Effects of a Portable Computerized Cognitive Training System on the Visual-perceptual Function of Stroke Patients with Mild Cognitive Impairment : A Pilot Study

Min-Jae Jeon(전민재),Jong-Hoon Moon(문종훈) 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회논문지 Vol.13 No.8

본 연구는 휴대용 전산화 인지훈련 시스템이 경도 인지손상이 있는 뇌졸중 환자의 시지각에 미치는 효과를 알고자 하였다. 재활병원에 입원 중인 경도인지 손상이 있는 12명의 뇌졸중 환자가 본 연구에 참여하였다. 모든 대상자들은 실험군과 대조군으로 6명씩 할당되었다. 모든 대상자들은 실험군 또는 대조군의 훈련을 하루 30분, 주 5회, 4주 동안 수행하였다. 실험군은 휴대용 전산화 인지훈련 시스템을 실시하였으며, 대조군은 보편적인 인지훈련을 수행하였다. 시지각을 측정하기 위하여, MVPT-3(Motor-Free Visual Perception-3)을 측정하였다. 연구 결과, 두 군은 중재 전과 후로 MVPT-3 total score에서 유의한 향상을 보였다(p<.05). 두 군 간 변화량 비교에서 실험군은 대조군보다 MVPT-3 total score와 visual short-term memory of sub-item of MVPT-3에서 유의하게 더 큰 향상을 보였다(p<.05). 이러한 결과는 휴대용 전산화 인지훈련 시스템이 경도인지손상이 있는 뇌졸중 환자의 시지각 능력 향상에 긍정적인 효과를 이끌어 낼 수 있는 중재방법이 될 수 있음을 시사한다. This pilot study investigated the effects of a portable computerized cognitive training system on the visual-perceptual function of stroke patients with mild cognitive impairment. Subjects were twelve stroke patients with mild cognitive impairment, who were assigned to an experimental group (n=6) or a control group (n=6). All subjects were trained in their respective groups for 30 min/day, five times a week, for four weeks. In each session, the experimental group received a portable computerized cognitive training program, and the control group received conventional cognitive training. The Motor-Free Visual Perception-3 (MVPT-3) was used to measure subjects’ visual-perceptual ability. The MVPT-3 total scores for both groups significantly improved after the intervention (p<.05). The total score on the MVPT-3 and the score on the visual short-term memory subcategory of the MVPT-3 significantly improved for the experimental group compared to the control group (p<.05). These findings suggest that the portable computerized cognitive training system might be effective to improve the visual-perceptual function of stroke patients with mild cognitive impairment.

이산화티타늄계 광촉매를 이용한 벤젠의 처리 특성

전의찬,송민종,김전희 동신대학교 환경연구소 1999 환경연구 Vol.4 No.1

An available methods for abating VOC(including Benzene) are thermal or catalytic incineration, liquid absorption, solid adsorption, condensing, membranes, biodegradation and plasma discharge, but a number of defects are these VOC abating methods, including ; requires a auxiliary fuel, generate secondary pollutants(waste catalysts, waste absorbents, waste adsorbents, ozone, etc.), a large scale, etc.. But photoactive catalysts, when illuminated with UV-light, generate highly reactive radicals that can oxidize the organic contaminants in gas. One methods to increase the efficiency of the process, and thereby reduce the light energy requirement, is by developing more active catalysts. Because of, ball type TiO₂ catalyst were obtained commercially and/or prepared in laboratory were examined for their photoacivity, and they are TiO₂ added some annex(Al₂O₃, SiO₂, KsO, P₂O_(5), etc.). The organic compounds used to identify the best photo catalysis condition were benzene. This study also examined the impact of catalyst structure, light intensity, existence of oxygen as an electron acceptor and Benzene initial concentration on the reaction kinetics. Labratory experiments were performed to investigate TiO₂ photo catalysis for treating test gas contaminated with Benzene. and TiO₂ photo catalysis efficiency for mineralization of Benzene is also evaluated. The photo oxidation of Benzene was carried out in a photo catalytic reactor at room temperature. I performed BTX photo catalytic oxidation experiments using a single-pass annular reactor. The organic-contaminated gas was prepared in Teflon sampling bag(25L) and passing through photo catalytic reactor by vacuum pump which is located reactor outlet. The BTX diluted with mixture air or nitrogen gas. Flow rates for test gas stream were controlled by micro flow meter going out the reactor. The reactor illuminated with 15W near-UV lamp, BLB lamp or Fluorescent lamp. The light intensity at the catalyst surface were estimated to be 0.8 to 6mW cm-2s-1. The inner cell of the reactor was packed with ball type titanium dioxide(Ø 6mm). Benzene was determined by GC-FID of gas samples taken from the a glass sampling bulb which was located at reactor outlet by gas-tight syringe. TiO₂ photo catalysis for treating test gas contaminated with Benzene. and TiO₂ photo catalysis efficiency for mineralization of Benzene is also evaluated. Using the anatase type photo catalyst, Benzene conversion rate is greater than that of rutile(92% conversion of 100ppmv Benzene using anatase type photo catalyst, 80% conversion of 100ppmv Benzene using rutile type photo catalyst at 0.5L/min) Effect of light intensity on the rate of Benzene photo catalytic decomposition was investigated by three type lamps within the reactor. When light intensity to increase, the Benzene conversion rate to increase. Using the BLB lamp showed higher activity than the Fluorescent lamp, but UV lamp showed the hight photo catalytic activity(26% conversion of 100ppmv Benzene with Fluorescent lamp, 63.5% conversion of 100ppmv Benzene with BLB lamp, 92% conversion of 100ppmv Benzene with UV lamp at 0.5L/min). Experiments with added oxygen as an electron acceptor improved the reaction rate considerably(92% conversion of 100ppmv Benzene without oxygen, 66.1% conversion of same Benzene concentration with mixture air at 0.5L/min). The Benzene conversion rate begins to decrease while Benzene initial concentration begins to increase. We have thus concentrated our effects on the study of Benzene degradation kinetics in vary initial Benzene concentration.

