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Jung Kyung Hee,Kim Sang Eun,Go Han Gyeol,Lee Yun Ji,Park Min Seok,Ko Soyeon,Han Beom Seok,Yoon Young-Chan,Cho Ye Jin,Lee Pureunchowon,Lee Sang-Ho,Kim Kipyo,Hong Soon-Sun 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.6
According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated kidney injury and fibrosis. First, we identified RSL3-induced ferroptosis in renal tubular epithelial HK-2 and HKC-8 cells. Lipid peroxidation and cell death induced by RSL3 were synergistically mitigated by the combination of melatonin and zileuton. Combination treatment significantly downregulated the expression of ferroptosis-associated proteins, 4-HNE and HO-1, and upregulated the expression of GPX4. The expression levels of p-AKT and p-mTOR also increased, in addition to that of NRF2 in renal tubular epithelial cells. When melatonin (20 mg/kg) and zileuton (20 mg/kg) were administered to a unilateral ureteral obstruction (UUO) mouse model, the combination significantly reduced tubular injury and fibrosis by decreasing the expression of profibrotic markers, such as α-SMA and fibronectin. More importantly, the combination ameliorated the increase in 4-HNE levels and decreased GPX4 expression in UUO mice. Overall, the combination of melatonin and zileuton was found to effectively ameliorate ferroptosis-related kidney injury by upregulating the AKT/mTOR/ NRF2 signaling pathway, suggesting a promising therapeutic strategy for protection against ferroptosis-mediated kidney injury and fibrosis.
Anti-Inflammatory Effect of By-Products from<i>Haliotis discus hannai</i>in RAW 264.7 Cells
Rho, Ho-Seok,Kim, Hyang,Kim, Jung-Ae,Karadeniz, Fatih,Ahn, Byul-Nim,Nam, Ki-Ho,Seo, Youngwan,Kong, Chang-Suk Hindawi Limited 2015 Journal of chemistry Vol.2015 No.-
<P>Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone,<I>Haliotis discus hannai</I>viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of<I>H. discus hannai</I>was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of<I>H. discus hannai</I>mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-<I>α</I>, IL-1<I>β</I>, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals<I>in vitro</I>. In conclusion, by-products of<I>H. discus hannai</I>are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.</P>
권역단위 농촌지역개발사업의 주민역량 측정을 위한 설문도구개발
리신호 ( Shin Ho Rhee ),민흥기 ( Heung Gi Min ),윤성수 ( Sung Soo Yoon ),정남수 ( Nam Su Jung ),장우석 ( Woo Seok Chang ) 한국농촌계획학회 2014 농촌계획 Vol.20 No.4
The purpose of this study was to develop survey tools for diagnosis of capacity levels in business promotion of rural residents when performing a rural development project of a regional unit. The cases of previous studies were analyzed to select community capacity indicators related to a rural development project. Five indicators were derived : social capital, consciousness of participation, community spirit, and leadership. Based on the five indicators, measurement items of various capacities were selected and 54 survey items were selected through evaluation of experts twice. The pilot tests were conducted and targeted at Jeonnam song ho-jung village and Gyeongnam Haegeumgang village to identify derived survey items. In addition, descriptive statistic analysis and reliability analysis were conducted. As a result, survey items were corrected by reducing 10 items of the total 54 items. This results showed that using this tool could help us understand capacity levels of rural residents.
高血壓患者에서 血壓降下劑에 의한 赤血球膜 Na-pump의 變化
鄭政九,昔廷鎬,李載欣 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2
In the essential hypertensive patients, to study the effect of antihypertensive agents on the Na-transport mechanism across the cell membrane, we carried out the experiments of ouabain sensitive Rb-uptake and furosemide sensitive Rb-uptake in the erythrocytes. In the erythrocyte of normotensive persons, major Rb-transport systems were the ouaba sensitive pathway(Na-pump, 77%) and furosemide sensitive pathway(Na/K-cotransport, 15%), In the erythrocyte of hypertensive patients, the activity of Na-pump was reduced(40%) and Na/K-cotransport system was also inhibited(40%) with the administration of diltiazem and propranolol to the hypertensive patient for 3 or 4 months, inhibited activity of Na-pump was increased but inhibited Na/K-cotransport system was not recovered. From this results, it is suggested that it is possible to recover the decreasel Na-pump activityin the erythrocyte of hypertensive patient by the administration of several antihypertensive agents.
