Characteristics of the De Brujin ( dB ) and dB-Cube Interconnection Networks for Massively Parallel Computers

Shunji Okugawa 대한전자공학회 1994 JTC-CSCC : Joint Technical Conference on Circuits Vol.- No.-

物語談話における連體修飾節 -日本語母語話者と中國人學習者の作文比較-

오천육자 ( Okugawa Ikuko ) 한국일본어교육학회 2011 日本語敎育 Vol.55 No.-

本稿では、物語談話における連體修飾節(以下、連體節)の類型と機能について考察を行った。調査協力者は、日本語母語話者30名、中國語母語の日本語學習者50名(上級25名、中級25名)の合計80名で、調査手順は次の通りである。①資料內の連體節を抽出する②連體節を限定/非限定に分ける③それぞれの連體節がどのような特徵を持っているのか考察する。その結果、物語談話には大きく分けて、2種類の連體節(<談話展開型連體節>と<新人物導入型連體節>)があることが明らかになった。<談話展開型連體節>は、主人公や主要人物を主名詞に取り、時系列に事を連ね談話展開するという機能がある。一方、<新人物導入型連體節>は、物語上あまり重要でない人物の新規導入時に使用され、登場人物の情報を背景的に連體節にj組み입み場面設定を行っている。また<談話展開型連體節>は上級になっても使用されにくいが、<新人物導入型連體節>は中級にも比較的使用されやすいということが明らかになった。

Safety evaluation of abdominal trachelectomy in patients with cervical tumors ≥2 cm: a single-institution, retrospective analysis

Kaoru Okugawa,Hideaki Yahata,Kenzo Sonoda,Tatsuhiro Ohgami,Masafumi Yasunaga,Eisuke Kaneki,Kiyoko Kato 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4

Objective: For oncologic safety, vaginal radical trachelectomy is generally performed onlyin patients with cervical cancers smaller than 2 cm. However, because inclusion criteriafor abdominal trachelectomy are controversial, we evaluated the safety of abdominaltrachelectomy for cervical cancers ≥2 cm. Methods: We began performing abdominal trachelectomies at our institution in 2005,primarily for squamous cell carcinoma ≤3 cm or adenocarcinoma/adenosquamous carcinoma≤2 cm. If a positive sentinel lymph node or cervical margin was diagnosed intraoperativelyby frozen section, the trachelectomy was converted to a hysterectomy. Medical records ofthese patients were reviewed retrospectively. Patients who had undergone simple abdominaltrachelectomy were excluded from this study. Results: We attempted trachelectomy in 212 patients. Among the 135 patients with tumors<2 cm, trachelectomy was successful in 120, one of whom developed recurrence and noneof whom died of their disease. Among 77 patients with tumors ≥2 cm, trachelectomy wassuccessful in 62, 2 of whom developed recurrence and 1 of whom died of her disease. Theoverall relapse rate after trachelectomy was 1.6% (0.8% in <2 cm group and 3.2% in ≥2 cmgroup), and the mortality rate was 0.5% (0% in <2 cm group and 1.6% in ≥2 cm group). Recurrence-free survival (p=0.303) and overall survival (p=0.193) did not differ significantlybetween the <2 cm and ≥2 cm groups. Conclusions: Abdominal trachelectomy with intraoperative frozen sections of sentinel lymphnodes and cervical margins is oncologically safe, even in patients with tumors ≥2 cm.

ROLE OF PARTICULATE MATTER IN TRANSPORTATION OF MUTAGENS IN AQUATIC ENVIRONMENTS

( Koji Okugawa,Takashi Kusui ) 한국물환경학회 1997 제6차 국제수질보전학회 아시아 태평양지역 학술회의 Vol.1 No.-

An update of oncologic and obstetric outcomes after abdominal trachelectomy using the FIGO 2018 staging system for cervical cancer: a single-institution retrospective analysis

Kaoru Okugawa,Hideaki Yahata,Tatsuhiro Ohgami,Masafumi Yasunaga,Kazuo Asanoma,Hiroaki Kobayashi,Kiyoko Kato 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3

