A Comparative Experimental Study of the, In-vitro Efficiency of Hypertonic, Saline-Enhanced Hepatic Bipolar and, Monopolar Radiofrequency Ablation

Lee, Jeong Min,Han, Joon Koo,Kim, Se Hyung,Sohn, Kyu Li,Lee, Kyoung Ho,Ah, Su Kyung,Choi, Byung Ihn Korean Radiological Society 2003 Korean Journal of Radiology Vol.4 No.3

Rheology of Decamethylceclopentasiloxane (cyclomethicone) W/O Emulsion System

Choi, Min-Hyung,Jeong, So-Ra,Nam, Sang-In,Shim, Sang-Eun,Chang, Yoon-Ho The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.12

A highly dispersed W/O emulsion of silicone oil (cyclomethicone)/water system was prepared with a nonionic surfactant. The surface and interfacial tension between the oil and water were characterized in terms of the droplet size distribution and viscosity change of the emulsion. When the dispersed phase concentration was relatively high, the viscosity of the emulsion was rapidly increased and the droplet size of the emulsion was decreased. The rheological behavior of the emulsion system showed non-Newtonian and shear thinning phenomena depending upon the content of the dispersed phase. The droplet size of the emulsion was decreased with increasing surfactant content and water concentration. The relative viscosity of the emulsion was better predicted with the Choi-Schowalter model than with the Taylor model. The value of the complex modulus increased with increasing surfactant concentration. The linear viscoelastic region was expanded with a dispersed phase concentration. According to the change in the viscosity, the behavior was classified into three distinct regions: [I] linear viscoelastic, [II] partially viscoelastic, and [III] viscous. The creep/recovery behaviors in each region were characterized.

Surface Modification of Block Copolymer Through Sulfur Containing Plasma Treatment

Choi, Sang Wook,Shin, Jae Hee,Jeon, Min Hwan,Mun, Jeong Ho,Kim, Sang Ouk,Yeom, Geun Young,Kim, Kyong Nam American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.10

<P>Some of the important issues of block copolymer (BCP) as an application to the potential low cost next generation lithography are thermal stability and deformation during pattern transfer process in addition to defect density, line edge/width roughness, etc. In this study, sulfur containing plasma treatment was used to modify the BCP and the effects of the plasma on the properties of plasma treated BCP were investigated. The polystyrene hole pattern obtained from polystyrene polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) was initially degraded when the polystyrene hole was annealed at 190 degrees C for 15 min. However, when the hole pattern was treated using sulfur containing plasmas using H2S or SF6 up to 2 min, possibly due to the sulfurization of the polystyrene hole surface, no change in the hole pattern was observed after the annealing even though there is a slight change in hole shapes during the plasma treatment. The optimized plasma treated polystyrene pattern showed the superior characteristics as the mask layer by showing better thermal stability, higher chemical inertness, and higher etch selectivity during plasma etching.</P>

Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats

Jeong, Dong Won,Kim, Young Hoon,Kim, Hui Hyun,Ji, Hye Young,Yoo, Sun Dong,Choi, Won Rack,Lee, Soo Min,Han, Chang-Kyun,Lee, Hye Suk WILEY PUBLISHERS 2007 BIOPHARMACEUTICS AND DRUG DISPOSITION Vol.28 No.2