이산화티타늄계 광촉매를 이용한 톨루엔의 처리 특성

전의찬,송민종,김전희 동신대학교 환경연구소 2000 환경연구 Vol.5 No.1

각종 급ㆍ만성의 건강장해를 일으킬 뿐만 아니라, 광화학 반응에 의해 오존을 형성하는 것으로 알려진 휘발성유기화합물 중 대표적인 물질인 톨루엔을 광촉매산화법으로 처리할 경우 최적 처리조건을 분석하고자 광촉매의 결정구조, 광원의 세기, 전자수용체로서 산소의 유무 등에 따른 톨루엔의 처리효율을 분석하였다. 실험결과 루틸령 결정구조에 비해 아나타제형 결정구조를 갖는 이산화티타늄의 톨루엔 처리효율이 높게 나타났으며, 광원의 세기가 높을수록 전자수용체로서 산소가 존재할 경우 높은 처리효율을 나타내었다. 시간과 공간적인 제약으로 물, 오존 그리고 증기와 같은 다양한 전자수용체가 존재할 경우의 톨루엔의 처리효율을 파악하지 못하였으며, 온도, 습도 및 촉매활성에 영향을 주는 여러 가지 인자들을 대상으로 그것들의 변화에 따른 처리효율의 고찰을 못하였다. 앞으로 보다 효율적인 이산화티타늄계 광촉매의 제조방법 개발과 이산화티타늄계 광촉매를 이용한 다양한 VOC 처리방법의 개발이 요구된다. An available methods for abating VOC(including Toluene) are thermal or catalytic incineration, liquid absorption, solid adsorption, condensing, membranes, biodegradation and plasma discharge, but a number of defects are these VOC abating methods, including ; requires a auxiliary fuel, generate secondary pollutants(waste catalysts, waste absorbents, waste adsorbents, ozone, etc.), a large scale, etc.. But photoactive catalysts, when illuminated with UV-light, generate highly reactive radicals that can oxidize the organic contaminants in gas. One methods to increase the efficiency of the process, and thereby reduce the light energy requirement, is by developing more active catalysts. Because of, ball type TiO2 catalyst were obtained commercially and/or prepared in laboratory were examined for their photoacivity, and they are TiO2 added some annex(Al203, SiO2, KsO, P205, etc.). The organic compounds used to identify the best photocatalysis condition were toluene. This study also examined the impact of catalyst structure, light intensity, existence of oxygen as an electron acceptor and Toluene initial concentration on the reaction kinetics. Labratory experiments were performed to investigate TiO2 photocataysis for treating test gas contaminated with Toluene. and TiO2 photocatalysis efficiency for mineralization of Toluene is also evaluated. The photooxidation of Toluene was carried out in a photocatalytic reactor at room temperature. I performed Toluene photocatalytic oxidation experiments using a single-pass annular reactor. The organic-contaminated gas was prepared in teflon sampling bag(25L) and passing through photocatalytic reactor by vacuum pump which is located reactor outlet. The Toluene diluted with mixture air or nitrogen gas. Flow rates for test gas stream were controlled by micro flow meter going out the reactor. The reactor illuminated with 15W near-UV lamp, BLB lamp or Fluorescent lamp. The light intensity at the catalyst surface were estimated to be 0.8 to 6㎽ ㎝-2s-1. The inner cell of the reactor was packed with ball type titanium dioxide(φ 6㎜). Toluene was determined by GC-FID of gas samples taken from the a glass sampling bulb which was located at reactor outlet by gas-tight syringe. TiO2 photocataysis for treating test gas contaminated with Toluene. and TiO2 photocatalysis efficiency for mineralization of Toluene is also evaluated. Using the anatase type photocatalyst, Touene conversion rate is greater than that of rutile(86.1% conversion of 100ppmv Toluene using anatase type photocatalyst, 78% conversion of 100ppmv Touene using rutile type photocatalyst at 0.5L/min) Effect of light intensity on the rate of Toluene photocatalytic decomposition was investigated by three type lamps within the reactor. When light intensity to increase, the Toluene conversion rate to increase. Using the BLB lamp showed higher activity than the Fluorescent lamp, but UV lamp showed the hight photocatalytic activity(19.1% conversion of 100ppmv Toluene with Fluorescent lamp, 60.4% conversion of 100ppmv Toluene with BLB lamp, 86.1% conversion of 100ppmv Toluene with UV lamp at 0.5L/min). Experiments with added oxygen as an electron acceptor improved the reaction rate considerably(86.1% conversion of 100ppmv Toluene without oxygen, 62.5% conversion of same Toluene concentration with mixture air at 0.5L/min).

