2005학년도 신입생 실태조사

김두화,박종필,박정환 濟州大學校 職業能力開發院 2006 學生生活硏究 Vol.27 No.-

The purpose of the survey is to collect basic data on freshmen in 2005 and to understand students' general matters for make substantial measures on academic affairs in our university, For the purpose of the study, the researcher composed a questionnaire(on students' current conditions, values, university life etc) based on earlier surveys and distributed and collected during the orientation period of . 1802 students are answered the questionnaire and the results of the survey suggest that : 1. It needs to increase the opportunities to take career guidance and counseling. When asked main concerns, most students answered that their main concern or interest is 'getting a job' or 'entering a school of higher grade' Also they answered that the reason to enter the university is to find more prospective Job and want to take coundeling service on 'getting a job' or 'entering a school of higher grade'. Thus, to meet their needs, it needs to increase the opportunity to take psychological test, career guidance and counseling with close cooperation with other related university offices. 2. It needs to increase the opportunities of oversea training for students. Most of the students had a positive image on the oversea training and these experience is directly related with students' competitiveness in job markets. Thus, it needs to take supportive steps to collect sufficient fund for the oversea training. 3. It needs to support students who want to be a public official or teacher. Most of the students preferred to be a public officer or teachers, so that the university should take some measures to support these students. 4. The current strategy for university advertisement should be reappraised. Cheju National University holds several expositions for highschool graduates to advertise the university, but it revealed that these expositions are not effective because many students replied that they found useful information through university's homepage, highschool teachers. Thus, the university should change current strategy based on exposition for highschool students and make more effective plans for advertising departments and the university. 5. The university should take some measures to increase students' pride which is related to the university. 52.8% of the students replied that they are proud of the university, but 43.4% of the students replied that they are not. Finally, the university collect data only from freshmen, and results from these data analysis have some limitation to understand all students in the university. Thus, to get more accurate information and to make more effective decision making, the survey should extended to all students in the university.

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

"이순신" 멀티미디어 정보 시스템 설계 및 구현

이혜정,박원환,박두순 순천향대학교 부설 산업기술연구소 2000 순천향 산업기술연구소논문집 Vol.6 No.1

The purpose of this paper is service system development which enables to carry out the mission of preserving worldwide Korean cultural relics, internationally to contact the informations about our country's cultural relics on the Cyber space, to make atmosphere that makes it possible to appreciate them, and to provide information service by performing mutimedia service which is related to Soon-sin Lee using Virual Reality. For that, creating Virtual Reality information and Video Informaion which is related to Soon-sin Lee, especially Gubooksun by using Virtual Reality technique, 3-Degree image manufacture technique, animation manufacture technique, video manufacture and service technique and Internet/Web technique, and then manufacturing and storing them in the digital data type, and carry out Information Service through connecting the system of serving these informations with the Information SuperHighway

분산 Model의 해석적 비교에 관한 연구

朴慶愛,鄭一鉉,姜斗煥 단국대학교 대학원 1984 學術論叢 Vol.8 No.-

Estimates of dispersion coefficients in flowing fluids may be made from measurements of the step response of this system and comparisons of the experimental output concentration with the concentration calculated from theoretical consideration. Comparisons of theoretical and experimental concentration in the time domain and in the Laplace transform domain are considered. When the outlet signal was calculated by the method of moments, an accurate value of the dispersion coefficient could not be found when dispersion was small because of the effect of errors in the tails of the response. It is found that good estimates of dispersion coefficients can be made from comparisons in the Laplace transform the appropriate ranges of transform parameters are chosen for the comparisons. The optimum weighting factors are defined as those which give the most reliable parameter estimated from the experimental data. The application of the weighted moments method of parameter estimation to typical models in R.T.D. work has been considered, and it has been found superior the to variance method. The relation of this method to other methods has been demonstrated, and a physical interpretation of the method, which provides insight into the optimum choice of the weighting factor, is given. This work took advantage of the step response method that was not affected by the fluid flow in the tracer injection method. So, we were looking for the character of the axial dispersion and the accurate axial dispersion coefficient D_L in fixed bed. The result showed that axial dispersion coefficient D_L was related liearly to superficial velocity and particle diameter, respectively. The equation for the axial dispersion coefficient in the liquid fixed bed is expressed as D_L=0.698U_5^0.532dp^0.643.

