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- 저자 : Kwon Hyouk-Soo (검색결과 65 건)
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Kwon, Hyouk-Soo,Lee, So-Hee,Yang, Min-Suk,Lee, Sang-Min,Kim, Sae-Hoon,Kim, Deok-In,Sohn, Seong-Wook,Park, Chang-Han,Park, Heung-Woo,Kim, Sun-Sin,Cho, Sang-Heon,Min, Kyung-Up,Kim, You-Young,Chang, Yoon The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.4
<P>The Asthma Control Test (ACT) is a patient-completed questionnaire developed to assess asthma control. Health-related quality of life (HRQL) in asthmatics has shown relatively low correlations with parameters of asthma control and the relationship between the ACT and HRQL in asthmatics is yet unclear. Because revalidations of translated versions of questionnaires are critical for its utilization, we first sought to validate the Korean version of ACT and then to evaluate the relationship between the ACT and HRQL. Patients (n=117) completed the ACT and asthma-related quality of life questionnaire (AQLQ) at 3 physician visits. Pulmonary function was measured and an asthma specialist rated asthma control. The Korean version of ACT was found to be reliable, valid, and responsive to changes in asthma control over time up to three consecutive visits. ACT scores correlated significantly (<I>p</I>=0.001) with symptoms domain (r=0.72), activity domain (r=0.65), emotional domain (r=0.69), and environmental domain (r=0.67) of AQLQ. In conclusion, the Korean version of the ACT was found to be a reliable and valid tool for measuring asthma control, and to correlate well with AQLQ scores. Moreover, the ACT was responsive to changes in AQLQ scores over time.</P>
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Ultrafine particles: unique physicochemical properties relevant to health and disease
Hyouk-Soo Kwon,Min Hyung Ryu,Christopher Carlsten 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Ultrafine particles (UFPs) are aerosols with an aerodynamic diameter of 0.1µm (100nm) or less. There is a growing concern in the public health community about the contribution of UFPs to human health. Despite their modest mass and size, they dominate in terms of the number of particles in the ambient air. A particular concern about UFPs is their ability to reach the most distal lung regions (alveoli) and circumvent primary airway defenses. Moreover, UFPs have a high surface area and a capacity to adsorb a substantial amount of toxic organic compounds. Harmful systemic health effects of PM10 or PM2.5 are often attributable to the UFP fraction. In this review, we examine the physicochemical characteristics of UFPs to enable a better understanding of the effects of these particles on human health. The characteristics of UFPs from diesel combustion will be discussed in the greatest detail because road vehicles are the primary source of UFP emissions in urban pollution hotspots. Finally, we will elaborate on the role of UFPs on global climate change, since the adverse effects of UFPs on meteorological processes and the hydrological cycle may even be more harmful to human health than their direct toxic effects.
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Identification of subtypes of refractory asthma in Korean patients by cluster analysis.
Jang, An Soo,Kwon, Hyouk-Soo,Cho, You Sook,Bae, Yun Jeong,Kim, Tae Bum,Park, Jong Sook,Park, Sung Woo,Uh, Soo-Taek,Choi, Jae-Sung,Kim, Yong-Hoon,Hwang, Hyeon-Kyu,Moon, Hee-Bom,Park, Choon Sik Springer International 2013 Lung Vol.191 No.1
<P>Refractory asthma, a subtype of asthma with uncontrolled symptoms despite antiasthma medications, is a heterogeneous syndrome with variable clinical features, presumably different etiologies, and pathophysiological mechanisms. The heterogeneity of refractory asthma, however, is poorly understood. We aimed to characterize refractory asthma and to improve our understanding of the heterogeneity of refractory asthma patients. We identified refractory asthma patients (n = 96) as defined by the American Thoracic Society's criteria from a cohort of Korean asthma patients (n = 2,187). Then, cluster analysis was conducted to classify subtypes of refractory asthma. Among the study group, 4.4 % (n = 96) of all asthma patients had refractory asthma. Cluster analysis identified four distinct groups of refractory asthma. Age at onset was younger in clusters 1 and 2 than in clusters 3 and 4. Patients in cluster 1 had the most well-preserved pulmonary function; patients in cluster 2 had a female predominance and the most severe airway obstruction; patients in cluster 3 were mostly female and had the most enhanced bronchial hyperresponsiveness; and patients in cluster 4 were most male and tended to be cigarette smokers. The current results suggest that refractory asthma is a heterogeneous syndrome and could be classified into four subtypes. Underlying pathogenesis and therapeutic approaches may differ for the different subtypes and further research is needed.</P>
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Korean version of the Cough Symptom Score: clinical utility and validity for chronic cough
( Jae-woo Kwon ),( Ji-yong Moon ),( Sae-hoon Kim ),( Woo-jung Song ),( Min-hye Kim ),( Min-gyu Kang ),( Kyung-hwan Lim ),( So-hee Lee ),( Sang Min Lee ),( Jin Young Lee ),( Hyouk-soo Kwon ),( Kyung-mo 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5
Background/Aims: The Cough Symptom Score (CSS) is a simple, useful tool for measuring cough severity. However, there is no standard Korean version of the CSS. We developed a Korean version of the CSS and evaluated its clinical utility and validity for assessing chronic cough severity. Methods: The CSS was adapted for Korean use following a forward-backward translation procedure. Patients with chronic cough enrolled from five university hospitals were graded using the CSS and a 100-mm linear visual analog scale (VAS) of cough severity at each visit. Patients completed the Leicester Cough Ques-tionnaire (LCQ) upon presentation and completed the LCQ and Global Rating of Change at follow-up visits after 2 to 4 weeks. The concurrent validity, repeatabili-ty, and responsiveness of the Korean version of the CSS were determined. Results: Correlation coefficients between the CSS and LCQ, and between the CSS and VAS, were -0.66 and 0.52, respectively. There was a weak correlation between the scores for night and day symptoms (r = 0.24, p = 0.0006). The repeatability of the CSS in patients with no change in cough (n = 23) was high (intra-class cor-relation coefficient, 0.75; 95% confidence interval [CI], 0.51 to 0.88). Patients who reported an improvement in cough (n = 30) at follow-up visits had a significant improvement in the CSS (median, -2; 95% CI, -3 to -1; p = 0.0003). Conclusions: The Korean version of the CSS correlated well with other tools for accessing cough severity in chronic cough patients. Therefore, it could be a reli-able method for measuring chronic cough severity.
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Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma.
Lee, Taehoon,Kwon, Hyouk-Soo,Bang, Bo-Ram,Lee, Yoon Su,Park, Mi-Young,Moon, Keun-Ai,Kim, Tae-Bum,Lee, Ki-Young,Moon, Hee-Bom,Cho, You Sook Springer 2012 Journal of clinical immunology Vol.32 No.6
<P>Antioxidants have been suggested to alleviate the pathophysiological features of asthma, and grape seed proanthocyanidin extract (GSPE) has been reported to have powerful antioxidant activity.</P>
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