Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes

Jeong Hannah,Kim Jwa-Young,Che Xiangguo,Choi Je-Yong,Jang Insan,Kim Seong-Gon 대한치과교정학회 2023 대한치과교정학회지 Vol.53 No.6

Objective: To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models. Methods: Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group). The remaining 20 healthy rats were divided into control and 4HR groups. We administered 4HR subcutaneously at a weekly dose of 10 mg/kg until the rats were euthanized. At 16 weeks of age, whole blood was collected, and micro-computed tomography of the skull and femur was performed. Results: All craniofacial linear measurements were smaller in the STZ group than in the control group. The mandibular molar width was significantly smaller in the 4HR group than in the control group (P = 0.031) but larger in the STZ/4HR group than in the STZ group (P = 0.011). Among the diabetic animals, the STZ/4HR group exhibited significantly greater cortical bone thickness, bone mineral density, and bone volume than the STZ group. Serum testosterone levels were also significantly higher in the STZ/4HR group than in the STZ group. Conclusions: 4HR administration may have divergent effects on mandibular growth and bone mass in healthy and diabetic rats. In the context of diabetes, 4HR appears to have beneficial effects, potentially through the modulation of mitochondrial respiration.

Solitary Median Maxillary Central Incisor를 가진 II급 부정교합 치험례

정한나(Hannah Jeong),장인산(Insan Jang),최동순(Dong-Soon Choi) 대한구순구개열학회 2023 대한구순구개열학회지 Vol.26 No.2

Solitary median maxillary central incisor (SMMCI) is a rare congenital anomaly characterized by the absence of one of the maxillary central incisors, with the remaining incisor positioned centrally in the midline. While SMMCI can manifest independently, it can also be associated with holoprosencephaly, a condition resulting from incomplete or failed separation of the cerebral hemispheres. A 14.9-year-old female patient presented with a congenital absence of one maxillary central incisor and an anterior overjet of 14.3 mm. She was diagnosed with Class II division 1 malocclusion with SMMCI. The treatment approach included the extraction of the SMMCI and orthodontic treatment using the fixed orthodontic appliances. Following the orthodontic treatment, there was a notable enhancement in anterior occlusion and aesthetics, with proper space distribution for restorative procedures in the maxillary anterior region.

엄마대학원생의 학업 : 육아 양립 경험에 관한 현상학적 연구

서정원(Jeong-one Hannah Seo) 한국여성정책연구원 2015 여성연구 Vol.89 No.-

본 연구가 주목한 엄마대학원생은 엄마와 대학원생의 역할을 동시에 수행하는 여성으로 그동안 학문적으로 알려진 바가 매우 제한적이었다. 이에 대해 연구는 엄마대학원생들의 학업 - 육아 양립의 경험을 심층적으로 탐구하고자 현상학적 연구를 수행하였다. 그 결과 엄마대학원생은 제한된 시간과 물리적 힘을 두고 대학원생의 역할과 엄마의 역할이 경합하는 역할갈등을 경험한다는 것을 발견하였다. 엄마대학원생은 우선, 대학원생인 엄마로서 생산과 재생산의 딜레마, 우울감과 자격지심, 모성비난과 자책감을 경험한다. 또 자녀를 보육시설에 맡기고 공부를 할 수 밖에 없는 상황에 대해 주변으로부터 받는 나쁜 엄마라는 모성비난과 자신의 욕심 때문에 자녀를 희생시킨다는 자책감도 공부하는 엄마이기 때문에 겪게 되는 경험으로 나타났다. 다음, 엄마인 대학원생으로서 대학원동료와 교수의 이해부족을 대면하게 되고, 대학원과 어린이집이라는 상이한 시간체계를 살고, 엄마대학원생의 젠더수행이 고려되지 않은 공간에서 모성성의 소외를 경험한다. 이러한 발견을 통해 국외의 연구에서 나타난 부분과 유사점도 있지만, 국내 대학원 교육의 특성에 따른 상이한 경험들도 있는 것으로 나타났다. Graduate student parents are a newly emerging population with the increase of higher education for females; the time period for a female to accumulate human capitals as the next generation of the academia overlaps with the time period for reproduction. Graduate student moms are in charge of both tasks as a graduate student and a mother at the same time. However, the government and the higher educational institutions are not equipped with the supportive policies and programs for them to help keeping the balance between the different tasks in the academia and home. Therefore, the mothers are under the circumstance of having a lack of understanding from the colleagues and their supervisors. And, they are having a difficulty handling different time schedules of daycare and the graduate school programs. Besides, student moms are marginalized on campus where maternity and gender performances are not considered. Also, their existential distresses, the insecure feeling of not-belonging either group, are reported to have been caused by their financial helplessness, dual duties, and the isolation from the institution.