최호택, 정석환 培材大學校 社會科學硏究所 2013 사회과학연구 Vol.35 No.1
This study applied a theory in cognitive psychology that human decision making should work through environmental data processing and studied the inauguration speech of Park Geun-hye as the 18th President of the Republic of Korea to explore the national administration direction by analyzing Park's cognitive system. The results of this study can be summarized as follows. First, as for national administration, President Park has established four sectoral cognition systems at large and integrated them to make a holistic system based on national development as a policy variable. Second, major policy variables recognized by President include national development, creative economy, economic prosperity, national competitiveness, economic democratization, personal capacity, cultural prosperity, and national happiness. Third, policy variables of President's cognition system form mutually dynamic circulatory relations, resulting in one policy variable. This reasonably forecasts policy consistency to a significant extent. The results of this study work as empirical evidence to clarify theories in policy psychology, enhancing further academic development.
이주호, 최정석, 정준영, 최양일 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.3
This study was undertaken to compare the quality characteristics of dairy beef ham. Dairy beef hams were manufactured using non-preferred portion (top round). 5 treatments were prepared: T1(beef 50% + pork emulsion 50%), T2(beef 65%emulsion 35%), T3(beef 80%emulsion 20%), T4(beef 90%emulsion 10%), T5(beef 100%emulsion 0%). In chemical composition, dairy beef content increases, moisture content was increased, fat content was decreased. In the meat quality characteristics, T5 showed higher (p<0.05) water holding capacity value than the others. Dairy beef content increases, product loss and cooking loss were decreased. In hunter color, dairy beef content increases, redness was increased. In texture profile analysis, T4 and T5 were significantly higher than the others. As a result, dairy beef ham with 80~90% dairy beef and 10~20% pork emulsion has low fat content, high product yield and superior texture profile, which could be developed as a dairy beef hams using non-preferred portion.
Memory 소자 응용을 위한 BST(Ba_xSr_1-_xTiO_3) 강유전체 박막과 전극과의 계면특성
정민재,조정희,홍석민,김호건,김옥경 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1
BaxSr1-xTiO3 powders were prepared by changing stoichiometry of Ba and Sr. After they were calcined and sintered at 1,200℃ and 1,300℃ respectively, BST sputtering targets were made in 3inch mould. For MIM structure capacitors. Pt-based structures such as Pt/TiN/SiO2/Si, Pt/Ti/Si3N4/Si, Pt/SiO2/Si, Ru/SiO2/Si and Ru/Si3N4/Si were used for bottom electrodes, and subsequently, the BaxSrl-xTiO3 thin films were sputtered on them. After the analysis of their structures by XRD, Al was evaporated on the BST films for MIM capacitor. We found that the structures of the films showed good crystallinity above 550℃ from the results of XRD measurements. The largest dielectric constant of films was obtained with 0.7mol% of Ba. The electric properties of the capacitors were very good with Pt/TiN/SiO2/Si electrodes.
송아지고기 소시지와 시중에 판매되는 우육과 돈육 소시지 제품의 저장특성 비교
이주호, 최정석, 이현진, 정구용, 최양일 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1
This study was undertaken to compare the storage characteristics between veal sausage and commercial pork and beef sausages in Korean domestic market. We manufactured 3_types of sausages and purchased 2_types of sausages in the market: T1(B-company product), T2(O-company product) and we made T3(smoked veal sausage), T4(smoked veal sausage with pepper) and T5(cooked veal sausage) products. During 20 days of storage at 4oC, T5 showed significantly higher in TBA value and VBN value (p<0.05). But TBA and VBN values showed normal range in all products. T3, T4, and T5 showed higher total microbial count than T1 and T2 (p<0.05). According to the result, beef and pork sausages in the market showed different total microbial count and VBN values from those made in laboratory. This result could be come from the different additives used and manufacturing processes. However, all products can be stored up to 20 days in the cooler.