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간외담관 폐쇄에서의 초음파소견 : 담관벽 경계소실의 중요성 Significance of Decreased Echotexture of Bile Duct Wall-Interface
신현준,손은주,이창희,최영칠,전혜정,박정희,이태의 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Ultrasound is very useful in evaluation of obstructive jaundice. We retrospectively evaluated the useful findings of ultrasonography in differentiating benign extrahepatic duct obstruction from malignant diseases. Among the 36 patients, 25 patients were benign extrahepatic obstruction and 11 patients were malignant obstruction. The shapes of extrahepatic dilatation were classified into fustiform, meniscus, and abrupt cut off by bowel gas. The diameter, length, and bile duct wall-interface were compared between benign and malignant groups and serum bilirubin and alkaline phosphatase were also compared between two groups retrospectively. The results were as follows. The most common form of extrahepatic dilatation was meniscus(10 of 26 patients, 38%) in benign obstruction, and fusiform(8 of 11 patients, 73%) in malignant obstruction. No significant difference was noted in diameter, length, serum bilirubin, and alkaline phosphatase between benign and malignant groups. Only one case showed decreased bile duct wall-interface in benign obstruction, but loss or decrease of bile duct wall-interface were 8 patients in malignant obstruction. The combined findings of fusiform dilatation and loss of bile duct wall-interface in ultrasonography will be helpful in differential diagnosis of malignant extrahepatic bile obstruction from benign conditions.
초등학생의 Molar Incisor Hypomineralization 유병률과 제1대구치 치아우식증 및 수복상태 조사
신종현,안울진,김신,정태성 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2
Molar Incisor Hypomineralization(MIH) have recently gained intensive research interests and various clinical trials. Most prevalence, etiology, treatment studies in MIH were carried out in the European countries, and data from the Korean were seldom. This study aimed to investigate the prevalence of MIH and the status of dental caries and treatment on the first permanent molars in primary school children. For this study, 1.344 primary school students in Busan and Ulsan cities were examined directly the permanent incisors and first molars. The results of the survey were as follows: 81 MIH cases were identified among 1.344 cases. The prevalence of MIH in this group of children was 6.0%. Children with MIH showed a significantly higher DMFT value for permanent teeth than children without MIH. The mean number of decayed, missed, and filled in 1st permanent molars(DMFT index) was 1.17. The rate of children with restoration on 1st permanent molar was 13.6% and the sequence of restoration materials was as follows: composite resin, amalgam, gold inlay. Molar Incisor Hypomineralization(MIH)에 관하여 최근 많은 연구적 관심이 집중되고 여러 임상적 대처방법들이 제시되고 있다. 이미 세계적으로는 MIH의 빈도, 병인, 치료 등에 관한 많은 연구보고가 있었으나, 우리나라에서는 이에 대한 관심이 아직 미미한 것으로 사료된다. 본 연구는 초등학생의 MIH 유병률과 제1대구치 우식 및 치료 실태에 대하여 조사할 목적으로 시도되었다. 부산 및 울산광역시에 거주하는 1,344명의 초등학생을 대상으로, 상하 제1대구치와 전치부를 직접 시진하여, MIH 유병률, 제1대구치 우식경험지수와 치료 상태를 조사하여 다음과 같은 결과를 얻었다. 총 1,344명 의 조사 대상 중 81명에서 MIH가 나타나, 유병률은 6.0%를 보였으며, MIH에 이환왼 어린이의 제1대구치 우식경험지수는 비이환군에 비해 통계적으로 유의하게 높았다(P<0.05) 한편, 제1대구치 우식경험지수는 1.17개로 나타났다. 조사 대상 제1대구치의 13.6%가 수복되어 있었고, 수복재 별로는 복합 레진, 아말감, gold inlay의 순이었다.