<P>The pharmacokinetics of oleanolic acid was evaluated in vitro and in vivo. From Caco-2 cell permeation studies, oleanolic acid was a low permeability compound with no directional effects, suggesting a low in vivo absorption mediated by a passive diffusion. Oleanolic acid was metabolically unstable following incubation with rat liver microsomes in the presence of NADPH. After intravenous injection at doses of 0.5, 1 and 2 mg/kg doses, oleanolic acid showed dose-linear pharmacokinetics as evidenced by unaltered CL (28.6–33.0 ml/min/kg), V<SUB>ss</SUB> (437–583 ml/kg), dose-normalized AUC (16.0–17.9 µg min/ml based on 1 mg/kg) and t<SUB>1/2</SUB> (41.9–52.7 min). Following oral administration of oleanolic acid at doses of 10, 25 and 50 mg/kg, T<SUB>max</SUB>, t<SUB>1/2</SUB>, dose-normalized C<SUB>max</SUB> (66–74 ng/ml based on 25 mg/kg) and dose-normalized AUC (5.4–5.9 µg min/ml based on 25 mg/kg) were comparable between 25 and 50 mg/kg dose, but the plasma concentrations at 10 mg/kg dose were not measurable as they were below the limit of quantitation (2 ng/ml). The absolute oral bioavailability was 0.7% for oral doses of 25 and 50 mg/kg. The extent of urinary excretion was minimal for both i.v. and oral doses. The very low oral bioavailability of oleanolic acid could be due to a poor absorption and extensive metabolic clearance. Copyright © 2007 John Wiley & Sons, Ltd.</P>

Effects of hydrogen plasma treatment on SnO2:F substrates for amorphous Si thin film solar cells

Min-Seung Choi,Young-Ju Lee,Jung-Dae Kwon,Yongsoo Jeong,Ju-Yun Park,강용철,Pung Keun Song,Dong-Ho Kim 한국물리학회 2013 Current Applied Physics Vol.13 No.8

We investigated the effects of hydrogen plasma treatment on the physical and electrical properties of fluorine-doped tin oxide (FTO) films used for amorphous silicon (a-Si) thin film solar cells. A slight increase in carrier concentration by the hydrogen doping effect was observed for the FTO film exposed to the hydrogen plasma for 5 min. For further exposure to the plasma, the chemical reduction became prominent and resulted in deterioration of the electrical and optical properties of the film. XPS analysis revealed that the chemical reduction of SnO2 to Sn metallic state occurs on the surface region. It was found that the defects formed by hydrogen plasma act as recombination centers at the interface between FTO electrode and p-layer of a-Si solar cells. This phenomenon resulted in the deterioration of the cell performance. The averaged conversion efficiency (6.82%) of the cells on pristine FTO hydrogen substrate was decreased to 5.81% for the cells on FTO treated for 5 min, which is mainly attributed to the decrease in short-circuit current density.

Comparison of Dual Probe Bipolar Mode with Monopolar and Single Probe Bipolar Modes : Comparison of Dual Probe Bipolar Mode with Monopolar and Single Probe Bipolar Modes

Lee, Jeong Min,Han, Joon Koo,Kim,Se Hyung,Lee, Jae Young,Kim, Dae Jin,Lee, Min Woo,Cho, Gyung goo,Han, Chang Jin,Choi, Byung Ihn Korean Radiological Society 2004 Korean Journal of Radiology Vol.5 No.2

백서 척수후근절로부터 슈반세포의 효과적인 체외 배양법

김성민,이종호,김남열,안강민,최원재,최시호,차미주,이주영,황순정,장정원,명훈,최진영,서병무,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Schwann cells(SCs), an important component of the peripheral nervous system, intract with nerous to mutually support growth and replication for the peripheral nerve regentation. Recently, ading SCs to the lumen of guidance channel is widely tried to improve regeneration or to make regeneration possible over otherwise irreparable gaps. however, it is not easy to isolate and multiplicate SCs as much as enough to help the axonal regeneration. For the allogeneic SCs source for tubular nerve guidance, we developed a little bit improved technique of harvesting and multiplicating SCs. by culturing dispersed dorsal root ganglia in specially designed medium with growth factors and serial processing, we repeatedlly generate relatively homogenous SC cultures. Our technique was compared with other methods of literature using immunostaining methods such as GFAP, S100, BDNF and the total SC count assessment at different time interval after primary culture.