Objective: To apply the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system to all patients who underwent trachelectomy in our previous study and to update the oncologic and obstetric results. Methods: We retrospectively reviewed the medical records of patients in whom abdominal trachelectomy was attempted between June 2005 and September 2021. The FIGO 2018 staging system for cervical cancer was applied to all patients. Results: Abdominal trachelectomy was attempted for 265 patients. Trachelectomy was converted to hysterectomy in 35 patients, and trachelectomy was completed successfully in 230 (conversion rate: 13%). Applying the FIGO 2018 staging system, 40% of the patients who underwent radical trachelectomy had stage IA tumors. Among 71 patients who had tumors measuring ≥2 cm, 8 patients were classified as stage IA1 and 14 as stage IA2. Overall recurrence and mortality rates were 2.2% and 1.3%, respectively. One hundred twelve patients attempted to conceive after trachelectomy; 69 pregnancies were achieved in 46 patients (pregnancy rate: 41%). Twenty-three pregnancies ended in first-trimester miscarriage, and 41 infants were delivered between gestational weeks 23 and 37; 16 were deliveries at term (39%) and 25 were premature deliveries (61%). Conclusion: This study suggested that patients judged to be ineligible for trachelectomy and patients receiving overtreatment will continue to appear using the current standard eligibility criteria. With the revisions to the FIGO 2018 staging system, the preoperative eligibility criteria for trachelectomy, which were based on the FIGO 2009 staging system and tumor size, should be changed.

Circulating microRNA-203 predicts prognosis and metastasis in human colorectal cancer

Hur, Keun,Toiyama, Yuji,Okugawa, Yoshinaga,Ide, Shozo,Imaoka, Hiroki,Boland, C Richard,Goel, Ajay BMJ Publishing Group Ltd 2017 Gut Vol.66 No.4

<P>Conclusions High levels of serum miR-203 associate with poor survival and metastasis, suggesting it to be a promising non-invasive prognostic and metastasis-predictive biomarker in patients with CRC.</P>

Genetic Polymorphisms in Dopamine- and Serotonin-Related Genes and Treatment Responses to Risperidone and Perospirone

Atsushi Tsutsumi,Tetsufumi Kanazawa,Hiroki Kikuyama,Gaku Okugawa,Hiroyuki Uenishi,Toshio Miyamoto,Naoki Matsumoto,Jun Koh,Kazuhiro Shinosaki,Toshifumi Kishimoto,Hiroshi Yoneda,Toshihiko Kinoshita 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.3

We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients. We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients.

Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey

( Akio Tamura ),( Toshihiko Tomita ),( Tadayuki Oshima ),( Fumihiko Toyoshima ),( Takahisa Yamasaki ),( Takuya Okugawa ),( Takashi Kondo ),( Tomoaki Kono ),( Katsuyuki Tozawa ),( Hisatomo Ikehara ),( 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.4

Background/Aims Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits and (2) to examine the prevalence of constipation using the Japanese Society of Internal Medicine (JSIM) and the Rome III criteria using an online survey. Methods An online questionnaire composed of items on the frequency, interval, form of defecation, the management, and self-recognition of constipation (reference standard of constipation) was created. A total of 5155 valid responses were received. In addition, constipation symptoms were evaluated through a survey using the JSIM and the Rome III criteria. Results In the internet survey, 28.4% of the respondents considered themselves to be constipated. Stratified by sex, significantly more females (37.5%) than males (19.1%) considered themselves to be constipated (P < 0.001). The prevalence of constipation among the respondents was 28.0% using the Rome III, but only 10.1% using the JSIM. The diagnostic accuracy was 73.2% for the Rome III and 78.1% for the JSIM, while the diagnostic specificity was 81.1% for the Rome III and 97.5% for the JSIM. However, the diagnostic sensitivities for both measures were low, at 52.2% and 29.2% for the Rome III and the JSIM, respectively. Conclusions The online survey developed for this study was able to provide clarification regarding defecation patterns. The results also suggest a discrepancy between the self-recognized prevalence of constipation in Japan and prevalence of constipation based on the JSIM criteria.

