청장년에서 관찰된 관상동맥의 비죽종성 석회화와 동맥류 : 부검증례보고

이지신,이영직,박종태 大韓法醫學會 1997 대한법의학회지 Vol.21 No.1

Coronary artery calcification(CAC) is found frequently in the atheromatous plaques. CAC is known to have increased frequency above 40 years. CAC without evidence of atherosclerosis in young adults is quite rare, however, CAC combined with aneurysms in young adults have been infrequently reported in patients with a past history of a Kawasaki disease in child. We report an autopsy case showing CAC and aneurysm in the absence of macroscopically identified atherosclerotic lesions in a healthy 23-year-old man. The autopsy examination revealed aneurysmal dilatation of the right coronary artery, which was connected with calcified lesion. A calcified lesion of the left anterior descending coronary artery was aslo noted. Microscopically, aneurysmal wall was non-specific except for hyalinized wall and foci of calcification. A striking histologic finding of calcified mass was ring calcification along the wall of the coronary artery. Antecedent Kawasaki disease in the past was suggestive as other reports.

흑염소육 중탕액의 저장기간 중 지방 산화에 관한 연구

박창일,김영직 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.1

This experiment was carried out to investigate the changes in proximate composition, pH, thiobarbituric acid value(TBA) and fatty acid composition of pure jemsosojoo(PJ), jemsosojoo added medicinal herbs(JMH) and medicinal herbs(MH) during storage period(30days) at 4℃. Three black goat with 18~19㎏ live weight were slaughtered to obtain samples from extracts. The results were as follows : moisture, crude protein, crude fat content of PJ were higher than other treatment, but ash content in MH was higher than others. Chemical composition did not affect storage period. The pH of the PJ was ranged from 6.47~6.57, the JMH was ranged from 5.05~5.09, the MH was ranged from 4.68~4.70. The pH of MH was lower than other treatment. The TBA value of all treatment were gradually increased during storage period. Oleic acid, palmitic acid, stearic acid were major fatty acids of the PJ and the JMH. Especially, linolenic acid and linoleic acid content were higher in the JMH than those of the PJ. Lipid oxidation tend to be delayed with the addition medicinal herbs.

육아종성 심근염에 속발된 급성 미만성 심근염에서 심부전의 병태생리적 기전

박종태,이영직 大韓法醫學會 1997 대한법의학회지 Vol.21 No.1

The heart, 500g in weight, with subacute myocarditis associated with granulomatous myocarditis may be a good model for the study on the pathophysiologic mechanism of cardiac failure. Furthermore, the clinical data of this case is enough to clarify his all clinical course from admission to death due to cardiac failure. So, we analyzed the clinical data, histologic findings, and morphometric pattern of histologically intact myocardial cells and inflammatory reaction to investigate the pathophysiologic mechanism of the cardiac failure. The results were summarized as follows. 1. Clinically, the heart showed cardiac failure of diastolic phase and abnormal conduction system related to sudden cardiac death. However, it might be adapted to the relatively stable vital signs due to pericardial positive pressure by slowly progressed pericardial effusion. 2. The distribution pattern of area of intact myocardial cell area and inflammation reaction showed relatively even spread of inflammatory reaction and extremely decreased area of myocardial cells to about 21% of total heart. So, its contractility might be decreased below to the 21% of the normal cardiac contractility. 3. The mechanism of the cardiac failure in myocarditis may be sudden inflammatory involvement of conduction system and/or extremely decreased myocardial cell volume due to inflammatory destruction. 4. Morphometric analysis may be a useful objective method to grading the severity of old and recent form of myocarditis. From the above results, the cardiac failure of myocarditis is influenced by the adaptability at the inflammatory abnormality of the conduction system, contractility of injured myocardial cells, and compensation activity of pericardial effusion.

