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김선정,나현식 호남대학교 정보통신연구소 2001 정보통신연구 Vol.11 No.-
This paper deals with the application firewall system which is used the proxy toolkit files. The application firewall system is required the security policy, and simultaneously the cost minimization. Here, we propose the practical method on the build a application firewall system. To implement the proposed firewall system, we used the bastian host-based proxy toolkit as netacl, telnet, ftp and sendmail offered from TIS(Trus Information Systems).
Lee, Seon Min,Kim, Na-Hyun,Ji, Yeong Kwang,Kim, Yun Na,Jeon, You-Jin,Heo, Jeong Doo,Jeong, Eun Ju,Rho, Jung-Rae The Korean Society of Phycology 2020 ALGAE Vol.35 No.2
The inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn disease are characterized by chronic inflammation throughout the gastrointestinal tract. The prevalence of IBD has been increasing worldwide, and has sometimes led to irreversible impairment of gastrointestinal structure and functions. In the present study, we identified a new sulfoquinovosylmonoacylglycerols (SQMG) (1) together with two known SQMGs (2 and 3) regulating intestinal inflammation from the brown alga Turbinaria ornata. The anti-inflammatory properties of two bioactive SQMGs, 1 and 2 were evaluated using an in vitro co-culture system consisting of human epithelial Caco-2 cells and PMA (phorbol 12-myristate 12-acetate)-differentiated THP-1 macrophages. Treatment with 1 or 2 inhibited the production nitric oxide and prostaglandin E<sub>2</sub> induced by lipopolysaccharide and interferon γ challenge. The expressions of inducible nitric oxide synthase and cyclooxygenase 2 were markedly down-regulated in response to inhibition of nuclear factor κB translocation to nucleus. These findings suggest the potential use of the brown alga T. ornata and its biologically active metabolites SQMGs as pharmaceutical adjuvants in the treatment of inflammation-related diseases, including IBD.
관상동맥 중재술을 받은 급성 심근경색증 환자에서 체질량 지수의 영향
정선영 ( Seon Young Jeong ),이정애 ( Jung Ae Rhee ),정명호 ( Myung Ho Jeong ),황선호 ( Seon Ho Hwang ),윤남식 ( Nam Sik Yoon ),홍서나 ( Seo Na Hong ),이상록 ( Sang Rok Lee ),김계훈 ( Kye Hun Kim ),문재연 ( Jae Youn Moon ),홍영준 ( 대한내과학회 2007 대한내과학회지 Vol.73 No.6
목적: 비만은 관상동맥 질환의 위험인자로 알려져 있으나, 급성 심근경색증 환자에서 비만이 미치는 영향이나 관상동맥 중재술 후 장기 예후에 대한 영향은 잘 알려져 있지 않다. 본 연구를 통해 급성 심근경색증 환자에서 비만이 미치는 영향과 관상동맥 중재술 후 장기 예후에 미치는 영향을 알아보고자 하였다. 방법: 2002년 2월 1일부터 2006년 6월 30일까지 전남대학교 심장센터에서 급성 심근경색증으로 진단되어 관상동맥 중재술을 시행한 309예(60.5±11.3세, 남:여=243:66)를 대상으로 하였다. 체질량 지수가 25 kg/m2미만인 194예의 환자를 I 군(61.7±11.1세, 남:여=151:43), 체질량 지수가 25 kg/m2 이상인 115예의 환자를 II 군(58.6±11.5세, 남:여=92:23)으로 하여 두 군 간의 임상적 특성이나 위험인자들을 비교하였고, 6개월간 추적 경과관찰 동안 발생한 주요 심장 사건을 분석하였다. 결과: I 군에서 II 군에 비하여 나이가 많았고(61.7±11.1세 vs. 58.6±11.5세, p=0.017), II 군에서 고혈압(59/115 vs. 75/194예, p=0.033)과 고지혈증(60/115 vs. 75/194예, p=0.024)의 빈도가 높았다. 