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Hurh, Joon,Markus, Josua,Kim, Yeon-Ju,Ahn, Sungeun,Castro-Aceituno, Veronica,Mathiyalagan, Ramya,Kim, Yu Jin,Yang, Deok Chun KLUWER 2017 JOURNAL OF NANOPARTICLE RESEARCH Vol. No.
<P>Gold nanoparticles (GNPs) are forecasted to provide an attractive platform in biomedicine and catalysis with their potentials of combining a variety of biophysicochemical properties into an integrated nanodevice with great therapeutic and optical functions. There are several reports of crude plant extracts mediating the conversion of metal ions into nanoparticles. However, we aimed to investigate the capability of single bioactive compounds, namely ginsenosides compound K (C-K) and Rh2, to accommodate a synergistic chemical reduction of gold salts by one-pot green chemistry. Ginsenosides C-K and Rh2 are unique triterpenoid saponins present in Panax ginseng Meyer, a perennial plant traditionally used as an oriental medicinal herbal with long history. C-K and Rh2 have demonstrated diverse pharmacological properties such as anticancer, anti-inflammation, anti-aging, and neuroprotective properties. The reduction of gold ions by these ginsenosides led to the production of nontoxic GNPs as tested in mousemacrophage (J774A. 1) and human kidney epithelial (HEK-293) in vitro. The kinetics of the bioreduction and the influence of pH were examined by an ultraviolet-visible (UV-Vis) spectrophotometer. GNPs were characterized by field emission transmission electron microscopy (FE-TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and Fourier transform infrared (FTIR) spectroscopy. Ginsenoside loading efficiency of C-K-GNPs and Rh2-GNPs was determined to be approximately 62.83% and 54.91%, respectively, by thermogravimetric analysis (TGA). These results suggest that onepot synthesis by ginsenosides C-K and Rh2may be useful for producing ginsenoside-loaded gold nanocarriers.</P>
Kim Min Ju,Hurh Joon,Kim Ha-Rim,Lee Sang-Wang,Sin Hong-Sig,Kim Sang-Jun,Noh Eun-mi,Oh Boung-Jun,Kim Seon-Young 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.4
This study confirmed the change in functional composition and alcohol-induced acute liver injury in Aloe arborescens after fermentation. An acute liver injury was induced by administration of ethanol (3 g/kg/day) to C57BL/6J mice for 5 days. A fermented A. arborescens Miller leaf (FAAL) extract was orally administered 30 minutes before ethanol treatment. After fermentation, the emodin content was approximately 13 times higher than that of the raw material. FAAL extract significantly attenuated ethanol-induced aspartate aminotransferase, alanine aminotransferase, and triglyceride increases in serum and liver tissue. Histological analysis revealed that FAAL extract inhibits inflammatory cell infiltration and fat accumulation in liver tissues. The cytochrome P450 2E1, superoxide dismutase, and glutathione (GSH), which involved in alcohol-induced oxidative stress, were effectively regulated by FAAL extract in serum and liver tissues, except for GSH. FAAL also maintained the antioxidant defense system by upregulating heme oxygenase 1 and nuclear factor erythroid 2-related factor 2 protein expression. In addition, FAAL extract inhibited the decrease in alcohol dehydrogenase and aldehyde dehydrogenase activity, which promoted alcohol metabolism and prevented the activation of inflammatory response. Our results suggest that FAAL could be used as a potential therapeutic agent for ethanol-induced acute liver injury.
새로운 Anthraquinone 유도체, DHAQ-97의 항암작용: 아폽토시스에 의한 인체 유방암세포 사멸 유도
허연진(Yeon-Jin Hurh),김정환(Jung-Hwan Kim),장정희(Jung-Hee Jang),안병준(Byung-Zun Ahn),서영준(Young-Joon Surh) 한국환경성돌연변이발암원학회 2000 한국환경성돌연변이·발암원학회지 Vol.20 No.1
DHAQ-97, (2-(3-[p-bis(2-chloroethyl)aminophenyl]-2-formylaminopropanoyloxy)methyl-1,4-dihydroxy-9,10-anthraquinone), is a novel anthraquinone derivative synthesized for use as an anti-neoplastic agent. In the present study, we have evaluated the selective cytotoxicity of DHAQ-97 by comparing its effects on viability and proliferation of human breast cancer cell line (MCF-7) versus normal immortalized breast epithelial cell line (MCF-10A). Thus, DHAQ-97 reduced both viability and proliferation of MCF-7 cells to a much greater extent than did for MCF-10A cells. The growth inhibitory and anti-proliferative properties of DHAQ-97 appear to be attributable to its ability to induce apoptosis as revealed by positive staining after in situ nick-end labeling<br/> (TUNEL), cleavage of poly(ADP-ribose)polymerase, release of mitochondrial cytochrome c into cytoplasm, and increased expression of pro-apoptotic Bax protein. Recent studies have indicated possible involvement of the ubiquitous eukaryotic transcription factor, NF-kappa B (NF-kB) in the regulation of apoptotic cell death. In line with this notion, the NF-kB inhibitor pyrrolidine dithiocarbamate significantly attenuated the DHAQ-97-induced cytotoxicity in cultured MCF-7 cells. Furthermore, mild activation of NF-kB, as determined by its increased DNA binding capability, was observed 30 min after treatment with 10 μM DHAQ-97. Taken together, the above findings suggest that DHAQ-97 exerts selective cytotoxicity towards cancer cells through induction of<br/> apoptosis, which appears to be regulated by NF-kB.