대동맥 박리에 의한 우심방 심근경색 부검례 보고

이영직,이지신,박종태 大韓法醫學會 1997 대한법의학회지 Vol.21 No.1

Aortic dissection may be considered the result of a discrepancy between the strength of the aortic wall and the intramural pressure. And factors that predispose to aortic dissection may include systemic hypertension, cystic medial necrosis, Marfan's syndrome, atherosclerosis, disease of aortic valve, pregnancy, giant cell arteritis, hyperthyroidism, and blunt chest trauma. A few of aortic dissection may extend retrograde toward the aortic valve and involve the coronary arteries. Coronary artery occlusions due to mural dissection are an uncommon but well documented cause of myocardial infarction. Although rare, extramural hematoma compressing the coronary artery is another cause of myocardial infarction. At autopsy of 43 years old male who had no critical external wound, pericardial sac was distended and contained 400ml of dark red and clotted blood. Examination of the aorta revealed only minute atherosclerosis, intact aortic valve, and patent coronary ostia. 0.5cm sized aortic rupture was noted at the 3.5cm distal to the aortic valve. DeBakey type Ⅱ aortic dissection was found to involve the ascending aorta and brachiocephalic trunk. Three intimal tears were 1.5cm, 8cm, 11.5cm distal to the aortic valve and two false lumens which had intact area between them extended 3.5cm distal to the third intimal tear and proximally in a retrograde fashion to the aortic root. Microscopically, sections of aorta showed relatively intact arrangement of smooth muscle and elastic fibers, except mild vascular ectasia and scattered several foci of the small sized aggregation of foamy histiocytes, and there was no evidence of cystic medial degeneration in aorta. Sections of both coronary arteries did not show mural dissection or atherosclerosis. Sections of right atrium and sinus node showed inflammatory reaction, extensive replacement of myocardium by active fibrous tissue consistent with infarction. There was no histologic evidence of myocardial infarction in the walls of other chambers or septum of the heart. We believe that extramural compression of the artery to sinus node by the dissecting hematoma was the cause of myocardial infarction involving the right atrium and the sinus node.

두부외상에 의한 미만성 축삭손상의 임상적 병리학적 관찰

신영귀,이민철,이영직,박창수,김재휴,박문선 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.6

비외상성 폐손상

이영직,박종태 大韓法醫學會 1997 대한법의학회지 Vol.21 No.2

Injury is generally defined as morphological changes due to physical or chemical stress, inflammatory or repair process, or secondary events of the other disease. In the nontraumatic injuries of the lung, direct physical effects to the lung such as contusion or rupture of the lung must be excluded. So, the types of nontraumatic injuries of lung are all pathologic changes of lung except for congenital anomalies; infectious of inflammatory disease, aspiration induced injuries, environmental or occupational lung disease, postoperative pulmonary changes, poison or drug induced toxic injuries, radiation injury, etc ······.

석회판의 강도증가에 관한 연구

이영석,이건직,박권필 順天大學校 1999 論文集 Vol.18 No.1

This study focused on the increase of lime plate strength by adding reinforced material into limestone and chemical reaction with carbon dioxide gas. Also we did experiment to find the optimum content of plaster as a binding component. Carbon fiber as reinforced material has disadvantages. It did not mixed well in the forming process and had low cohesion force with limestone. Content of glass fiber showed optimum at 1.0cm, 4.16 wt% in lime plate. The increase of strength in lime plate was ??, after reaction with CO₂at 70℃ for 6hr. When lime plate consists of 40wt% of plaster, 4.16 wt% of 1.0cm glass fiber, its strength was ??