초기 자궁내막암 환자에서의 복강경유도하 질식 자궁절제술과 복식 자궁절제술에 대한 비교 연구

김민규 ( Min Kyu Kim ),최동석 ( Dong Seok Choi ),김우영 ( Woo Young Kim ),최철훈 ( Chel Hun Choi ),김태중 ( Tae Joong Kim ),이정원 ( Jeong Won Lee ),김병기 ( Byoung Gie Kim ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo Bae ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12

목적: 초기 자궁내막암의 수술적치료 시 복강경유도하 질식 자궁절제술 및 골반림프절절제술군과 복식수술군의 수술결과 및 재발율에 대해 비교하고자하였다. 연구 방법: 2003년 3월부터 2005년 5월까지 초기 자궁내막암 환자를 인구학적 특성이 같은 63명을 선택하여 복강경유도하 질식 자궁절제술 및 골반림프절절제술군 26명, 복식수술군 37명으로 나누어 수술 전후 혈색소 차이, 평균수술시간, 취득한 골반림프절갯수, 평균재원일수, 추가치료율, 재발률을 비교하였다. 결과: 복강경유도하 질식 자궁절제술 및 골반림프절절제술을 시행한 군과 복식수술을 시행한 군과의 비교에서 수술 전후 혈색소 차이, 평균수술시간, 취득한 골반림프절 갯수, 평균재원일수, 재발률에 통계적으로 유의한 차이가 없었다. 결론: 초기 자궁내막암의 수술 시 복강경유도하 질식자궁절제술 및 골반림프절절제술 방법이 복식방법에 비해 수술결과 및 재발률에 통계적으로 유의한 차이가 없으며 그 대체 수술법으로 많은 활용이 기대되었다. Objective: To compare laparoscopic surgery with conventional abdominal surgery in patients with early stage endometrial cancer. Methods: A retrospective review of 63 patients with early stage endometrial cancer managed between March 2003 and May 2005. Two groups were defined whether they had been treated by laparoscopy (case group: n=26) or by laparotomy (control group: n=37). We compared age, body mass index (BMI), hemoglobin change, operation time, number of pelvic lymph nodes, hospital stay, case with adjuvant treatment and recurrence between two groups. Results: There was no statistical difference in characteristics (age, BMI, nulliparity, previous abdominal surgery, FIGO stage, histologic grade). between case and control group. In addition, there was no statistical difference in operation data and outcomes between two groups. Hemoglobin changes were 1.1 g/dL (case group) vs 1.7 g/dL (control group) (p=0.072). Operation time was 131 min vs. 115 min. The numbers of lymph nodes obtained were 8.7 vs 7.7 (right) 9.2 vs. 7.6 (left). Hospital stays were 8.4 vs. 9.2 days. Adjuvant treatment cases were 7 vs. 15. Recurrent case was one in each group. Two patients initially evaluated by laparoscopy were converted to laparotomy due to bleeding and adhesion. Conclusion: Laparoscopic surgery for treatment of early endometrial cancer is a safe and effective alternative to laparotomy . However, long-term survival and risk of recurrence have yet to be determined.

Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

Ha-Neul Choi,Yang-Hee Jang,Min-Joo Kim,Min Jeong Seo,Byoung Won Kang,Yong Kee Jeong3,,Jung-In Kim 대한지역사회영양학회 2014 Nutrition Research and Practice Vol.8 No.2

