Electroactive nano-Biohybrid actuator composed of gold nanoparticle-embedded muscle bundle on molybdenum disulfide nanosheet-modified electrode for motion enhancement of biohybrid robot

신민규,최진하,Lim Joungpyo,Cho Sungwoo,Ha Taehyeong,Jeong Jae Hyun,최정우 나노기술연구협의회 2022 Nano Convergence Vol.9 No.24

There have been several trials to develop the bioactuator using skeletal muscle cells for controllable biobybird robot. However, due to the weak contraction force of muscle cells, the muscle cells could not be used for practical applica‑ tions such as biorobotic hand for carrying objects, and actuator of biohybrid robot for toxicity test and drug screen‑ ing. Based on reported hyaluronic acid-modified gold nanoparticles (HA@GNPs)-embedded muscle bundle on PDMS substrate, in this study for augmented actuation, we developed the electroactive nano-biohybrid actuator composed of the HA@GNP-embedded muscle bundle and molybdenum disulfide nanosheet ­(MoS 2 NS)-modified electrode to enhance the motion performance. The ­MoS 2 NS-modified Au-coated polyimide (PI) electrode to be worked in mild pH condition for viable muscle cell was utilized as supporting- and motion enhancing- substrate since it was electro‑ chemically active, which caused the movement of flexible PI electrode. The motion performance of this electroactive nano-biohybrid actuator by electrical stimulation was increased about 3.18 times compared with that of only HA@ GNPs embedded-muscle bundle on bare PI substrate. The proposed electroactive nano-biohybrid actuator can be applied to the biorobotic hand and biohybrid robot.

축냉재 포접화합물의 열물성에 관한 실험적 연구(Ⅲ) : 충전량 변화 Variations of Charging Conditions

임재경,고광옥,김진흥,정낙규,하옥남 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

The objective of this paper is to investigate the thermal properties of TMA-clathrate compound in order to applicate cold storage system to residential air-conditioning. Especially, the test tube experiments are performed by comparing and analyzing the concentration of TMA-clathrate compound, the temperature of heat source, and the phase change temperature, specific heat and subcooling characteristics on the point of the variation of charge capacity. The results are summarized as follows; 1) When the temperature of heat source is -15℃, the stability of the thermal properties is appeared high in the whole experiments 2) The effect of subcooling suppression is improved around 0.6℃ when the temperature of heat source is -15℃, while the teemperature of subcooling is about 2.2℃ when the temperature of heat source is -10℃. Especially, it did not almost present any subcooling in the 26wt% of the 5g and the 25wt%, 30wt% of the 10g. Thus, we concluded that TMA-clathrate compound has thermal properties as the cold storage medium for residential air-conditioning.

터키안와 및 상부 종양의 임상적 고찰

임재현,하은주,이종수,이승재,박효일 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.2

Tumorous lesion of intra- and suprasellar area showed unique clinical pictures and also was very hazardous and difficult to remove surgically because of the surrounding important anatomical structures. Here, authors analyzed 28 confirmed tumor of this area during last two and half years retrospctively. Histopathologically, 28 cases were classified in 14 pituitary adenoma cased6 cases of non-functioning adenoma, 1 GH-secreting adenoma and 7 cases of prolactinoma), 7 craniopharyngioma cases, 3 meninigioma cases and each one case of germinoma, Rathke's cleft cyst, pituitary abscess and hamartoma. Sexual incidence was 6 : 22 in male vs female ratio. Twenty two cases were measured its diameter over 2cm and they extended to suprasellar area in all cases. Five cases of microadenoma were analyzed and they were all enclosed in sella turcica. Visual impairment was the most frequent and prominent clinical symptom. of which incidence was 78.57% (22 cases). The next frequent symptoms were headache and generalized lethargy. Diabetes insipidus was a presenting symptom in 4 cases and hydrocephalus was noted in 4 cases preoperatively. Surgical intervention was carried out in 23 cases, by the way, the performed type of surgery in 21 cases was a conventional transcranial frontotemporal(pterional) microsurgical method. Post-operatively, diabetes insipidus was complicated in 78.26 % and pituitary hypofunction was noted 34.78%. Two cases of intracranial hemorrhage was developed after surgery and one was died. Through 6 to 28 months follow up. 82.1 % of cases were improved in its clinical status including 7 cured cases.

