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Ning, Fangkun,Wang, Chao,Berry, Karin Zemski,Kandasamy, Pitchaimani,Liu, Haolin,Murphy, Robert C.,Voelker, Dennis R.,Nho, Chu Won,Pan, Choel-Ho,Dai, Shaodong,Niu, Liwen,Chu, Hong-Wei,Zhang, Gongyi The Federation of American Societies for Experimen 2014 The FASEB Journal Vol.28 No.12
<P>The short palate, lung and nasal epithelial clone 1 (SPLUNC1) protein is a member of the palate, lung, and nasal epithelium clone (PLUNC) family, also known as bactericidal/permeability-increasing (BPI) fold-containing protein, family A, member 1 (BPIFA1). SPLUNC1 is an abundant protein in human airways, but its function remains poorly understood. The lipid ligands of SPLUNC1 as well as other PLUNC family members are largely unknown, although some reports provide evidence that lipopolysaccharide (LPS) could be a lipid ligand. Unlike previous hypotheses, we found significant structural differences between SPLUNC1 and BPI. Recombinant SPLUNC1 produced in HEK 293 cells harbored several molecular species of sphingomyelin and phosphatidylcholine as its ligands. Significantly, <I>in vitro</I> lipid-binding studies failed to demonstrate interactions between SPLUNC1 and LPS, lipoteichoic acid, or polymyxin B. Instead, one of the major and most important pulmonary surfactant phospholipids, dipalmitoylphosphatidylcholine (DPPC), bound to SPLUNC1 with high affinity and specificity. We found that SPLUNC1 could be the first protein receptor for DPPC. These discoveries provide insight into the specific determinants governing the interaction between SPLUNC1 and lipids and also shed light on novel functions that SPLUNC1 and other PLUNC family members perform in host defense.—Ning, F., Wang, C., Berry, K. Z., Kandasamy, P., Liu, H., Murphy, R. C., Voelker, D. R., Nho, C. W., Pan, C.-H., Dai, S., Niu, L., Chu, H.-W., Zhang, G. Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands.</P>
Studies on the Soybean Cyst Nematode (Heterodera glycines) in China
Liu, Wei-Zhi,Liu, Ye,Duan, Yu-Xi,Hong, Quan-Chun,Wang, Ke-Ning Korean Society of Applied Entomology 1995 한국응용곤충학회지 Vol.34 No.2
Soybean has been cultivated in China for 5,000 years. The soybean cyst neamtode (SCN), Heterodra glycines, was recongnized in Northeastern China in 1899. Currently, it is known to occur in 12 provinces. The biology of SCN was investigated in several provinces. Six races of SCN were identified (race 1, 2, 3, 4, 5 and 7). About f10,000 soybean germplasm lines were evaluated for their resistance to race 1, 3, 4 and 5 of SCN. At least two black-seeded cultivars are resistant to all four races. Several tolerant soybean cultivars with yellow seed coat were released and are in production. Additional resistant cultivars are being developed. Nematicides were not applied in production Potential biocontrol agents and related aspects are being investigated.
Ning Liu,Kun Chen,Piao Jiang,Yi-Xiong Huang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.3
At present, most dust reduction methods do not consider the difference of dust particle diameter distribution along the tunnel and the applicability of droplet group under different parameters. In order to improve the dust reduction efficiency of each section, the particle size analyzer was used to analyze the dust samples of each section along the tunnel, and the migration law of dust of each particle diameter during the construction of Tunnel Boring Machine (TBM) was studied. The dust falling efficiency of droplets with different particle diameter under different sets of parameters was determined by the experimental platform built by ourselves. Research indicates: along the axis of tunnel, the farther away from the face of the tunnel, the higher the peak volume frequency of dust, and the distribution range of dust gradually narrowed to the direction of small particle diameter. The settling distance of dust with different particle diameter is quite different, and the content of small particle diameter dust shows an upward trend as a whole. The reduction efficiency of dust first increases and then decreases with the particle diameter, and there is particle diameter of the optimum dust reduction efficiency under the action of the same droplet group. The calculation formula of the air and water flow of the air-water nozzle and the particle diameter of the optimum dust reduction efficiency are put forward. This research can provide basis and guidance for multi-stage dust reduction and nozzle parameter setting in different sections of the tunnel.