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

허웅의 ‘훈민정음’에 대한 인식과 영향관계 : 19세기 말∼20세기 전반기, ‘국어학’ 학술네트워크 고찰을 위하여

서민정(Seo, Min-jeong),최규수(Choi, Kyu-soo) 부산대학교 인문학연구소 2020 코기토 Vol.- No.90

‘훈민정음’은 일제강점기 이후 일본 제국에 저항할 수 있는, 민족적 자부심이 담긴 대표적인 유산으로 여겨왔다. 그리고 그러한 인식은 19세기 말∼20세기 초의 지식인, 특히 국어학자들의 훈민정음에 대한 연구성과와 직접 연결되어 있다. 특히 ‘허웅’은 20세기 전반기의 국어학 연구나 언어에 대한 인식 등을 현재까지 잇는 중간 역할을 하였다는 측면에서 ‘허웅’의 훈민정음 인식에 대해 주목할 필요가 있다. 이 연구는 앞선 연구에서 주로 다루어 온 주시경, 권덕규, 김윤경, 최현배, 홍기문 등의 연구 성과를 바탕으로 허웅의 ‘훈민정음’에 대한 인식이나 연구에 대해 고찰하고자 한다. 그것은 허웅(1974가, 나)에서 볼 수 있듯이 그의 말과 글의 관계나, 한글전용과 같은 언어 정책에 대한 입장 등은 대부분 ‘훈민정음’ 특히 ‘어제서문’의 해석과 관련하여 설명되고 있어서 그의 ‘훈민정음’에 대한 인식을 검토할 필요성이 있기 때문이다. 한편 허웅은 학문에 대한 태도는 실증적이고 엄정하다는 평가를 받고 있고 스스로도 그러한 관점에서 연구하고자 하였다. 그러나 훈민정음 서문의 해석에서는 앞선연구의 전통을 그대로 이어받아 실증적이고 비판적인 태도를 찾아보기 힘들었다. 이 연구에서는 그러한 허웅의 관점이 허웅의 학문적 태도에서 출발했다기보다는 훈민정음에 대한 우리의 인식이 그만큼 맹목적인 부분이 있었기 때문이었음을 강조하고자 하였다. 허웅의 훈민정음에 대한 인식은 『한글과 민족 문화』(1974ㄱ)에 선명히 나타나 있는데, 이외에도 『우리말과 글의 내일을 위하여』(1974), 『우리말과 글에 쏟아진 사랑』(1979), 「세종의 언어 정책과 국어 순화 정신」 (1980), 『이삭을 줍는 마음으로』(1981) 등에서도 그의 훈민정음에 대한 인식을 엿볼 수 있다. 이 연구에서는 위의 자료를 바탕으로 허웅의 훈민정음에 대한 인식을 고찰하고자 한다. Since the flowering period, ‘Hunminjeongeum’ has been understood as a representative heritage showing the pride of the people who oppose the Western modernity or resist the Japanese empire. In this process, it was natural that the research related to the Hunminjeongeum of intellectuals, especially Korean scholars, became the basis. So far, in the previous study, discussions about Hunminjeongeum such as Ju Si Kyung, Kwon Duk Kyu, Kim Yoon Kyung, Choi Hyun Bae, and Hong Gi Moon have been discussed to some extent. However, there is a need for this research in that the review of the ‘Hunminjeongeum’ by Mr. Huh has not been done yet. As we can see in Huh Woong(1974, I) in particular, the relationship between his words and writings, and the position of language policy, such as Hangul, are mostly explained in relation to the contents of ‘Hunminjeongeum’, especially ‘Preface’, which makes it more necessary to examine his perception of ‘Hunminjeongeum’. On the other hand, as discussed in Seo Min-jeong(2011), “Hunminjeongeum” and “Preface” were translated into the language of the 15th century (say) and translated into the language of the 20th century in the first half of the 20th century. The material that reveals Huh Woong’s awareness of Hunminjeongeum is “Hangul and National Culture”(1974). Other than that, for the sake of Korean and Writing tomorrow (1974), Korean and Writing Love(1979), Sejong’s Language Policy and Korean Refinement Spirit(1980), Isaac’s Mind, etc.(1981), and the Korean and Korean Cultures(1974, Sejong University, and the Korean People’s Association(1974), The Korean language policy is also discussed, and the teacher’s recognition of the Hunminjeongeum can be said to be followed by the Korean language policy. Based on the above data, I would like to examine the perception of Hunminjeongeum by Mr. Huh. In this study, we found that the attitude of Huh Hung"s scholarship showed a different pattern in the interpretation of the preface of Hunminjeongeum. And it was examined that such aspect did not overcome the limitations of the situation of the times rather than the problem of attitude of Heung. Based on these considerations, we should recognize that it is time to reinterpret and evaluate Hunminjeongeum.