고지혈증의 경우 II 군이 I 군에 비해 혈중 총 콜레스테롤(201.4±42.6 mg/dL vs. 184.3±39.9 mg/dL, p=0.001), 중성지방(147.1±96.2 mg/dL vs. 121.2±61.6 mg/dL, p=0.005), 저밀도 콜레스테롤(134.1±37.8 mg/dL vs. 120.3±35.1 mg/dL, p=0.002)이 높았으나, 고밀도 콜레스테롤(42.3±10.2 mg/dL vs. 44.5±12.1mg/dL, p=0.109)은 차이가 없었다. 관상동맥 조영술이나 중재술과 연관된 인자는 두 군에서 차이가 없었다. 178예(I 군 109예, II 군 69예)의 환자에서 6개월 추적 관상동맥 조영술이 시행되었다. 재협착은 I 군에서 14예(12.8%), II 군에서 18예(26.1%)가 발생하여 II 군이 I 군에 비해 재협착율이 유의하게 높았다(p=0.025). 결론: 비만을 동반한 급성 심근경색증 환자에서는 고지혈증과 고혈압이 동반되는 경우가 많았으며, 관상동맥 중재술 후 재협착이 유의하게 많이 발생함을 알 수 있었다. 따라서 비만에 대한 적극적인 치료가 심근경색증 환자에서 중재술 후 재협착 예방에 중요할 것으로 생각되었다. Background: Obesity is one of the major risk factors for coronary artery disease. However, the long-term clinical effects of obesity after percutaneus coronary intervention (PCI) in Korean patients with acute myocardial infarction (AMI) have not been sufficiently evaluated. Methods: A total of 309 patients (mean age 60.5±11.3 years, M:F=243:66) that underwent PCI with a diagnosis of AMI between February 2002 and June 2006. Thepatients were divided into two groups according to the body mass index (BMI): group I (n=194; BMI<25 kg/m2; mean age 61.7±11.1 years, M:F=151:43) and group II (n=115; BMI≥25 kg/m2, mean age 58.2±11.3 years, M:F=92:23). Clinical characteristics and risk factors, and major adverse cardiac events during a six-month follow-up were compared between patients in the two gropus. Results: The mean age of group I patients was older than that of group II patients (61.7±11.1 years vs. 58.6±11.5 years, p=0.017). The prevalence of hypertension was higher in group II patients (75/194, 38.7% vs.59/115, 51.3%, p=0.033) and hyperlipidemia was more prevalent in group II patients (75/194, 38.7% vs. 60/115, 52.2%, p=0.024). The levels of total cholesterol (184.3±39.9 mg/dL vs. 201.4±42.6 mg/dL, p=0.001), triglycerides (121.2±61.6 mg/dL vs. 147.1±96.2 mg/dL, p=0.005), low-density lipoprotein-cholesterol (120.3±35.1 mg/dL vs. 134.1±37.8 mg/dL, p=0.002) were lower in group I patients than in group II patients. The restenosis rate on a follow-up coronary angiogram was higher in group II patients (18/69, 26.1%) than in group I patients (14/109, 12.8%, p=0.025). Conclusions: Obesity is associated with hyperlipidemia and hypertension in patients with AMI. The restenosis rate after PCI was higher in obese AMI patients. (Korean J Med 73:603-610, 2007)
조기 난소부전 환자에서 실시간 중합효소 연쇄 반응을 이용한 사립체 DNA copy 수의 정량적 분석
김정환 ( Kim Jeong Hwan ),이숙환 ( Lee Sug Hwan ),조성원 ( Jo Seong Won ),정혜진 ( Jeong Hye Jin ),김현아 ( Kim Hyeon A ),이윤정 ( Lee Yun Jeong ),나중열 ( Na Jung Yeol ),김인선 ( Kim In Seon ),윤태기 ( Yun Tae Gi ),강재성 ( Kang 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 본 연구는 조기 난소부전의 병태생리 중 중요한 역할을 하는 것으로 알려진 세포자멸사에 사립체 DNA (mtDNA)가 연관되어 있음을 이용하여, 혈중 성선자극호르몬 증가 외에 다른 증상이나 징후가 없는 젊은 여성을 대상으로, 향후 조기 난소부전으로의 이행 가능성을 선별할 수 있는 방법을 고안하고자 계획되었다. 연구 방법 : 40세 미만의 조기 난소부전 환자군 (n=30)과 2회 이상 출산의 경험이 있고 혈중 성선자극호르몬 수치가 정상인 40세 미 Objective : To design a screening method which identifies women with a potential of progression to the premature ovarian failure (POF) in near future, particularly among young women who have high FSH level but no symptoms and signs of POF. Methods : Perip