일본 초/중학교간의 제휴/접목에 관한 실증적 연구: 주요 5과목, 기능 4과목, 특별활동, 종합적인 학습시간 및 쉬는 시간에 관한 동기부여와 학업성적의 자기평가와의 관계

오오이에마유미 ( Oie Mayumi ),카키하나신이치로 ( Kakihana Shinichiro ),후지에야스히코 ( Fujie Yasuhiko ),오쿠가와유 ( Okugawa Yu ),이타카쇼코 ( Iitaka Shoko ),우에부치히사시 ( Uebuchi Hisashi ) 성신여자대학교 인문과학연구소 2015 人文科學硏究 Vol.33 No.-

본 연구는 일본 초등학교 5학년부터 중학교 2학년까지의 이행기에 있어 주요 5과목과 기능 4과목, 특별활동, 종합적인 학습시간 및 쉬는 시간의 동기부여의 변용을 검토하는 것을 목적으로 한다. 조사 대상자는 초등학교 5학년 491명(남자 248명, 여자 243명), 초등학교 6학년 486명(남자 224명, 여자 262명), 중학교 1학년 464명(남자 228명, 여자 236명), 중학교 2학년 374명(남자 208명, 여자 166명), 총 1815명(남자 908명, 여자 907명)이며, 모두 일본 수도권의 국공립 초·중학교에 다니는 학생들을 대상으로 하였다. 설문조사 내용은 교과, 교과 외 시간의 선호도 및 학업에 관한 자기평가로 구성되었다. 교과의 취향과, 교과 외 시간의 취향의 득점(기술을 제외한 13시간)을 이용해 클러스터 분석을 사용했다. JP: 교과 선호도와 교과 외 시간의 선호도 득점(기술을 제외한 13시간)을 이용하여 클러스터 분석을 실시하였다. 그 결과, 제1클러스터는 음악, 공작, 미술, 가정, 영어를 싫어하는 경향이 드러나 "기능 과목의 동기 부여가 낮은 그룹"이라고 이름을 붙였다. 한편, 제2클러스터는 주요 5과목의 동기 부여가 낮고, 쉬는 시간이나 급식, 클럽 동아리 활동을 좋아하는 경향을 볼 때 "주요 5과목의 동기부여 가 낮은 그룹"이라 이름을 붙였다. 제3클러스터는 체육, 가정, 공작, 미술을 좋아하면서 주요 5과목의 동기 부여가 낮은 경향이 있어 "기능 과목의 동기부여가 높은 그룹"이라고 이름을 붙였다. 또한 제4클러스터는 전 교과 및 교과 외 시간의 동기 부여가 높아 "전 교과의 동기부여가 높은 그룹"이라고 이름을 붙였다. χ 2검정와 잔차 분석의 결과, 초등학교 5학년이 다른 학년에 비해 기능 과목의 동기부여가 높은 그룹이 많고, 기능 과목의 동기부여, 주요 5과목의 동기부여가 낮은 그룹이 적었다. 중학교 1학년에서는 전 과목의 동기부여가 높은 그룹이 유의하게 많았다. 중학교 2학년에서는 기능 과목의 동기부여가 낮은 그룹이 많고, 한편 기능 과목의 동기부여가 높은 그룹이 적은 것이 밝혀졌다. 또한, 어느 클러스터도 학년이 올라갈수록 학업 성적에 대한 자기 평가가 떨어졌다.

Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

( Haruki Asano ),( Toshihiko Tomita ),( Kumiko Nakamura ),( Takahisa Yamasaki ),( Takuya Okugawa ),( Takashi Kondo ),( Tomoaki Kono ),( Katsuyuki Tozawa ),( Yoshio Ohda ),( Tadayuki Oshima ),( Hirokaz 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.3

Background/Aims Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD. Methods Forty healthy subjects and 94 PDS type FD patients were enrolled in the study. The volunteers and patients ingested a radiolabeled (technetium-99m) solid test meal, and scintigraphic images were recorded. Gastric accommodation and emptying were assessed by scintigraphic imaging. The patients` dyspeptic symptoms were also explored using self-completed symptom questionnaires with 10 variables (4 scales, 0-3 points) at the same time. Results In 94 Japanese FD patients, the prevalence of impaired gastric accommodation and delayed emptying were 14.9% (14/94) and 10.6% (10/94), respectively. Gastric motility abnormalities were seen in 25.5% (24/94) of FD patients. There was no association between gastric motility abnormalities and dyspeptic symptoms. Conclusions Gastric motility abnormalities were seen in 25.5% of Japanese PDS type FD patients. However, there was no association between gastric motility abnormalities and dyspeptic symptoms on gastric scintigraphy. (J Neurogastroenterol Motil 2017;23:392-399)