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RISS 인기검색어
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- 저자 : Lei Zhu (검색결과 313 건)
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MiR-886-5p Inhibition Inhibits Growth and Induces Apoptosis of MCF7 Cells
Zhang, Lei-Lei,Wu, Jiang,Liu, Qiang,Zhang, Yan,Sun, Zhu-Lei,Jing, Hong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background and Aims: To explore the molecular mechanisms of miR-886-5p in breast cancer., we examined roles in inhibiting growth and migration of MCF-7 cells. Methods: MiR-886-5p mimics and inhibitors were used to express or inhibit MiR-886-5p, respectively, and MTT and clone formation assays were used to determine the survival and proliferation. Hoechst 33342/ PI double staining was applied to detect apoptosis. The expression of caspase-3, caspase-8, caspase-9, MT1-MMP, VEGF-C and VEGF-D was detected by Western blotting, and the levels of MMP2 and MMP9 secreted from MCF-7 cells were assessed by ELISA. MCF-7 cell migration was determined by wound healing and Transwell assays. Results: We found that the growth of MCF-7 cells was inhibited upon decreasing miR-886-5p levels. Inhibiting miR-866-5p also significantly induced apoptosis and decreased the migratory capacity of these cells. The expression of VEGF-C, VEGF-D, MT1-MMP, MMP2, and MMP9 was also found to be decreased as compared to controls. Conclusions: Our data show that downregulation of miR-886-5p expression in MCF-7 cells could significantly inhibit cell growth and migration. This might imply that inhibiting miR-886-5p could be a therapeutic strategy in breast cancer.
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Lei Zhu,조순복,Shu Ye,Kefayat Ullah,오원춘 한국세라믹학회 2014 한국세라믹학회지 Vol.51 No.3
This paper introduces a microwave-assisted synthesis method to prepare hybrid Bi2Se3-GR/TiO2 nanocomposites, which exhibitsuperior properties over single component materials. The as-prepared composites were characterized by XRD, UV-vis absorbancespectra, SEM,TEM, EDX, and BET analyses, revealing uniform covering of the graphene nanosheet with Bi2Se3 and TiO2nanocrystals. For visible light photocatalysis of Rh.B, a significant enhancement in the reaction rate was consequently observedwith Bi2Se3-GR/TiO2 composites. The degradation rate(kapp) obtained for sonophotocatalysis was 6.8× 10-3 min-1, roughly 2.2 timesbetter than that of VL photocatalysis under higher concentrations of Rh.B. The sonophotocatalysis was faster due to greaterformation of reactive radicals as well as an increase of the active surface area of the Bi2Se3-GR/TiO2 composites. The high activityis attributed to the synergetic effects of high charge mobility and red shift of the absorption edge of Bi2Se3-GR/TiO2.
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Lei Yang,Shuai Guo,Qiuling Yang,Yuankun Zhu,Bing Dai,Hailing Yu,Pei Lei,Jiecai Han,Ying Hou,Jiaqi Zhu 대한금속·재료학회 2015 ELECTRONIC MATERIALS LETTERS Vol.11 No.6
The preferentially oriented In2O3 thin films were prepared on glass substrates by conventional magnetron sputtering with Ar+ plasma exposure at room temperature. Based on the x-ray diffraction, x-ray photoelectron spectroscopy, and UV photoelectron spectroscopy results, it was found that the Ar+ plasma exposure not only enhanced the low-temperature crystallization of In2O3 thin films, but also led to a dramatic improvement in the work function. Furthermore, it demonstrated that the shift mechanism of the work function in In2O3 thin films mainly combined with theelimination of oxygen defects and the change of the preferential orientation of In2O3 film surface.
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Lei Zhu,임창성,Ze-Da Meng,최종근,박종연,Trisha Ghosh,조광연,오원춘 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.3
Nanoscale ZnS-photosensitized TiO2 particles supported on acid functionalized multi-wall carbon nanotubes (MWCNTs) were prepared via a mild hydrothermal route. The new optical properties and porous structure of the as-prepared samples were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), BET surface area analysis,UV-vis DRS and X-ray diffraction (XRD). The photocatalytic activities of the composite catalysts were evaluated by the decomposition of an MB solution under visible light irradiation. The results indicate that the addition of an appropriate amount of MWCNTs as supports for TiO2 and ZnS efficiently inhibit the agglomeration of ZnS/TiO2 thus improving the dispersion of nanoparticles and the activity of visible photodegradation was remarkably improved.
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Lei Zhu,Yali Zhang,Wen Zhang,Jiang Lu 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2
The effects of exogenous abscisic acid (ABA) on phenolic characteristics of grapes and wines were investigated in Vitis vinifera cvs. Merlot and Cabernet Sauvignon. Exogenous ABA treatment at veraison significantly improved phenolic contents, mainly anthocyanins and flavonols, and antioxidant properties of the grape skins, but had no effects on total phenolics and antioxidant activities in the seeds or on basic fruit qualities. The wines made from ABA-treated grapes were also consequently enhanced in total phenolics, anthocyanins, flavonols and antioxidant activities. The proportions of methylated anthocyanins in the skins and acylated anthocyanins and derived pigments in the wines were decreased to some degree by exogenous ABA treatment. No distinct relationships were observed between ABA concentrations and phenolic characteristics, and the effects were observed even with 200 mg/L ABA. The results revealed that exogenous ABA applied at veraison offered opportunities to improve phenolic contents and nutritional values of grape skins and wines.