중파자외선에 대한 남극산 해조류의 광합성 및 자외선 흡수물질 형성 반응

한태준,박병직,한영석,강성호,이상훈 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.3

남극에 생육하는 5종의 홍조류(Curdiea racovitzae, Gigartina skottsbergii, Mazzaella obovata, Myriogram- me manginii, Palmaria decipiens)를 대상으로 인공 중파 자외선과 태양광선에 대한 종별 생리적 반응을 광합성이라는 파라미터를 사용하여 조사 연구하였다. 실험실 연구 결과,종간에 중파 자외선에 대한 내성 차이가 확인되었으며 이러한 차이는 각 종들이 채집되기 전에 서식하고 있었던 수심과 매우 밀접한 관계가 있어서 20~30m의 수심에서 채집된 M. manginii와 P. decipi-ens의 자외선 내성이 다른 종들에 비하여 작게 나왔다. 본 연구 결과는 서식지 주변의 광환경이 해조류의 자외선 내성을 결정해 주는 한 요인이라는 가설을 입증해주었을 뿐 아니라 형광 변화를 이용한 광합성 측정법은 자외선 내성을 타진하는데 있어서 매우 신속하고 비파괴적인 방법으로 이용될 수 있음을 입증하였다. 두 종의 홍조류(M. manginii, P. decipiens)를 대상으로 태양광선 하에서의 광합성 효율을 관찰한 결과, 정오 에 최저 광합성을 보인 반면 저녁에는 광합성 능력이 회복되는 현상을 나타내었다. 이같은 동적인 광저해 현 상(dynamic photoinhibition)은 일종의 광적응 능력으로서 식물이 비교적 강한 태양광선에 노출된 지역에 성공적으로 서식하는데 크게 기여하는 것으로 사료된다. 본 연구에서는 또한 태양광선내 중파자외선 포함 유무에 따라 광합성 회복 속도에 차이가 나는 것을 볼 수 있었는데 중파자외선이 포함된 태양 광선 하에서는 광합성의 회복이 느린 반면,중파 자외선이 제거된 조건에서는 광합성이 비교적 빨리 회복되는 것을 관찰할 수 있었고 이는 중파 자외선이 광합성 회복 기작을 지연시키는 작용을 한 것으로 해석될 수 있다. 야외에서 자외선 민감성을 비교한 결과, P decipiens가 M. manginii에 비하여 자외선 내성이 큰 것으로 나타났는데,두 종 공히 조간대로부터 조하매 상부까지 서식하는 종임에도 불구하고 이러한 내성차이를 보인 이유는 자외선 흡수물질의 정량적인 차이에 기인한다고 할 수 있다. M. manginii와 P. decipiens에서 발견된 자외선 흡수물질의 양은 약 1.2 정도의 비율을 보였는데 이러한 정량적 차이가 자외선 민감성에 기여한 것으로 사료된다. 본 연구에서는 또한 계절별 그리고 채집 수심별로 자외선 흡수물질의 정량적 차이를 발견할 수 있었는데 태양광선이 풍부한 여름철에 그리고 고광량이 도달되는 수심 얕은 곳에 서식하는 개체가 더욱 많은 양의 자외선 흡수물질을 함유한 것으로 나타났다. Effects of artificial and solar UV-B radiation on five rhodophytes (Curdiea racovitzae, Gigartina skottsbergii, Mazzaella obovata, Myriogramme manginii, Palmaria decipiens) from Antarctica have been investigated using PAM fluorescence in laboratory and in the field. Laboratory studies showed that there were significant differences in the UV sensitivity between different species, and that the differences appeared to be correlated with the depth of collection of the specimens. It was apparent from the observations that the samples such as M. manginii and P. decipiens collected from 20∼30 m depths were more sensitive to UV-B radiation compared with those collected from shallower depths. The present study confirmed that an acclimation to the surrounding light regime could be an important factor to determine the UV-sensitivity of a species or individuals and that PAM measurements are rapid and non-destructive methods to evaluate UV influences. From field studies on M. manginii and P. decipiens it was observed that both plants exhibited changes in the effective quantum yield, with the minimum values at noon followed by a recovery in the evening. Photoinhibition occurred in these species could therefore be accounted for by so-called dynamic photoinhibition. It seems likely that this protective mechanism may contribute to survival of the species in shallow water where they may encounter intense solar radiation. The presence or absence of the UV-B component under solar radiation differently affected the photosynthetic recovery process, and the rate of recovery was much slower in UV-present than in UV-absent conditions. Functional role of UV-B appears to delay the recovery of photosynthesis in the studied macroalgae. Differential sensitivity to UV-B recognised between M. manginii and P. decipiens seemed to correspond well with the amount of UV-absorbing substances(UVAS) contained in the respective species. Higher tolerance to solar radiation by the latter species may be due to the higher amount of UVAS. There were variations of UVAS concentrations in algal thalli depending on the season and depth of collection.

다공질 실리콘 카바이드의 제작 및 광발광 성질

이기환,오제직,최석남,박병빈,이태호,김영유 공주대학교 사범대학 과학교육연구소 1998 과학교육연구 Vol.29 No.1

p-type α-SiC(4H, 6H, 15R polytype)를 사용하여 다공질 실리콘(porous silicon; PS)의 제작방법과 유사하게 HF/H₂O/C₂H??OH 용액에서 전기화학적으로 에칭을 하여 광발광 특성을 가지는 다공질 실리콘 카바이드(porous silicon carbide; PSC)를 제작하였다. PSC의 다공질의 분포는 전류밀도가 증가할수록 증가하고 다공질의 크기는 감소하였으며 광발광(photoluminescence; PL) 스펙트럼의 분석을 통해 전극 표면에서의 산화반응은 공급되는 전자의 양과 전류밀도에 의존하며 전류밀도가 증가할수록 전극의 산화반응은 억제된다는 결과를 얻었다. Porous silicon carbide(PSC) having photoluminescence(PL) can be prepared by a technique very similar to that used in porous silicon preparation, by electrochemical etching of crystalline p-type α-SiC(4H, 6H, 15R polytype) in ?? solution. The results show that porous distribution increase with increasing of the current densities while pore size decrease with that. Through the PL spectra analysis anodic oxidation of electrode surface was dependent on the amount of provided electrons and the current densities and inhibited with increasing of the current densities.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.