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An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.
효소 Lipoxygenase의 신규기질 : Acylglycerol, acylethanolamide, lysophospholipids 및 phospholipids
황룡쌍,류희문,박천호,석대은 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-
Lipoxygenase belongs to a diverse family of nonheme ferroproteins that oxygenate polyenoic fatty acids containing 1,4-pentadiene structure to form their corresponding hydroperoxy derivatives. Lipoxygenases (LOXs), widely distributed in animals and plants, have a key function in the formation of biologically active substances from pulyunsaturated fatty acids. Generally, free polyunsaturated fatty acids, liberated from membrane phospholipids via phospholipase-catalyzed hydrolysis, are used as substrates for LOXs. Although it is acknowledged that free polyunsaturated fatty acids are preferred to phospholipids or triglycerides as substrates, there have been recent reports that mammalian enzymes can oxidize certain phospholipids. Especially, reticulocyte LOX (15-LOX) leukocyte 15-LOX, leukocyte LOX (12-LOX) can oxygenate complex substrates such as phospholipids and biomembranes. In addition, acylglycerol and acylethanolamide are utilized by lipoxygeanse as well as cycoloxygenase; the latter enzyme contributes to generation of bioactive prostanoids derivative. Furthermore, lysophosphatidylcholine or lysophosphatidic acid containing linoleoyl or arachidonoyl moieties are known to be oxygenated by reticulocyte LOX, leukocyte 15-LOX or leukocyte-type 12-LOX; oxygenated lysophospholipids can play a carrier role in transporting oxygenated derivatives. Thus, the use of various lipid substrates as new substrates for lipoxygenase may extend the physiological roles of those lipids containing unsaturated fatty acyl chains.
Nanoparticle additions for enhanced flux pinning in YBCO HTS films
N.M. Strickland,N.J. Long,E.F. Talantsev,P. Hoefakker,J.A. Xia,M.W. Rupich,W. Zhang,X. Li,T. Kodenkandath,Y. Huang 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
We describe a method for forming a nanoparticle dispersion in YBa₂Cu₃O7 superconducting lms grown by metal-organic depositionon RABiTS substrates. Two separate precursor modications have been shown by transmission electron microscopy to give nanopar-ticles of (Y,Dy)₂O₃ and BaZrO₃ with size distributions of 10-50 nm and 10-25 nm, respectively and that are well dispersed in the lm.These particles are eective ux pinning centers and enhance the transport critical current by up to 100% at 77 K for a magnetic eld of 1.5 T applied perpendicular to the tape. The processing required to grow these lms is not greatly altered from that of unmodied YBCO and can be readily transferred to continuous processing of long-length wires.
Dry reforming of methane over Ni/SBA-15 catalysts prepared by homogeneous precipitation method
Qiulin Zhang,Jing Wang,Ping Ning,Tengfei Zhang,Mingzhi Wang,Kaixian Long,Jianhong Huang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.11
Ni/SBA-15 catalyst was prepared by homogeneous precipitation method (Ni-HP) and used for dry reforming of methane (DRM). The related characterization results indicated that the Ni particles were highly dispersed with a size range of 2-5 nm. Compared with Ni/SBA-15 catalyst prepared by impregnation (Ni-IM), the reduction temperature of Ni-HP obtained from H2-TPR was greatly improved, suggesting the stronger metal-support interaction. After reacting at 700 oC for 100 h, the CH4 conversion of DRM over Ni-HP catalyst slightly decreased from 74.5% to 73.8%. While, for the Ni-IM catalyst, the CH4 conversion dropped from 61.7% to 37.3%. Furthermore, the average particle size of Ni-HP was 3.7 nm and 4.7 nm before and after the long-time stability test, respectively, ascribed to the good antisintering property. Although a certain amount of coke was produced, mainly with disorder filamentous carbon of basegrowth, the Ni/SBA-15 prepared by homogeneous precipitation exhibited excellent catalytic activity and stability.
