Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

( Haruki Asano ),( Toshihiko Tomita ),( Kumiko Nakamura ),( Takahisa Yamasaki ),( Takuya Okugawa ),( Takashi Kondo ),( Tomoaki Kono ),( Katsuyuki Tozawa ),( Yoshio Ohda ),( Tadayuki Oshima ),( Hirokaz 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.3

Background/Aims Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD. Methods Forty healthy subjects and 94 PDS type FD patients were enrolled in the study. The volunteers and patients ingested a radiolabeled (technetium-99m) solid test meal, and scintigraphic images were recorded. Gastric accommodation and emptying were assessed by scintigraphic imaging. The patients` dyspeptic symptoms were also explored using self-completed symptom questionnaires with 10 variables (4 scales, 0-3 points) at the same time. Results In 94 Japanese FD patients, the prevalence of impaired gastric accommodation and delayed emptying were 14.9% (14/94) and 10.6% (10/94), respectively. Gastric motility abnormalities were seen in 25.5% (24/94) of FD patients. There was no association between gastric motility abnormalities and dyspeptic symptoms. Conclusions Gastric motility abnormalities were seen in 25.5% of Japanese PDS type FD patients. However, there was no association between gastric motility abnormalities and dyspeptic symptoms on gastric scintigraphy. (J Neurogastroenterol Motil 2017;23:392-399)

Analysis of Effects of Supplying Scent Related to Kagawa Prefecture on Driving Behavior

( Haruki Asano ),( Ryo Tanabe ),( Suzuki Keisuke ) 한국감성과학회 2019 한국감성과학회 국제학술대회(ICES) Vol.2019 No.-

The purpose of this study is to analyze the effects of supplying the scent related to Kagawa prefecture on driving behavior and accident-reduction effects. It has been already revealed that supplying a scent of aroma oils is effective in the maintenances of drive’s concentration and arousal level in various kinds of studies. However, there are few studies that evaluate how much the effects of scents except for aroma oils are. Thus, in this study, considering that a lot of traffic fatal accidents are caused in Kagawa prefecture in Japan, we focused on reducing it by using the scent which is composed of the pine oil extracted from Matsu and Bonsai related to Kagawa prefecture. We conducted a driving simulator experiment and analyzed driving behavior against a risk event in the two conditions of supplying the scent or not. Additionally, we performed the simulation analysis based on time-series reliability model proposed by authors in a previous study to quantify the accident-reduction effects by supplying the scent. We found that there was a significant shortening in braking reaction time when supplying the scent. As a result, the accident-reduction effects of 43.8 % by supplying a scent was shown.

Effects of Supplying Aroma on Driving Behavior

Haruki Asano,Keisuke Suzuki 대한인간공학회 2018 대한인간공학회 학술대회논문집 Vol.2018 No.5

Due to the spread of driving support systems and the development of collision safety technologies to reduce the damage caused by traffic accidents, the number of fatal accidents tends to be decreasing. On the other hand, factors of current fatal accidents are mostly related to aimless driving. That is because the driver"s concentration and arousal level decrease, and psychological stress increases during continuous driving. Recently, developments of driving interfaces using auditory stimulation and visual stimulation, such as TCAS (Traffic alert and Collision Avoidance System) and LDWS (Lane Departure Warning System), are being promoted to support driver"s cognitive judgment. In addition, many researches which describe the effects of supplying fragrance such as aroma oil to the driver and stimulating the olfactory sensation are reported by authors, and it has been confirmed that supplying aroma is effective for accident prevention. However, it was not clarified that the reason why supplying aroma improves driving behavior and it is effective for accident prevention. Therefore, in this study, we analyzed the driving behavior using a driving simulator by investigating the reaction time to visual stimulus task and considered the factors of the improvement of the driving performance based on some biological signals such as the electroencephalogram and electrocardiogram.

A randomized double-blind placebo-controlled trial on the effect of magnesium oxide in patients with chronic constipation

Sumire Mori,Toshihiko Tomita,Kazuki Fujimura,Haruki Asano,Tomohiro Ogawa,Takahisa Yamasaki,Takashi Kondo,Tomoaki Kono,Katsuyuki Tozawa,Tadayuki Oshima,Hirokazu Fukui,Takeshi Kimura,Jiro Watari,Hiroto 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.4

Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life. Results One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003). Conclusion Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms. Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life. Results One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003). Conclusion Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms.