High fluence 1064-nm Q-Switched Nd:YAG laser : safe and effective treatment of cafe-au-lait macules in Asian patients

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Cafe-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Objectives: To investigate the efficacy and safety of a high fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients. Methods: The medical records of thirty-five Korean patients (age range: 1 to 40 years old, mean age : 18.5 years) diagnosed with isolated CALMs were reviewed retrospectively. The patients were treated with a 1064-nm Q-switched Nd:YAG laser. The parameters were a spot size of 7 mm, a fluence of 2.2-2.4 J/cm2 with a slow single sliding-stacking pass, and a pulse rate of 10Hz with a one-week interval for 20-50 sessions. Results: At the week of the final treatment, all treated CALMs showed considerable pigmentation removal without any permanent side effects, such as scaring, mottled hypopigmentation, and post-inflammatory hyperpigmentation (PIH). All treated CALMs showed more than 50% clinical improvement. No recurrence was observed in any of the patients after 12 months of follow up. Conclusion: A high fluence 1064-nm Q-switched Nd:YAG laser treatment of CALMs in Asian patients is a safe and effective method without side effects and recurrence.

[P231] Hair collar sign in an infant with aplasia cutis congenita associated with nevus flammeus

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Jinok Baek ),( Hyang Joon Park ),( Joo Young Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Aplasia cutis congenita (ACC) is a heterogeneous group of disorders in which localized or widespread areas of skin are absent at birth. ACC manifests as a solitary defect on the scalp in 70% of cases. Although most commonly seenon the scalp, ACC can affect any part of the body. Although pathogenesis of ACC is still unclear, proposed hypotheses are divided into two categories : endogenous causes (developmental failure, congenital syndromes) and exogenous ones (intrauterine trauma, infarction, skin fissure caused by rapid growth). Hair collar sign is a ring of darker and coarser terminal hairs on the scalp, typically surrounding ACC, dermoid cyst, encephalocele, or meningocele. It has been described as a relatively specific marker of neuroectodermal defect. A 5-month-old boy presented with round bald patches with underlying a large reddish patch on posterior occiput. It was surrounded by a rim of terminal hairs. Hair collar sign can be a specific clue for diagnosing ACC. Pregnancy and the delivery had been unremarkable and the baby wasotherwise healthy. Histopathology of the skin showed flattened epidermis, vascular dilatation in the superficial dermis, thickening of vessel walls in the reticular dermis, and absence of adnexal structures. It is assumed that association of ACC with nevus flammeus is that fetal skin development including capillary network formation might have been affected since cranial tube was not closed properly.

[P300] Two cases of primary cutaneous nocardiosis caused by intralesional injection

( Jeongsoo Kim ),( Seha Park ),( Seul Ki Lee ),( Ha Ryeong Ryu ),( Heejoo Kim ),( Joo Young Roh ),( Hyang Joon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Nocardiosis is a rare localized or systemic suppurative disease caused by several species of bacteria of the genus Nocardia. Nocardia is an aerobic, filamentous gram-positive, partially acid-fast bacteria belonging to the Actinomycetales order and found in soil, decayed organic matter, water, and air worldwide. Cutaneous nocardiosis is an uncommon infectious disease that presents a primary cutaneous infection or as a part of disseminated pulmonary nocardiosis. First case is a 50-year-old woman who had erythematous patches with swelling on her right arm, who had been treated with triamcinolone intralesional injection at the private clinic. Histopathology of the skin showed diffuse lymphohistiocytic infiltration in the dermis and subcutaneous layer. On Gram staining, gram-positive bacilli were seen, and on modified AFB staining, the branching hyphae stained red purple. White colonies were formed on blood agar medium in pus culture. By bacterial culture and rDNA gene sequencing, the causative organism was identified as N. farcinica. Second case is a 34-year-old woman who presented with erythematous patches and tenderness on Lt.arm. She had been also treated with triamcinolone intralesional injection for keloid at the same clinic as the first patient. She was diagnosed with primary cutaneous nocardiosis by pus culture. Herein, we report rare two cases of primary cutaneous norcardiosis after intralesional injection.

Eosinophils play a role in the pathogenesis of psoriasis by stimulating inflammatory cytokine and chemokine production and neutrophil chemotaxis

( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ),( Heejoo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Eosinophilic cytokine profile including IL-23/Th17 axis and their immunomodulatory interaction with other immune cells imply their possible involvement in psoriasis pathogenesis. Objectives: This study was to examine the potential role of eosinophils in imiquimod (IMQ)-induced psoriasiform dermatitis using ΔdblGATA mice, an eosinophil lineage-ablated mouse line. Methods: After topical IMQ application, inflammatory cytokine gene expression and Inflammatory cell populations were analyzed by qRT-PCR and flow cytometry, respectively. Results: Psoriatic features like epidermal thickening, erythema, and scale were less prominent in ΔdblGATA mice after IMQ treatment. Inflammatory cytokines important in psoriasis, like IL-1β, IL-6, IL-22, IL-23, and IL-17, and Th1-/neutrophil-related chemokines CCL2 and CXCL12 were also downregulated, and neutrophils were constantly decreased in the skin, LN, and spleen of ΔdblGATA mice compared to WT mice after IMQ treatment. Although IMQ application increased eosinophils in the skin of WT mice, the absolute cell count was much lower than neutrophils, a major player in psoriasis. Conclusion: The small size of eosinophil population and constant reduction of neutrophil in ΔdblGATA mice than WT mice after IMQ treatment suggest that eosinophils would influence psoriasis indirectly via their inflammatory profile and affecting other mediators in psoriasis, such as neutrophils.

A case of drug-induced hemolytic anemia associated with antibiotic prophylaxis

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

A 68-year-old male patient presented with a dark brownish nodule on nose. In a local clinic, he underwent skin biopsy and was diagnosed as basal cell carcinoma. We performed wide excision to remove remaining lesion and clear margin obtained. Immediately before and after the operation he received intravenous cefotetan for antibiotic prophylaxis. On post-operate day 8, he felt dizziness and fell down. Hemoglobin was 3.5g/dL and hematocrit was 12.8%, whereas the initial CBC was normal. There was no evidence of bleeding on physical exam. Total bilirubin (6.86mg/dL), reticulocyte (6.2%) were elevated and direct antiglobulin test was positive. He was diagnosed as drug-induced immune hemolytic anemia (DIIHA) due to cefotetan. After systemic steroid treatment and transfusion a CBC revealed a hemoglobin of 9.4g/dL and hematocrit of 29.3%. He had complete resolution of symptoms and was discharged 5 days later. DIIHA is a rare acquired form of hemolytic anemia caused by interaction of drug with the immune system. Drug adsorption, drug-dependent antibody, and autoimmune induction are the three mechanism of hemolysis. Cefotetan-induced hemolytic anemia (CIHA) has been described to occur through all three mechanisms. Prompt diagnosis and massive systemic steroid administration are essential in minimizing mortality from hemolysis. Herein, we report a rare case of CIHA and hope to be aware of occurrence of CIHA associated with antibiotic prophylaxis.

Harmonic-Percussive Sound Separation from Monaural Music Using Generalized Complementary Diffusion

Jeongsoo Park(박정수),Jaeyoung Shin(신재영),Kyogu Lee(이교구) 한국통신학회 2016 한국통신학회 학술대회논문집 Vol.2016 No.6

Postoperative radiation therapy following keloidectomy

( Jeongsoo Kim ),( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Keloid is a problem that dermatologists encounter. Patients typically present with cosmetic concerns, although keloids can cause pruritus, pain. Keloids have been treated with multimodal therapy. Radiotherapy treatment after keloidectomy is known to be an effective method for reducing the rate of recurrence. A 40-year-old male presented with erythematous hard plaques on chin, shoulder, right foot. He was treated with steroid intradermal injection for several years but there was no improvement. A 26-year-old female presented an erythematous hard plaque on Lt. upper arm appeared 20 years earlier because of vaccination. She was performed surgical excision but keloid recurred. They had thought in common about new treatment. They were treated with steroid intralesional injection three times before surgery. Keloids were treated with surgical excision, followed by a total radiation dose of 1,800 cGy in three fractions over three days. We will observe their lesion whether keloids recur for 18 months. Postoperative electron-beam irradiation may control collagen synthesis by inhibiting the promotion of abnormal activated and normal fibroblasts. Furthermore, many researchers are trying to set the proper protocols of radiation, keloids should be treated with dose protocols customized by site. Postoperative electron-beam irradiation expects effectively to prevent recurrence of keloid and a safe treatment modality due to absence of complications.

Chemical Characteristics of Particulate Matter from Vehicle Emission using High Resolution Time of Flight Aerosol Mass Spectrometer (HR-ToF-AMS)

Taehyun Park,Jongtae Lee,Jeongsoo Kim,Jihwan Son,Heung-Min You,Kijoon Kim,Seokwon Kang,Gyutae Park,Taehyoung Lee 한국대기환경학회 2015 한국대기환경학회 학술대회논문집 Vol.2015 No.11

