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( Hyun Hee Kim ),( Ji Hun Kim ),( Sung Hoon Park ),( Seong Kyu Kim ),( Ok Dong Kim ),( Jung Yoon Choe ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.2
Background/Aims: To examine the correlation between radiological joint damage and serological parameters in early rheumatoid arthritis (RA). Methods: This retrospective study reviewed the records of 216 patients diagnosed with RA and classified them according to disease duration: group 1, ≤24 months; group 2, >24 months; and group 3, all patients combined. The extent of joint damage was assessed from plain radiographs using a modified version of the Larsen method and compared among groups. Results: The mean radiographic joint damage score was significantly higher in patients who had established RA (10.1 points) compared with those who had early RA. In group 1, the inflammatory parameters, erythrocyte sedimentation rate, and C-reactive protein were positively correlated with the joint damage score, but rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody were not. A subgroup analysis revealed that the anti-CCP positive patients in groups 1 and 2 had greater joint damage scores than did the anti-CCP negative patients, but no difference in RF was observed between subgroups. Anti-CCP positivity was not significantly correlated with joint damage sores in group 3. Conclusions: Anti-CCP positivity was significantly correlated with more severe joint damage at diagnosis. A correlation was observed between the radiological joint damage score and inflammatory parameters in early and established RA, indicating that anti-CCP can serve as a diagnostic tool and predict structural joint damage. These findings suggest anti-CCP positive patients should receive aggressive therapeutic intervention. (2010;25:201-206)
Long-term extracorporeal membrane oxygenation after severe blunt traumatic lung injury in a child
Ok Jeong Lee,Yang Hyun Cho,황진욱,Inae Yoon,Young-Ho Kim,Joongbum Cho 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.3
Managing acute respiratory distress syndrome (ARDS) after severe blunt traumatic lung injury can be challenging. In cases where patients are refractory to conventional therapy, extracorporeal membrane oxygenation (ECMO) should be considered. In addition, the heparin-coated circuit can reduce hemorrhagic complications in patients with multiple traumas. Although prolonged ECMO may be necessary, excellent outcomes are frequently associated. In this study, we report long-term support with venovenous-ECMO applied in a child with severe blunt trauma in Korea. This 10-year-old and 30-kg male with severe blunt thoracic trauma after a car accident developed severe ARDS a few days later, and ECMO was administered for 33 days. Because of pulmonary hemorrhage during ECMO support, heparin was stopped for 3 days and then restarted. He was weaned from ECMO successfully and has been able to run without difficulty for the 2 years since discharge.
The Effect of Electric Cortical Stimulation after Focal Traumatic Brain Injury in Rats
Yoon, Yong-Soon,Yu, Ki Pi,Kim, Hyojoon,Kim, Hyoung-ihl,Kwak, Soo Hyun,Kim, Bong Ok Korean Academy of Rehabilitation Medicine 2012 Annals of Rehabilitation Medicine Vol.36 No.5
<P><B>Objective</B></P><P>To evaluate the effects of electric cortical stimulation in the experimentally induced focal traumatic brain injury (TBI) rat model on motor recovery and plasticity of the injured brain.</P><P><B>Method</B></P><P>Twenty male Sprague-Dawley rats were pre-trained on a single pellet reaching task (SPRT) and on a Rotarod task (RRT) for 14 days. Then, the TBI model was induced by a weight drop device (40 g in weight, 25 cm in height) on the dominant motor cortex, and the electrode was implanted over the perilesional cortical surface. All rats were divided into two groups as follows: Electrical stimulation (ES) group with anodal continuous stimulation (50 Hz and 194 µs duration) or Sham-operated control (SOC) group with no electrical stimulation. The rats were trained SPRT and RRT for 14 days for rehabilitation and measured Garcia's neurologic examination. Histopathological and immunostaining evaluations were performed after the experiment.</P><P><B>Results</B></P><P>There were no differences in the slice number in the histological analysis. Garcia's neurologic scores & SPRT were significantly increased in the ES group (p<0.05), yet, there was no difference in RRT in both groups. The ES group showed more expression of c-Fos around the brain injured area than the SOC group.</P><P><B>Conclusion</B></P><P>Electric cortical stimulation with rehabilitation is considered to be one of the trial methods for motor recovery in TBI. However, more studies should be conducted for the TBI model in order to establish better stimulation methods.</P>
