http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Seha Park ),( Jaewoo Lim ),( Shinyoung Song ),( Seulki Lee ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: High-intensity focused ultrasound (HIFU) is a noninvasive technology used to treat skin laxity and provide tightening with minimal risk and recovery time. Objectives: This clinical trial aimed to verify the safety and effectiveness of HIFU on skin and subcutaneous tissue elasticity by adding the applied areas to the eyebrow lifting already approved by the FDA. Methods: A total of 43 Korean subjects were enrolled in this prospective clinical trial and treated with HIFU on both the cheeks, arms, lower abdomen, and thighs. We used a HIFU device with 8 different cartridges. Skin elasticity was measured before and after treatment using a Cutometer. Three blinded, dermatologists evaluated paired pre- and post-treatment (weeks 4 and 12) photographs according to the Investigator Global Aesthetic Improvement Scale (IGAIS). Participants also completed self-assessments using the Subject GAIS (SGAIS). Subjects rated their pain on a numeric rating scale (NRS) immediately and 7 days after treatment. Results: Skin elasticity was significantly improved at 4 and 12 weeks after treatment at all treated sites. IGAIS and SGAIS scores improved significantly 12 weeks after treatment. Immediately after treatment, the mean NRS score was 4.90 ± 2.01, but pain was significantly reduced at 7 days post-treatment (0.45 ± 0.83). Conclusion: HIFU can meet the demand for noninvasive skin lifting and tightening of the face and body. Newly developed various transducers could effectively deliver HIFU energy.
( Seha Park ),( Shinyoung Song ),( Seulki Lee ),( Jeongsoo Kim ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Mist equipped with silver foam and tourmaline ceramic balls was used to minimize the risk of infection and to provide proper moisturizing care considering the vulnerability of atopic dermatitis (AD) skin. The mist is expected to provide proper moisturizing care to AD patients by changing the water into weak alkaline water with tourmaline ceramic ball and sterilization. Objectives: We aimed to evaluate the change in moisturization and atopic symptoms before and after using mist equipped with silver foam and tourmaline ceramic balls in patients with mild AD. Methods: An open-label, single center prospective clinical study that utilized themist was conducted. This study included 36 patients with mild AD patients. Two visits to the hospital at days 1, 7 for evaluation were made. The effects of the mist were assessed by measuring corneometer and visual analogue scale (VAS). Results: Patients using the mist showed significant decreases in moisture level both immediately after the use and weekly after the use. The VAS was significantly reduced. One of the 36 adverse events reported in this study was acute contact dermatitis. The adverse reaction was mild and it was related to the product, but it showed a remarkable improvement after 1 day with discontinuing use of the product. Conclusion: It was considered to be effective in improving moisturization and atopic dermatitis lesion, and overall satisfaction was high.It also showed that it is a safe and easy-to-us moisturizing product.
( Seha Park ),( Shinyoung Song ),( Seulki Lee ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Calcinosis cutis is an uncommon disorder and defined as the deposit of insoluble calcium salts in the skin. It is classified as dystrophic, metastatic, idiopathic, and iatrogenic according to etiology. The dystrophic type is the most common and occurs in the previously damaged tissue, including connective tissue diseases, panniculitis, inherited disorders, benign and malignant tumors, and a variety of scarring caused by burn, radiation, trauma, surgery, and keloid. Considering that peripheral neuropathy resulted from leprosy makes the patients vulnerable to various skin traumas leading eventually to chronic ulcers and scars, leprosy can be an additional cause of dystrophic calcinosis cutis. Treatment options are limited. Whereas medical therapy is usually not very effective, surgical intervention has shown to be beneficial and is indicated when painful masses, recurrent infection, ulcerations, functional impairment, and cosmetic concerns exist. Herein, we report two cases of dystrophic calcinosis cutis associated with longstanding, painful, ulcerated cutaneous lesions in the extremities successfully treated with surgical excision in patient with leprosy.
Clinical evaluation of 42 Korean patients with rosacea: associated with chronic systemic diseases
( Seha Park ),( Shinyoung Song ),( Seulki Lee ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Rosacea is a common chronic inflammatory cutaneous disorder which is characterized by erythema of the central face. It has been associated with systemic comorbidities, but studies addressing rosacea’s association with systemic comorbidities are scarce. Objectives: This study aimed to elucidate the clinical manifestations of rosacea and the association between rosacea and systemic comorbidities and if the severity of rosacea is impacted by comorbidities. Methods: We performed a prospective analysis of 42 patients who were diagnosed with rosacea from November 2015 to July 2017 at Gil medical center. A structured interviewer administered questionnaire collected detailed medical history and current comorbidities, information on demographics and life style factors. Results: The ratio of males to females was 1:2. The mean age at the time of diagnosis was 49.8±9.9 years. In 42 patients, we observed a significant association between rosacea and gastrointestinal disease(42.9%), hypertension and metabolic disease(40.5%), hormone imbalance(23.8%), allergies (air borne, food)(21.4%). Compared with mild to moderate, severe rosacea was significantly associated with gastrointestinal diseases. Conclusion: Rosacea is associated with numerous systemic comorbidities and we observed association with severity of rosacea and gastrointestinal diseases. Physicians should be aware of these associations to provide comprehensive care to patients with rosacea, especially to those with more severe disease
[P453] Granulomatous pigmented purpuric dermatosis: : A precursor of mycosis fungoides?