Lysobacter panacihumi sp. nov., isolated from ginseng cultivated soil
HUO YUE,강종표,Joon Hurh,Yaxi Han,안종찬,MATHIYALAGANRAMYA,Chunhong Piao,양덕춘 한국미생물학회 2018 The journal of microbiology Vol.56 No.10
A Gram-negative, non-motile, aerobic, catalase-, and oxidasepositive bacterial strain, designated DCY117T, was isolated from ginseng cultivated soil in Gochang-gun, Republic of Korea, and was characterized taxonomically using a multifaceted approach. 16S rRNA gene sequence analysis revealed that strain DCY117T showed highest similarity to Lysobacter ruishenii CTN-1T (95.3%). Phylogenetic analysis revealed that closely related relatives of strain DCY117T were L. aestuarii S2-CT (95.1%), L. daejeonensis GH1-9T (95.0%), and L. caeni BUT-8T (94.9%). Diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE) were the major polar lipids of strain DCY117T. The major isoprenoid quinone was Q-8. The major cellular fatty acids of strain DCY117T were iso-C15:0, iso-C16:0, and summed feature 9 (comprising iso-C17:1 ω9c and/or 10-methyl-C16:0). Genomic DNA G + C content was 61.8 mol%. On the basis of our findings, strain DCY117T is a novel species in the genus Lysobacter. We propose the name Lysobacter panacihumi sp. nov., and the type strain is DCY117T (= KCTC 62019T = JCM 32168T).
Li, Jin Feng,Rupa, Esrat Jahan,Hurh, Joon,Huo, Yue,Chen, Ling,Han, Yaxi,Ahn, Jong chan,Park, Jin Kyu,Lee, Hyun A.,Mathiyalagan, Ramya,Yang, Deok-Chun Elsevier 2019 Optik Vol.183 No.-
<P><B>Abstract</B></P> <P>Zinc Oxide nanoparticles were synthesized via co precipitation methods from <I>Cordyceps militaris</I> fungus. In this method zinc nitrate hex- hydrate were used as a precursor. The Synthesized nanoparticles were characterized through different analytical method for identification of morphology, size, crystallinity and also purity. The nanoparticles gave highest peak at 350 in Uv–vis spectroscopy which confirmed the formation of <I>Cordyceps</I> zinc oxide nanoparticles. The Field emission transmission electron microscopy (FE-TEM) analyzed the morphology, purity and elemental distribution of the nanoparticles. The X-ray powder diffraction (XRD) study explored the size is about 10.15 nm. Finally, the functional group of plant and nanoparticles were identified using FT-IR analyzer. The <I>Cordyceps militaris</I> zinc oxide nanoparticles have ability to degrade hazardous dye Methylene blue about 97% in the presence of Uv-radiation. So this study emphasizes that the <I>Cordyceps militaris</I> zinc oxide nanoparticles can be the best photo catalyst for the safety of our environment from dangerous water pollution.</P>
한국 현대음악에 나타난 전통음악적 요소에 대한 분류연구 및 현대적 음향군이론 정립
권순호(Soon Ho Kwon),최승준(Seung Joon Choi),허방자(Bang Ja Hurh),여영환(Young Hwan Yoe),정지영(Ji young Jung),권오연(Oh Yeon Kwon),이혜영(Hye Young Lee),김지민(Ji Min Kim) 낭만음악사 2007 낭만음악 Vol.19 No.4
한국의 현대음악은 서양음악의 수용 이래로 다양하게 발전되어 왔다. 초기 수용의 단계에는 이론적인 수용과 철학적이고 정서적인 면이 강조 된 작품들이 성악곡들을 중심으로 발전 되었고 1950년대 이후에는 수용을 넘어 진정한 현대적 의미의 음악들이 적극적으로 창작 되어 왔다. 한국의 현대 음악은 조성의 부정과 전통적인 정서가 함께 공존하여 발전 하는 형태가 나타난 시기가 바로 1950년대라고 할 수 있다. 김동진의 ‘신창악 운동’을 시작으로 라운영의 ‘한국민족음악의 정립과 토착화,’ 이건용과 제3세대 작곡가들의 ‘민족음악론’ 등 작곡가들의 노력과 가치있는 결실로 오늘날 창작 음악계는 많은 발전을 가져 왔다. 특별히, 1980년대와 1990년대 이후 서양 음악적 소재를 사용하더라도 주체적이고 독창적인 음악관을 가지고 한국의 정체성을 창작 작품에 담아내는 많은 작품들을 작곡하였다. 한국적 정체성을 담을 많은 창작 작품들은 한국의 전통 음악적 소재를 인용 또는 변화 발전 시켜 도입하는 경향을 가진다. 