Possibility of Application of Artificial Insemination Buffer (AIB) for Increasing of Production Efficiency of Female Cow Offspring

Jae‐Il Bang,A‐Na Ha,A‐Ra Cho,Kyeong‐Lim Lee,MD. Fakruzzaman,Il‐Keun Kong 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1

The present research was carried out to evaluate the possibility of female offspring production using artificial insemination buffer (AIB) before artificial insemination (AI). To do it, we carried out the optimization of AIB, making of AIB gun and analysis of affecting AI rate after AIB treatment. AIB made with the base of Tris‐buffer supplemented with L‐arginine and several materials that could be reduced the motility of male sperm compared with female one. This mean that female sperm could be increased the possibility of fertilization with ovum compared with male one. AIB must be deposited into 2nd to 4th cervix by the guide of AIB gun. After 15 min of AIB insertion, frozen semen was deposited into same place after. Total 352 cattle were inseminated with AIB insemination and was not significant difference between AIB and traditional AI rate (56.8 vs. 55.7%). However, AIB AI rate was significantly differs among 12 different farms. The parturition number of cows did not effect on AIB AI rate among 1st to 7th parturition number of cows. The proportion of AIB AI success rates in hanwoo cows was significantly higher than in dairy cows (61.0% vs. 48.7%), but the average AI success rate was not different between AIB and conventional AI (56.8% vs. 55.7%). The female offspring production rate in 2nd to 4th cervix deposition place was significantly higher than in uterus body (77.7% vs. 59.6%, p<0.05). The injection volume of AIB in 5 and 10 ml was significantly higher than in 2 ml (77.7, 78.7 vs. 51.8%, p<0.05), but not different between 5 and 10 ml ABI volume. The best exposure time of AIB in the cervix was 10 and 15 min rather than that of 5 min (79.2%, 77.2% vs. 63.2%, p< 0.05), and so AIB have to expose at least 10 min to get higher female offspring. In conclusion, AIB could be used in AI industry to produce female offspring and also AIB AI can be increased the AI success rate compared with traditional AI rate.

유화중합을 이용한 4원공중합 바인더의 제조와 특성

임종민,하선희,임재길,설수덕 東亞大學校 大學院 2004 大學院論文集 Vol.29 No.-

Styrene-Acrylonitrile-Ethylacrylate-N-Methyloacryamide Prepared by emulsion polymerization has broad applications for additives such as paint binder, adhesive for wood and paper due to its low glass transition temperature which help to plasticize substrate resins. Since emulsion polymerization has disadvantage that surfactant and ionic initiator degrade properties of the product polymer, Poly(St-EA-AN-NMA) was synthesized using ammonium persulfate(APS) as catalyst and sodium lauryl sulfate(SLS) as emulsion to prevent the degradation. The copolymer binder product was internally plasticized and has enhanced colloid stability, adhesion, tensile strength and elongation. During binder emulsion polymerization, no coagulation and complete conversion occur with the reactant mixture of 3.34wt%/monomer ammonium persulfate, 2.33wt%/monomer sodium lauryl sulfate, and the balanced monomer that the weight ratio of Styrene, Ethylacrylate, Acrylonitrile are 47wt%/monomer, 32wt%/monomer, 6.4wt%/monomer. The activation energies for 37, 42, 47, 52% Styrene content were checked as 28.1~36kcal/mol by Kissinger's method. Actually, reasonable solid content could be considered as 56% because of activation energy and adhesive characteristics.

마이크로 콘트롤러를 사용한 극배치 PID 자기동조기의 구성

하재해,추연규,임영도,최부귀 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.2

In this paper, a speed controller using one-chip microcontroller is implemented and applied to a DC Servo Motor. Adaptive control is applied to a system for which a priori knowledge to its mathematical model is insufficient, on the basis of input and output data an apropriate controller is constructed through which the system input is synthesized. The pole-placement PID self tuning control algorithms as a control algorithm is used to research the performance of the controller through experiments.

진행성 골화성 섬유 이형성증의 1예

임태영,조영신,정춘해,박유환,하상호,유재원 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

진행성 골화성 섬유 이형성증은 2 백만명 중에 1명 발생하는 매우 드문 유전질환이다. 저자들은 2차례의 외상후 심해진 진행성 섬유 이형성증환자에서 최근 다시 발생된 외상후 생긴 병변부위에 biphosphonate와 steroid 투여로 최근수상부위의 근육 골화와 경화를 현저한 호전을 보였으나, 기존의 골화가 이미 진행된 병변에서는 잘 반응하지 않음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Fibrodysplasia ossificans progressiva(FOP) is an extremely rare hereditary disorder characterised by progressive heterotopic ossification of the soft tissue. The resulting progressive immobilization of the limbs, jaw and chest wall generally leads to severe disability. We present an 20-rear-old man with advanced FOP. He had two operative interventions by prior traffic accident and recent biopsy. It resulted abnormal ossification. Treatment for this disorder is avoidance of exacerbating factors and medical strategies is biphosphonate and steroid. We observed the course of ossification and muscle atrophy during biphosphonate and steroid therapy in advanced FOP.