( Haryeong Ryu ),( Seha Park ),( Seulki Lee ),( Jungsu Kim ),( Heejoo Kim ),( Jinok Baek ),( Hyangjoon Park ),( Jooyoung Roh ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Pigmented purpuric dermatoses (PPD) are vascular disorders of varying morphology and unknown etiology. There are 5 major forms of PPD and the unusual presentations include a granulomatous form. PPD may be biologically related to mycosis fungoides (MF). A 15-year-old girl presented with purpuric and pigmented macules on left dorsum of foot for two years. The first biopsy from the lesional skin showed a band-like lymphoplasmocytic infiltrate in the superficial and deep dermis with RBC extravasation and pigmentary incontinence in papillary dermis. Lymphocytic atypia and epidermotropism were observed. She was diagnosed as MF based on the first biopsy from other clinic. Second biopsy was performed on 1 month later. It revealed a dense lymphoplasmocytic infiltrate occupying papillary and reticular dermis and epidermotropism was not observed. Immunohistochemically lymphocytes were CD3+, CD4+, CD8+, CD20+, and negative for CD30 expression. T-cell receptor gene rearrangement analysis performed on the second biopsy demonstrated polyclonality. Laboratory findings, peripheral blood smear, and PET CT were all within normal limits. For early phase of MF, histopathologic, immunohistochemical, and molecular work-up are not sufficient for definite diagnosis. Taken together with a progressive clinical course and peculiar pathologic findings, it should be monitored for the development of early phase MF superimposed on granulomatous variant of PPD.
( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ),( Heejoo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Eosinophilic cytokine profile including IL-23/Th17 axis and their immunomodulatory interaction with other immune cells imply their possible involvement in psoriasis pathogenesis. Objectives: This study was to examine the potential role of eosinophils in imiquimod (IMQ)-induced psoriasiform dermatitis using ΔdblGATA mice, an eosinophil lineage-ablated mouse line. Methods: After topical IMQ application, inflammatory cytokine gene expression and Inflammatory cell populations were analyzed by qRT-PCR and flow cytometry, respectively. Results: Psoriatic features like epidermal thickening, erythema, and scale were less prominent in ΔdblGATA mice after IMQ treatment. Inflammatory cytokines important in psoriasis, like IL-1β, IL-6, IL-22, IL-23, and IL-17, and Th1-/neutrophil-related chemokines CCL2 and CXCL12 were also downregulated, and neutrophils were constantly decreased in the skin, LN, and spleen of ΔdblGATA mice compared to WT mice after IMQ treatment. Although IMQ application increased eosinophils in the skin of WT mice, the absolute cell count was much lower than neutrophils, a major player in psoriasis. Conclusion: The small size of eosinophil population and constant reduction of neutrophil in ΔdblGATA mice than WT mice after IMQ treatment suggest that eosinophils would influence psoriasis indirectly via their inflammatory profile and affecting other mediators in psoriasis, such as neutrophils.
( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Heejoo Kim ),( Jooyoung Roh ),( Hyangjoon Park ),( Jinok Baek ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Cafe-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Objectives: To investigate the efficacy and safety of a high fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser treatment of CALMs in Asian patients. Methods: The medical records of thirty-five Korean patients (age range: 1 to 40 years old, mean age : 18.5 years) diagnosed with isolated CALMs were reviewed retrospectively. The patients were treated with a 1064-nm Q-switched Nd:YAG laser. The parameters were a spot size of 7 mm, a fluence of 2.2-2.4 J/cm2 with a slow single sliding-stacking pass, and a pulse rate of 10Hz with a one-week interval for 20-50 sessions. Results: At the week of the final treatment, all treated CALMs showed considerable pigmentation removal without any permanent side effects, such as scaring, mottled hypopigmentation, and post-inflammatory hyperpigmentation (PIH). All treated CALMs showed more than 50% clinical improvement. No recurrence was observed in any of the patients after 12 months of follow up. Conclusion: A high fluence 1064-nm Q-switched Nd:YAG laser treatment of CALMs in Asian patients is a safe and effective method without side effects and recurrence.
( Shinyoung Song ),( Seha Park ),( Seulki Lee ),( Jin Ok Baek ),( Joo Young Roh ),( Hyangjoon Park ),( Hee Joo Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: The clinical characteristics of cutaneous lupus erythematosus (CLE) are well delineated in adults, but pediatric data, particularly in Asian populations, are limited. Objectives: Therefore, we evaluated the characteristics of pediatric cases by retrospectively reviewing the medical records of children with CLE during a 15-year period in a tertiary care dermatology clinic in South Korea. Methods: The study included 21 children (8 males and 13 females), 4 of whom had neonatal lupus erythematosus (NLE). Results: Among 17 patients with CLE, discoid lupus erythematosus (DLE) was most common (47.1%), followed by acute CLE (ACLE, 35.3%). All ACLE cases had systemic lupus erythematosus (SLE). Female predominance was conspicuous in ACLE/SLE (6/11 females versus 0/6 males), as was older age, whereas DLE and NLE showed near equal sex distributions. The median age at the diagnosis of CLE was significantly higher in females than in males (15 years versus 4.5 years, p=0.02). All patients with ACLE/ SLE simultaneously showed skin and systemic symptoms from onset. The kidney was the most commonly involved organ. Conclusion: This study revealed unique characteristics of pediatric CLE, further warranting a comprehensive review among various ethnicities to understand the wide spectrum of CLE in the pediatric population.