특히 본청-하청의 선율구조는 중심음-상대음의 구조로 발전 되어 한국적 색채감을 드러내고 있으며 5음 음계 구조에서 가장 많이 나타나는 장2도와 완전4도의 화성 구조를 다양한 음악적 배경 속에 도입하고 있다. 리듬에 있어서도 고유한 장단의 사용과 함께 한국적 이미지를 담은 다채로운 리듬형태를 창조하였고 또한, 한국 특유의 즉흥적인 연주의 리듬 또한 창작 음악의 주요한 소재로 사용되었다. 이러한 공통적인 요소들을 중심으로 한국 창작 음악을 논리적으로 해석하고 분석하고자 현대음악이론에 입각한 실제적인 이론화를 시도하였다. 이런 이론화는 실제적으로 창작 활동을 하는 음악가들에게 일반적인 이론 체계로 접근하여 기법화를 실현 시킬 수 있다는 목적을 가지며 또한 많은 이론가들과 음악학자들에게는 창작 작품들이 가지는 예술적 측면뿐만 아니라 음악이 가지는 새로운 학술적 측면을 제시 할 수 있다는 가치를 가진다. Korean contemporary music has been developed from variously musical points of views, since the acceptance of Western music in the late 19th century. In the its early stages of the acceptance, music compositions in Korea took just the theory of Western music and are usually focused on vocal works which are emphasized on emotional and philosophical senses. In the 1950s, there are many compositions composed in the genuine and modern sense beyond simple uses of Western music theory. In the 1950s, it is the time to evolve and coexist both creative contemporary music which got into atonal music and original traditional Korean music. There are many composers and movements of music such as ‘Shin-Changak Movement’ by Dong-Jin Kim, ‘The establishment and nativization of Korean nationalism’ by Yun-Young La, ‘Nationalism Music’ by Gun-Yong Lee and the third generations. They played an important role to make Korean music developed. In particular, between 1980s and 1990s, although most of composers employed various of compositional techniques from Western music, their works based on creative and independent identity. At the research on the actual condition about applications and performances of Korean contemporary music at the concert hall, many works are performed at the public concerts and they are not limited to academic values any more. Performances of Korean contemporary music are getting increased through statistical researches of performances and programs of the major concerts in Seoul and five etropolitan cities between 2000 and 2005 even though a few metropolitan cities still have not enough concerts for contemporary music. The Korean identity of comtemporary music are very important to Korean composers in the 1980s and 1990s. Therefore they have been tried to quote and develop variously Korean traditional music in their works. Especially the melodic structure of the center tone-relative tone derived form the melodic structure of Bon-Chong and Ha-Chong in the Korean traditional music. The important intervals, the perfect 4th and the major 2nd in pentatonic scale which is a primary musical materials in Korean traditional music, became the main material to construct harmony structure. Jangdan is also very important materials from the rhythmic point of view and composers variated the Jangdan in many ways and besides that composers tried to create Korean traditional rhythms based on the improvisations of Korean music. These common facts in music can be established as a compositional theory. This kind of experiment produce a lot of possibilities for both composers and theorists. Practically, this theorization is to get a analytical tool for many kinds of music based on Koran contemporary music. In addition to this, it can be developed as a compositional techniques to express Korean traditional sense of music. Therefore, this kind of attempt has academic value as well as artistic value.