Enhanced Production of Recombinant Proteins in Escherichia coli Through rnpA Gene Knockdown

Hannah CHUNG,Jiyong KIM,Yong Jae LEE,Kyeong Rok CHOI,Ki Jun JEONG,Geun-Joong KIM,Hanwen XU,Sang Yup LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

Virtual surgical planning and patient-specific implant design system for fractured orbital wall reconstruction

Hannah Kim(김한나),Hyun A Kim(김현아),Tae-guen Son(손태근),Hyunchul Cho(조현철),Jerome Charton(샤통 제롬),Woo Shik Jeong(정우식),Jong Woo Choi(최종우),Youngjun Kim(김영준) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11

Orbital wall is the thinnest bone that surrounds eyeballs. When there is an external force to mid-upper face, it is blown out to protect the eye from the pressure. Orbital fracture is a common traumatic deformity, but it can cause not only functional problems, but also esthetical problems such as exophthalmos or enophthalmus, and diplopia. The surgeon corrects eyeball position by placing plates to the fractured sites, but limited intra-operative view and complex anatomy make it difficult. 3D surgical software systems have been used for seeming the patient safety and getting reliable outcomes. However, these are not specialized for the surgery and time-consuming manual works are needed frequently. Thus, we propose a virtual surgical planning and implant design system. We focus on increasing usability by automated functions and minimized user interaction. There are four main modules in the proposed system. First, 3D patient’s model is automatically reconstructed from CT data, and the next, the fractured region is detected and visualized by registration of both orbits. Based on the detected area, patient-specific implant is designed using template models. After the surgery, pre-and post-operative 3D models can be compared and analyzed by using synchronized dual view, measurement tools and visualization of the difference of both models. We performed visual inspection for 3D modeling and fractured detection. As a result, the orbital wall of 3D facial model is properly reconstructed without unnecessary holes and the detected regions include real fractured sites properly. The average processing time takes about 4 minutes. In comparison with conventional systems, ours covers most functions and has strengths for automated functions such as orbital wall segmentation and fracture detection. We expect that the automated and optimized functions can reduce pre-operation time and improved surgical outcomes can be derived by using patient-specific 3D printed implant.

Nanomaterial for Skeletal Muscle Regeneration

Jeong Gun-Jae,Castels Hannah,Kang Innie,Aliya Berna,Jang Young Charles 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.2

Skeletal muscle has an innate regenerative capacity to restore their structure and function following acute damages and injuries. However, in congenital muscular dystrophies, large volumetric muscle loss, cachexia, or aging, the declined regenerative capacity of skeletal muscle results in muscle wasting and functional impairment. Recent studies indicate that muscle mass and function are closely correlated with morbidity and mortality due to the large volume and location of skeletal muscle. However, the options for treating neuromuscular disorders are limited. Biomedical engineering strategies such as nanotechnologies have been implemented to address this issue. In this review, we focus on recent studies leveraging nano-sized materials for regeneration of skeletal muscle. We look at skeletal muscle pathologies and describe various proof-of-concept and pre-clinical studies that have used nanomaterials, with a focus on how nano-sized materials can be used for skeletal muscle regeneration depending on material dimensionality. Depending on the dimensionality of nano-sized materials, their application have been changed because of their different physical and biochemical properties. Nanomaterials have been spotlighted as a great candidate for addressing the unmet needs of regenerative medicine. Nanomaterials could be applied to several types of tissues and diseases along with the unique characteristics of nanomaterials. However, when confined to muscle tissue, the targets of nanomaterial applications are limited and can be extended in future research.

SVR Rate (12 Weeks and 1 Year) and Improvement of Fibrosis after Daclatasvir/Asunaprevir Treatment in Gen-otype 1b HCV-Infected Patients

