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Mikio Sakakibara,Mitsuhiko Kido,Jun Kuribayashi,Hiroshi Okada,Ataru Igarashi,Hiroyuki Kamei,Toshitaka Nabeshima 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2
Objective: The pharmacological effects of generic (GE) donepezil are the same as Aricept, its brand-name counterpart. However, little is known as to whether these two drugs provide the same quality of life (QOL). The study subjects were patients with Alzheimer’s disease who were taking donepezil hydrochloride tablets, and were selected by visiting either the local pharmacies or the patients’ homes. We chose the brand-name drug Aricept and its GE form donepezil to investigate, from a long-term caregiver’s perspective, the influence of both drugs on the patients’ QOL. Methods: An EuroQol-5 Dimension (EQ-5D) was used to assess the QOL of patients with Alzheimer’s disease, before and after various Aricept and/or donepezil regimens. Patients were divided into four groups: first time users of Aricept (n=43), first time users of GE donepezil (n=45), users refilling previous prescriptions of Aricept (n=51), and users switching from Aricept to GE donepezil (n=51). Results: The average change in the EQ-5D utility indices rose significantly in the patients starting a new regimen of Aricept and its GE drug. The patients continuing an existing regimen of Aricept showed no significant differences, even after Aricept was switched to a GE drug. Conclusion: The QOL of patients starting a new regimen of Aricept and its GE drug improved. The QOL was maintained upon switching to the GE drug form.
Mikio Mikami,Satoru Nagase,Wataru Yamagami,Kimio Ushijma,Hironori Tashiro,Hidetaka Katabuchi 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4
Objective: Recent evidence has supported the concept that epithelial ovarian cancer (EOC)arises from the cells of the fallopian tube or endometrium. This study investigated currentpractice in Japan with respect to performing opportunistic bilateral salpingectomy (OBS)during gynecological surgery for benign disease for Ovarian Cancer Prevention. Methods: We mailed a questionnaire to 767 hospitals and clinics, comprising 628 accreditedtraining institutions of the Japan Society of Obstetrics and Gynecology (JSOG), Japan Societyof Gynecologic Oncology (JSGO), or Japan Society of Gynecologic and Obstetric Endoscopyand Minimally Invasive Therapy (JSGOE) and 139 private institutions with at least one JSGOEcertifiedlicensed gynecologic laparoscopist. Results: Among the 767 institutions, 444 (57.9%) provided responses, including 91 (20.6%)that were both JSGOE and JSGO accredited, 71 (16.0%) that were only JSGO accredited, 88(19.8%) that were only JSGOE accredited, and 194 (43.7%) that were unaccredited. It wasfound that awareness and performance of OBS largely depended on the JSGO and/or JSGOEaccreditation status. OBS was only performed at 54.0% of responding institutions and just6.8% of the institutions were willing to participate in randomized controlled trials to validatethis method for reducing the incidence of ovarian cancer. Conclusion: The JSOG Gynecologic Tumor Committee will announce its opinion onsalpingectomy for ovarian cancer prevention to all JSOG members and will develop a systemfor monitoring the number of OBS procedures in Japan.
일반논문 : 좌등직방(佐藤直方)의 사상(思想) ―학문론(學問論)과 공부론(工夫論)을 중심(中心)으로―
( Mikio Seki ) 퇴계학부산연구원 2013 退溪學論叢 Vol.22 No.-
佐藤直方( 1650- 1719)は江호中期の崎門學派の學者であり、山崎闇齊(1618-1682)の高弟である。直方は晩年『冬至文』を著し、道統の中に退溪を位置づけ、さらにそれ以降道の擔い手はいない之した。また、同じく晩年の著述である『道學標的』·『道學標的講義』では、學問の目的について言及し、道の追求之俗學異端の排除之いう點を强調する。ここに朱子學を純수に理解·繼承しよう之していた直方の姿勢が示されている之思われる。そこで本稿では、直方の退溪に대する評가を取りあげ、また直方の著述を通しその學問관を考察する。 Sato Naokata(1650-1719) is the Kimon(崎門)-school scholar. He wrote "Toujibun(『冬至文』)", "Dougaku-hyouteki(『道學標的』)",and "A lecture on Dougaku-hyouteki(『道學標的講義』)" in his years. In "Toujibun", he had a high opinion of Toegye(退溪). He insisted that Toegye strictly took over the tradition of the Zhuxi school- Confucianism and no one could do so when Toegye had been gone. In "Dougaku-hyouteki" and "A lecture on Dougaku-hyouteki", he referred to the aim of studying Confucianism, and emphasized both the pursuit of truth(道) and the need to reject the scholars; those who have narrow insights, Taoists, or Buddhists. From these two books, we can notice that he managed to succeed to the orthodox Neo-Confucianism. In this paper, therefore, I will identify his estimation for Toegye, and then consider his view on the method of learning from his writings.
Role of lymphadenectomy for ovarian cancer
Mikio Mikami 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4
Japan Society of Gynecologic Oncology (JSGO) recently revised its Ovarian Cancer Treatment Guidelines and the 4th edition will be released next year. This Guidelines state that lymphadenectomy is essential to allow accurate assessment of the clinical stage in early ovarian cancer, but there is no randomized controlled trial that shows any therapeutic efficacy of lymphadenectomy. In patients with advanced stage tumors, lymphadenectomy should be considered if optimal debulking has been performed. I fully agree with this recommendation of the JSGO and I would like to discuss the role of lymphadenectomy in the management of ovarian cancer.