( Hyun Chin Cho ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( In Gyu Bae ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.1
Several cases of Polygonum multiflorum Thunb-induced hepatitis have been reported worldwide. Anthraquinone is an active ingredient of P. multiflorum Thunb. that has been thought to play a role in its hepatotoxicity. Here we report the case of a 34-year-old Korean man who had P. multiflorum Thunb-induced hepatitis and reactivation of pulmonary tuberculosis caused by bone marrow suppression, which developed simultaneously. He was admitted to our hospital with recently developed fatigue and aggravated jaundice. He was a previously healthy man except for the sequelae of pulmonary tuberculosis seen on chest X-ray. He had a 30-day history of ingesting the root of P. multiflorum as a form of liquor and tea. The patient was diagnosed with P. multiflorum Thunb-induced hepatitis after excluding all other potential causes of acute hepatitis. Liver function gradually improved following the total cessation of the consumption of the material. However, he suffered from spiking fever with progressive pancytopenia during the hospital stay. A bone marrow biopsy showed markedly hypocellular marrow, suggesting transient bone marrow suppression, which was probably caused by extrinsic factors such as drugs, toxins, and viral infection. Although he began to complain of a dry cough, repeated sputum investigations revealed positive acid-fast bacillus staining. The fever subsided and pancytopenia improved after treatment for pulmonary tuberculosis. These observations suggest that P. multiflorum Thunb induces both bone marrow suppression and hepatotoxicity. (Gut and Liver 2009;3:52-56)
Hydrogenophaga bisanensis sp. nov., isolated from wastewater of a textile dye works.
Yoon, Jung-Hoon,Kang, So-Jung,Ryu, Seung Hyun,Jeon, Che Ok,Oh, Tae-Kwang Society for General Microbiology 2008 International journal of systematic and evolutiona Vol.58 No.2
<P>A Gram-negative, non-spore-forming, rod-shaped, Hydrogenophaga-like bacterial strain, K102(T), was isolated from wastewater collected from a textile dye works in Korea and subjected to a polyphasic taxonomic study. Strain K102(T) grew optimally at pH 7.0-8.0 and 30-37 degrees C in the presence of 0.5 % (w/v) NaCl. It contained Q-8 as the predominant ubiquinone and C(16 : 0), C(16 : 1)omega7c and/or iso-C(15 : 0) 2-OH and C(18 : 1)omega7c as the major fatty acids. The DNA G+C content was 64.8 mol%. A neighbour-joining phylogenetic tree based on 16S rRNA gene sequences showed that strain K102(T) fell within the radiation of the cluster comprising species of the genus Hydrogenophaga. Strain K102(T) exhibited 16S rRNA gene sequence similarity values of 95.9-98.9 % to the type strains of recognized Hydrogenophaga species. Levels of DNA-DNA relatedness between strain K102(T) and the type strains of its four phylogenetically most closely related species, together with differential phenotypic properties, revealed that strain K102(T) could be distinguished from all recognized species of the genus Hydrogenophaga. On the basis of phenotypic, phylogenetic and genetic data, strain K102(T) is considered to represent a novel species of the genus Hydrogenophaga, for which the name Hydrogenophaga bisanensis sp. nov. is proposed. The type strain is K102(T) (=KCTC 12980(T) =CCUG 54518(T)).</P>
Yoon, Ok J.,Kim, Hyun W.,Kim, Duck J.,Lee, Hyun J.,Yun, Ji Y.,Noh, Yoo H.,Lee, Do Y.,Kim, Do H.,Kim, Sung S.,Lee, Nae-Eung WILEY-VCH Verlag 2009 Plasma Processes and Polymers Vol.6 No.2
<P>The conductance of amine-functionalized SWCNTs (a-SWCNTs), obtained by inductively coupled N<SUB>2</SUB>/H<SUB>2</SUB> plasma treatment of commercially available carboxyl-functionalized SWCNTs (c-SWCNTs), was decreased compared to that of the c-SWCNTs. As a result, the diameter and surface energy of electrospun PLGA/a-SWCNT nanocomposites decreased and increased, respectively, compared to those of electrospun PLGA/c-SWCNT nanocomposites. The results also showed that the a-SWCNTs were well dispersed in the nanocomposites, improved adhesion of SWCNTs to the surrounding polymer matrix and thereby enhanced the tensile modulus of electrospun PLGA/c-SWCNT and PLGA/a-SWCNT nanocomposites by 127 and 226%, respectively, compared to that of electrospun PLGA membranes.</P><P> <img src='wiley_img/16128850-2009-6-2-PPAP200800081-gra001.gif' alt='wiley_img/16128850-2009-6-2-PPAP200800081-gra001'> </P>