Huang, Long Shuang,Kim, Mee Ree,Sok, Dai-Eun WILEY-VCH Verlag 2009 European journal of lipid science and technology Vol.111 No.6
<P>Some lipid peroxides are known to be converted to their corresponding alcohols in cells containing glutathione peroxidase (GPx). In this respect, we examined the enzymatic conversion of lysophosphatidylcholine (lysoPC) hydroperoxides to hydroxyl derivatives using RBL-2H3 cells and erythrocyte GPx-1. First, the incubation of RBL-2H3 cells with arachidonoyl lysoPC led to the formation of a major product, with maximal UV absorbance at 234 nm and m/z [M+H]<SUP>+</SUP> at 560.2, corresponding to monohydroxyeicosatetraenoyl lysoPC. Similarly, linoleoyl lysoPC was also converted to its hydroxyl derivative in RBL-2H3 cells. Separately, lysoPC hydroperoxide, generated from soybean lipoxygenase 1-catalyzed oxygenation of linoleoyl lysoPC, arachidonoyl lysoPC or docosahexaenoyl lysoPC, was converted by GPx-1 to the corresponding hydroxyl derivatives. When the kinetic values were determined, the K<SUB>m</SUB> values (3.1–32.3 µM) of the polyunsaturated lysoPC hydroperoxides increased with decreasing number of double bonds, in contrast to a similar value of V<SUB>m</SUB> among them. Moreover, the catalytic efficiency of docosahexaenoyl lysoPC hydroperoxide was much greater than that of H<SUB>2</SUB>O<SUB>2</SUB> as substrate of GPx-1. In related experiments, where phosphatidylcholine hydroperoxides were incubated with phospholipase A<SUB>2</SUB> and GPx-1, the complete conversion of phosphatidylcholine hydroperoxides to hydroxyl derivatives was confirmed by LC/MS. Taken together, it is proposed that GPx-1-type enzymes may participate in the conversion of polyunsaturated lysoPC hydroperoxides to hydroxyl derivatives in cell systems.</P>
Biological Actions of Polyunsaturated Fatty Acyl Lysophospholipids
Long Shuang Huang,Sok, Dai-Eun 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-
Lysophosphatidylcholine (lysoPC) and polyunsaturated fatty acids are known to be generated from the hydrolysis of phosphatidylcholine by enzymes such as secretary phospholipase A₂, lipoprotein-specific phospholipase A₂, lecithin/cholesterol acyl transferase or endothelial lipase. Free polyunsatuarted fatty acids have been known to be oxygenated by lipoxygenases to produce various bioactive compounds, which are known to exert antioxidant and anti-inflammatory actions. Meanwhile, lysoPC and its hydrolysis product, lysophosphatidic acid (lysoPA), are known to express a variety of bioactivities. However, most of the studies on the bioactivities of lysoPC and lysoPA were examined using lysophospholipids with saturated fatty acyl chains. Recently, the activities of unsaturated lysophospholipids have been of increasing interest, since unsaturated lysophospholipids, present to a substantial level in vivo, have been reported to be utilized as substrates for enzymes such as lipoxygenase. In this review, the biological activities of lysophospholipids, saturated or unsaturated, were discussed in an attempt to stress on the peculiar activities of polyunsaturated lysophospholipids such as 1-linoleoyl lysoPC and 1-docosahexaenoyl lysoPC.
Phytate Determination in Various Cultivars of Korean Rice
Long Shuang Huang,Dai-Eun Sok,Hyoung Chin Kim,Won Kee Yoon,Hwan Mook Kim,Mee Ree Kim 한국식품영양과학회 2006 Preventive Nutrition and Food Science Vol.11 No.1
To determine the amount of phytate in rice grains from various cultivars, two methods were employed and compared in respect of the accuracy and conveniency. Phytate in rice samples was extracted with HCl, and then the extracts were subjected to an anion-exchange column. Finally, the phytate in eluate was quantitated using two methods: one method is based on the complex formation between ferric ion and sulfosalicylic acid in the presence of phytate, and the other is the prior acid digestion of phytate sample, followed by the colorimetric determination of liberated phosphorus. Although two methods showed similar values of phytate in rice samples, the former method is simpler and more precise than the latter. Moreover, the former is more reliable for the samples with lower phytate levels. Especially, the dilution condition of rice sample before anion exchange column separation was important for the recovery of phytate in rice samples. Based on the former method, the amount of phytate in rice of various cultivars was estimated to range from 7.3 ㎎/g to 12.4 ㎎/g rice. This method would be useful for the determination of phytate in crop samples with a lower level of phytate, one of anti-nutrients in some agricultural plants.