Ning Liu,Y. F. Zhang,Wen Feng Lu 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.2
Improving energy efficiency has been one of main objectives in modern manufacturing enterprises. Various approaches aiming at efficient energy management have been proposed/developed, among which minimizing energy consumption by energy-sensible production scheduling techniques has emerged as a promising one. However, reported workshop models are quite simple and unrealistic. This paper studies a more realistic workshop model called ultra-flexible job shop (uFJS). In an uFJS, the sequence among operations for a job can be changed within certain constraints. To formulate this energy-efficient scheduling problem, a mixed-integer linear programming model was developed. To deal with large-sized problems, a specially designed genetic algorithm (GA) was subsequently proposed and implemented. Numerical results showed the proposed GA worked with decent effectiveness and efficiency. Finally, several comparative studies are carried out to further demonstrate its efficacy in terms of energy efficiency improvement. The advantage of the uFJS as compared to other relative simple workshop models is also shown. By considering the flexibility in operation sequencing in each job, the uFJS effectively integrates process planning and scheduling in discrete parts manufacturing system, thus providing a much larger solution space for more energy-efficient solutions. It therefore provides an excellent platform for decision-makers when developing energy-efficient techniques and strategies
750 GeV diphoton resonance in a vector-like extension of Hill model at a 100 TeV hadron collider
Liu, Ning,Wang, Wenyu,Zhang, Mengchao,Zheng, Rui World Scientific 2016 International Journal of Modern Physics A Vol.31 No.25
<P> In this paper, we study the recent 750 GeV diphoton excess in the Hill model with vector-like fermions. The singlet-like Hill boson is chosen as the 750 GeV diphoton resonance. Such a scalar is mainly produced by gluon fusion via vector-like top and bottom quark loops and decays to diphoton via the vector-like quark and lepton loops. Under the current experimental and theoretical constraints, we find that the mixing angle of the singlet and doublet Higgs bosons lies within [Formula: see text] and the 750 GeV diphoton cross-section can be maximally enhanced to about 6 fb at 13 TeV LHC. Moreover, we find that the Hill boson pair production in [Formula: see text] channel can be probed at [Formula: see text] significance if [Formula: see text] and [Formula: see text] at a 100 TeV collider with 3000 fb[Formula: see text] luminosity. </P>
p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid
Liu, Jia,Wu, Ning,Ma, Lei-Na,Zhong, Jia-Teng,Liu, Ge,Zheng, Lan-Hong,Lin, Xiu-Kun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, it is still unclear that what molecular signaling is responsible for this effect. In this study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the molecular mechanisms underlying OA anti-tumor activity. We found that activation of MAPK pathways, including p-38 MAPK, JNK and ERK, was triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. Activation was accompanied by cleavage of caspases and PARP as well as cytochrome C release. SB203580 (p38 MAPK inhibitor), but not SP600125 (JNK inhibitor) and U0126 (ERK inhibitor), rescued the pro-apoptotic effect of OA on A549 and BXPC-3 cells. OA induced p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibited Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event was indispensable for p38 MAPK-dependent apoptosis in cancer cells. In vivo, p38 MAPK knockdown A549 tumors proved resistant to the growth-inhibitory effect of OA. Collectively, we elucidated that activation of ROS/ASK1/p38 MAPK pathways is responsible for the apoptosis stimulated by OA in cancer cells. Our finding can contribute to a better understanding of molecular mechanisms underlying the antitumor activity of nutritional components.
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Liu, Ning 성균관대학교 동아시아학술원 2002 Sungkyun Journal of East Asian Studies Vol.2 No.1
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