도암호의 수질과 어류군집 특성 연구

이상하,최재석,이광열,장영수,임인수,허우명,김재구,김범철 강원대학교 부속 환경연구소 2005 Journal of the Environment Vol.2 No.-

To investigate nutrient dynamics of the lake and fish community, both water and fish samples were collected at three different areas (dam site, upper inflowing and downstream of lake outfow) for one year from Sep.2004 to Aug.2005 During the experimental periods, mean concentration of chl, a in epilimnetic layer (0-5m) was 18.5mg^(-3) and transparency ranged from 0.3m to 2.4m, respectively. In nutrient, mean concentrations of TP and TN were 111 mgP m^(-3) and 4.4 mgN L^(-1), respectively. Based on the water quality standard suggested by U.S.EPA(*1976), the trophic state of Lake Doam was classified as eutrophic state. Total number of fish collected in Lake Doam was 9,600 indiveduals in 26 species of 6 family. Sixteen of Korean endemic soecies including H. mylodon, A. signifer, P. tenuicorpa occurred. O. mykiss as introduced fish was also found in Lake Doam. Dominant and subdominant species were P. herzi and Z. platypus that took about 34.6% and 22.5% of total fish composition, respectively. Six species including A. signifer. P. tenuicorpa. and R. kumgangensis were rare in Lake Doam. Pelagic typw of figh commonly occurred at upper regions, whereas benthic type was mainly domenated at downstream area. Therefore, pollution source inflowed from the upper regions did not seriously affect downstream area (Songcheon water system) due to the role of dam as pollutant barrier. In addition high appearance of Comat type of fish that si hybrid between gold fish (C.auratus) and C. auratus was found in the lake, It was unclear the reasons that high prorortion of mutant species apperared in the lake. Further more researches are required in this area.

대전지역 소아 야뇨증에 관한 역학 조사

이재현,하용원,임재성,윤율로,설종구 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Purpose: Nocturnal enuresis is defined as at least one wet night per month in children older than five years of age. Despite being a common disorder in children, not many reports about prevalence of enuresis in Korea have been written. To establish the prevalence of childhood enuresis in Taejon, an epidemiologic study was performed. Materials and methods: We evaluated 1,030 preschool and elementary school children living in Taejon city. The ages were between 5 and 10 years-old and the mean age was 7.5 years-old. The percentage of boys was 52.4% and the girls' was 47.6%. The questionaires was completed by the parents. Results: The overall prevalence of enuresis in Taejon city was 7%. The prevalence of enuresis was higher in boys(54.2%) than in girls(45.8%). The prevalence of primary and secondary enuresis was 55.6% and 44.4%, respectively. The inability to wake up in order to void because of deep sleep was 29.2% and positive family history was 20.8%. On the aspect of enuretic frequency, one episode per month was most common. The cases combined with diurnal enuresis were 9.7%. Among the enuretic children, the most common traditional treatment was self-voiding by awakening during night and most favored treatment was herbal medicine. Conclusion: These data show that the prevalence of nocturnal enuresis in Taejon city is lower than in other countries. It's prevalence is related to the positive family history, guilt feeling, diurnal enuresis, and early sleeping. However, concerning the prevalence of enuresis, there is statistically significant difference only in family history.

축냉재 포접화합물의 열물성에 관한 실험적 연구 (IV) : 온도 변화 Changing of Temperature

고광옥,임재경,김창오,김진홍,정낙규,하옥남 조선대학교 에너지.자원신기술연구소 2000 에너지·자원신기술연구소 논문지 Vol.22 No.2

The objective of this paper is to investingate the thermal properties of TMA-clathrate applicable to cold storage system for building air-conditioning in order to use energy reasonably. Especially, the test tube experiments are performed by comparing and to analyzing the temperature of phase change, specific heat and subcooling characteristic according to the variation of concentrations and temperature of heat source in TMA clathrate. The result are summarized as follows; 1) temperature of phase change is dropped as the temperature of heat source is lower 2) specific heat of TMA-clathrate is about 24~95 % of pure-water 3) subcooling is smalled as the temperature of heat source is lower. Thus, it apears that TMA-clathrate has thermal properties as the cold storage medium for residential air-conditioning