( Hannah Ra ),( Seung Kak Shin ),( So Jeong Kim ),( Gyu Cheon Kyung ),( Youn-i Choi ),( Oh Sang Kwon ),( Jong-beom Shin ),( Young-joo Jin ),( Jin-woo Lee ),( Sangheun Lee ),( Ki Jun Han ),( Young Nam 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The long term data with daclatasvir (DCV)/asunaprevir (ASV) treatment for genotype 1b (GT1b) HCV-infected patients was not reported in Korea. This study investigated the efficacy in virologic response (SVR12 and SVR_48~60), improvement of liver function and fibrosis markers after DCV/ASV treatment. Methods: HCV GT1b patients who had not resistant associated substitute (RAS) were enrolled in 5 tertiary Korean hospitals. A total of 287 patients treating with DCV/ASV were observed for SVR₁₂. Virologic response was measured at 12 weeks (SVR₁₂), and 48-60 weeks (SVR_48-60) after the end of treatment. In patients with cirrhosis, liver function, aspartate transaminase to platelet ratio index (APRI), FIB-4 index, fibrosis index (FI), and liver stiffness measurement (LSM) were compared between before and after treatment (at SVR_48-60). Results: SVR₁₂ was obtained in 97.6% (280/287) patients. Among them, 189 patients were observed for SVR_48-60. Baseline characteristics (n=189): age (55±11 years), male 91(48%), cirrhosis 57(30.2%), treatment-naive 135(71.4%), ALT (58±53 IU/L), and HCV RNA (1,738,132±2,279,517 IU/mL) were shown. SVR_48-60 was obtained in 96.8 % (183/189) patients. In cirrhotic patients (n=57), changes of ALT (52±36 to 25±13 IU/L, P<0.001), total bilirubin (1.0±0.8 to 0.9±0.5 mg/dL, P=0.112), albumin (3.9±0.7 to 4.2±0.5 g/dL, P=0.003), and platelet (130±96 to 144±80 103/mm3, P=0.132) were observed. The changes of APRI score (2.1±0.3 to 0.8±0.1, P<0.001), FIB-4 index (7.2±0.9 to 3.7±0.4, P<0.001), FI (2.8±0.2 to 2.4±0.2, P=0.021), and LSM (n=16, 19.3±3.1 to 13.0±2.0 kPa, P=0.015) were observed. The characteristics of patients who failed SVR_48~60 (n=6) were such as: age 62(47-78) years, female 5(83%), treatment-naive 3(50%), cirrhosis 2(33%), ALT 40(14- 62) IU/L, HCV RNA 2,599,557(459,017-12,149,394) IU/mL. Conclusions: DCV and ASV treatment for HCV GT1b infected Korean patients without RAS achieved high SVR rates. However, 3% patients who achieved SVR₁₂ failed in SVR_48~60. The cirrhotic patients with SVR_48~60 showed improvement of liver function and fibrosis markers.

IMAGE OF INTEREST : Widespread intracranial calcifications in a patient with hypoparathyroidism

( Jeong Young Seo ),( Ju Hyun Seo ),( Younghee Choe ),( Hannah Seok ),( Tae Seo Sohn ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2

Global gene expression analysis of cell-free RNA in amniotic fluid from women destined to develop preeclampsia

( Hannah Kim ),( Yong Wook Jung ),( So Hyun Shim ),( Yun-jeong Shin ),( Sung Han Shim ),( Sung Woon Chang ),( Dong Hyun Cha ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Preeclampsia(PE) is disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. There is no definite treatment for PE except delivery of the placenta. Purpose of this study was to elucidate the biological pathways involved in the development of PE and to discover a novel biomarker for PE by performing global gene expression analysis of amniotic fluid cell-free RNA. Methods: Participants were recruited at CHA Gangnam Medical Center for 12 months. 8 samples were collected from 8 subjects at second trimester who were later diagnosed with PE. From amniotic fluid samples, cell-free RNA extraction was performed and gene expression was analyzed using the GeneChip PrimeView Array. Transcriptome data previously analyzed by our group from 9 euploid mid-trimester amniotic fluid samples were used as the control for comparative analysis. Functional analysis of the probe sets was performed using the online Database for Annotation, Visualization, and Integrated Discovery(DAVID) toolkit. Results: We identified 1841 differentially expressed genes(DEGs) between PE and control group. 1557 genes were upregulated in PE group and 284 genes were upregulated in control. Functional annotation of DEGs identified specific enriched functions such as transport, signal transduction, and stress response. Functional annotation clustering with enriched genes in PE group revealed that translation-related genes, cell-cell adhesion genes, and immune-related genes were enriched. KEGG pathway analysis showed that several biological pathways, including ribosome pathway and various immune pathways, were dysregulated. Several genes, including RPS29, IGF-2, and UBC, were significantly upregulated in PE, up to tenfold. Conclusion: This study provides first genome-wide expression analysis of amniotic fluid cell-free RNA in PE. Results showed that gene expression involving ribosome pathway and immunologic pathways are dysregulated in PE. Our results will aid in understanding the underlying pathogenesis of PE.

여성 목소리로 경상도 사투리를 구사하는 AI 음성비서의 사용자 경험

이한나(Hannah Yi),이희주(Heeju Lee),전민경(Mingyeong Jeon),정유진(Yujin Jeong),장순규(Soonkyu Jang) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2

표준어를 구사하는 대부분의 AI 어시스턴트와 달리 여성 목소리로 경상도 사투리를 구사하는 AI 음성비서의 사용자 경험을 바탕으로 성별에 따른 사용자 반응 연구를 하였다. 연구는 여성 사투리 음성 AI 가 성별에 따른 사용자에게 미치는 영향에 대해 수집하는데 집중하였다. 연구 결과 남성 사용자들은 긍정적인 반응을 보였으며, 반면에 여성 사용자는 남성사용자에 반해 부정적인 반응을 보였다. 남성 사용자들은 여성 사투리 음성 AI의 추후 사용에도 긍정적인 반응을 나타낸다는 것을 확인하였다.