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Mathiyalagan, Ramya,Subramaniyam, Sathiyamoorthy,Kim, Yeon Ju,Natarajan, Sathishkumar,Min, Jin Woo,Kim, Se Young,Yang, Deok Chun Japan Society for Bioscience, Biotechnology, and A 2014 Bioscience, Biotechnology, and Biochemistry Vol.78 No.3
<P>The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.</P>
Insilico profiling of microRNAs in Korean ginseng (Panax ginseng Meyer)
Mathiyalagan, Ramya,Subramaniyam, Sathiyamoorthy,Natarajan, Sathishkumar,Kim, Yeon Ju,Sun, Myung Suk,Kim, Se Young,Kim, Yu-Jin,Yang, Deok Chun The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.2
MicroRNAs (miRNAs) are a class of recently discovered non-coding small RNA molecules, on average approximately 21 nucleotides in length, which underlie numerous important biological roles in gene regulation in various organisms. The miRNA database (release 18) has 18,226 miRNAs, which have been deposited from different species. Although miRNAs have been identified and validated in many plant species, no studies have been reported on discovering miRNAs in Panax ginseng Meyer, which is a traditionally known medicinal plant in oriental medicine, also known as Korean ginseng. It has triterpene ginseng saponins called ginsenosides, which are responsible for its various pharmacological activities. Predicting conserved miRNAs by homology-based analysis with available expressed sequence tag (EST) sequences can be powerful, if the species lacks whole genome sequence information. In this study by using the EST based computational approach, 69 conserved miRNAs belonging to 44 miRNA families were identified in Korean ginseng. The digital gene expression patterns of predicted conserved miRNAs were analyzed by deep sequencing using small RNA sequences of flower buds, leaves, and lateral roots. We have found that many of the identified miRNAs showed tissue specific expressions. Using the insilico method, 346 potential targets were identified for the predicted 69 conserved miRNAs by searching the ginseng EST database, and the predicted targets were mainly involved in secondary metabolic processes, responses to biotic and abiotic stress, and transcription regulator activities, as well as a variety of other metabolic processes.
Till 2018: a survey of biomolecular sequences in genus Panax
Vinothini Boopathi,Sathiyamoorthy Subramaniyam,MATHIYALAGANRAMYA,Deok-Chun Yang 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.1
Ginseng is popularly known to be the king of ancient medicines and is used widely in most of thetraditional medicinal compositions due to its various pharmaceutical properties. Numerous studies arebeing focused on this plant’s curative effects to discover their potential health benefits in most humandiseases, including cancerd the most life-threatening disease worldwide. Modern pharmacologicalresearch has focused mainly on ginsenosides, the major bioactive compounds of ginseng, because of theirmultiple therapeutic applications. Various issues on ginseng plant development, physiological processes,and agricultural issues have also been studied widely through state-of-the-art, high-throughputsequencing technologies. Since the beginning of the 21st century, the number of publications on ginsenghas rapidly increased, with a recent count of more than 6,000 articles and reviews focusing notably onginseng. Owing to the implementation of various technologies and continuous efforts, the ginseng plantgenomes have been decoded effectively in recent years. Therefore, this review focuses mainly on thecellular biomolecular sequences in ginseng plants from the perspective of the central molecular dogma,with an emphasis on genomes, transcriptomes, and proteomes, together with a few other related studies.
Lysobacter panacihumi sp. nov., isolated from ginseng cultivated soil
HUO YUE,강종표,Joon Hurh,Yaxi Han,안종찬,MATHIYALAGANRAMYA,Chunhong Piao,양덕춘 한국미생물학회 2018 The journal of microbiology Vol.56 No.10
A Gram-negative, non-motile, aerobic, catalase-, and oxidasepositive bacterial strain, designated DCY117T, was isolated from ginseng cultivated soil in Gochang-gun, Republic of Korea, and was characterized taxonomically using a multifaceted approach. 16S rRNA gene sequence analysis revealed that strain DCY117T showed highest similarity to Lysobacter ruishenii CTN-1T (95.3%). Phylogenetic analysis revealed that closely related relatives of strain DCY117T were L. aestuarii S2-CT (95.1%), L. daejeonensis GH1-9T (95.0%), and L. caeni BUT-8T (94.9%). Diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE) were the major polar lipids of strain DCY117T. The major isoprenoid quinone was Q-8. The major cellular fatty acids of strain DCY117T were iso-C15:0, iso-C16:0, and summed feature 9 (comprising iso-C17:1 ω9c and/or 10-methyl-C16:0). Genomic DNA G + C content was 61.8 mol%. On the basis of our findings, strain DCY117T is a novel species in the genus Lysobacter. We propose the name Lysobacter panacihumi sp. nov., and the type strain is DCY117T (= KCTC 62019T = JCM 32168T).