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Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.
Semiparametric estimation methods for the accelerated failure time mixture cure model
Jiajia Zhang,Yingwei Peng 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
This paper provides an overview of two semiparametric estimation methods recently proposed in the literature for the accelerated failure time mixture cure model. We prove that the two estimation methods are asymptotically equivalent. A simulation is conducted to investigate the rate of convergence of the two methods. We apply these methods to fit the accelerated failure time mixture cure model to the survival times of leukemia patients receiving bone marrow transplantation.
Research on the rheological properties of a silicone oil-based ferrofluid
Zhang Jiajia,Cui Hongchao,Han Shida,Li Zhenkun,Lu Jingjing 한국유변학회 2023 Korea-Australia rheology journal Vol.35 No.3
To study the overall rheological characteristics of the silicone oil-based ferrofluid, a chemical co-precipitation method was adopted for preparation, and transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used for characterization. The average size of Fe3O4 magnetic particles was 10.4 nm and the saturation magnetization of the ferrofluid was 5.98 emu/g. Then, the fluidity, magnetoviscous effect and viscoelasticity of the ferrofluid were studied using a rotational rheometer. The results showed obvious shear thinning of the silicone oil-based ferrofluid under an external magnetic field, and the yield stress of the ferrofluid could not be accurately obtained by fitting the flow curve with an H–B model at a continuous shear rate. A strong magnetoviscous effect could be observed at different shear rates and temperatures. The magnetoviscous parameter R increased with the increase of temperature and its variation decreased with the increase of shear rate. Moreover, based on the magnetic particle chain model and the viscosity–temperature characteristics of the base carrier liquid, different mechanisms of temperature influence on the magnetoviscous effect were analyzed. Finally, a discussion of the microstructure evolution mechanism of the ferrofluid in the modulus changing with frequency was presented through the viscoelastic analysis of the silicone oil-based ferrofluid.
Semiparametric estimation methods for the accelerated failure time mixture cure model
Zhang, Jiajia,Peng, Yingwei 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3
This paper provides an overview of two semiparametric estimation methods recently proposed in the literature for the accelerated failure time mixture cure model. We prove that the two estimation methods are asymptotically equivalent. A simulation is conducted to investigate the rate of convergence of the two methods. We apply these methods to fit the accelerated failure time mixture cure model to the survival times of leukemia patients receiving bone marrow transplantation.
Welding Performance of Low-Yield-Strength Steel Shear Panel Dampers Under Large Plastic Deformation
Chaofeng Zhang,Shixi Chen,Junhua Zhao,Xuchuan Lin,Lingxin Zhang,Jiajia Zhu,Weili Wang 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.6
Characterized by large plastic deformation and energy-dissipation capacity, low-yield-strength steel shear panel dampers (LYSPDs) are widely used as energy-dissipating members in seismic engineering. However, the eff ect of welding on the properties of LYSPDs remains unclear. Hence, in this study, we investigated the matching performance between low-yieldstrength steel (LYS) and two diff erent welding materials. Subsequently, the quality of welding between LYS and dissimilar metals was investigated. Furthermore, the fracture characteristics of the welding seam of LYS under large plastic deformation were explored. Finally, the welding performance of LYSPDs under large plastic deformation was verifi ed under cyclic loading. The results of this study are signifi cant in terms of the eff ect of welding on the properties of LYSPDs.
Jiajia Pei,Zhi Wang,Yu Gao,Haoming Zhang 한국물리학회 2019 Current Applied Physics Vol.19 No.4
A series of Mo doped Ni-Mn-Zn ferrites compounds with the formula Ni0.5Zn0.5Mn0.5-xMoxFe1.5O4 (x=0, 0.025, 0.05, 0.075 and 0.1) were first synthesized by sol-gel auto-combustion method. The X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM) analysis were carried out to characterize the microstructural and magnetic properties of ferrites. Rietveld refinement of X-ray diffraction data confirmed the formation of cubic spinel structure and the emergence of FeMoO4 phase with the substitution of Mo6+ contents. The grain size increased remarkably due to the formation of the liquid phase. The saturation magnetization (Ms) increased while the coercivity (Hc) decreased from 67.3 to 12.1 Oe due to the decrease of magneto-crystalline anisotropy constant. The initial permeability (μi) increased significantly from 34 (x=0) to 114 (x=0.075) and later decreased for x=0.1. In our experiment, Ni0.5Zn0.5Mn0.425Mo0.075Fe1.5O4 ferrite presented the best microstructure and soft magnetic properties.
Jiajia Bi,Xianlu Zeng,Ruifei Wang,Yue Zhang,Xiaoqing Han,Khamal Kwesi Ampah,Wenguang Liu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.6
Lipid rafts are related to cell surface receptor function. Integrin is a major surface receptor protein in cell adhesion and migration on the extracellular matrix (ECM). Here, we showed that lipid rafts played a critical role in human melanoma A375 cell spreading and migration on fibronectin; an important component of the ECM that interacts with 1 integrin. We found that the disruption of lipid rafts did not markedly inhibit the expression and activation of 1 integrin. By coimmunoprecipitation and mass spectrometry, we investigated the influence of lipid rafts on the 1 integrin complex and identified nucleolin as a potential lipid-raft-dependent 1-integrin-interacting protein. Upon confirmation of the interaction between 1 integrin and nucleolin, further studies revealed that nucleolin colocalized with 1 integrin in lipid rafts and raft disruption interrupted their association. In addition, knockdown of nucle-olin markedly attenuated A375 cell spreading and migration on fibronectin. Taken together, we demonstrated that nucleolin is a critical lipid-raft-dependent 1-integrin-inte-racting protein in A375 cell spreading and migration on fibronectin.
Hydroxide MgSn(OH)6: A Promising New Photocatalyst for Methyl Orange Degradation
Jiajia Tao,Zhaoqi Sun,Miao Zhang,Gang He,Xiaoshuang Chen 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.4
Highly crystalline hydroxide MgSn(OH)6 (MHS) polyhedral particleswere synthesized by changing reaction time (10, 15 and 20 h) in ahydrothermal process. The structural and morphological poperties ofobtained samples were characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM), and UV-vis diffuse reflectancespectroscopy (DRS). The photocatalytic activity of the MHS wasfurther evaluated by the degradation of methyl orange (MO) underultraviolet (UV) light illumination. Compared with commercial TiO2(Degussa P25), the MHS prepared for 15 h showed similar degradationefficiency of methyl orange (MO), mainly due to its higher specificsurface area (55 m2g−1) and better optical properties.