금불초 종(種) 및 개화시기에 따른 금불초 꽃 추출물의 항산화 효능

권순식 ( Soon Sik Kwon ),전소하 ( So Ha Jeon ),전지민 ( Ji Min Jeon ),천종우 ( Jong Woo Cheon ),박수남 ( Soo Nam Park ) 대한화장품학회 2013 대한화장품학회지 Vol.39 No.3

본 연구에서는 금불초(Inula britannica) 종(種) 및 개화시기에 따른 금불초 추출물의 항산화 효능을 알아보았다. 이들 추출물의 free radical 소거활성을 살펴본 결과, 만개한 금불초 꽃(I. britannica var. chinensis) 추출물의 경우 500 μg/mL의 농도에서 79.89%의 free radical 소거활성을 보였으나, 금불초 유사종인 가는 금불초(I. britannica var. linariaefolia Regel), 가지 금불초(I. britannica var. ramosa) 및 버들 금불초(I. salicina var. asiatica)의 꽃 추출물의 경우 free radical 소거활성이 거의 나타나지 않았다. 또한 꽃이 만개하였을 경우 꽃 추출물 분획에서는 93.62%의 free radical 소거활성을 보였으며, 봉우리 추출물 분획은 43.28%, 낙화추출물 분획은 14.11%를 나타냈다. 금불초의 종 및 개화시기를 선정 후, 추출용매, 온도, 시간을 조절하여 최적의 추출조건을 확립하였다. 그 결과, 65 ℃ 에탄올 추출물에서 가장 높은 DPPH free radical 소거활성이 나타났으며, 시간에 따른 유의적 차이는 없는 것으로 나타났다. 만개한 금불초 꽃 추출물에 대하여 rose-bengal로 증감된 사람 적혈구의 광용혈 실험에서 세포보호효과를 측정한 결과, 5 ~ 50 μg/mL의 범위에서 농도 의존적으로 세포 보호 효과를 나타내었다. 특히 50 μg/mL의 농도에서 τ50이 116.1 min으로 비교물질인 (+)-α-tocopherol에 비해 1.58배 더 큰 세포 보호활성이 있음을 알 수 있었다. HPLC로 금불초 꽃 추출물을 분석한 결과 flavonoid의 일종인 quercetin이 다량 함유되어 있는 것을 확인하였다. 이상의 결과들은, 65 ℃ 에탄올로 추출한 만개한 금불초 꽃 추출물의 경우 다량의 quercetin을 함유하며, 그로 인하여 free radical 소거활성 및 ROS에 대항하여 세포막을 효과적으로 보호함으로써 태양 자외선에 노출된 피부를 보호하는 항산화제로서 작용할 수 있을 것으로 사료되며, 기능성 화장품 원료로서 응용 가능성이 있음을 시사한다. In this study, antioxidative effects of the extracts of different species and flowering periods of Inula britannica were investigated. According to the free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity of the extracts, The I. britannica var. chinensis flower extract (500 μg/mL) was measured in a 79.89% free radical scavenging activity, but the flower extracts of similar species (I. britannica var. linariaefolia Regel, I. britannica var. ramosa, I. salicina var. asiatica) did not show any effect on the free radical scavenging activity. The effects of the free radical scavenging activity of I. britannica var. chinensis flower extracts were exhibited in the order of full bloom (93.68%), bud (43.28%), and fallen blossom (14.11%). Next, we established optimum condition of extract solvent, temperature, extraction time. The extract from ethanol at 60 ℃ showed the most free radical scavenging activity among other conditions and extraction time not relevant in free radical scavenging activity. The protective effects of the extract of I. britannica var. chinensis flower on the photohemolysis of human erythrocytes by using rose bengal were increased in a concentration-dependent manner (5 ∼ 50 μg/mL). In particular, the extract in 50 μg/mL concentration exhibited better protective activity (τ₅₀ = 116.1 min) than (+)-α-tocopherol (τ₅₀ = 73.44 min), which is a known lipophilic antioxidant. Principle component of I. britannica var. chinensis flower was identified as quercetin of flavonoids by high-performance liquid chromatography (HPLC). These results indicate that the extract of I. britannica var. chinensis flower can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging free radical and ¹O₂, and protect cellular membranes against ROS. It is concluded that the antioxidative effects of the extract of I. britannica var. chinensis flower could be applicable to functional cosmetics.