리튬이 도핑된 막을 이용한 실리콘-실리콘 접합

정지원,주병권,최우범,정성재,이남양,최두진,오명환 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

Silicon-to-silicon anodic bonding was accomplished using lithium doped interlayer. Lithium doped interlayers were deposited on silicon substrates by electron beam evaporation, which has a fast deposition rate compared with sputtering method. Silicon-to-silicon bonding occurs in the range of temperatures from 250℃ to 300℃ with the applied voltages from 70V_(DC) to 100V_(DC). The bonding strength obtained from tensile test was about 5MPa under the condition of 80V_(DC) in 300℃. The surface morphology of lithium doped interlayer was studied with the atomic force microscopy (AFM). Finally, secondary ion mass spectroscopy (SIMS) analysis was carried out in order to investigate the role of the lithium ions in bonding mechanism.

Bis(triphenylphosphine) copper(1) tetrahydroborate에 의한 4-Bromophenyacetylchloride의 환원반응

조성동,김두화,박정환,김인경,조재흥 조선대학교 기초과학연구소 1991 自然科學硏究 Vol.14 No.1

4-Bromophenylacetylchroride was reduced to 4-bromophenylacetaldehyde in good yield by bis(triphenylhosphine) copper(1) tetrahydroborate.

Carbosulfan의 피부자극성, 안점막 자극성 및 피부감작성등의 알러지성 효과에 관한 연구

이상훈,이동연,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Many studies have been published on the human health effects of carbosulfan toxicity. Carbosulfan used as an insecticide can produce an irritating and allergenic effect when acting on the skin. In this study, a sensitization test on albino guinea pigs and intradermal reactivity and occular irritation test on albino rabbits were carried out with carbosulfan. Signs of acute skin inflammation appeared along with the clinical symptom of chronic dermatosis caused by the solution irritating characteristics. Moreover, carbosulfan showed severe eye irritation with conjuctival redness and severe opacity on cornea. Preventive measures should involve workers' obligatory instructions on the noxious impact on human skin and strict observance of industrial safety rules.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

신규개발된 제초제 metamifop 현탁농축액제에 대한 급성독성평가

이동연,이상훈,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Metamifop, (R)-2-[4-[(6-chloro-2-benzoxazolyloxyphenoxy]-N-(2-fluorophenyl)-N-methyl propanamide, was newly developed by Dongbu Hannong Chemicals in Korea. In the present study we conducted acute oral toxicity and acute dermal toxicity test. The values of LD_(50) of metamifop was found to be over 5,000 mg/kg for ICR mice. On the other hand, metamifop showed no acute dermal toxicity to SD rats.

Pyriminobac-methyl과 azimsulfuron 합제의 신규제형인 분산형 정제에 대한 독성 평가

백경진,이동연,이상훈,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Dispersible tablets disintegrate either to form a stabilized suspension rapidly in water, or to disperse instantaneously in the rice field without the aid of water. In this study, the newly formulated dispersible tablet form of herbicidal combination, pyriminobac-methyl and azimsulfuron, was evaluated the safety for human and animals in the toxicological viewpoints. The LD_(50) value of dispersible tablet form for pyriminobac-methyl and azimsulfuron was above 2,500 mg/kg for the oral route and above 2,000 mg/kg for the dermal route. It is considered to have low acute oral and dermal toxicity based on the findings of the present studies. In addition, the combination of pyriminobac-methyl and azimsulfuron showed mild skin irritant under the conditions of this study and conjunctival redness and slight opacity on cornea appeared from 1 hour after application.