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The Effect of Impeller Indent Distance on the Performance of Vortex Pumps
Lei DAI,Lei GU,Jun WANG,Xiang AO,Xiaobo ZHU 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.1
Low efficiency is an urgent problem to be solved for vortex pumps due to large number of vortices and backflows. This paper concentrates on the performance improvement of vortex pumps caused by changing the indent distance of the impeller. First, a complete numerical model was established by selecting the optimal length of inlet and outlet and appropriate mesh quantity. Then, the reliability of this model was validated by comparing simulation results with experimental data. Based on this model, the internal flows of vortex pumps with different impeller indent distances were observed in simulations and the fitted curves of head and efficiency were created. Finally, the cause of the performance improvement was demonstrated by analyzing the flow field in vortex pumps.
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Analysis on the Operation of a Charging Station with Battery Energy Storage System
Zhu, Lei,Pu, Yongjian The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.5
Fossil oil, as the main energy of transportation, is destined to be exhausted. The electrification of transportation is a sustainable solution to the energy crisis, since electric power could be acquired from the inexhaustible sun, wind and water. Among all the problems that hinder the development of Electric Vehicle (EV) industry, charging issue might be the most prominent one. In this paper, the service process of a charging station with Battery Energy Storage System (BESS) is analyzed by means of $Cram{\acute{e}}r$ - Lundberg model which has been intensively utilized in ruin theory. The service quality is proposed in two dimensions: the service efficiency and the service reliability. The arrival rate and State of Charge (SOC) upon arrival are derived from 2009 National Household Travel Survey (NHTS). The simulations are performed to show how the service quality is determined by the system parameters such as the number of servers, the service rate, the initial capacity, the charge rate and the maximum waiting time. At last, the economic analysis of the system is conducted and the best combination of the system parameters are given.
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Lei Zhu,조순복,조정환,Shu Ye,Kefayat Ullah,오원춘 한국세라믹학회 2014 한국세라믹학회지 Vol.51 No.3
Activated carbon fiber (ACF) was modified with MnS nanoparticles to prepare MnS-ACF, and it was employed for preparationof MnS-ACF/TiO2 composites with titanium (IV) n-butoxide (TNB). The properties of MnS-ACF/TiO2 composites were characterizedby XRD, SEM, and EDX. EDX results showed the presence of C, O, and Ti as major elements and traces of the metal elementsMn and S. The photocatlytic activity was evaluated by degradation of methyl blue (MB) and methyl orange (MO) dye. Theresults demonstrated that as-prepared samples could effectively photodegrade MB and MO under UV irradiation. Subsequently,the decomposition of MB solution showed the combined effects of adsorptions by ACF and enhanced photocatalytic effect by TiO2. Finally, the photocatalytic effect increased due to photo-induced-electron absorption effect by ACF and electron trap effect by comodified MnS nanoparticles.
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ZHU LEI,조대헌,이소영 한국국토정보공사 2017 지적과 국토정보 Vol.47 No.2
Visible Infrared Imaging Radiometer Suite Day-Night Band (VIIRS-DNB) data provides a much higher capability for observing and quantifying nighttime light (NTL) brightness in comparison with Defense Meteorological Satellite-Operational Linescan System (DMSP-OLS) data. In South Korea, there is little research on the detection of NTL brightness change using VIIRS-DNB data. This study analyzed the spatial distribution and change of NTL brightness between 2013 and 2016 using VIIRS-DNB data, and detected its spatial relation with possible influencing factors using regression models. The intra-year seasonality of NTL brightness in 2016 was also studied by analyzing the deviation and change clusters, as well as the influencing factors. Results are as follows: 1) The higher value of NTL brightness in 2013 and 2016 is concentrated in Seoul and its surrounding cities, which positively correlated with population density and residential areas, economic land use, and other factors; 2) There is a decreasing trend of NTL brightness from 2013 to 2016, which is obvious in Seoul, with the change of population density and area of industrial buildings as the main influencing factors; 3) Areas in Seoul, and some surrounding areas have high deviation of the intra-year NTL brightness, and 71% of the total areas have their highest NTL brightness in January, February, October, November and December; and 4) Change of NTL brightness between summer and winter demonstrated a significantly positive relation with snow cover area change, and a slightly and significantly negative relation with albedo change.
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Zhu, Lei,Jo, Sun-Bok,Jo, Jung-Hwan,Ye, Shu,Ullah, Kefayat,Oh, Won-Chun The Korean Ceramic Society 2014 한국세라믹학회지 Vol.51 No.3
Activated carbon fiber (ACF) was modified with MnS nanoparticles to prepare MnS-ACF, and it was employed for preparation of MnS-$ACF/TiO_2$ composites with titanium (IV) n-butoxide (TNB). The properties of MnS-$ACF/TiO_2$ composites were characterized by XRD, SEM, and EDX. EDX results showed the presence of C, O, and Ti as major elements and traces of the metal elements Mn and S. The photocatlytic activity was evaluated by degradation of methyl blue (MB) and methyl orange (MO) dye. The results demonstrated that as-prepared samples could effectively photodegrade MB and MO under UV irradiation. Subsequently, the decomposition of MB solution showed the combined effects of adsorptions by ACF and enhanced photocatalytic effect by $TiO_2$. Finally, the photocatalytic effect increased due to photo-induced-electron absorption effect by ACF and electron trap effect by comodified MnS nanoparticles.
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