Park, Ui-Hyun,Jeong, Hong-Suk,Jo, Eun-Young,Park, Taesun,Yoon, SeungKew,Kim, Eun-Joo,Jeong, Ji-Cheon,Um, Soo-Jong American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.15
<P>This study investigated the antiadipogenic activity of black pepper extract and its constituent piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both black pepper extract and piperine, without affecting cytotoxicity, strongly inhibited the adipocyte differentiation of 3T3-L1 cells. The mRNA expression of the master adipogenic transcription factors, PPAR gamma, SREBP-1c, and C/EBP beta, was markedly decreased. Intriguingly, mRNA levels of PPAR gamma target genes were also down-regulated. Moreover, a luciferase reporter assay indicated that pipierine significantly represses the rosiglitazone-induced PPAR gamma transcriptional activity. Finally, GST-pull down assays demonstrated that piperine disrupts the rosiglitazone-dependent interaction between PPAR gamma and coactivator GBP. Genome-wide analysis using microarray further supports the role of piperine in regulating genes associated with lipid metabolism. Overall, these results suggest that piperine, a major component of black pepper, attenuates fat cell differentiation by down-regulating PPAR gamma activity as well as suppressing PPAR gamma expression, thus leading to potential treatment for obesity-related diseases.</P>
노의정(Ui Jeong Roh),김정환(Jeong Hwan Kim),이후민(Hoomin Lee),강석준(Seok Jun Kang),김현기(Hyun Ki Kim),최문기(Moon Ki Choi),김문기(Moon Ki Kim) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
SPCT is a new type of testing method to measure creep life of metallic materials. A dead load is applied into the spherical punch ball to penetrate a small metal sheet specimen. It has several advantages to the conventional UCT such as fingernail-sized specimen (10x10x0.5mm³), short test time, etc. Since the size of the specimen is small, it can be obtained from in-service power plant with semi-destructive way. However, there are some disadvantages that prevents this test to be used in the industrial field and standardization. In this study, therefore, the presenting authors have proposed a stress based creep life evaluation method for SPCT. For verification, Inconel 617 was tested by both UCT and SPCT. Also, a SPCT FEM for this material was performed to validate the proposed methodology. Finally, a comparison using Larson-Miller model was conducted for Inconel 617 at 700℃.
만다린 잡종에서 자연발생 배수체의 발생 빈도와 생장 특성
송관정(Kwan Jeong Song),김샛별(Sat Byul Kim),박재현(Jae Hyun Park),오은의(Eun Ui Oh),이경욱(Kyunguk Lee),김동욱(Dong Wook Kim),강종훈(Jong-Hoon Kang),김정순(Jeong-Soon Kim),오정환(Jeong Hwan Oh),Fred G. Gmitter 한국원예학회 2011 원예과학기술지 Vol.29 No.6
자연발생 배수체를 이용한 다양한 육종 소재를 개발함에 있어 그 효율성을 평가하고자 종자의배형성이 다른 일부 만다린 잡종에 대해 종자 형성 정도, 자연발생 배수체의 발생빈도, 배수체의 생장 특성을 분석하였다. 다배성의 "Amakusa", "Haruka", "Hayaka" 및 "Seminole" 4품종과 단배성의 "Benibae"와 "Harehime" 2품종에 대해 방임수분된 과실로부터 종자를 채취하였다. 과실당 종자수는 10.0개이었고, 이 중 소형의 발육종자 형성 빈도는 25.1%이었다. 이들 소형 종자의 기내발아 식물체에 대해 배수체 분석기 및 염색체 분석으로 배수성을 분석하고 배수체를 선발하였다. "Harehime" 3배체 1개, "Amakusa" 4배체 1개, 그리고 "Benibae" 4배체 1개가 각각 획득되었다. 이들 4배체와 3배체의 잎의 형태, 두께, 엽병 길이 및 절간장을 2배체와 비교하였는데, 큰 차이는 나타나지 않았다. 그러나 기공의 크기와 분포에 있어서는 분명한 차이를 나타내어 3 또는 4배수체 식물에서 기공의 크기가 커지고 분포 밀도는 감소하였다. 엽록소 함량을 나타내는 SPAD 값과 광합성 정도에 있어서는 큰 차이를 나타내지 않았다. 본 연구결과로 감귤 만다린 잡종에서 방임수분으로도 자연발생 배수체 생산이 가능하며, 다배성보다는 단배성에서 발생 빈도가 높은 것을 확인할 수 있었다. The study was conducted to determine the efficiency in producing spontaneous polyploids in some mandarin hybrids with different seed embryony. Seed formation by open pollination, frequency of spontaneous polyploids, and plant growth characteristics were evaluated in four mandarin hybrids with polyembryony such as "Amakusa", "Haruka", "Hayaka", and "Seminole" and two with monoembryony such as "Benibae" and "Harehime". The mean number of the developed seeds per fruit was 10.0 and frequency of small seeds was 25.1%. Polyploids were selected from plants germinated in vitro by a flow cytometry and confirmed by chromosome analysis. One triploid was produced from "Harehime", one tetraploid, "Amakusa", and one tetrapoid, "Benibae". There were little differences in leaf shape, thickness, petiole length, and internode length between diploids and polyploids such as tri- or tetraploid. However, polyploids had larger stomata and lower density of stomata in abaxial epidermis than diploids. SPAS indicating chlorophyll con tent and photosynthetic rate were significantly affected by ploidy level. The results indicated that spontaneous polyploids might be produced by open pollination in some mandarin hybrids and monoembryony had higher frequency in polyploid occurrence than polyembryony.