원산지별 감초추출물의 항산화활성 증가를 위한 효율적인 추출조건 탐색

하지훈 ( Ji Hoon Ha ),이혜미 ( Hye Mi Lee ),권순식 ( Soon Sik Kwon ),김해수 ( Hae Soo Kim ),김문진 ( Moon Jin Kim ),전소하 ( So Ha Jeon ),정유민 ( Yoo Min Jeong ),황준필 ( Jun Pil Hwang ),박종호 ( Jong-ho Park ),최영기 ( Yung-key 대한화장품학회 2013 대한화장품학회지 Vol.39 No.4

본 연구에서는 한국 및 중국산 감초(Glycyrrhiza uralensis), 그리고 우즈베키스탄산 감초(Glycyrrhiza glabra)를 대상으로 추출용매, 추출온도, 추출시간 등 추출조건별 추출물을 제조하고 이들 추출물들의 추출 수율과 항산화 활성을 비교하여 최적의 추출조건을 선정하였다. 항산화 활성 중 자유 라디칼(1,1-phenyl-2-pic-rylhydrazyl, DPPH) 소거활성은 85% 에탄올로 60 ℃에서 6 h 동안 추출한 조건에서 한국 감초로부터 얻은 추출물이 가장 높은 활성(46.05%)을 나타내었다. 루미놀 발광법을 이용한 추출물들의 총 항산화능 측정 실험과 피부 광노화에 중요한 ¹O₂으로 유도된 세포막 손상에 대한 추출물들의 세포 보호 효과를 측정한 실험 모두에서도 위의 조건에서 가장 높은 항산화 활성을 나타내었다. 특히, 한국 감초는 τ₅₀이 116.4 min으로 비교 물질인(+)-α-tocopherol (28.5 min)보다 약 4 배나 높은 세포 보호 효과를 나타내었으며, 추출 수율은 18.75%로 우즈베키스탄 및 중국 감초보다 각각 1.2 배 및 2.5 배의 추출 수율을 나타내었다. 따라서, 본 연구 결과는 항산화 소재로 화장품에 응용하기 위하여 감초로부터 추출물을 얻기 위한 최적의 조건은 85% 에탄올로 60 ℃에서 6시간 동안 추출하는 것임을 보여주었다. In this work, licorice extracts were prepared using various extraction conditions such as extraction solvent, temperature, and time from Glycyrrhiza uralensis (G. uralensis) produced in Korea and China and Glycyrrhiza glabra (G. glabra) in Uzbekistan. The optimum extraction condition was selected from the extraction yields and antioxidative activities of extracts. Korea licorice extracts showed the highest free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scav-enging activity (46.05%) under the extraction condition of 85% ethanol at 60 ℃ for 6 hours. The prominent ROS (reactive oxygen species) scavenging activity using luminol-dependent chemiluminescence assay and the cellular protective effect against ¹O₂ induced cellular membrane damage were also shown from the extracts obtained from the same condition. Especially, Korea G. uralensis extracts exhibited the higher prominent protective effect (τ₅₀ = 116.4 min) than (+)-α-tocopherol (τ₅₀ = 28.5 min) and the extraction yield of Korea licorice extract was 18.75%, which is 1.2 times and 2.5 times higher than that of Uzbekistan and China, respectively. These results indicate that the extraction condition of 85% ethanol at 60 ℃ for 6 hours is optimal to prepare licorice extracts, which can be applicable as antioxidative cosmetic materials.