장하나 ( Ha-Na Jang ),박문식 ( Mun-Sik Park ),연승재 ( Seung-Jae Yeon ),채도원 ( Do-Won Chae ),정승환 ( Seung-Hwan Jeong ),정은정 ( Eun Jeong Jeong ),손광표 ( Kwang-Pyo Son ),강승모 ( Seung-Mo Kang ),안선용 ( Seon-Yong Ahn ),양승 한국폐기물자원순환학회 2020 한국폐기물자원순환학회지 Vol.37 No.8
Recently, MBT (Mechanical Biological Treatment) facilities were built up and operated to separate and recycle MSW (Municipal Solid Wastes)in South Korea. However, the size distribution of MSW is very rough, and it is causing operation problem because MSW would be crushed in undersize diameter by mechanical equipment before feeding each separation process. Also, the organic material should be pre-separated to reuse recycle material in MSW. In this research, the reactor of 1ton/batch using hydro-thermal reaction was tested to present the separation efficiency and the size distribution of MSW by experimental factors.
반응표면분석법을 이용한 쌀귀리 단백질의 알칼리 추출 공정 최적화
정용선(Yong-Seon Jeong),김정원(Jeong-Won Kim),이의석(Eui-Seok Lee),길나영(Na-Young Gil),김산성(San-Seong Kim),홍순택(Soon-Taek Hong) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.9
알칼리 추출법을 이용하여 쌀귀리로부터 단백질을 추출하고 추출수율을 최적화하기 위한 알칼리 농도 조건 및 침전 pH 조건을 반응표면분석을 통해 검토하였다. 추출수율은 추출용매인 알칼리 농도가 증가할수록 그리고 침전 pH 4.9 부근에서 높은 경향을 보였으며, 알칼리 농도가 침전 pH에 비하여 보다 큰 영향을 미치는 것으로 나타났다. 알칼리 추출 공정으로 얻어진 귀리 단백질 농축물의 질소용해지수는 등전점 부근인 pH 5에서 최소값을 나타내었고, pH 3 이하, pH 7 이상에서는 급격히 증가하였다. 알칼리 추출 공정의 최적화를 위한 회귀분석 결과, 알칼리 농도 0.06 N, 침전 pH 4.7에서 최대 수율 85.89%로 예측되었으며 예측모델식과 실제 측정값을 비교하였을 때 유의적인 차이가 크게 나타나지 않아 설계된 실험모델식은 적합한 것으로 나타났다. 따라서 기존의 연구들은 알칼리 추출법을 이용한 귀리 단백질 추출 시 알칼리 농도와 침전 pH가 각기 다름을 보였지만, 본 연구를 통하여 귀리 단백질 농축물 제조를 위한 알칼리추출 공정의 최적 조건은 알칼리 농도 0.06 N, 침전 pH 4.7인 것으로 확인되었다. In this study, an attempt was made to produce oat protein concentrates from defatted oat groat by alkali extraction. Independent variables formulated by D-optimal design were NaOH concentration (X1, 0.005~0.06 N) for extraction and precipitation pH (X2, pH 4.0~6.0), and the dependent variable was extraction yield (Y1, %). Experimental results were analyzed by response surface methodology to determine optimized extraction conditions. Extraction yield increased both with an increase in NaOH concentration of the extraction solution and when approaching a precipitation pH of 4.9, and NaOH concentrations were a major influencing parameter. Solubility of oat protein concentrates showed a minimum value (i.e., 0.1%) at pH 5 and increased substantially at pH values in the range of ≤ pH 3 or ≥ pH 7, reaching a maximum value at pH 11 (i.e., 76%). Regression equation coincided well with the results of the experiment. Optimized extraction conditions to maximize extraction yield were 0.06 N NaOH (X1) for extraction and pH 4.7 (X2) for precipitation.