한국어판 성인용 스트레스 지각 척도(K-PSS-11) 타당화 연구

박정수(Jeongsoo Park) 한국웰니스학회 2022 한국웰니스학회지 Vol.17 No.4

본 연구에서는 전세계적으로 널리 쓰이고 있는 스트레스 지각 척도(Perceived Stress Scale; PSS)의 타당화 연구를 실시했다. 원척도는 14문항으로 구성되어 있고, 이를 토대로 한 단축형 10문항, 4문항 버전이 있는데, 본 연구는 원척도 14문항을 번안해 사용했다. 만20세~69세 이하, 성인 남녀 500명을 대상으로 스트레스 지각을 비롯해, 우울, 불안, 코로나 관련 스트레스, 삶의 만족도를 측정했다. 무작위로 두 집단을 추출해 첫 번째 집단에서 문항-총점 상관, 내적 신뢰도, 탐색적 요인분석을 실시해, 무력감 지각 및 자기 효능감 지각 2요인으로 구성된 최종 11문항을 확인했다. 두 번째 집단을 대상으로 확인적 요인분석 및 타당도 분석을 실시해 적절한 모형 적합도가 산출되었고, 스트레스 지각 척도는 우울 및 불안, 코로나 관련 스트레스와 정적 상관, 삶의 만족도와 부적 상관이 있었다. 더구나, 하위 요인으로 확인된 무력감 지각 및 자기 효능감 지각의 상관이 유의하지 않아 서로 다른 개념임이 시사된다. 일반 성인을 대상으로 실시한 한국어판 성인용 스트레스 지각 척도(K-PSS-11) 타당화 연구의 결과는 이 척도가 스트레스 지각을 측정하는데 적절하며, 다른 성인 집단 연구에도 널리 사용될 수 있음을 시사한다. This study validated the Perceived Stress Scale (PSS) for Korean adults. The PSS is a scale that is most widely used all over the world. The original scale consists of 14 items (PSS-14), along with short 10-item and 4-item versions. The present study translated 14 items. A total of 500 adults aged 20~69 participated in this study measuring perceived stress, depression, anxiety, life satisfaction, and COVID-19 related stress. Two groups of participants were randomly selected. For the first group, item-total correlations, reliabilities, and exploratory factor analysis were conducted. Results indicated 11 items that had a two-factor structure: perceived helplessness and perceived self-efficacy. For the second group, confirmatory factor analysis indicated good model fits. Also, a high level of perceived stress was significantly correlated to a high level of depression, anxiety, and COVID-19 related stress. Subjective life satisfaction had significantly negative correlations with perceived stress. In addition, the correlation between two subfactors – helplessness and self-efficacy was not significant, which indicates two distinct components. Based on the results, this study indicates that K-PSS-11 is an appropriate scale to measure perceived stress for adults that can be used in a larger group of adult population in Korea.

헬레니즘 시대 유대교와 기독교의 가족 에토스

박정수 ( Jeongsoo Park ) 성결대학교 다문화평화연구소 2020 다문화와 평화 Vol.14 No.2

기원후 70년 예루살렘과 제2성전의 파괴로 유대인들은 민족과 신앙의 상징적 공간을 상실하고 이국땅에서 디아스포라 공동체를 이루고 살아가야 했다. 이 시기를 포함해서 제2성전 시기 특히 헬레니즘 시대 유대인 공동체의 실제적인 존속형태는 가족이었다. 유대인의 역사는 출산에 의해 존속되고 교육으로 건설된다. 혈연과 유대교 전통의 계승이 역사의 씨줄과 날줄이었다면 토라는 역사라는 시공간의 철학적 토대였다. 가족 에토스는 그런 역사 철학과 토라의 종교인 유대교에 터한 유대인의 민족적 에토스를 건설하는 근간이었다. 헬레니즘 시대 유대교에서 출생한 예수 운동은 ‘하나님의 가족’이라는 공동체적 정체성을 가지고 출발했다. 이는 “하나님의 뜻을 행하는 자는 누구나”가 들어올 수 있는 개방성을 가지고 있으며, 혈연 혹은 사회적 계층이나 민족적 범주를 넘어서는 보편성을 가지고 있었다. 예수의 식탁공동체 형성은 이웃사랑의 에토스를 통해서 ‘하나님의 가족’의 보편성을 구체화하는 예수의 상징행위였다. 또한 헬레니즘 시대 유대교의 가족의 근간은 형제자매의 관계였다. 이러한 토대에서 초기 기독교 공동체는 가족에 관한 언어로 자신들의 신앙을 표현하며 예수를 주인으로, 공동체 구성원을 형제자매로 표현할 수 있었다. 그들은 이 언어적 상징의 중심에서 예수의 이웃사랑을 새로운 삶의 중심 가치인 형제사랑의 에토스로 구현했다. 바로 이것이 기독교의 신앙언어가 가족의 용어로 표현된 ‘삶의 자리’이다. The destruction of Jerusalem and the Second Temple in 70 A.D. caused Jews to lose symbolic space of ethnicity as well as faith and to live in a diaspora community on foreign lands. Including this period, the actual form of existence of the Jewish community in the Second Temple, was Family especially in the whole Hellenistic period. The Jewish history is preserved by birth and built with education. The succession of blood ties and Jewish traditions were the lines of history, Tora was the philosophical foundation of history as time and space. The family ethos was the basis for building such historical philosophy and the ethnic ethos of Jews in the Jewish religion of Torah. Born in Hellenistic Judaism, the ‘Jesus movement’ started with the community identity of ‘Family of God’. This had the openness in terms of that “anyone who practices God’s will” could be accepted, and universality beyond blood ties or social classes or ethnic categories. The formation of a table community of Jesus was his symbolic action which realizes the universality of the table community concretely through the ethos of neighborly love. Also, the basis of the Jewish family in Hellenistic period was the relationship between siblings. On this basis, early Christian communities were able to express their faith in the language of their families, expressing Jesus as their ‘Lord’ and their community members as ‘Sister and brother.’ In the center of this linguistic symbol, they embodied Jesus’ love for his neighbor as the ethos of brotherly love, the central value of his new life. This is the “Sitz im Leben” in which Christian religious language is expressed in family terms.