. There are various factors that affect vehicle emissions; this research aims to find the most influential factors affecting CO₂ and NOx emissions using Adaptive Neural Fuzzy Inference System (ANFIS) as well as a systematic approach. The modified ANFIS (MANFIS) was developed to enhance modelling and Root Mean Square Error was used to evaluate the model performance. The results show that percentages of CO₂ from trucks represent the best input combination to model. While for NOx modelling, the best pair combination is the vehicle delay and percentage of heavy trucks. However, the final MANFIS structure involves two inputs, three membership functions and nine rules. For CO₂ modelling the triangular membership function is the best, while for NOx the membership function is two-sided Gaussian.