Lee, Hyun-Jeong,Kwon, Ji-Sun,Lee, Dong-Hun,Lee, Yu-Na,Youn, Ha-Na,Lee, Youn-Jeong,Kim, Min-Chul,Jeong, Ok-Mi,Kang, Hyun-Mi,Kwon, Jun-Hun,Lee, Joong-Bok,Park, Seung-Yong,Choi, In-Soo,Song, Chang-Seon American Association of Avian Pathologists [etc.] 2010 Avian diseases Vol.54 No.1
<P>Live bird markets (LBMs) provide an ideal environment for the evolution and interspecies transfer of avian influenza viruses (AIVs). In this study, we analyzed AIVs present in LBMs in Korea during the winter seasons of 2006-08. Sixty-five AIVs that belong to four hemagglutination (HA) subtypes ofAIV (H3, H4, H6, and H9) were isolated from 644 pooled tissue or swab samples collected in LBMs. Most H9 subtypes of AIVs were isolated from Galliformes (chickens, silky fowls, pheasants, and guinea fowls), and other subtypes were isolated from Anseriformes (Pekin ducks and mallards). In addition, we obtained a single H3N2 virus from nasal swabs of dogs sold in LBMs, and the virus was genetically identical to the canine influenza virus (CIV) isolated from pet dogs in Korea. Phylogenetic analysis suggests that the Korean H9N2 viruses prevalent in chickens have provided their gene segments to AIVs circulating in ducks. These gene transfers facilitated reassortment events among AIVs and likely generated the ancestors of CIV in Korea. An animal challenge study using chickens, quail, mice, and dogs had shown that the H4 and H6 subtypes could replicate in mice and that some H4 and H6 viruses could replicate in chickens without preadaptation. In addition, two H3 subtype viruses (H3N2 and H3N8) induced interstitial pneumonia that accompanied clinical signs and seroconversion in dogs. Our findings indicate that the newly evolved AIVs have been continuously generated by reassortment in ducks, and these reassortments could result in expanding the host range of AIVs.</P>
KIM, Han-Na,HAN, Na-Kyung,HONG, Mi-Na,CHI, Sung-Gil,LEE, Yun-Sil,KIM, Taehong,PACK, Jeong-Ki,CHOI, Hyung-Do,KIM, Nam,LEE, Jae-Seon Journal of Radiation Research Editorial Committee 2012 JOURNAL OF RADIATION RESEARCH Vol.53 No.2
<P>Exposure to environmental stressors can be measured by monitoring the cellular stress response in target cells. Here, we used the cellular stress response to investigate whether single or combined radio frequency (RF) radiation could induce stress response in human cells. Cellular stress responses in MCF10A human breast epithelial cells were characterized after exposure to 4 h of RF radiation [code division multiple access (CDMA) or CDMA plus wideband CDMA (WCDMA)] or 2 h RF radiation on 3 consecutive days. Specific absorption rate (SAR) was 4.0 W/kg for CDMA signal alone exposure and 2.0 W/kg each, 4.0 W/kg in total for combined CDMA plus WCDMA signals. Expression levels and phosphorylation states of specific heat shock proteins (HSPs) and mitogen-activated protein kinases (MAPKs) were analyzed by Western blot. It was found that HSP27 and ERK1/2 phosphorylations are the most sensitive markers of the stress response in MCF10A cells exposed to heat shock or ionizing radiation. Using these markers, we demonstrated that neither one-time nor repeated single (CDMA alone) or combined (CDMA plus WCDMA) RF radiation exposure significantly altered HSP27 and ERK1/2 phosphorylations in MCF10A cells (<I>p</I> > 0.05). The lack of a statistically significant alteration in HSP27 and ERK1/2 phosphorylations suggests that single or combined RF radiation exposure did not elicit activation of HSP27 and ERK1/2 in MCF10A cells.</P>