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

2000년대 광주광역시의 이동오염원 배출량 예측 연구

전의찬,송민종 東新大學校 工業技術硏究所 1997 工業技術硏究 Vol.3 No.-

For estimation of air pollutants emmision from mobile sources in Kwangju, we classified type of mobile sources as vehicles, railway trains, aircrafts and estimated quantity of air pollutants emmision in mobile sources in 1995 and 2002. Using NO₂ as a base, it is estimated that mobile sources emitted 17,309 ton/yr of air pollutants in 1995, as compared to 22,107 ton/yr estimate for 2002. It is also revealed that private cars were the source of 99% of air pollutants.

EFFECTS OF VIRTUAL REALITY COMBINED WITH BALANEC TRAINING ON UPPER LIMB FUNCTION, BALANCE, AND ACTIVITIES OF DAILY LIVING IN POST-STROKE : A PRELIMINARY STUDY

Jong-Hoon Moon,Min-Jae Jeon,Bo-Kyun Kim,Hwi-young Cho 한국엔터테인먼트산업학회 2019 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2019 No.11

The aim of this preliminary study was to investigate the effects of virtual reality combined with balance training on upper limb function, balance, and activities of daily living (ADL) in patients with acute stroke. The both groups received conventional rehabilitation for 30 min/days, 5 times a week, for 4 weeks. Additionally, the experimental group received 30 minutes of virtual reality training on unstable surface for each session, while the control group received 30 minutes of virtual reality training without unstable surface. To examine the upper limb function, balance, and ADL, the study used Manual Function Test (MFT), Berg Balance Scale (BBS), and Korean Modified Barthel Index (KMBI), respectively. The both groups showed significant improvements in MFT, BBS, KMBI before and after the intervention. The experimental group showed no significant difference in MFT, BBS, K-MBI after intervention compared with the control group. In the changes of fall risk, the experimental group showed a greater decrease in numbers of fall risk (BBS <45) before and after intervention than the control group. These finding suggest that the virtual reality training combined with balance training may have a better effect on balance improvement than virtual reality training without balance training in post-stroke.

HIV 감염/AIDS을 처음 진단받은 환자들의 특성과 임상에서 보편적인 HIV 검진의 가치

김종화,김태형,추은주,전민혁,서성우,이용관,최문한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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생물학적 흡수법을 이용한 악취물질의 처리

전의찬,송민종 동신대학교 환경연구소 1997 환경연구 Vol.2 No.1

그 동안 악취를 유발하는 대표적인 물질의 하나인 황화수소의 처리에 대한 많은 연구가 수행되었다. 그러나 이들 연구의 대부분은 물리ㆍ화학적인 방법에 의존하고 있어 설치 및 운영에 경제적인 문제가 수반되었으며, 이에 따라 최근에는 활성슬러지법과 토양흡착 등 미생물을 이용한 생물학적 처리방법들이 연구되어지고 있다. 본 연구에서는 미생물의 부착이 용이한 섬모상충진층을 설치한 바이오스크러버를 이용하여 황화수소를 제거하고자 하였다. 실험결과 바이오스크러버에 의한 황화수소의 제거효율은 일반적인 스크러버을 이용한 제거효율보다 약 40% 높게 나타났으며, 황화수소의 유입농도 및 유입유량이 낮을수록 높게 나타났다. An odor that causes people displeasure and disgust and sometimes that has lead people to start demonstration. Among these odors, H2S is the worst smelling, therefore many people have started dup studies a researches to find a way to remove this odor. To remove this odor, researchers have began to develop a process which is called a bio-scrubber. These bio-scrubbers have been built and are in the process of being tested and compared with a general scrubber, to see if it is as economical and effective as the general scrubber. The test results shows that the bio-scrubber has a fixed flow of 5milliliter per min. The bio-scrubber was compared with the general scrubber in all three stage. The results show that the bio-scrubber removes more H2S in stage one, two and three than the general scrubber removal in the same three stages. Thus proving to be far more effective than its predecessor.